Page last updated: 2024-09-04

ml-3000 and indomethacin

ml-3000 has been researched along with indomethacin in 10 studies

Compound Research Comparison

Studies
(ml-3000)
Trials
(ml-3000)
Recent Studies (post-2010)
(ml-3000)
Studies
(indomethacin)
Trials
(indomethacin)
Recent Studies (post-2010) (indomethacin)
13095629,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyml-3000 (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (30.00)18.2507
2000's2 (20.00)29.6817
2010's2 (20.00)24.3611
2020's3 (30.00)2.80

Authors

AuthorsStudies
Board, PG; Christ, AN; Clark, AG; Flanagan, JU; Hall, R; Hayes, JD; Hume, DA; Oakley, AJ; Smythe, ML; Weber, JE1
Dannhardt, G; Geffken, D; Hansen, FK; Khankischpur, M; Mesaros, R; Tolaymat, I1
El Kerdawy, AM; Gedawy, EM; Kassab, AE1
Bhatti, R; Kaur, J; Kumari, P; Singh, P1
Algate, DR; Atterson, PR; Augustin, J; Elsässer, R; Laufer, S; Munt, PL; Tries, S1
Albrecht, W; Algate, DR; Atterson, PR; Augustin, J; Elsässer, R; Guserle, R; Laufer, S; Munt, PL; Tries, S1
Claus, R; Deigner, HP; Fyrnys, B; Wolf, G1
Kulkarni, SK; Patil, CS; Singh, VP2
Aman, W; Dehpour, AR; Khan, MI; Mehrzadi, S; Nikoui, V; Ostadhadi, S1

Other Studies

10 other study(ies) available for ml-3000 and indomethacin

ArticleYear
Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:2

    Topics: Binding Sites; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glutathione Transferase; Hematopoiesis; Humans; Intramolecular Oxidoreductases; Lipocalins; Models, Molecular; Molecular Conformation; Nocodazole

2010
Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives.
    Bioorganic & medicinal chemistry letters, 2012, Aug-01, Volume: 22, Issue:15

    Topics: Arachidonate 5-Lipoxygenase; Carboxylic Acids; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Lipoxygenase Inhibitors; Protein Binding; Structure-Activity Relationship; Thiophenes

2012
Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors.
    European journal of medicinal chemistry, 2020, Mar-01, Volume: 189

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Arachidonate 5-Lipoxygenase; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Drug Design; Humans; Lipoxygenase Inhibitors; Male; Mice; Pyrazoles; Rats; Rats, Wistar; Stomach Ulcer; Sulfonamides

2020
Design, Synthesis, and Activity Evaluation of Stereoconfigured Tartarate Derivatives as Potential Anti-inflammatory Agents
    Journal of medicinal chemistry, 2021, 07-08, Volume: 64, Issue:13

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Design; Edema; Female; Humans; Lipoxygenase; Lipoxygenase Inhibitors; Male; Mice; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Tartrates

2021
Gastrointestinal tolerance of [2,2-dimethyl-6-(4-chlorophenyl-7-phenyl- 2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid in the rat.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:12

    Topics: Acetates; Animals; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Lipoxygenase Inhibitors; Male; Peptic Ulcer; Peptic Ulcer Hemorrhage; Pyrroles; Rats; Rats, Wistar

1994
Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4- chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid.
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:1

    Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Weight; Carrageenan; Cyclooxygenase Inhibitors; Edema; Female; Foot; Indomethacin; Male; Pyrroles; Rats; Rats, Wistar

1995
Oxidized low density lipoprotein stimulates protein kinase C (PKC) activity and expression of PKC-isotypes via prostaglandin-H-synthase in P388D1 cells.
    Advances in experimental medicine and biology, 1997, Volume: 407

    Topics: Acetates; Animals; Cyclooxygenase Inhibitors; Cytosol; Enzyme Activation; Enzyme Induction; Indomethacin; Isoenzymes; Leukemia P388; Lipoproteins, LDL; Lipoxygenase Inhibitors; Macrophages; Masoprocol; Mice; Neoplasm Proteins; Nitrobenzenes; Oxidation-Reduction; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Processing, Post-Translational; Pyrroles; Serum Albumin, Bovine; Sulfonamides

1997
Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation.
    Indian journal of experimental biology, 2005, Volume: 43, Issue:3

    Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Female; Humans; Indomethacin; Inflammation; Leukotriene B4; Lipid Peroxidation; Male; Mesentery; Mice; Neutrophils; Pyrroles; Rats; Stomach Ulcer; Time Factors

2005
Anti-inflammatory effect of licofelone against various inflammatory challenges.
    Fundamental & clinical pharmacology, 2006, Volume: 20, Issue:1

    Topics: Acetates; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Female; Freund's Adjuvant; Granuloma; Hyperalgesia; Indomethacin; Lipoxygenase Inhibitors; Mice; Pain Measurement; Pain Threshold; Pyrroles; Rats; Rats, Wistar; Time Factors; Touch

2006
Licofelone, a dual cyclooxygenase/5-lipoxygenase inhibitor, reverses endotoxin-induced impaired atrial chronotropic responsiveness to cholinergic stimulation in rats.
    European journal of pharmacology, 2020, Nov-15, Volume: 887

    Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Carbachol; Cholinergic Agents; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endotoxins; Heart Atria; Heart Rate; Hydrocortisone; Indomethacin; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Parasympathetic Nervous System; Pyrroles; Rats; Rats, Wistar

2020