Page last updated: 2024-09-03

modipafant and dihydropyridines

modipafant has been researched along with dihydropyridines in 29 studies

Compound Research Comparison

Studies (modipafant)	Trials (modipafant)	Recent Studies (post-2010) (modipafant)	Studies (dihydropyridines)	Trials (dihydropyridines)	Recent Studies (post-2010) (dihydropyridines)
29	3	3	5,022	529	969

Research

Studies (29)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	15 (51.72)	18.2507
2000's	10 (34.48)	29.6817
2010's	4 (13.79)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cooper, K; Fray, MJ; Parry, MJ; Richardson, K; Steele, J	1
Alabaster, VA; de Souza, RN; Keir, RF; Parry, MJ	1
Nourshargh, S; Walsh, DT; Weg, VB; Williams, TJ	1
Das, A; Larkin, SW; Nourshargh, S; Williams, TJ	1
Angus, RM; Barnes, NC; Barnes, PJ; Bone, MF; Chung, KF; Fairfax, AJ; Higenbotham, TW; Kuitert, LM; O'Connor, BJ; Piotrowska, B	1
Alabaster, VA; Cheeseman, HE; Cooper, K; deSouza, RN; Keir, RF; Parry, MJ	1
Bolanowski, MA; Nourshargh, S; Sanz, MJ; Weg, VB	1
Nourshargh, S; Sanz, MJ; Walsh, DT; Weg, VB; Williams, TJ	1
Barnes, PJ; Carty, TJ; Chung, KF; Eskra, JD; O'Connor, BJ; Uden, S	1
Barnes, NC; Burke, W; Hui, KP; Kuitert, LM; Newland, AC; Uden, S; Uthayarkumar, S	1
Norman, KE; Nourshargh, S; Pons, F; Rossi, AG; Williams, TJ	1
Jezequel, SG; Uden, S; Wastall, P	1
Chilvers, ER; Condliffe, AM; Haslett, C; Kitchen, E; Rossi, AG	1
Norman, KE; Rossi, AG; Williams, TJ	1
Hellewell, PG; Jeffery, PK; Miotla, JM	1
Aparecida, M; Beker, CL; Borges, CM; Freire-Maia, L; Silveira, MR; Teixeira, MM	1
Andrade, SP; Cara, DC; Cassali, GD; Coutinho, SF; Poole, SP; Silveira, MR; Souza, DG; Teixeira, MM	1
Au, BT; Collins, PD; Teixeira, MM; Williams, TJ	1
Ishii, S; Nicoli, JR; Pinho, VS; Shimizu, T; Soares, AC; Souza, DG; Teixeira, MM	1
Benjamim, CF; Cunha, Fde Q; Ferreira, SH; Rios-Santos, F; Zavery, D	1
Ishii, S; Pinho, V; Shimizu, T; Soares, AC; Souza, DG; Teixeira, MM	1
Andrade, SP; Barcelos, LS; Campos, PP; Ferreira, MA; Teixeira, MM; Vasconcelos, AC	1
Arantes, EC; Coelho, AM; Coelho, FM; Pessini, AC; Pinho, VS; Souza, DG; Teixeira, AL; Teixeira, MM	1
Bélanger, C; Borgeat, P; Elimam, H; Lefebvre, J; Marleau, S	1
Amaral, FA; Atrasheuskaya, A; Bukin, E; Cunha, FQ; Fagundes, CT; Ignatyev, G; Kroon, EG; Sachs, D; Sousa, LP; Souza, AL; Souza, DG; Souza, RS; Teixeira, MM	1
Borgeat, P; Flamand, N; Lefebvre, JS; Lévesque, T; Marleau, S; Milot, V; Picard, S	1
Campos, RD; Lacerda-Queiroz, N; Quesniaux, VF; Rachid, MA; Rodrigues, DH; Soriani, FM; Sousa, LP; Teixeira, AL; Teixeira, MM; Vilela, MC	1
Cunha, FQ; Cunha, TM; Ferreira, SH; Guerrero, AT; Pinto, LG; Verri, WA; Vieira, SM; Zaperlon, AC; Zarpelon, AC	1
Campos, MA; de Miranda, AS; Kroon, EG; Lacerda-Queiroz, N; Lima, GK; Pedroso, VS; Rachid, MA; Rodrigues, DH; Teixeira, AL; Teixeira, MM; Vilela, MC	1

