mometasone-furoate and xylometazoline

Thirty-six persistent allergic rhinitis (PAR) sufferers were studied, to both compare and correlate 15 minute response to nasal xylometazoline (XYLO) with 28 day response to nasal mometasone furoate (MF). 0.1% XYLO (1 spray each nostril) response was measured on two occasions, then a randomised double blind cross-over comparison of MF (200 mcg daily) to placebo conducted. Outcomes were peak nasal inspiratoly flow (PNIF), nasal forced inspiratory volume in one second (nFIV1) and nasal blockage score (NBS) improvements. Thirty-one participants completed per protocol. Within subject standard deviation for percentage improvement to XYLO was 26.0 for PNIF and 25.2 for nFIV1. Median % improvement (95%CI) in PNIF for XYLO vs. MF was 20.0 (11.4 to 31.0) vs. 9.6 (3.2 to 15.8) and in nFIV1 was 17.8 (10.0 to 28.1) vs. 3.3 (-4.3 to 19.1). XYLO effects were greater than MF (p<0.05) for PNIF, nFIV1 and NBS. There was no significant correlation of MF to XYLO improvements in PNIF, nFIV1 or NBS. In conclusion, acute reversibility to XYLO showed poor repeatability and XYLO reversibility is not predictive of decongestant response to nasal corticosteroid. XYLO was a stronger decongestant than MF but rhinitis medicamentosa still precludes any preference for long term XYLO therapy at this time.

Topics: Administration, Intranasal; Anti-Allergic Agents; Chi-Square Distribution; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Imidazoles; Male; Mometasone Furoate; Nasal Decongestants; Pregnadienediols; Rhinitis, Allergic, Perennial; Spirometry; Statistics, Nonparametric; Treatment Outcome

This study revealed that the nasal topical drops, which could be purchased without a proper prescription, should not be used randomly and non-selectively.. To investigate the effect of nasal drops and sprays on the nasal air flow and mucociliary transport time (MTT) in healthy volunteers with no septal deviation and no history of frequent upper respiratory infection.. Saline, fluticasone propionate drops and sprays, mometasone furoate, budesonide, xylometasoline chloride, fusafungine spray, Ringer's lactate and sea water were selected as the agents to be investigated. Volunteers were subdivided into two subgroups according to their rhinomanometric scores: group 1 consisted of subjects with nasal respiration > or =500 ml at 150 daPa and group 2 consisted of those with nasal air flow <500 ml.. No statistically significant difference was found among the effects of these agents on MTT in group 1. In group 2, xylometasoline chloride, fluticasone propionate spray and sea water sprays prolonged the MTT. When the rhinomanometric scores at 150 daPa were assessed, use of xylometasoline chloride, fluticasone propionate drops, budesonide, fusafungine, sea water and Ringer's lactate were found to diminish the nasal air flow with respect to normal values in group 1. In group 2, no significant difference was noticed between normal values and values acquired after use of nasal drops. Comparing the same agents, we did not find a significant difference between groups 1 and 2 regarding MTT and nasal air flow.

Topics: Administration, Intranasal; Adult; Aerosols; Androstadienes; Anti-Bacterial Agents; Anti-Inflammatory Agents; Budesonide; Depsipeptides; Female; Fluticasone; Fusarium; Humans; Imidazoles; Isotonic Solutions; Male; Mometasone Furoate; Mucociliary Clearance; Nasal Decongestants; Nasal Mucosa; Nonprescription Drugs; Pregnadienediols; Pulmonary Ventilation; Rhinomanometry; Ringer's Lactate; Seawater; Sodium Chloride; Solutions; Young Adult