morphiceptin has been researched along with naloxone in 32 studies
| Studies (morphiceptin) | Trials (morphiceptin) | Recent Studies (post-2010) (morphiceptin) | Studies (naloxone) | Trials (naloxone) | Recent Studies (post-2010) (naloxone) |
|---|---|---|---|---|---|
| 139 | 0 | 12 | 20,134 | 1,257 | 3,321 |
| Protein | Taxonomy | morphiceptin (IC50) | naloxone (IC50) |
|---|---|---|---|
| Cytochrome P450 2D6 | Homo sapiens (human) | 2 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.043 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0219 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.0397 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1896 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.05 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0795 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0154 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0089 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.0055 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (56.25) | 18.7374 |
| 1990's | 11 (34.38) | 18.2507 |
| 2000's | 2 (6.25) | 29.6817 |
| 2010's | 1 (3.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dornan, WA; Matuszewich, L | 1 |
| Członkowski, A; Widy-Tyszkiewicz, E | 1 |
| Macdonald, RL; Werz, MA | 3 |
| Basbaum, AI; Levine, JD; Perry, F; Taiwo, YO | 1 |
| Herblin, WF; Kauer, JC; Tam, SW | 1 |
| Kastin, AJ; Zadina, JE | 1 |
| Haddad, GG; Schaeffer, JI | 1 |
| Portoghese, PS; Takemori, AE | 1 |
| Gorzalka, BB; Pendleton, N; Pfaus, JG | 1 |
| Haddad, GG; Jeng, HJ; Lai, TL | 1 |
| Villiger, JW | 1 |
| Han, JS; Xie, CW | 1 |
| Billington, CJ; Gosnell, BA; Levine, AS; Morley, JE | 1 |
| Chang, JK; Chang, KJ; Cuatrecasas, P; Hazum, E; Lillian, A | 1 |
| Chang, JK; Pasternak, GW; Zhang, AZ | 1 |
| Day, AR; Freer, RJ; Liao, CS | 1 |
| Chang, JK; Chang, KJ; Cuatrecasas, P; Wei, ET | 1 |
| Han, JS; Li, SJ | 1 |
| Goodman, M; Malmberg, AB; Ro, S; Schiller, P; Yaksh, TL | 1 |
| Donahoe, RM; Ketelsen, D; Madden, JJ; Oleson, D; Whaley, WL | 1 |
| Aoki, Y; Katao, Y; Katsumata, S; Minami, M; Nakagawa, T; Onogi, T; Satoh, M | 1 |
| de Andrés, I; Reinoso-Barbero, F | 1 |
| Hull, EM; Lorrain, DS; Matuszewich, L; Moses, J; Ormsby, JL | 1 |
| Benyhe, S; Borsodi, A; Magyar, A; Medzihradszky, K; Rónai, AZ; Sartania, N | 1 |
| Rózsa, KS; Rubakhin, SS; Stefano, GB; Szücs, A | 1 |
| Joshi, S; Lee, JW; Wong, YH | 1 |
| Erdö, F; Fürst, S; Gyarmati, Z; Makó, E; Orosz, G; Rónai, AZ; Székely, JI; Timár, J; Tóth, G | 1 |
| Göcze, PM; Környei, JL; Kovács, KA; Vértes, M; Vértes, Z | 1 |
| Al-Khrasani, M; Benyhe, S; Kató, E; Kocsis, L; Lengyel, I; Orosz, G; Rónai, AZ; Tóth, G; Tóthfalusi, L | 1 |
| Dong, S; Li, M; Ma, G; Zhou, L | 1 |
32 other study(ies) available for morphiceptin and naloxone
| Article | Year |
|---|---|
Bilateral injections of a selective mu-receptor agonist (morphiceptin) into the medial preoptic nucleus produces a marked delay in the initiation of sexual behavior in the male rat.
Topics: Analgesics; Animals; Copulation; Depression, Chemical; Ejaculation; Endorphins; Injections; Male; Naloxone; Preoptic Area; Rats; Receptors, Opioid; Receptors, Opioid, mu; Sexual Behavior, Animal | 1992 |
Normotensive Wistar rats differ from spontaneously hypertensive and renal hypertensive rats in their cardiovascular responses to opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Blood Pressure; Endorphins; Heart Rate; Hemodynamics; Hypertension, Renal; Injections, Intraventricular; Male; Molecular Sequence Data; Naloxone; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Inbred Strains | 1991 |
Dynorphin and neoendorphin peptides decrease dorsal root ganglion neuron calcium-dependent action potential duration.
