Page last updated: 2024-09-05

monoisoamyl-2,3-dimercaptosuccinate and succimer

monoisoamyl-2,3-dimercaptosuccinate has been researched along with succimer in 48 studies

Compound Research Comparison

Studies
(monoisoamyl-2,3-dimercaptosuccinate)
Trials
(monoisoamyl-2,3-dimercaptosuccinate)
Recent Studies (post-2010)
(monoisoamyl-2,3-dimercaptosuccinate)
Studies
(succimer)
Trials
(succimer)
Recent Studies (post-2010) (succimer)
530191,66557269

Protein Interaction Comparison

ProteinTaxonomymonoisoamyl-2,3-dimercaptosuccinate (IC50)succimer (IC50)
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 21.72

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (18.75)18.2507
2000's19 (39.58)29.6817
2010's15 (31.25)24.3611
2020's5 (10.42)2.80

Authors

AuthorsStudies
Holscher, MA; Jones, MM; Singh, PK; Xu, C1
Eybl, V; Jones, MM; Kotyzová, D; Koutenský, J; Singh, PK1
Blanusa, M; Jones, MM; Kostial, K; Piasek, M; Singh, PK2
Blanusa, M; Jones, MM; Kargacin, B; Kostial, K; Piasek, M; Singh, PK1
Bellés, M; Domingo, JL; Gómez, M; Jones, MM; Sánchez, DJ; Singh, PK1
Domingo, JL; Gómez, M; Jones, MM; Llobet, JM; Sánchez, DJ; Singh, PK1
Carter, CE; Dietrich, MS; Johnson, JE; Jones, MM; Singh, PK; Xu, C; Yan, H1
Arora, U; Flora, GJ; Seth, PK1
Chauhan, RS; Dubey, R; Flora, SJ; Jaiswal, DK; Kannan, GM; Pant, BP1
Flora, SJ; Jaiswal, DK; Kannan, GM; Pant, BP2
Prasad, S; Siddiqui, MK; Singh, S; Srivastava, S; Tandon, SK1
Flora, SJ; Mehta, A; Pande, M1
Chatterjee, M; Dwivedi, VK; Khandekar, K; Mathur, N; Prasad, S; Singh, S; Tandon, SK1
Bhaskar, AS; Dube, SN; Flora, SJ; Kannan, GM; Mehta, A; Pant, BP; Rao, PV1
Flora, SJ; Kannan, GM1
Bhadauria, S; Flora, SJ2
Flora, SJ; Saxena, G1
Bhadauria, S; Dhaked, RK; Flora, SJ; Pant, SC1
Flora, SJ; Mehta, A; Saxena, G1
Flora, SJ; Modi, M1
Flora, SJ; Gautam, P; Jatav, PC; Mehta, A; Pathak, U1
Bhadauria, S; Flora, SJ; Kannan, GM; Singh, N1
Flora, SJ; Mehta, A; Mishra, D; Pachauri, V; Saxena, G1
Flora, SJ; Mehta, A1
Baran, EJ; Williams, PA; Zinczuk, J1
Flora, SJ; Gupta, R; Kushwah, P; Mishra, D; Pant, SC; Satish, HT1
Bhatt, K; Dwivedi, N; Flora, SJ; Kushwah, PK; Pachauri, V1
Binukumar, BK; Dwivedi, N; Flora, SJ; Gill, KD; Mehta, A; Yadav, A1
Badisa, RB; Badisa, VL; Buggs, R; Darling-Reed, SF; Ikediobi, CO; Latinwo, LM; Odewumi, CO; Owens, MA1
Bhadauria, S; Flora, SJ; Pachauri, V; Yadav, A1
Acharya, S; Basu, AK; Bhattacharya, D; Chatterjee, S; Chaudhuri, S; Dasgupta, S; Flora, SJ; Kumar, P; Singh, MK1
Dubey, M; Flora, SJ; Kushwaha, P; Pachauri, V; Yadav, A1
Flora, SJ; Mehta, A; Mishra, D; Pachauri, V1
Flora, SJ; Ram Kumar, M; Reddy, GR1
Flora, SJ; Kushwaha, P; Pachauri, V; Srivastava, P; Yadav, A1
Gottipolu, RR; Kadeyala, PK; Sannadi, S2
Babbar, AK; Flora, SJ; Kaushik, MP; Kushwaha, P; Lomash, V; Mathur, R; Mishra, AK; Pathak, U; Samim, M; Yadav, A1
Flora, SJS; Kushwaha, P; Samim, M; Yadav, A1
Davuljigari, CB; Kumar, KP; Reddy, GR; Saritha, S1
Flora, SJS; Sathua, K; Srivastava, S1
Flora, SJS; Patwa, J; Sharma, A; Thakur, A1
Flora, SJS; Kumar, P; Naqvi, S1
Flora, SJS; Sachdeva, S; Sharma, A1
Flora, SJS; Jain, K; Panghal, A; Patwa, J1

