morin and tangeretin
morin has been researched along with tangeretin* in 1 studies
Other Studies
1 other study(ies) available for morin and tangeretin
| Article | Year |
|---|---|
Inhibition of 11beta-hydroxysteroid dehydrogenase in guinea pig kidney by three bioflavonoids and their interactions with gossypol.
To study the effects of some bioflavonoids on the gossypol-induced hypokalemia.. The 11beta-hydroxysteroid dehydrogenase (11beta-OHSD) protein was prepared from guinea pig kidney. The activity of 11beta-OHSD with NAD as the coenzyme was measured by HPLC. The drug interaction was analysed by isobolographic method.. The 11beta-OHSD can be inhibited by some bioflavonoids. The IC50 (95 % confidence limits) values were: quercetin 164 (79 - 341) micromol/L, morin 913 (385 - 2173) micromol/L, and naringenin 2193 (1114 - 4315) micromol/L. When the 11beta-OHSD was treated with quercetin, tangeretin, morin, naringenin plus gossypol, the combination index (CI) values were 0.92, 0.85, 0.98, and 1.01 respectively.. The interaction of some bioflavonoids with gossypol might be one of the factors for gossypol-induced hypokalemia. Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Depression, Chemical; Drug Synergism; Enzyme Inhibitors; Flavones; Flavonoids; Gossypol; Guinea Pigs; Hydroxysteroid Dehydrogenases; Hypokalemia; Male; NAD; Quercetin | 2002 |