morphiceptin, n-me-phe(3)- has been researched along with enkephalin, ala(2)-mephe(4)-gly(5)- in 21 studies
| Studies (morphiceptin, n-me-phe(3)-) | Trials (morphiceptin, n-me-phe(3)-) | Recent Studies (post-2010) (morphiceptin, n-me-phe(3)-) | Studies (enkephalin, ala(2)-mephe(4)-gly(5)-) | Trials (enkephalin, ala(2)-mephe(4)-gly(5)-) | Recent Studies (post-2010) (enkephalin, ala(2)-mephe(4)-gly(5)-) |
|---|---|---|---|---|---|
| 95 | 1 | 1 | 151 | 0 | 71 |
| 95 | 1 | 1 | 2,727 | 1 | 374 |
| Protein | Taxonomy | morphiceptin, n-me-phe(3)- (IC50) | enkephalin, ala(2)-mephe(4)-gly(5)- (IC50) |
|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 0.003 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 0.003 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 0.003 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 0.003 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 0.003 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 1.2415 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0132 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.004 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.0014 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0048 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0283 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.52) | 18.7374 |
| 1990's | 18 (85.71) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Ananthan, S; Bartlett, JL; Bilsky, EJ; Davis, P; Dersch, CM; Khare, NK; Porreca, F; Rothman, RB; Saini, SK; Seitz, LE | 1 |
| Costa, EM; Hoffmann, BB; Loew, GH | 1 |
| Chavkin, C; Wimpey, TL | 2 |
| Olianas, MC; Onali, P | 1 |
| Caudle, RM; Chavkin, C | 1 |
| Caudle, RM; Chavkin, C; Wagner, JJ | 1 |
| Knapp, RJ; Yamamura, HI | 1 |
| Burks, TF; Fox, DA | 1 |
| Burks, TF; Shook, JE | 1 |
| Chen, C; de Riel, JK; Kunapuli, SP; Liu-Chen, LY; Xue, JC; Yu, L; Zhu, J | 1 |
| Bidlack, JM; Chung, NN; Dooley, CT; Houghten, RA; Pasternak, GW; Schiller, PW; Wilkes, BC | 1 |
| Ge, LJ; Hackler, L; Kastin, AJ; Zadina, JE | 1 |
| De Lander, GE; Keil, GJ | 1 |
| Meyer, ME | 1 |
| Chang, LR; Lee, CR; Lue, WM; Tao, PL | 1 |
| Cahill, CM; Sawynok, J; White, TD | 1 |
| Kolaj, M; Randic, M | 1 |
| Bivalacqua, TJ; Champion, HC; Friedman, DE; Kadowitz, PJ; Kastin, AJ; Zadina, JE | 1 |
| Bivalacqua, TJ; Champion, HC; Kadowitz, PJ; Kastin, AJ; Zadina, JE | 1 |
21 other study(ies) available for morphiceptin, n-me-phe(3)- and enkephalin, ala(2)-mephe(4)-gly(5)-
| Article | Year |
|---|---|
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].
Topics: Analgesics; Animals; Binding Sites; Brain; Drug Tolerance; Electric Stimulation; Guinea Pigs; Hydromorphone; Ileum; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred ICR; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Oxymorphone; Pyridines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 2004 |
Opioid agonists binding and responses in SH-SY5Y cells.
Topics: Alprostadil; Analgesics; Cyclic AMP; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; GTP Phosphohydrolases; Humans; Meperidine; Morphinans; Naloxone; Narcotics; Oxymorphone; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured | 1992 |
8-Bromo-cAMP blocks opioid activation of a voltage-gated potassium current in isolated hippocampal neurons.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic GMP; Depression, Chemical; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; Ion Channel Gating; Male; Membrane Potentials; Neurons; Phosphorylation; Potassium; Potassium Channels; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1992 |
Characterization of opioid receptors mediating stimulation of adenylate cyclase activity in rat olfactory bulb.
Topics: Adenylyl Cyclases; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme Activation; Male; Narcotic Antagonists; Olfactory Bulb; Oligopeptides; Opioid Peptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1992 |
Mu opioid receptor activation reduces inhibitory postsynaptic potentials in hippocampal CA3 pyramidal cells of rat and guinea pig.