Topics: Action Potentials; Animals; beta-Endorphin; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Ganglia, Spinal; Ion Channels; Mice; Naloxone; Protein Precursors; Receptors, Opioid; Sodium; Time Factors | 1985 |
Paradoxical analgesia produced by low doses of the opiate-antagonist naloxone is mediated by interaction at a site with characteristics of the delta opioid receptor.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Male; Morphine; Naloxone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Photoinactivation of the mu opioid receptor using a novel synthetic morphiceptin analog.
Topics: Affinity Labels; Animals; Brain; Chemical Phenomena; Chemistry; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; In Vitro Techniques; Light; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Interactions of Tyr-MIF-1 at opiate receptor sites.
Topics: Animals; Binding, Competitive; Brain; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; MSH Release-Inhibiting Hormone; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Regulation of ventilation and oxygen consumption by delta- and mu-opioid receptor agonists.
Topics: Animals; Blood Gas Analysis; Carbon Dioxide; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hydrogen-Ion Concentration; Naloxone; Oxygen; Oxygen Consumption; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration | 1985 |
Receptors for opioid peptides in the guinea-pig ileum.
Topics: Alkylation; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1985 |
Dual effect of morphiceptin on lordosis behavior: possible mediation by different opioid receptor subtypes.
Topics: Analgesics; Animals; Endorphins; Estradiol; Female; Naloxone; Posture; Progesterone; Rats; Rats, Inbred Strains; Receptors, Opioid; Sexual Behavior, Animal | 1986 |
Effect of endorphins on heart rate and blood pressure in adult dogs.
Topics: Animals; Atropine; Blood Pressure; Consciousness; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Heart; Heart Rate; Naloxone; Naltrexone | 1986 |
Morphiceptin: biphasic inhibition of mu-opiate receptor ligands.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Endorphins; Fentanyl; In Vitro Techniques; Kinetics; Membranes; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1984 |
Dynorphin reduces calcium-dependent action potential duration by decreasing voltage-dependent calcium conductance.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Dynorphins; Endorphins; Enkephalin, Leucine; Ganglia, Spinal; Ion Channels; Mice; Naloxone; Peptide Fragments; Receptors, Opioid | 1984 |
Dynorphin: potent analgesic effect in spinal cord of the rat.
Topics: Analgesia; Analgesics; Animals; Drug Tolerance; Dynorphins; Endorphins; Female; Injections, Intraventricular; Injections, Spinal; Morphine; Naloxone; Pain; Peptide Fragments; Rats; Sensory Thresholds; Spinal Cord | 1984 |
Which opioid receptor mechanism modulates feeding?
Topics: Animals; Azocines; Diprenorphine; Dynorphins; Endorphins; Feeding Behavior; Humans; Mice; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1984 |
Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu) receptors.
Topics: Animals; Binding, Competitive; Caseins; Dihydromorphine; Endorphins; Enkephalins; Guanosine Triphosphate; Guinea Pigs; Ileum; Male; Mice; Naloxone; Rats; Receptors, Opioid; Sodium; Vas Deferens | 1981 |
The actions of naloxazone on the binding and analgesic properties of morphiceptin (NH2Tyr-Pro-Phe-Pro-CONH2), a selective mu-receptor ligand.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Endorphins; Enkephalins; In Vitro Techniques; Kinetics; Ligands; Naloxone; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1981 |
Morphiceptin ( beta-casomorphin (1-4) amide): a peptide opioid antagonist in the field stimulated rat vas deferens.
Topics: Animals; beta-Endorphin; Caseins; Electric Stimulation; Endorphins; Humans; Male; Naloxone; Rats; Rats, Inbred Strains; Vas Deferens | 1981 |
Analgesic activity of intracerebroventricular administration of morphiceptin and beta-casomorphins: correlation with the morphine (micro) receptor binding affinity.
Topics: Analgesia; Animals; Binding, Competitive; Brain; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Male; Naloxone; Rats; Receptors, Opioid | 1982 |
Opioid peptides with differential affinity for mu and delta receptors decrease sensory neuron calcium-dependent action potentials.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Endorphins; Enkephalin, Leucine; Ganglia, Spinal; In Vitro Techniques; Mice; Naloxone; Neurons, Afferent; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors | 1983 |
Depressor and bradycardic effect following intrathecal injection of [NMePhe3,D-Pro4]morphiceptin in rats.