Reviews

2 review(s) available for monoisoamyl-2,3-dimercaptosuccinate and succimer

ArticleYear
Arsenic induced oxidative stress and the role of antioxidant supplementation during chelation: a review.
    Journal of environmental biology, 2007, Volume: 28, Issue:2 Suppl

    Topics: Acetylcysteine; Animals; Antioxidants; Arsenic Poisoning; Ascorbic Acid; Chelating Agents; Chelation Therapy; Dimercaprol; Drug Therapy, Combination; Environmental Pollutants; Humans; Melatonin; Oxidative Stress; Plant Extracts; Selenium; Succimer; Taurine; Thioctic Acid; Vitamin E; Zinc

2007
Chemistry, Pharmacology, and Toxicology of Monoisoamyl Dimercaptosuccinic Acid: A Chelating Agent for Chronic Metal Poisoning.
    Chemical research in toxicology, 2022, 10-17, Volume: 35, Issue:10

    Topics: Animals; Antidotes; Antioxidants; Arsenic; Arsenic Poisoning; Cadmium; Chelating Agents; Heavy Metal Poisoning; Mercury; Rats; Rats, Wistar; Succimer

2022

Other Studies

46 other study(ies) available for monoisoamyl-2,3-dimercaptosuccinate and succimer

ArticleYear
Effect of monoisoamyl meso-2,3-dimercaptosuccinate on the pathology of acute cadmium intoxication.
    Journal of toxicology and environmental health, 1995, Volume: 45, Issue:3

    Topics: Acute Disease; Animals; Cadmium; Cadmium Chloride; Chelating Agents; Chlorides; Cysteine; Drug Combinations; Kidney; Male; Rats; Rats, Wistar; Succimer; Testis

1995
Effect of chelators, monoisoamyl meso-2,3-dimercaptosuccinate and N-(4-methylbenzyl)-4-O-(beta-D-galactopyranosyl)-D-glucamine-N-carbodit hioate, on cadmium and essential element levels in mice.
    The Analyst, 1995, Volume: 120, Issue:3

    Topics: Animals; Brain; Cadmium; Chelating Agents; Disaccharides; Kidney; Liver; Male; Mice; Mice, Inbred ICR; Succimer; Testis; Thiocarbamates

1995
Reduction of lead retention by mono-3-methylbutan-1-yl meso-2,3-dimercaptosuccinate in suckling rats.
    The Analyst, 1995, Volume: 120, Issue:3

    Topics: Animals; Animals, Suckling; Bone and Bones; Brain; Chelating Agents; Kidney; Lead; Liver; Rats; Rats, Wistar; Spectrophotometry, Atomic; Succimer

1995
Monoisoamyl meso-2,3-dimercaptosuccinate as a delayed treatment for mercury removal in rats.
    Environmental health perspectives, 1994, Volume: 102 Suppl 3

    Topics: Aging; Animals; Animals, Suckling; Chelation Therapy; Mercury Poisoning; Rats; Rats, Wistar; Succimer; Time Factors

1994
Assessment of the protective activity of monisoamyl meso-2,3-dimercaptosuccinate against methylmercury-induced maternal and embryo/fetal toxicity in mice.
    Toxicology, 1996, Jan-08, Volume: 106, Issue:1-3

