morphinans and 1-1-diphenyl-2-picrylhydrazyl

morphinans has been researched along with 1-1-diphenyl-2-picrylhydrazyl* in 1 studies

Other Studies

1 other study(ies) available for morphinans and 1-1-diphenyl-2-picrylhydrazyl

Article	Year
Two new morphinane alkaloids from Sinomenium acutum. Journal of Asian natural products research, 2011, Volume: 13, Issue:6 Two new morphinane alkaloids, 1-hydroxy-10-oxo-sinomenine (1) and 4,5-epoxy-14-hydroxy sinomenine N-oxide (2), have been isolated from the stems of Sinomenium acutum. Their structures were established by various spectral analyses, especially 2D NMR experiments. The structure of 2 was confirmed by single crystal X-ray diffraction. The absolute configurations of 1 and 2 were deduced by comparison of CD spectra with the known alkaloid sinomenine (3). Compound 1 was tested for DPPH inhibition and gave IC(50) of 27.9 μM. Compound 2 was tested for neuroprotective effect and showed significant activity against β-amyloid(25-35)-induced oxidative injury (*P < 0.05) at 10 μM in PC-12 cells. Topics: Alkaloids; Animals; Biphenyl Compounds; Cyclic N-Oxides; Drugs, Chinese Herbal; Molecular Structure; Morphinans; Neuroprotective Agents; Nuclear Magnetic Resonance, Biomolecular; PC12 Cells; Picrates; Plant Stems; Rats; Sinomenium; X-Ray Diffraction	2011

Article

Year

Two new morphinane alkaloids from Sinomenium acutum.

Journal of Asian natural products research, 2011, Volume: 13, Issue:6

Two new morphinane alkaloids, 1-hydroxy-10-oxo-sinomenine (1) and 4,5-epoxy-14-hydroxy sinomenine N-oxide (2), have been isolated from the stems of Sinomenium acutum. Their structures were established by various spectral analyses, especially 2D NMR experiments. The structure of 2 was confirmed by single crystal X-ray diffraction. The absolute configurations of 1 and 2 were deduced by comparison of CD spectra with the known alkaloid sinomenine (3). Compound 1 was tested for DPPH inhibition and gave IC(50) of 27.9 μM. Compound 2 was tested for neuroprotective effect and showed significant activity against β-amyloid(25-35)-induced oxidative injury (*P < 0.05) at 10 μM in PC-12 cells.

Topics: Alkaloids; Animals; Biphenyl Compounds; Cyclic N-Oxides; Drugs, Chinese Herbal; Molecular Structure; Morphinans; Neuroprotective Agents; Nuclear Magnetic Resonance, Biomolecular; PC12 Cells; Picrates; Plant Stems; Rats; Sinomenium; X-Ray Diffraction

2011