mometasone-furoate and tixocortol-pivalate

Mometasone furoate is a new corticosteroid, synthesized to have an improved ratio of anti-inflammatory potential to adverse effects. The guinea pig maximization test was used to determine the sensitizing capacity of mometasone furoate, and also to investigate cross-reaction patterns in animals sensitized to tixocortol pivalate and budesonide, respectively. Tixocortol pivalate was shown to be a sensitizer in the guinea pig, but cross-reactions to other tested corticosteroids were not observed. Furthermore, no sensitizing capacity could be demonstrated for budesonide or mometasone furoate.

Topics: Administration, Cutaneous; Administration, Topical; Animals; Anti-Inflammatory Agents; Budesonide; Cross Reactions; Dermatitis, Allergic Contact; Female; Glucocorticoids; Guinea Pigs; Hydrocortisone; Immunization; Injections, Intradermal; Mometasone Furoate; Patch Tests; Prednisolone; Pregnadienediols; Pregnenediones; Time Factors; Triamcinolone Acetonide