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Chelating Agents; Chelation Therapy; Disease Models, Animal; Embryonic and Fetal Development; Female; Fetal Death; Male; Methylmercury Compounds; Mice; Pregnancy; Succimer

1996
Effects of monoisoamyl meso-2,3-dimercaptosuccinate on arsenite-induced maternal and developmental toxicity in mice.
    Research communications in molecular pathology and pharmacology, 1995, Volume: 89, Issue:3

    Topics: Animals; Arsenites; Chelating Agents; Female; Injections, Subcutaneous; Maternal Behavior; Maternal Welfare; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; Pregnancy; Succimer; Time Factors

1995
Prolonged oral treatment with two monoesters of meso-2,3-dimercaptosuccinic acid for depleting inorganic mercury retention in suckling rats.
    Pharmacology & toxicology, 1995, Volume: 77, Issue:3

    Topics: Administration, Oral; Animals; Animals, Suckling; Brain; Chelating Agents; Female; Isotope Labeling; Kidney; Liver; Male; Mercury; Rats; Rats, Wistar; Succimer; Tissue Distribution

1995
Cadmium-induced apoptosis in the urogenital organs of the male rat and its suppression by chelation.
    Journal of toxicology and environmental health, 1997, Oct-10, Volume: 52, Issue:2

    Topics: Animals; Apoptosis; Biotin; Cadmium Chloride; Chelating Agents; Chromatin; DNA Fragmentation; DNA Nucleotidylexotransferase; Enzyme-Linked Immunosorbent Assay; Epididymis; Injections, Intraperitoneal; Kidney; Male; Mutagens; Prostate; Rats; Rats, Wistar; Seminal Vesicles; Succimer; Uridine Triphosphate; Urinary Bladder; Urogenital System

1997
Influence of combined therapeutic potential of meso 2,3-dimercaptosuccinic acid and calcium disodium edetate on lead-induced testicular alterations in rats.
    Biomedical and environmental sciences : BES, 1999, Volume: 12, Issue:4

    Topics: Animals; Chelating Agents; Edetic Acid; Lead; Male; Rats; Succimer; Testicular Neoplasms; Testis

1999
Meso 2,3-dimercaptosuccinic acid (DMSA) and monoisoamyl DMSA effect on gallium arsenide induced pathological liver injury in rats.
    Toxicology letters, 2002, Jun-07, Volume: 132, Issue:1

    Topics: Alanine Transaminase; Animals; Arsenicals; Aspartate Aminotransferases; Catalase; Chelating Agents; Chemical and Drug Induced Liver Injury; Gallium; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Liver Function Tests; Male; Metals; Oxidation-Reduction; Oxidative Stress; Porphobilinogen Synthase; Rats; Succimer; Superoxide Dismutase

2002
Combined administration of oxalic acid, succimer and its analogue for the reversal of gallium arsenide-induced oxidative stress in rats.
    Archives of toxicology, 2002, Volume: 76, Issue:5-6

    Topics: Aminolevulinic Acid; Animals; Arsenicals; Chelating Agents; Copper; Drug Therapy, Combination; Gallium; Glutathione; Glutathione Disulfide; Kidney; Liver; Male; Malondialdehyde; Oxalic Acid; Oxidative Stress; Porphobilinogen Synthase; Protoporphyrins; Rats; Rats, Wistar; Spleen; Succimer; Tissue Distribution; Zinc

2002
Reversal of lead-induced oxidative stress by chelating agent, antioxidant, or their combination in the rat.
    Environmental research, 2002, Volume: 90, Issue:1

    Topics: Acetylcysteine; Aminolevulinic Acid; Animals; Antioxidants; Brain; Catalase; Chelating Agents; Free Radical Scavengers; Glutathione; Kidney; Lead; Lead Poisoning; Male; Malondialdehyde; Oxidative Stress; Rats; Succimer

2002
The efficacy of monoisoamyl ester of dimercaptosuccinic acid in chronic experimental arsenic poisoning in mice.
    Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 2003, Volume: 38, Issue:1

    Topics: Administration, Oral; Animals; Arsenic Poisoning; Disease Models, Animal; Infusions, Parenteral; Kidney; Liver; Male; Mice; Oxidative Stress; Succimer

