mobiflex and ethyl-acetate

In this report we describe the preparation and characterization of four polymorphic forms of tenoxicam; they are, three 1:1 stoichiometric solvates with acetonitrile, dioxane, and N,N-dimethylformamide, and an amorphous phase obtained by recrystallization in various solvents. Polymorph IV and solvates with dioxane and N,N-dimethylformamide are reported for the first time in this paper. In addition, three solvates were crystallized in acetone, ethyl acetate, and isopropyl alcohol. These solid forms were characterized by X-ray powder diffraction, differential scanning calorimetry, infrared spectroscopy, thermogravimetry, optical microscopy, and elemental analysis. Solid-state properties, intrinsic dissolution rate, and dissolution kinetics from formulated tablets are also provided.

Topics: 1-Butanol; 2-Propanol; Acetamides; Acetates; Acetone; Acetonitriles; Benzene; Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry, Physical; Chloroform; Crystallography, X-Ray; Dimethylformamide; Dioxanes; Hydrogen-Ion Concentration; Kinetics; Piroxicam; Solubility; Solvents; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet