Compounds > morphiceptin

Page last updated: 2024-09-03

morphiceptin and endomorphin 2

morphiceptin has been researched along with endomorphin 2 in 14 studies

Compound Research Comparison

Studies (morphiceptin)	Trials (morphiceptin)	Recent Studies (post-2010) (morphiceptin)	Studies (endomorphin 2)	Trials (endomorphin 2)	Recent Studies (post-2010) (endomorphin 2)
139	0	12	443	0	112

Protein Interaction Comparison

Protein	Taxonomy	morphiceptin (IC50)	endomorphin 2 (IC50)
Delta-type opioid receptor	Mus musculus (house mouse)		0.0482
Mu-type opioid receptor	Rattus norvegicus (Norway rat)		0.001
Mu-type opioid receptor	Mus musculus (house mouse)		0.0241

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (7.14)	18.2507
2000's	11 (78.57)	29.6817
2010's	2 (14.29)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dervarics, M; Fülöp, F; Martinek, TA; Otvös, F; Tóth, G	1
Gao, Y; Liu, W; Liu, X; Qi, Y; Wang, R; Zhou, Y	1
Cacciatore, I; Davis, P; Feliciani, F; Giordano, C; Hruby, V; Lai, J; Lucente, G; Ma, SW; Masi, A; Mollica, A; Pinnen, F; Porreca, F; Punzi, P; Sansone, A	1
do-Rego, JC; Fichna, J; Gach, K; Janecka, A; Janecki, T; Kluczyk, A; Perlikowska, R; Piekielna, J; Toth, G; Wyrębska, A	1
Erdö, F; Fürst, S; Gyarmati, Z; Makó, E; Orosz, G; Rónai, AZ; Székely, JI; Timár, J; Tóth, G	1
Boissard, C; Chung, NN; Keller, M; Lemieux, C; Mutter, M; Patiny, L; Schiller, PW	1
Campos, CR; Davis, TP; Hau, VS; Huber, JD; Lipkowski, AW; Misicka, A	1
Fichna, J; Janecka, A; Kosson, P; Krajewska, U; Mirowski, M; Rozalski, M; Zalewska-Kaszubska, J	1
Costentin, J; do-Rego, JC; Fichna, J; Janecka, A; Kosson, P	1
Chung, NN; Costentin, J; do-Rego, JC; Fichna, J; Janecka, A; Kosson, P; Kruszynski, R; Schiller, PW	1
Ambo, A; Costentin, J; do-Rego, JC; Fichna, J; Janecka, A; Kruszynski, R; Sasaki, Y	1
Al-Khrasani, M; Benyhe, S; Kató, E; Kocsis, L; Lengyel, I; Orosz, G; Rónai, AZ; Tóth, G; Tóthfalusi, L	1
Broeck, JV; Burgeon, E; Fichna, J; Gach, K; Janecka, A; Piestrzeniewicz, M; Poels, J	1
Costentin, J; do-Rego, JC; Fichna, J; Janecka, A; Kosson, P; Schiller, PW	1