Trials

3 trial(s) available for modipafant and dihydropyridines

Article	Year
Effect of a novel potent platelet-activating factor antagonist, modipafant, in clinical asthma. American journal of respiratory and critical care medicine, 1995, Volume: 151, Issue:5 Topics: Adult; Aged; Asthma; Dihydropyridines; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Imidazoles; Male; Middle Aged; Peak Expiratory Flow Rate; Platelet Activating Factor; Quality of Life; Single-Blind Method	1995
Inhibitory effect of UK,74505, a potent and specific oral platelet activating factor (PAF) receptor antagonist, on airway and systemic responses to inhaled PAF in humans. American journal of respiratory and critical care medicine, 1994, Volume: 150, Issue:1 Topics: Administration, Inhalation; Administration, Oral; Airway Resistance; Bronchoconstriction; Dihydropyridines; Dose-Response Relationship, Drug; Double-Blind Method; Eicosanoids; Humans; Imidazoles; Leukocyte Count; Leukotriene E4; Male; Neutropenia; Neutrophils; Platelet Activating Factor; Thromboxane B2	1994
Effect of the platelet-activating factor antagonist UK-74,505 on the early and late response to allergen. The American review of respiratory disease, 1993, Volume: 147, Issue:1 Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Provocation Tests; Dihydropyridines; Double-Blind Method; Forced Expiratory Volume; Humans; Imidazoles; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation	1993

