mobiflex and propacetamol

A prospective, randomized, double-blind, placebo-controlled, comparative study was undertaken to assess the efficacy of the preemptive use of propacetamol, tenoxicam or the combination of both in arthroscopic, outpatient surgery of the knee. One hundred patients aged 18 to 65 years, ASA 1-2, scheduled for arthroscopy were randomized to receive propacetamol 30 mg/kg i.v. (repeated after 6 hours), tenoxicam 0.5 mg/kg i.v. (max. 40 mg), the combination of both or placebo one hour prior to a standard anesthetic. There were no differences with regard to total dose opioid consumption, sedation scores and side effects in the four groups.

Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Arthroscopy; Double-Blind Method; Drug Combinations; Endoscopy; Female; Humans; Injections, Intravenous; Knee Joint; Male; Middle Aged; Pain, Postoperative; Piroxicam; Placebos; Postoperative Nausea and Vomiting; Premedication; Prospective Studies

Between April 1994 and June 1997, 197 thyroidectomies and 21 cervical explorations for hyperparathyroidism were performed under hypnosedation (HYP) and compared to the operative data and postoperative courses of a closely-matched population (n = 121) of patients operated on under general anaesthesia (GA). Conversion from hypnosis to GA was needed in two cases (1%). All surgeons reported better operating conditions for cervicotomy using HYP. All patients having HYP reported a very pleasant experience and had significantly less postoperative pain while analgesic use was significantly reduced in this group. Hospital stay was also significantly shorter, providing a substantial reduction of the medical care costs. The postoperative convalescence was significantly improved after HYP and full return to social or professional activity was significantly shortened. We conclude that HYP is a very efficient technique providing physiological, psychological and economic benefits to the patient.

Topics: Acetaminophen; Adult; Analgesics; Anesthesia, General; Anti-Inflammatory Agents, Non-Steroidal; Conscious Sedation; Female; Health Care Costs; Hospitalization; Humans; Hyperparathyroidism; Hypnosis, Anesthetic; Intraoperative Complications; Length of Stay; Male; Middle Aged; Pain, Postoperative; Parathyroidectomy; Patient Satisfaction; Piroxicam; Prodrugs; Recovery of Function; Thyroidectomy