Other Studies

14 other study(ies) available for morphiceptin and endomorphin 2

Article	Year
Ligand-based prediction of active conformation by 3D-QSAR flexibility descriptors and their application in 3+3D-QSAR models. Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: Amino Acids; Drug Design; Ligands; Models, Molecular; Molecular Conformation; Oligopeptides; Quantitative Structure-Activity Relationship; Statistics as Topic; Stereoisomerism; Thermodynamics	2005
Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3 or 4. Bioorganic & medicinal chemistry letters, 2006, Jul-15, Volume: 16, Issue:14 Topics: Analgesics; Animals; Binding Sites; Brain; Endorphins; Half-Life; Inhibitory Concentration 50; Ligands; Mice; Molecular Mimicry; Oligopeptides; Pain Measurement; Phenylalanine; Receptors, Opioid, mu; Time Factors; Tissue Extracts	2006
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2. European journal of medicinal chemistry, 2010, Volume: 45, Issue:10 Topics: Analgesics, Opioid; Cell Line; Endorphins; Humans; Oligopeptides; Proline; Protein Binding; Receptors, Opioid; Receptors, Opioid, mu	2010
Effect of 2',6'-dimethyl-L-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs. Bioorganic & medicinal chemistry, 2011, Dec-01, Volume: 19, Issue:23 Topics: Amino Acid Sequence; Animals; Drug Interactions; Endorphins; Male; Mice; Oligopeptides; Opioid Peptides; Peptides, Cyclic; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Tyrosine	2011
Diprotin A, an inhibitor of dipeptidyl aminopeptidase IV(EC 3.4.14.5) produces naloxone-reversible analgesia in rats. Life sciences, 1999, Volume: 64, Issue:2 Topics: Analgesia; Analgesics, Opioid; Animals; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Dose-Response Relationship, Drug; Drug Synergism; Endorphins; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle, Smooth; Naloxone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Wistar	1999
Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation. Journal of medicinal chemistry, 2001, Nov-08, Volume: 44, Issue:23 Topics: Animals; Brain; Endorphins; Guinea Pigs; Ileum; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Mice; Muscle Contraction; Muscle, Smooth; Oligopeptides; Oxazoles; Proline; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiazoles; Vas Deferens	2001
Effect of guanidino modification and proline substitution on the in vitro stability and blood-brain barrier permeability of endomorphin II. Journal of pharmaceutical sciences, 2002, Volume: 91, Issue:10 Topics: Amino Acid Substitution; Animals; Blood Proteins; Blood-Brain Barrier; Cattle; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Drug Stability; Endorphins; Endothelium, Vascular; Guanidines; Half-Life; Indicators and Reagents; Injections, Intraventricular; Lipids; Male; Mice; Mice, Inbred ICR; Oligopeptides; Pain Measurement; Permeability; Proline; Protein Binding; Solubility	2002
Binding of the new morphiceptin analogs to human MCF-7 breast cancer cells and their effect on growth. Regulatory peptides, 2004, Aug-15, Volume: 120, Issue:1-3 Topics: Animals; Breast Neoplasms; Cell Proliferation; Convulsants; Endorphins; Humans; Ligands; Male; Oligopeptides; Protein Binding; Rats; Rats, Wistar; Receptors, Opioid, mu; Tumor Cells, Cultured	2004
Characterization of antinociceptive activity of novel endomorphin-2 and morphiceptin analogs modified in the third position. Biochemical pharmacology, 2005, Jan-01, Volume: 69, Issue:1 Topics: Amino Acid Substitution; Analgesics; Animals; Dose-Response Relationship, Drug; Endorphins; Male; Mice; Oligopeptides; Pain Measurement; Rats; Rats, Wistar	2005
Novel endomorphin-2 analogs with mu-opioid receptor antagonist activity. The journal of peptide research : official journal of the American Peptide Society, 2005, Volume: 66, Issue:3 Topics: Alanine; Analgesics; Animals; Dose-Response Relationship, Drug; Endorphins; Guinea Pigs; Male; Mice; Naphthalenes; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, mu; Structure-Activity Relationship	2005
Synthesis and antinociceptive activity of cyclic endomorphin-2 and morphiceptin analogs. Biochemical pharmacology, 2005, Dec-19, Volume: 71, Issue:1-2 Topics: Analgesics, Opioid; Animals; Brain; Endorphins; Guinea Pigs; Male; Mice; Motor Activity; Oligopeptides; Rats; Receptors, Opioid	2005
Partial and full agonism in endomorphin derivatives: comparison by null and operational model. Peptides, 2006, Volume: 27, Issue:6 Topics: Animals; Brain; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; Morphine Derivatives; Naloxone; Oligopeptides; Rats; Receptors, Opioid, mu; Vas Deferens	2006
Functional characterization of opioid receptor ligands by aequorin luminescence-based calcium assay. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 317, Issue:3 Topics: Aequorin; Analgesics, Opioid; Animals; Biological Assay; Calcium; CHO Cells; Cricetinae; Cricetulus; Endorphins; Ligands; Luminescent Agents; Oligopeptides; Receptors, Opioid	2006
[(35)S]GTPgammaS binding stimulated by endomorphin-2 and morphiceptin analogs. Biochemical and biophysical research communications, 2006, Jun-23, Volume: 345, Issue:1 Topics: Animals; Binding Sites; Brain; Brain Chemistry; Cells, Cultured; Endorphins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Oligopeptides; Protein Binding; Protein Isoforms; Radioligand Assay; Rats; Rats, Wistar; Sulfur Radioisotopes	2006