mobic and didodecyldimethylammonium

The potential of positively charged polymeric nanoparticles in improving therapeutic efficacy of meloxicam (MLX), a poorly water-soluble anti-inflammatory agent was evaluated. MLX loaded positively charged nanoparticles were prepared by using poly-epsilon-caprolactone (PCL) as a biodegradable polymer and didodecyldimethylammonium bromide (DDAB) as a cationic surfactant. The MLX nanoparticles were characterized for particle size and encapsulation efficiency. MLX loaded PCL nanoparticles and MLX suspension were evaluated for their in vivo anti-inflammatory activity and ulcerogenic potential. MLX loaded PCL nanoparticles had particle sizes of approximately 300 nm and the encapsulation efficiency of MLX was approximately 90%. The polymeric nanoparticles significantly improved the anti-inflammatory activity of MLX (P< 0.01) as compared to that of MLX suspension. The higher anti-inflammatory effect was maintained for a longer duration (6 h). The polymeric nanoparticles also resulted in less ulcerogenicity as compared to that of MLX suspension.

Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caproates; Carrageenan; Edema; Foot; Freeze Drying; Lactones; Male; Meloxicam; Nanoparticles; Particle Size; Polymers; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Surface-Active Agents; Suspensions; Thiazines; Thiazoles