modipafant has been researched along with web 2086 in 6 studies
*WEB 2086: structure given in first source; PAF antagonist [MeSH]
*WEB 2086: structure given in first source; PAF antagonist [MeSH]
| Studies (modipafant) | Trials (modipafant) | Recent Studies (post-2010) (modipafant) | Studies (web 2086) | Trials (web 2086) | Recent Studies (post-2010) (web 2086) |
|---|---|---|---|---|---|
| 6 | 0 | 0 | 600 | 8 | 31 |
| 29 | 3 | 3 | 600 | 8 | 31 |
| Protein | Taxonomy | modipafant (IC50) | web 2086 (IC50) |
|---|---|---|---|
| Platelet-activating factor receptor | Cavia porcellus (domestic guinea pig) | 0.1093 | |
| Platelet-activating factor receptor | Homo sapiens (human) | 0.1735 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cooper, K; Fray, MJ; Parry, MJ; Richardson, K; Steele, J | 1 |
| Bures, MG; Carrera, GM; Davidsen, SK; Guinn, DE; Heyman, HR; May, PD; Phillips, JG; Pireh, D; Sheppard, GS; Steinman, DH | 1 |
| Alabaster, VA; Cheeseman, HE; Cooper, K; deSouza, RN; Keir, RF; Parry, MJ | 1 |
| Chilvers, ER; Condliffe, AM; Haslett, C; Kitchen, E; Rossi, AG | 1 |
| Aparecida, M; Beker, CL; Borges, CM; Freire-Maia, L; Silveira, MR; Teixeira, MM | 1 |
| Borgeat, P; Flamand, N; Lefebvre, JS; Lévesque, T; Marleau, S; Milot, V; Picard, S | 1 |
6 other study(ies) available for modipafant and web 2086
| Article | Year |
|---|---|
1,4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl)phenyl derivatives.
Topics: Animals; Dihydropyridines; Dogs; Imidazoles; Mice; Molecular Structure; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Structure-Activity Relationship | 1992 |
3-(2-(3-Pyridinyl)thiazolidin-4-oyl)indoles, a novel series of platelet activating factor antagonists.
Topics: Administration, Oral; Animals; Capillary Permeability; Edema; In Vitro Techniques; Indoles; Magnetic Resonance Spectroscopy; Male; Mice; Platelet Activating Factor; Rabbits; Rats; Rats, Sprague-Dawley; Serotonin; Skin; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 1994 |
Pharmacological profile of UK-74,505, a novel and selective PAF antagonist with potent and prolonged oral activity.
Topics: Administration, Oral; Animals; Aorta; Azepines; Blood Platelets; Brain; Calcium Channels, L-Type; Capillary Permeability; Cattle; Dihydropyridines; Diltiazem; Gallopamil; Guinea Pigs; Hypotension; Imidazoles; In Vitro Techniques; Kinetics; Male; Membranes; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle Proteins; Nitrendipine; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Potassium Chloride; Rabbits; Rats; Rats, Sprague-Dawley; Skin; Triazoles; Tritium | 1994 |
Demonstration of reversible priming of human neutrophils using platelet-activating factor.
Topics: Adult; Azepines; Cell Adhesion; Cell Polarity; Cell Size; Cells, Cultured; Dihydropyridines; Enzyme Activation; Humans; Imidazoles; Macrophage-1 Antigen; Microspheres; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Burst; Superoxides; Time Factors; Triazoles; Tumor Necrosis Factor-alpha | 1996 |
Scorpion venom-induced neutrophilia is inhibited by a PAF receptor antagonist in the rat.
Topics: Animals; Azepines; Dihydropyridines; Drug Antagonism; Imidazoles; Leukocyte Count; Male; Neutrophil Activation; Neutrophils; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Scorpion Venoms; Triazoles | 2000 |
Toll-like receptor ligands induce polymorphonuclear leukocyte migration: key roles for leukotriene B4 and platelet-activating factor.
Topics: Animals; Azepines; Cell Movement; Dihydropyridines; Female; Flagellin; Humans; Imidazoles; Leukotriene B4; Ligands; Mice; Mice, Inbred C57BL; Neutrophils; Platelet Activating Factor; Poly I-C; Propionates; Quinolines; Thienopyridines; Toll-Like Receptors; Triazoles | 2010 |