mocimycin and efrotomycin

mocimycin has been researched along with efrotomycin* in 2 studies

Other Studies

2 other study(ies) available for mocimycin and efrotomycin

Article	Year
Differential susceptibilities of enterococcal species to elfamycin antibiotics. Journal of clinical microbiology, 1994, Volume: 32, Issue:8 The elfamycins are a class of naturally occurring antibiotics not currently used in the therapy of human disease. Enterococcus faecium and closely related species (Enterococcus durans and Enterococcus hirae) are susceptible to these antibiotics, while isolates of Enterococcus faecalis and other enterococcal species are highly resistant. Among enterococci, susceptibility or resistance to elfamycins appears to be determined by the bacterial protein synthesis elongation factor EF-Tu. Elfamycin susceptibility may be a useful adjunct for rapidly distinguishing E. faecalis and E. faecium in the clinical microbiology laboratory and/or as a supplementary test for use in determining the species of enterococci. Topics: Anti-Bacterial Agents; Aurodox; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Enterococcus; Enterococcus faecium; Pyridones	1994
Comparison of the Tu elongation factors from Staphylococcus aureus and Escherichia coli: possible basis for elfamycin insensitivity. Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:11 In a previous study (C. C. Hall, J. D. Watkins, and N. H. Georgopapadakou, Antimicrob. Agents Chemother. 33:322-325, 1989), the elongation factor Tu (EF-Tu) from Staphylococcus aureus was found to be insensitive to a series of kirromycin analogs which were inhibitory to the EF-Tu from Escherichia coli. In the present study, the EF-Tu from S. aureus was partially purified and characterized. Its apparent molecular mass was approximately 41,000 Da, and the enzyme copurified with EF-Ts (molecular mass, 34,000 Da). S. aureus EF-Tu differed from its E. coli counterpart in that it bound negligible amounts of [3H]GDP, in addition to being insensitive to pulvomycin and aurodox (50% inhibitory concentrations, approximately 100 and 1,000 microM, respectively, versus 2 and 0.2 microM, respectively, for E. coli). The results are consistent with the formation of a stable EF-Tu.EF-Ts complex that affects the interaction of EF-Tu with guanine nucleotides and inhibitors. Topics: Adenosine Triphosphatases; Aminoglycosides; Anti-Bacterial Agents; Aurodox; Chromatography, DEAE-Cellulose; Drug Resistance, Microbial; Escherichia coli; Guanosine Diphosphate; Guanosine Triphosphate; Molecular Weight; Peptide Biosynthesis; Peptide Elongation Factor Tu; Peptides; Pyridones; Staphylococcus aureus	1991

Article

Year

Differential susceptibilities of enterococcal species to elfamycin antibiotics.

Journal of clinical microbiology, 1994, Volume: 32, Issue:8

The elfamycins are a class of naturally occurring antibiotics not currently used in the therapy of human disease. Enterococcus faecium and closely related species (Enterococcus durans and Enterococcus hirae) are susceptible to these antibiotics, while isolates of Enterococcus faecalis and other enterococcal species are highly resistant. Among enterococci, susceptibility or resistance to elfamycins appears to be determined by the bacterial protein synthesis elongation factor EF-Tu. Elfamycin susceptibility may be a useful adjunct for rapidly distinguishing E. faecalis and E. faecium in the clinical microbiology laboratory and/or as a supplementary test for use in determining the species of enterococci.

Topics: Anti-Bacterial Agents; Aurodox; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Enterococcus; Enterococcus faecium; Pyridones

1994

Comparison of the Tu elongation factors from Staphylococcus aureus and Escherichia coli: possible basis for elfamycin insensitivity.

Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:11

In a previous study (C. C. Hall, J. D. Watkins, and N. H. Georgopapadakou, Antimicrob. Agents Chemother. 33:322-325, 1989), the elongation factor Tu (EF-Tu) from Staphylococcus aureus was found to be insensitive to a series of kirromycin analogs which were inhibitory to the EF-Tu from Escherichia coli. In the present study, the EF-Tu from S. aureus was partially purified and characterized. Its apparent molecular mass was approximately 41,000 Da, and the enzyme copurified with EF-Ts (molecular mass, 34,000 Da). S. aureus EF-Tu differed from its E. coli counterpart in that it bound negligible amounts of [3H]GDP, in addition to being insensitive to pulvomycin and aurodox (50% inhibitory concentrations, approximately 100 and 1,000 microM, respectively, versus 2 and 0.2 microM, respectively, for E. coli). The results are consistent with the formation of a stable EF-Tu.EF-Ts complex that affects the interaction of EF-Tu with guanine nucleotides and inhibitors.

Topics: Adenosine Triphosphatases; Aminoglycosides; Anti-Bacterial Agents; Aurodox; Chromatography, DEAE-Cellulose; Drug Resistance, Microbial; Escherichia coli; Guanosine Diphosphate; Guanosine Triphosphate; Molecular Weight; Peptide Biosynthesis; Peptide Elongation Factor Tu; Peptides; Pyridones; Staphylococcus aureus

1991