2003
Beneficial effect of combined administration of some naturally occurring antioxidants (vitamins) and thiol chelators in the treatment of chronic lead intoxication.
    Chemico-biological interactions, 2003, Jun-15, Volume: 145, Issue:3

    Topics: Animals; Antidotes; Antioxidants; Ascorbic Acid; Chelating Agents; Cysteinyldopa; Disease Models, Animal; Drug Therapy, Combination; Lead Poisoning; Male; Oxidative Stress; Porphobilinogen Synthase; Protoporphyrins; Rats; Rats, Wistar; Succimer; Treatment Outcome; Vitamin E

2003
Reversal of cadmium induced oxidative stress by chelating agent, antioxidant or their combination in rat.
    Toxicology letters, 2003, Dec-10, Volume: 145, Issue:3

    Topics: Acetylcysteine; Administration, Oral; Animals; Antioxidants; Brain; Cadmium Chloride; Cadmium Poisoning; Catalase; Chelating Agents; Drug Synergism; Drug Therapy, Combination; Glutathione; Liver; Male; Malondialdehyde; Mannitol; Oxidative Stress; Rats; Succimer; Superoxide Dismutase

2003
Therapeutic potential of monoisoamyl and monomethyl esters of meso 2,3-dimercaptosuccinic acid in gallium arsenide intoxicated rats.
    Toxicology, 2004, Feb-15, Volume: 195, Issue:2-3

    Topics: Aminolevulinic Acid; Animals; Antidotes; Arsenic Poisoning; Arsenicals; Biomarkers; Chelating Agents; Chelation Therapy; Comet Assay; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Gallium; Injections, Intraperitoneal; Liver; Male; Protoporphyrins; Rats; Rats, Wistar; Succimer; Treatment Outcome

2004
Chronic arsenic poisoning in the rat: treatment with combined administration of succimers and an antioxidant.
    Ecotoxicology and environmental safety, 2004, Volume: 58, Issue:1

    Topics: Animals; Antioxidants; Arsenic; Arsenic Poisoning; Ascorbic Acid; Brain Chemistry; Chelating Agents; Drug Interactions; Drug Therapy, Combination; Heme; Male; Oxidative Stress; Rats; Rats, Wistar; Succimer; Tissue Distribution

2004
Arsenic induced inhibition of delta-aminolevulinate dehydratase activity in rat blood and its response to meso 2,3-dimercaptosuccinic acid and monoisoamyl DMSA.
    Biomedical and environmental sciences : BES, 2004, Volume: 17, Issue:1

    Topics: Administration, Oral; Animals; Arsenic Poisoning; Arsenicals; Enzyme Inhibitors; Injections, Intraperitoneal; Male; Mice; Porphobilinogen Synthase; Rats; Succimer

2004
Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats.
    Journal of biochemical and molecular toxicology, 2004, Volume: 18, Issue:4

    Topics: Animals; Brain; Chelating Agents; Drug Therapy, Combination; Edetic Acid; Glutathione; Hemoglobins; Kidney; Lead; Lead Poisoning; Male; Metals; Oxidative Stress; Porphobilinogen Synthase; Protoporphyrins; Rats; Rats, Wistar; Succimer; Unithiol

2004
Arsenic induced blood and brain oxidative stress and its response to some thiol chelators in rats.
    Life sciences, 2005, Sep-16, Volume: 77, Issue:18

    Topics: 5-Aminolevulinate Synthetase; Animals; Arsenic; Arsenic Poisoning; Chelating Agents; DNA Damage; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Male; Oxidative Stress; Porphobilinogen Synthase; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Unithiol

2005
Response of arsenic-induced oxidative stress, DNA damage, and metal imbalance to combined administration of DMSA and monoisoamyl-DMSA during chronic arsenic poisoning in rats.
    Cell biology and toxicology, 2007, Volume: 23, Issue:2

    Topics: Animals; Antidotes; Arsenic Poisoning; Chelating Agents; Copper; DNA Damage; Drug Therapy, Combination; Erythrocytes; Kidney; Liver; Male; Oxidative Stress; Rats; Rats, Wistar; Succimer; Zinc

