modafinil and pitolisant

modafinil has been researched along with pitolisant in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.69)29.6817
2010's7 (53.85)24.3611
2020's5 (38.46)2.80

Authors

AuthorsStudies
Anaclet, C; Arnulf, I; Bastuji, H; Dauvilliers, Y; Kocher, L; Lecomte, JM; Lehert, P; Ligneau, X; Lin, JS; Parmentier, R; Perrin, D; Robert, P; Roux, M; Schwartz, JC; Yanagisawa, M1
Beardsley, PM; Belliard, S; Lecomte, JM; Ligneau, X; Perrin, D; Schwartz, JC; Uguen, M1
Strambi, LF1
Arnulf, I; Bassetti, C; Dauvilliers, Y; Ding, CL; Lammers, GJ; Lecomte, JM; Lehert, P; Mayer, G; Rodenbeck, A; Schwartz, JC1
Arnulf, I; Bassetti, CL; Dauvilliers, Y; Ding, CL; Lammers, GJ; Lehert, P; Mayer, G; van der Heide, A; van Dijk, JG; van Schie, MK1
Bassetti, CL; Kallweit, U1
Falissard, B; Lehert, P1
Arnulf, I; Dodet, P; Leu-Semenescu, S1
Javaheri, S1
de Biase, S; Gigli, GL; Pellitteri, G; Valente, M1
Cavalli, F; Franceschini, C; Pizza, F; Plazzi, G1
Belliard, S; Berrebi-Bertrand, I; Finance, O; Giret, M; Krief, S; Lecomte, JM; Ligneau, X; Nagmar, I; Perrin, D; Robert, P; Schwartz, JC; Uguen, M1
Apel, D; Ellwardt, E; Fleischer, V; Groppa, S; Kallweit, U; Lang, C; Winter, Y1

Reviews

6 review(s) available for modafinil and pitolisant

ArticleYear
Pharmacological management of narcolepsy with and without cataplexy.
    Expert opinion on pharmacotherapy, 2017, Volume: 18, Issue:8

    Topics: Adult; Benzhydryl Compounds; Cataplexy; Drug Therapy, Combination; Humans; Modafinil; Narcolepsy; Neuropeptides; Off-Label Use; Orexins; Piperidines; Quality of Life; Sleep; Sodium Oxybate; Venlafaxine Hydrochloride; Wakefulness-Promoting Agents

2017
Multiple treatment comparison in narcolepsy: a network meta-analysis.
    Sleep, 2018, 12-01, Volume: 41, Issue:12

    Topics: Adult; Cataplexy; Humans; Modafinil; Narcolepsy; Network Meta-Analysis; Odds Ratio; Piperidines; Risk Assessment; Sleepiness; Sodium Oxybate

2018
Precision Medicine for Idiopathic Hypersomnia.
    Sleep medicine clinics, 2019, Volume: 14, Issue:3

    Topics: Central Nervous System Stimulants; Clarithromycin; Flumazenil; GABA Modulators; Humans; Idiopathic Hypersomnia; Mazindol; Modafinil; Orexins; Piperidines; Polysomnography; Precision Medicine; Sleep; Sodium Oxybate; Wakefulness; Wakefulness-Promoting Agents

2019
Update on Persistent Excessive Daytime Sleepiness in OSA.
    Chest, 2020, Volume: 158, Issue:2

    Topics: Carbamates; Disorders of Excessive Somnolence; Humans; Modafinil; Phenylalanine; Piperidines; Sleep Apnea, Obstructive; Wakefulness-Promoting Agents

2020
Evaluating pitolisant as a narcolepsy treatment option.
    Expert opinion on pharmacotherapy, 2021, Volume: 22, Issue:2

    Topics: Animals; Cataplexy; Humans; Modafinil; Narcolepsy; Piperidines; Sleep; Sodium Oxybate; Treatment Outcome

2021
A practical guide to the pharmacological and behavioral therapy of Narcolepsy.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021, Volume: 18, Issue:1

    Topics: Behavior Therapy; Carbamates; Counseling; Humans; Modafinil; Narcolepsy; Phenylalanine; Piperidines; Wakefulness-Promoting Agents

2021

Trials

3 trial(s) available for modafinil and pitolisant

ArticleYear
An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients.
    Neurobiology of disease, 2008, Volume: 30, Issue:1

    Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Disease Models, Animal; Female; Histamine Agonists; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Modafinil; Narcolepsy; Neuropeptides; Orexins; Piperidines; Polysomnography; Prospective Studies; Reaction Time; Severity of Illness Index; Single-Blind Method; Sleep Stages; Wakefulness

2008
Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial.
    The Lancet. Neurology, 2013, Volume: 12, Issue:11

    Topics: Adult; Benzhydryl Compounds; Double-Blind Method; Female; Histamine Agonists; Humans; Male; Middle Aged; Modafinil; Narcolepsy; Piperidines; Placebos; Severity of Illness Index; Treatment Outcome; Wakefulness-Promoting Agents; Young Adult

2013
Comparing Treatment Effect Measurements in Narcolepsy: The Sustained Attention to Response Task, Epworth Sleepiness Scale and Maintenance of Wakefulness Test.
    Sleep, 2015, Jul-01, Volume: 38, Issue:7

    Topics: Adult; Attention; Benzhydryl Compounds; Cataplexy; Double-Blind Method; Female; Humans; Male; Modafinil; Narcolepsy; Piperidines; Reproducibility of Results; Sleep Stages; Time Factors; Treatment Outcome; Wakefulness

2015

Other Studies

4 other study(ies) available for modafinil and pitolisant

ArticleYear
Preclinical evaluation of the abuse potential of Pitolisant, a histamine H₃ receptor inverse agonist/antagonist compared with Modafinil.
    British journal of pharmacology, 2013, Volume: 169, Issue:3

    Topics: Animals; Behavior, Addictive; Behavior, Animal; Benzhydryl Compounds; Central Nervous System Stimulants; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Drug Antagonism; Drug Evaluation, Preclinical; Drug Inverse Agonism; Drugs, Investigational; Histamine Agonists; Histamine Antagonists; Macaca mulatta; Male; Mice; Modafinil; Motor Activity; Nucleus Accumbens; Piperidines; Rats; Receptors, Histamine H3; Wakefulness-Promoting Agents

2013
A need for new treatments in narcolepsy.
    The Lancet. Neurology, 2013, Volume: 12, Issue:11

    Topics: Benzhydryl Compounds; Female; Histamine Agonists; Humans; Male; Modafinil; Narcolepsy; Piperidines; Wakefulness-Promoting Agents

2013
Pitolisant, a wake-promoting agent devoid of psychostimulant properties: Preclinical comparison with amphetamine, modafinil, and solriamfetol.
    Pharmacology research & perspectives, 2021, Volume: 9, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Uptake Inhibitors; Amphetamine; Animals; Carbamates; Corpus Striatum; Disorders of Excessive Somnolence; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Evaluation, Preclinical; Drug Inverse Agonism; Feeding Behavior; Histamine Antagonists; Locomotion; Mice; Modafinil; Narcolepsy; Neostriatum; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Phenylalanine; Piperidines; Receptors, Histamine H3; Sleep Apnea, Obstructive; Wakefulness-Promoting Agents

2021
Pitolisant-supported bridging during drug holidays to deal with tolerance to modafinil in patients with narcolepsy.
    Sleep medicine, 2023, Volume: 112

    Topics: Benzhydryl Compounds; Disorders of Excessive Somnolence; Humans; Modafinil; Narcolepsy; Piperidines; Quality of Life

2023