Other Studies

26 other study(ies) available for modipafant and dihydropyridines

Article	Year
1,4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl)phenyl derivatives. Journal of medicinal chemistry, 1992, Aug-21, Volume: 35, Issue:17 Topics: Animals; Dihydropyridines; Dogs; Imidazoles; Mice; Molecular Structure; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Structure-Activity Relationship	1992
UK-74,505, a novel and selective PAF antagonist, exhibits potent and long lasting activity in vivo. Agents and actions. Supplements, 1991, Volume: 34 Topics: Animals; Blood Cells; Bronchoconstriction; Capillary Permeability; Cell Aggregation; Dihydropyridines; Dogs; Female; Guinea Pigs; Imidazoles; Male; Platelet Activating Factor; Pyridines; Rats; Rats, Inbred Strains; Time Factors	1991
Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators. British journal of pharmacology, 1995, Volume: 114, Issue:7 Topics: Animals; Antibodies, Monoclonal; Biphenyl Compounds; Chlorpheniramine; Dihydropyridines; Dose-Response Relationship, Drug; Edema; Female; Guinea Pigs; Imidazoles; Indoles; Inflammation; Isoindoles; Neurokinin-1 Receptor Antagonists; Pyrans; Quinolones; Skin; Substance P; Time Factors	1995
Interleukin-1-induced leukocyte extravasation across rat mesenteric microvessels is mediated by platelet-activating factor. Blood, 1995, May-01, Volume: 85, Issue:9 Topics: Animals; Azepines; Cell Adhesion; Chemotaxis, Leukocyte; Dihydropyridines; Edema; Imidazoles; Inflammation; Interleukin-1; Leukocytes; Male; Mesentery; Microcirculation; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Skin; Triazoles	1995
Pharmacological profile of UK-74,505, a novel and selective PAF antagonist with potent and prolonged oral activity. Journal of lipid mediators and cell signalling, 1994, Volume: 10, Issue:3 Topics: Administration, Oral; Animals; Aorta; Azepines; Blood Platelets; Brain; Calcium Channels, L-Type; Capillary Permeability; Cattle; Dihydropyridines; Diltiazem; Gallopamil; Guinea Pigs; Hypotension; Imidazoles; In Vitro Techniques; Kinetics; Male; Membranes; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle Proteins; Nitrendipine; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Potassium Chloride; Rabbits; Rats; Rats, Sprague-Dawley; Skin; Triazoles; Tritium	1994
IL-1 is a potent inducer of eosinophil accumulation in rat skin. Inhibition of response by a platelet-activating factor antagonist and an anti-human IL-8 antibody. Journal of immunology (Baltimore, Md. : 1950), 1995, Feb-01, Volume: 154, Issue:3 Topics: Animals; Antibodies, Monoclonal; Calcium; Chemotaxis, Leukocyte; Dactinomycin; Dihydropyridines; Edema; Eosinophils; Imidazoles; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Interleukin-8; Leukotriene B4; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Sialoglycoproteins; Skin	1995
Differential effects of the PAF receptor antagonist UK-74,505 on neutrophil and eosinophil accumulation in guinea-pig skin. British journal of pharmacology, 1994, Volume: 113, Issue:2 Topics: Animals; Blood Proteins; Calcium; Dihydropyridines; Edema; Eosinophils; Female; Guinea Pigs; Imidazoles; Leukotriene B4; Neutrophils; Passive Cutaneous Anaphylaxis; Peritoneal Cavity; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Skin; Zymosan	1994
Role of platelet-activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long-acting PAF antagonist, UK-74,505. British journal of pharmacology, 1993, Volume: 109, Issue:1 Topics: Animals; Arthus Reaction; Blood Platelets; Calcium; Dihydropyridines; Edema; Fura-2; Imidazoles; In Vitro Techniques; Indium Radioisotopes; Platelet Activating Factor; Platelet Aggregation; Rabbits; Serum Albumin; Skin; Zymosan	1993
Modipafant, a new PAF antagonist: pharmacokinetics and disposition in rat, dog and man. Xenobiotica; the fate of foreign compounds in biological systems, 1996, Volume: 26, Issue:9 Topics: Administration, Oral; Animals; Blood Proteins; Dihydropyridines; Dogs; Female; Humans; Imidazoles; Injections, Intravenous; Male; Platelet Aggregation Inhibitors; Protein Binding; Rats; Sex Characteristics; Tissue Distribution	1996
Demonstration of reversible priming of human neutrophils using platelet-activating factor. Blood, 1996, Dec-01, Volume: 88, Issue:11 Topics: Adult; Azepines; Cell Adhesion; Cell Polarity; Cell Size; Cells, Cultured; Dihydropyridines; Enzyme Activation; Humans; Imidazoles; Macrophage-1 Antigen; Microspheres; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Burst; Superoxides; Time Factors; Triazoles; Tumor Necrosis Factor-alpha	1996
Comparison of the reversed passive Arthus and local Shwartzman reactions of rabbit skin: effects of the long-acting PAF antagonist UK-74,505. British journal of pharmacology, 1997, Volume: 120, Issue:7 Topics: Animals; Arthus Reaction; Cell Aggregation; Dihydropyridines; Imidazoles; Neutrophils; Platelet Activating Factor; Rabbits; Shwartzman Phenomenon	1997
Platelet-activating factor plays a pivotal role in the induction of experimental lung injury. American journal of respiratory cell and molecular biology, 1998, Volume: 18, Issue:2 Topics: Animals; Capillary Permeability; Dihydropyridines; Disease Models, Animal; Elapid Venoms; Extravascular Lung Water; Female; Humans; Imidazoles; Lipopolysaccharides; Lung; Mice; Mice, Inbred BALB C; Neutrophils; Peroxidase; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Distress Syndrome; Serum Albumin; Skin; Zymosan	1998
Scorpion venom-induced neutrophilia is inhibited by a PAF receptor antagonist in the rat. Journal of leukocyte biology, 2000, Volume: 67, Issue:4 Topics: Animals; Azepines; Dihydropyridines; Drug Antagonism; Imidazoles; Leukocyte Count; Male; Neutrophil Activation; Neutrophils; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Scorpion Venoms; Triazoles	2000