2007
Reversal of lead-induced neuronal apoptosis by chelation treatment in rats: role of reactive oxygen species and intracellular Ca(2+).
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:1

    Topics: Animals; Apoptosis; Behavior, Animal; Brain; Calcium; Chelating Agents; Edetic Acid; Lead; Male; Mitochondria; Neurons; Neurotransmitter Agents; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer

2007
Combined administration of iron and monoisoamyl-DMSA in the treatment of chronic arsenic intoxication in mice.
    Cell biology and toxicology, 2007, Volume: 23, Issue:6

    Topics: Animals; Arsenic; Arsenic Poisoning; Brain; Chronic Disease; Drug Therapy, Combination; Iron; Kidney; Liver; Male; Mice; Oxidative Stress; Succimer; Zinc

2007
Essential metal status, prooxidant/antioxidant effects of MiADMSA in male rats: age-related effects.
    Biological trace element research, 2007,Winter, Volume: 120, Issue:1-3

    Topics: Aging; Animals; Antioxidants; Chelating Agents; Copper; Glutathione; Glutathione Disulfide; Hemoglobins; Iron; Magnesium; Male; Metals; Oxidants; Porphobilinogen Synthase; Protoporphyrins; Rats; Rats, Wistar; Succimer; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Zinc

2007
Combinational chelation therapy abrogates lead-induced neurodegeneration in rats.
    Toxicology and applied pharmacology, 2009, Oct-15, Volume: 240, Issue:2

    Topics: Animals; Antioxidants; Apoptosis; Behavior, Animal; Biogenic Amines; Calcium; Captopril; Chelating Agents; Cytochromes c; Disease Models, Animal; DNA Damage; Drug Therapy, Combination; Exploratory Behavior; Lead Poisoning, Nervous System; Learning; Male; Membrane Potential, Mitochondrial; Memory; Mitochondria; Motor Activity; Nerve Degeneration; Neurons; Nitric Oxide; Organometallic Compounds; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer

2009
Monoisoamyl dimercaptosuccinic acid abrogates arsenic-induced developmental toxicity in human embryonic stem cell-derived embryoid bodies: comparison with in vivo studies.
    Biochemical pharmacology, 2009, Nov-15, Volume: 78, Issue:10

    Topics: Animals; Arsenites; Cell Culture Techniques; Cell Differentiation; Cell Line; Cell Survival; Chelating Agents; Congenital Abnormalities; Embryonic Development; Embryonic Stem Cells; Environmental Pollutants; Female; Gene Expression Regulation, Developmental; Germ Layers; Humans; Pregnancy; Rats; Rats, Wistar; Sodium Compounds; Succimer; Toxicity Tests

2009
On the interaction of vanadium species with the monoisoamyl ester of meso-2,3-dimercaptosuccinic acid.
    Biological trace element research, 2010, Volume: 134, Issue:2

    Topics: Chelating Agents; Hydrogen-Ion Concentration; Succimer; Vanadium

2010
Co-administration of monoisoamyl dimercaptosuccinic acid and Moringa oleifera seed powder protects arsenic-induced oxidative stress and metal distribution in mice.
    Toxicology mechanisms and methods, 2009, Volume: 19, Issue:2

    Topics: Animals; Antioxidants; Arsenic; Arsenic Poisoning; Body Weight; Brain; Chelating Agents; Drinking; Eating; Free Radicals; Glutathione; Kidney; Liver; Male; Metals; Mice; Moringa oleifera; Oxidative Stress; Seeds; Succimer; Tissue Distribution

2009
Co-administration of meso 2,3-dimercaptosuccinic acid monoesters reduces arsenic concentration and oxidative stress in gallium arsenide exposed rats.
    Clinical and experimental pharmacology & physiology, 2011, Volume: 38, Issue:7

    Topics: Aminolevulinic Acid; Animals; Arsenic; Arsenic Poisoning; Arsenicals; Catalase; Copper; Gallium; Glutathione; Heme; Kidney; Lipid Peroxidation; Liver; Male; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer; Superoxide Dismutase; Transaminases; Zinc

