monensin-b and 2-methylbutanoic-acid

monensin-b has been researched along with 2-methylbutanoic-acid* in 1 studies

Other Studies

1 other study(ies) available for monensin-b and 2-methylbutanoic-acid

ArticleYear
Biosynthesis of monensins A and B: the role of isoleucine.
    Folia microbiologica, 1986, Volume: 31, Issue:1

    Isoleucine added to the cultivation medium of Streptomyces cinnamonensis C-100-5 induced a relative increase of the production of monensin B at the expense of monensin A. U-14C-Isoleucine was found not to be a specific monensin B precursor. The incorporation of 1-13C-2-methylbutyrate into monensins A and B showed the label to be evenly incorporated in both products at carbon atoms originating from C(1) of propionate. In regulatory mutants insensitive to 2-amino-3-chlorobutyrate isoleucine influenced the production of monensins only slightly but strains resistant to 2-aminobutyrate and norleucine decreased their total production by 2-12% in the presence of isoleucine which was associated with a decrease of monensin A content by 14-52%. The inhibitory effect of isoleucine on the biosynthesis of valine, a specific precursor of the butyrate unit of monensin A, is discussed.

    Topics: Aminobutyrates; Butyrates; Furans; Isoleucine; Monensin; Mutation; Norleucine; Streptomyces; Valine

1986