Topics: Animals; Blood Pressure; Depression, Chemical; Endorphins; Female; Heart Rate; Injections, Spinal; Male; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, mu; Vagotomy | 1984 |
Characterization of the spinal antinociceptive activity of constrained peptidomimetic opioids.
Topics: Amino Acid Sequence; Analgesia; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Injections, Spinal; Male; Mice; Molecular Sequence Data; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Oligopeptides; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Structure-Activity Relationship; Vas Deferens | 1995 |
Mitogenic activation of human T lymphocytes induces a high affinity morphine binding site.
Topics: Analgesics; beta-Endorphin; Cells, Cultured; Culture Media; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Interleukin-2; Ligands; Lymphocyte Activation; Mitogens; Morphine; Naloxone; Phytohemagglutinins; Receptors, Opioid; T-Lymphocytes | 1995 |
DAMGO, a mu-opioid receptor selective ligand, distinguishes between mu-and kappa-opioid receptors at a different region from that for the distinction between mu- and delta-opioid receptors.
Topics: Amino Acid Sequence; Analgesics; Animals; Cells, Cultured; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ligands; Molecular Sequence Data; Morphine; Naloxone; Oligopeptides; Opioid Peptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins; Somatostatin; Structure-Activity Relationship | 1995 |
Effects of opioid microinjections in the nucleus of the solitary tract on the sleep-wakefulness cycle states in cats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cats; Drug Interactions; Electroencephalography; Endorphins; Microinjections; Morphine; Naloxone; Pyrrolidines; Receptors, Opioid; Sleep Stages; Sodium Chloride; Solitary Nucleus | 1995 |
Effects of morphiceptin in the medial preoptic area on male sexual behavior.
Topics: Analgesics; Animals; Copulation; Endorphins; Female; Hypothalamus, Middle; Male; Maze Learning; Naloxone; Narcotic Antagonists; Preoptic Area; Rats | 1995 |
Opioid binding profile of morphiceptin, Tyr-MIF-1 and dynorphin-related peptides in rat brain membranes.
Topics: Analgesics; Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Dynorphins; Endorphins; Guinea Pigs; Ileum; Male; MSH Release-Inhibiting Hormone; Muscles; Naloxone; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Radioligand Assay; Rats; Receptors, Opioid; Structure-Activity Relationship; Tritium | 1996 |
Met-enkephalin and morphiceptin modulate a GABA-induced inward current in the CNS of Lymnaea stagnalis L.
Topics: Animals; Endorphins; Enkephalin, Methionine; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Lymnaea; Membrane Potentials; Naloxone; Neurons; Synaptic Transmission | 1996 |
Stimulation of phospholipase C by the cloned mu, delta and kappa opioid receptors via chimeric G alpha(q) mutants.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cloning, Molecular; COS Cells; DNA, Complementary; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme Activation; GTP-Binding Proteins; Mice; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins; Type C Phospholipases | 1999 |
Diprotin A, an inhibitor of dipeptidyl aminopeptidase IV(EC 3.4.14.5) produces naloxone-reversible analgesia in rats.
Topics: Analgesia; Analgesics, Opioid; Animals; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Dose-Response Relationship, Drug; Drug Synergism; Endorphins; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle, Smooth; Naloxone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Wistar | 1999 |
Developmental changes in the inhibition of cultured rat uterine cell proliferation by opioid peptides.
Topics: Aging; Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Methionine; Enkephalins; Epidermal Growth Factor; Estradiol; Female; Inhibitory Concentration 50; Naloxone; Narcotic Antagonists; Opioid Peptides; Ovariectomy; Rats; Rats, Inbred Strains; Rats, Wistar; Uterus | 2003 |
Partial and full agonism in endomorphin derivatives: comparison by null and operational model.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; Morphine Derivatives; Naloxone; Oligopeptides; Rats; Receptors, Opioid, mu; Vas Deferens | 2006 |
Analgesic properties of chimeric peptide based on morphiceptin and PFRTic-amide.
Topics: Analgesia; Analgesics, Opioid; Animals; Arginine; Dose-Response Relationship, Drug; Endorphins; Guinea Pigs; Male; Mice; Morphinans; Naloxone; Naltrexone; Neuropeptides; Opioid Peptides; Proline; Receptors, Neuropeptide; Tetrahydroisoquinolines; Time Factors | 2012 |