2011
MiADMSA reverses impaired mitochondrial energy metabolism and neuronal apoptotic cell death after arsenic exposure in rats.
    Toxicology and applied pharmacology, 2011, Nov-01, Volume: 256, Issue:3

    Topics: Animals; Apoptosis; Arsenic Poisoning; Brain; Cells, Cultured; Chelating Agents; Electron Transport; Electron Transport Complex IV; Energy Metabolism; Male; Membrane Potential, Mitochondrial; Mitochondria; NADH Dehydrogenase; Neurons; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer; Succinate Dehydrogenase

2011
Mitigative action of monoisoamyl-2,3-dimercaptosuccinate (MiADMS) against cadmium-induced damage in cultured rat normal liver cells.
    Toxicology in vitro : an international journal published in association with BIBRA, 2011, Volume: 25, Issue:8

    Topics: Animals; Antioxidants; Cadmium; Catalase; Cell Cycle Checkpoints; Cell Line; Cell Survival; Chelating Agents; Environmental Pollutants; Glutathione Peroxidase; Glutathione Reductase; Hepatocytes; Rats; S Phase; Succimer

2011
Monoisoamyl 2, 3-dimercaptosuccinic acid (MiADMSA) demonstrates higher efficacy by oral route in reversing arsenic toxicity: a pharmacokinetic approach.
    Basic & clinical pharmacology & toxicology, 2012, Volume: 110, Issue:5

    Topics: Administration, Oral; Animals; Arsenic; Arsenic Poisoning; Chelating Agents; Chronic Disease; Copper; Dose-Response Relationship, Drug; Glutathione; Glutathione Disulfide; Kidney; Liver; Liver Function Tests; Male; Oxidative Stress; Rats; Rats, Wistar; Succimer; Zinc

2012
Therapeutic profile of T11TS vs. T11TS+MiADMSA: a hunt for a more effective therapeutic regimen for arsenic exposure.
    Asian Pacific journal of cancer prevention : APJCP, 2012, Volume: 13, Issue:6

    Topics: Animals; Apoptosis; Arsenic; Arsenic Poisoning; CD2 Antigens; Cell Transformation, Neoplastic; Chelating Agents; Chelation Therapy; Cytokines; Drug Therapy, Combination; Environmental Exposure; Lymphocytes; Mice; Oxidative Stress; Succimer

2012
Monensin potentiates lead chelation efficacy of MiADMSA in rat brain post chronic lead exposure.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:12

    Topics: Animals; Antioxidants; Biomarkers; Brain; Chelating Agents; DNA Damage; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Kidney; Lead; Male; Monensin; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2012
Arsenic induced neuronal apoptosis in guinea pigs is Ca2+ dependent and abrogated by chelation therapy: role of voltage gated calcium channels.
    Neurotoxicology, 2013, Volume: 35

    Topics: Animals; Apoptosis; Arsenic Poisoning; Arsenites; bcl-2-Associated X Protein; Calcium; Calcium Channels, L-Type; Caspase 3; Chelating Agents; Cytoprotection; Disease Models, Animal; Drug Therapy, Combination; Guinea Pigs; Kinetics; Male; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sodium Compounds; Succimer

2013
Monoisoamyl 2,3-dimercaptosuccinic acid attenuates arsenic induced toxicity: behavioral and neurochemical approach.
    Environmental toxicology and pharmacology, 2013, Volume: 36, Issue:1

    Topics: Animals; Arsenic Poisoning; Behavior, Animal; Brain; Catalase; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Hand Strength; Male; Maze Learning; Mitochondria; Motor Activity; Neuroprotective Agents; Rats; Rats, Wistar; Succimer; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2013
MiADMSA protects arsenic-induced oxidative stress in human keratinocyte 'HaCaT' cells.
    Biological trace element research, 2013, Volume: 153, Issue:1-3

    Topics: Arsenic; Cell Line; Dose-Response Relationship, Drug; Humans; Keratinocytes; Oxidative Stress; Succimer