Effects of the PAF receptor antagonist UK74505 on local and remote reperfusion injuries following ischaemia of the superior mesenteric artery in the rat. British journal of pharmacology, 2000, Volume: 131, Issue:8 Topics: Animals; Azepines; Capillary Permeability; Dihydropyridines; Disease Models, Animal; Dose-Response Relationship, Drug; Imidazoles; Intestine, Small; Male; Mesenteric Artery, Superior; Neutrophils; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Polysaccharides; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reperfusion Injury; Triazoles; Tumor Necrosis Factor-alpha	2000
Blockade of PAF receptors controls interleukin-8 production by regulating the activation of neutrophil CD11/CD18. European journal of pharmacology, 2001, Aug-03, Volume: 425, Issue:1 Topics: CD11 Antigens; CD18 Antigens; Cells, Cultured; Cytochalasins; Dihydropyridines; Epitopes; Humans; Imidazoles; Interleukin-8; Neutrophil Activation; Neutrophils; Phagocytosis; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Time Factors; Zymosan	2001
Role of the platelet-activating factor (PAF) receptor during pulmonary infection with gram negative bacteria. British journal of pharmacology, 2002, Volume: 137, Issue:5 Topics: Animals; Dihydropyridines; Female; Gram-Negative Bacteria; Imidazoles; Klebsiella Infections; Klebsiella pneumoniae; Lung; Mice; Mice, Inbred BALB C; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tumor Necrosis Factor-alpha	2002
A critical role of leukotriene B4 in neutrophil migration to infectious focus in cecal ligaton and puncture sepsis. Shock (Augusta, Ga.), 2003, Volume: 19, Issue:1 Topics: Animals; Cecum; Cell Movement; Dihydropyridines; Eicosanoids; Imidazoles; Indoles; Inflammation; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred C57BL; Neutrophils; Peritoneum; Platelet Activating Factor; Prostaglandins; Time Factors; Wounds, Penetrating	2003
Role of PAF receptors during intestinal ischemia and reperfusion injury. A comparative study between PAF receptor-deficient mice and PAF receptor antagonist treatment. British journal of pharmacology, 2003, Volume: 139, Issue:4 Topics: Animals; Dihydropyridines; Disease Models, Animal; Imidazoles; Intestinal Diseases; Intestines; Lung Diseases; Male; Mesenteric Artery, Superior; Mice; Mice, Inbred C57BL; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Reperfusion Injury	2003
Sponge-induced angiogenesis and inflammation in PAF receptor-deficient mice (PAFR-KO). British journal of pharmacology, 2004, Volume: 141, Issue:7 Topics: Acetylglucosaminidase; Administration, Topical; Animals; Blood Vessels; Chemokines; Dihydropyridines; Fibroblasts; Granulation Tissue; Granuloma; Hemoglobins; Imidazoles; Implants, Experimental; Inflammation; Macrophages; Mice; Mice, Inbred BALB C; Mice, Knockout; Neovascularization, Pathologic; Neutrophils; Peroxidase; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polyurethanes; Porifera; Receptors, G-Protein-Coupled; Skin	2004
Platelet activating factor receptors drive CXC chemokine production, neutrophil influx and edema formation in the lungs of mice injected with Tityus serrulatus venom. Toxicon : official journal of the International Society on Toxinology, 2007, Sep-01, Volume: 50, Issue:3 Topics: Animals; Chemokines, CXC; Dihydropyridines; Dose-Response Relationship, Drug; Edema; Granulocyte Colony-Stimulating Factor; Imidazoles; Interleukin-3; Lung Diseases; Male; Mice; Neutrophils; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Recombinant Proteins; Scorpion Venoms; Scorpions; Sulfonamides; Time Factors	2007
Involvement of endogenous leukotriene B4 and platelet-activating factor in polymorphonuclear leucocyte recruitment to dermal inflammatory sites in rats. Immunology, 2008, Volume: 124, Issue:3 Topics: Animals; Benzopyrans; Carboxylic Acids; Dermatitis; Dihydropyridines; Imidazoles; Leukotriene B4; Male; Neutrophil Infiltration; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pneumonia; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Leukotriene B4; Skin; Thiazoles	2008
Essential role of platelet-activating factor receptor in the pathogenesis of Dengue virus infection. Proceedings of the National Academy of Sciences of the United States of America, 2009, Aug-18, Volume: 106, Issue:33 Topics: Aedes; Animals; Brain; Cell Line; Cytokines; Dengue; Dengue Virus; Dihydropyridines; Disease Models, Animal; Humans; Imidazoles; Mice; Mice, Inbred BALB C; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Viral Load	2009
Toll-like receptor ligands induce polymorphonuclear leukocyte migration: key roles for leukotriene B4 and platelet-activating factor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, Volume: 24, Issue:2 Topics: Animals; Azepines; Cell Movement; Dihydropyridines; Female; Flagellin; Humans; Imidazoles; Leukotriene B4; Ligands; Mice; Mice, Inbred C57BL; Neutrophils; Platelet Activating Factor; Poly I-C; Propionates; Quinolines; Thienopyridines; Toll-Like Receptors; Triazoles	2010
Platelet-activating factor receptor is essential for the development of experimental cerebral malaria. The American journal of pathology, 2012, Volume: 180, Issue:1 Topics: Animals; Brain Chemistry; Caspase 3; Chemokines; Cytokines; Dihydropyridines; Imidazoles; Leukocytes; Lymphocyte Activation; Malaria, Cerebral; Mice; Mice, Inbred C57BL; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled	2012
The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia. Naunyn-Schmiedeberg's archives of pharmacology, 2013, Volume: 386, Issue:1 Topics: Animals; Dihydropyridines; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Imidazoles; Immune System Diseases; Inflammation; Joint Diseases; Leukocyte Disorders; Leukotriene B4; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prostaglandins; Receptors, G-Protein-Coupled; Time Factors; Zymosan	2013
Platelet Activating Factor (PAF) Receptor Deletion or Antagonism Attenuates Severe HSV-1 Meningoencephalitis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2016, Volume: 11, Issue:4 Topics: Animals; Brain; Dihydropyridines; Herpes Simplex; Herpesvirus 1, Human; Imidazoles; Male; Meningoencephalitis; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Severity of Illness Index	2016