Page last updated: 2024-09-04

monodesmethylcitalopram and fluoxetine

monodesmethylcitalopram has been researched along with fluoxetine in 6 studies

Compound Research Comparison

Studies
(monodesmethylcitalopram)
Trials
(monodesmethylcitalopram)
Recent Studies (post-2010)
(monodesmethylcitalopram)
Studies
(fluoxetine)
Trials
(fluoxetine)
Recent Studies (post-2010) (fluoxetine)
5051910,1001,6633,263

Protein Interaction Comparison

ProteinTaxonomymonodesmethylcitalopram (IC50)fluoxetine (IC50)
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)5.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.119
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.303
Muscarinic acetylcholine receptor M5Homo sapiens (human)1.358
Cytochrome P450 2D6Homo sapiens (human)0.7
Muscarinic acetylcholine receptor M1Homo sapiens (human)3.203
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)5.2
Alpha-2B adrenergic receptorHomo sapiens (human)1.528
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)5.2
Muscarinic acetylcholine receptor M3Homo sapiens (human)3.595
AcetylcholinesteraseHomo sapiens (human)0.13
Prostaglandin G/H synthase 1Homo sapiens (human)6
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.8332
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)6
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.452
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.1395
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)5.2
Sodium-dependent serotonin transporterHomo sapiens (human)0.0342
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.0538
Cytochrome P450 2C19Homo sapiens (human)0.0525
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)5.2
5-hydroxytryptamine receptor 6Homo sapiens (human)1.661
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)5.2
Sodium-dependent dopamine transporter Homo sapiens (human)5.984
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.3513
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)5.2
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0094
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)5.2
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.6751
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)5.2

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andersen, J; Bang-Andersen, B; Eildal, JN; Jørgensen, AM; Jørgensen, M; Kristensen, AS; Strømgaard, K1
Ekblad, U; Heikkine, T; Laine, K1
Lambert, WE; Maudens, KE; Van Peteghem, CH; Wille, SM1
Barrio, RJ; Goicolea, MA; Gómez-Caballero, A; Millán, S; Sallés, J; Sampedro, MC; Sánchez, A; Unceta, N1
Baumer, C; Koren, G; O'Brien, L; Sachs, H; Thieme, D1
Brose, SA; Golovko, MY; Henry, LK; Krout, D; Rodriquez, M; Thompson, BJ1

Other Studies

6 other study(ies) available for monodesmethylcitalopram and fluoxetine

ArticleYear
From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies.
    Journal of medicinal chemistry, 2008, May-22, Volume: 51, Issue:10

    Topics: Animals; Benzofurans; Blood Platelets; Brain; Cell Line; Citalopram; Humans; In Vitro Techniques; Norepinephrine Plasma Membrane Transport Proteins; Propylamines; Rats; Recombinant Proteins; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Synaptosomes

2008
Transplacental transfer of citalopram, fluoxetine and their primary demethylated metabolites in isolated perfused human placenta.
    BJOG : an international journal of obstetrics and gynaecology, 2002, Volume: 109, Issue:9

    Topics: Citalopram; Female; Fluoxetine; Humans; Maternal-Fetal Exchange; Placenta; Pregnancy; Prospective Studies; Protein Binding; Selective Serotonin Reuptake Inhibitors

2002
Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis.
    Journal of chromatography. A, 2005, Dec-09, Volume: 1098, Issue:1-2

    Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopram; Cyclohexanols; Desvenlafaxine Succinate; Fluoxetine; Gas Chromatography-Mass Spectrometry; Humans; Mianserin; Microchemistry; Mirtazapine; Piperazines; Reproducibility of Results; Sertraline

2005
Simultaneous determination of citalopram, fluoxetine and their main metabolites in human urine samples by solid-phase microextraction coupled with high-performance liquid chromatography.
    Journal of pharmaceutical and biomedical analysis, 2008, Mar-13, Volume: 46, Issue:4

    Topics: Chromatography, High Pressure Liquid; Citalopram; Fluoxetine; Humans; Hydrogen-Ion Concentration; Osmolar Concentration; Solid Phase Extraction; Temperature

2008
Changes in antidepressant metabolism in pregnancy evidenced by metabolic ratios in hair: a novel approach.
    Forensic science international, 2010, Mar-20, Volume: 196, Issue:1-3

    Topics: Adult; Antidepressive Agents; Citalopram; Cyclohexanols; Female; Fluoxetine; Gas Chromatography-Mass Spectrometry; Hair; Humans; Postpartum Period; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Third; Sertraline; Venlafaxine Hydrochloride

2010
Inhibition of the Serotonin Transporter Is Altered by Metabolites of Selective Serotonin and Norepinephrine Reuptake Inhibitors and Represents a Caution to Acute or Chronic Treatment Paradigms.
    ACS chemical neuroscience, 2017, 05-17, Volume: 8, Issue:5

    Topics: Animals; Citalopram; Fluoxetine; Mice; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Sertraline; Synaptosomes

2017