2013
Reversal effect of monoisoamyl dimercaptosuccinic acid (MiADMSA) for arsenic and lead induced perturbations in apoptosis and antioxidant enzymes in developing rat brain.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2013, Volume: 31, Issue:7

    Topics: Age Factors; Animals; Animals, Newborn; Antioxidants; Apoptosis; Arsenates; Brain; Catalase; Embryo, Mammalian; Female; Lead; Male; Malondialdehyde; Oxidative Stress; Pregnancy; Rats; Rats, Wistar; Succimer; Superoxide Dismutase

2013
Alterations in apoptotic caspases and antioxidant enzymes in arsenic exposed rat brain regions: reversal effect of essential metals and a chelating agent.
    Environmental toxicology and pharmacology, 2013, Volume: 36, Issue:3

    Topics: Animals; Antioxidants; Apoptosis; Arsenic; Brain; Calcium; Caspases; Chelating Agents; Lipid Peroxidation; Metals; Mitochondria; Oxidative Stress; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Succimer; Zinc

2013
Nanoencapsulation of DMSA monoester for better therapeutic efficacy of the chelating agent against arsenic toxicity.
    Nanomedicine (London, England), 2014, Volume: 9, Issue:4

    Topics: Animals; Arsenic; Arsenic Poisoning; Brain; Chelating Agents; Drug Carriers; Kidney; Liver; Male; Mice; Nanoparticles; Rabbits; Rats; Rats, Wistar; Succimer

2014
Combinatorial drug delivery strategy employing nano-curcumin and nano-MiADMSA for the treatment of arsenic intoxication in mouse.
    Chemico-biological interactions, 2018, Apr-25, Volume: 286

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Arsenic; Arsenic Poisoning; Curcumin; Deoxyguanosine; Drug Carriers; Drug Synergism; Enzymes; Glutathione; Liver; Male; Mice; Nanoparticles; Oxidative Stress; Reactive Oxygen Species; Succimer

2018
Effects of combined arsenic and lead exposure on the brain monoaminergic system and behavioral functions in rats: Reversal effect of MiADMSA.
    Toxicology and industrial health, 2019, Volume: 35, Issue:2

    Topics: Animals; Arsenic; Behavior, Animal; Biogenic Monoamines; Brain; Exploratory Behavior; Female; Lead; Male; Motor Activity; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar; Succimer

2019
MiADMSA ameliorate arsenic induced urinary bladder carcinogenesis in vivo and in vitro.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 128

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anticarcinogenic Agents; Arsenites; Cacodylic Acid; Carcinoma, Transitional Cell; Cell Line, Tumor; Cell Transformation, Neoplastic; Chelating Agents; DNA Damage; Humans; Male; Matrix Metalloproteinase 9; Nitrosative Stress; Rats, Sprague-Dawley; Sodium Compounds; Succimer; Survivin; Urinary Bladder Neoplasms

2020
Monoisoamyl DMSA reduced copper-induced neurotoxicity by lowering 8-OHdG level, amyloid beta and Tau protein expressions in Sprague-Dawley rats.
    Metallomics : integrated biometal science, 2020, 09-23, Volume: 12, Issue:9

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Amyloid beta-Peptides; Animals; Brain; Brain Chemistry; Copper; Male; Molecular Docking Simulation; Neuroprotective Agents; Rats, Sprague-Dawley; Succimer; tau Proteins

2020
Comparative efficacy of Nano and Bulk Monoisoamyl DMSA against arsenic-induced neurotoxicity in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 132

    Topics: Animals; Antioxidants; Arsenic Poisoning; Arsenites; Behavior, Animal; Biomarkers; Brain; Chelating Agents; Disease Models, Animal; Drug Compounding; Lipids; Male; Motor Activity; Nanoparticles; Oxidative Stress; Rats, Transgenic; Sodium Compounds; Succimer

2020
MiADMSA abrogates sodium tungstate-induced oxidative stress in rats.
    Drug and chemical toxicology, 2022, Volume: 45, Issue:6

    Topics: Animals; Antidotes; Arsenic; Biomarkers; Chelating Agents; Glutathione Disulfide; Male; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer; Thiobarbituric Acid Reactive Substances; Tungsten

2022