monooctanoin and sodium-nitrate

A method of individual selection of cholelitholytic agents was developed and tested in the clinic on the grounds of the findings of polarizing microscopy of bile and the results of study of gallstones by scanning electron microscopy. Its essence consists in visual appraisal of the effect of various solvents, used in the clinic, on the crystal structures of the patient's bile. The use of the developed method makes it possible to raise significantly the efficacy of contact solution of gallstones in combined treatment of cholelithiasis.

Topics: Aged; Caprylates; Cholelithiasis; Drug Therapy, Combination; Edetic Acid; Female; Glycerides; Humans; Microscopy, Electron, Scanning; Nitrates; Solvents

The techniques and results of contact dissolution of stones in the gallbladder of 27 patients subjected to laparoscopic cholecystostomy for acute cholecystitis were analysed. It was found that the main factors impeding effective dissolution were: the size of the stones over 1.5 cm and admixture of pigment in the concrements. The first Soviet produced litholytic preparation Oktalgin, synthesized by the authors jointly with the Zelinsky IOCh, AMS USSR, was used as the main solvent. The principal possibility of dissolving multiple stones of the gallbladder through laparoscopic cholecystostomy is proved.

Topics: Acute Disease; Caprylates; Cholecystitis; Cholelithiasis; Edetic Acid; Gallbladder; Glycerides; Humans; Laparoscopy; Nitrates; Solvents