Topics: Animals; Autoradiography; Dynorphins; Electrophysiology; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Microelectrodes; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity; Synapses | 1990 |
Opioids activate both an inward rectifier and a novel voltage-gated potassium conductance in the hippocampal formation.
Topics: Animals; Barium; Barium Compounds; Cadmium; Cadmium Chloride; Chlorides; Electric Conductivity; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Male; Narcotics; Neurons; Potassium; Rats; Rats, Inbred Strains | 1991 |
Endogenous opioids released from perforant path modulate norepinephrine actions and inhibitory postsynaptic potentials in guinea pig CA3 pyramidal cells.
Topics: Animals; Electric Stimulation; Electrophysiology; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Hippocampus; Male; Membrane Potentials; Naloxone; Norepinephrine; Propranolol; Pyramidal Tracts; Synapses | 1991 |
[3H][D-Pen2, D-Pen5]enkephalin binding to delta opioid receptors on intact neuroblastoma-glioma (NG 108-15) hybrid cells.
Topics: Animals; Binding, Competitive; Cell Survival; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hybrid Cells; Kinetics; Mice; Models, Biological; Morphine; Morphine Derivatives; Receptors, Opioid | 1990 |
Roles of central and peripheral mu, delta and kappa opioid receptors in the mediation of gastric acid secretory effects in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Gastric Acid; Male; Morphine; Naltrexone; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Comparison of the antinociceptive and antitransit effects of DAGO and PLO17 in mice.
Topics: Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gastrointestinal Motility; Male; Mice; Mice, Inbred ICR; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1985 |
The third extracellular loop of the mu opioid receptor is important for agonist selectivity.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Diprenorphine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Molecular Sequence Data; Morphine; Protein Conformation; Rats; Receptors, Opioid, mu; Sufentanil | 1995 |
An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library.
Topics: Amino Acid Sequence; Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Injections, Intraventricular; Male; Mice; Models, Molecular; Molecular Sequence Data; Naloxone; Opioid Peptides; Pain Measurement; Protein Conformation; Rats; Receptors, Opioid, mu; Stereoisomerism | 1994 |
Mu, delta, and kappa opiate receptor binding of Tyr-MIF-1 and of Tyr-W-MIF-1, its active fragments, and two potent analogs.
Topics: Amino Acid Sequence; Animals; Brain; Cerebellum; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Molecular Sequence Data; MSH Release-Inhibiting Hormone; Peptide Fragments; Peptides, Cyclic; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Synaptic Membranes | 1994 |
Antinociception induced by intrathecal coadministration of selective adenosine receptor and selective opioid receptor agonists in mice.
Topics: Adenosine; Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Mice; Narcotics; Phenethylamines; Receptors, Opioid; Receptors, Purinergic P1 | 1994 |
Behavioral effects of the mu-opioid peptide agonists DAMGO, DALDA, and PL017 on locomotor activities.
Topics: Amino Acid Sequence; Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Motor Activity; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1993 |
Alteration of the interaction of mu-opioid receptor and G protein after chronic PL017 treatment in rats.
Topics: Analgesics; Animals; Drug Tolerance; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Guanine Nucleotides; Guanylyl Imidodiphosphate; In Vitro Techniques; Kinetics; Male; Mesencephalon; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1995 |
Synergy between mu/delta-opioid receptors mediates adenosine release from spinal cord synaptosomes.
Topics: Adenosine; Animals; Drug Synergism; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Synaptosomes | 1996 |
mu-Opioid receptor-mediated reduction of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-activated current in dorsal horn neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Agonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Membrane Potentials; Molecular Sequence Data; Neurons; Patch-Clamp Techniques; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Opioid, mu; Somatostatin; Spinal Cord | 1996 |
Nitric oxide release mediates vasodilator responses to endomorphin 1 but not nociceptin/OFQ in the hindquarters vascular bed of the rat.
Topics: Adamantane; Animals; Blood Vessels; Endorphins; Endothelium, Vascular; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Meclofenamic Acid; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptin; Oligopeptides; Opioid Peptides; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Regional Blood Flow; Vasodilation; Vasodilator Agents | 1998 |
Vasodilator responses to the endomorphin peptides, but not nociceptin/OFQ, are mediated by nitric oxide release.
Topics: Adamantane; Analgesics, Opioid; Animals; Diuretics; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hindlimb; Meclofenamic Acid; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptin; Oligopeptides; Opioid Peptides; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 1999 |