ml-3000 has been researched along with dinoprostone in 8 studies
| Studies (ml-3000) | Trials (ml-3000) | Recent Studies (post-2010) (ml-3000) | Studies (dinoprostone) | Trials (dinoprostone) | Recent Studies (post-2010) (dinoprostone) |
|---|---|---|---|---|---|
| 130 | 9 | 56 | 29,105 | 1,346 | 6,357 |
| Protein | Taxonomy | ml-3000 (IC50) | dinoprostone (IC50) |
|---|---|---|---|
| Prostaglandin E2 receptor EP1 subtype | Homo sapiens (human) | 0.0155 | |
| Prostaglandin E2 receptor EP4 subtype | Homo sapiens (human) | 0.0031 | |
| Prostaglandin E2 receptor EP4 subtype | Rattus norvegicus (Norway rat) | 0.0021 | |
| Prostaglandin E2 receptor EP3 subtype | Homo sapiens (human) | 0.002 | |
| Prostaglandin E2 receptor EP2 subtype | Homo sapiens (human) | 0.0087 | |
| Prostacyclin receptor | Homo sapiens (human) | 0.26 | |
| Prostaglandin E2 receptor EP2 subtype | Rattus norvegicus (Norway rat) | 0.0052 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Massicotte, F; Paredes, Y; Pelletier, JP | 1 |
| Fernandes, JC; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Pelletier, JP | 1 |
| Guévremont, M; Laufer, S; Marcouiller, P; Martel-Pelletier, J; Pelletier, JP; Ranger, P; Reboul, P | 1 |
| Egido, J; Gómez-Gerique, JA; Gómez-Hernández, A; González, A; Ortega, L; Sánchez-Galán, E; Tuñón, J; Vidal, C | 1 |
| Albrecht, W; Bühring, U; Koeberle, A; Laufer, S; Northoff, H; Siemoneit, U; Werz, O | 1 |
| Kalonia, H; Kumar, A; Kumar, P | 1 |
| Gao, Y; He, C; He, S; Lai, L; Liu, Y; Wu, Y | 1 |
| Dulin, JN; Grill, RJ; Karoly, ED; Strobel, HW; Wang, Y | 1 |
8 other study(ies) available for ml-3000 and dinoprostone
| Article | Year |
|---|---|
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.
Topics: Acetates; Alkaline Phosphatase; Blotting, Western; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Nitrobenzenes; Osteoarthritis; Osteoblasts; Osteocalcin; Pyrroles; Quinolines; Sulfonamides | 2002 |
Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis.
Topics: Acetates; Animals; Antirheumatic Agents; Arthritis, Experimental; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Enzyme Inhibitors; Insulin-Like Growth Factor I; Leukotriene B4; Lipoxygenase Inhibitors; Osteoarthritis; Osteoblasts; Pyrroles; Urokinase-Type Plasminogen Activator | 2004 |
Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis.
Topics: Acetates; Aged; Arachidonic Acid; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipopolysaccharides; Male; Masoprocol; Naproxen; Osteoarthritis, Knee; Pyrroles; Signal Transduction; Synovial Membrane | 2005 |
Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis.
Topics: Acetates; Animals; Atherosclerosis; Chemokine CCL2; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Leukotriene B4; Lipids; Lipoxygenase Inhibitors; Macrophages; Male; NF-kappa B; Pyrroles; Rabbits; RNA, Messenger; Thromboxane B2; Tunica Intima | 2007 |
Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.
Topics: Adult; Animals; Cattle; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Humans; Intramolecular Oxidoreductases; Microsomes; Prostaglandin-E Synthases; Pyrroles; Sheep | 2008 |
Role of LOX/COX pathways in 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats: protective effect of licofelone.
Topics: Animals; Antioxidants; Apoptosis; Behavior, Animal; Body Weight; Caspase 3; Corpus Striatum; Dinoprostone; Huntington Disease; Interleukin-6; Lipid Peroxidation; Lipoxygenase; Male; Mitochondria; Motor Activity; Neuroprotective Agents; NF-kappa B; Nitrites; Nitro Compounds; Propionates; Prostaglandin-Endoperoxide Synthases; Pyrroles; Rats; Rats, Wistar; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2011 |
Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Cell-Free System; Databases, Factual; Dinoprostone; Humans; Intramolecular Oxidoreductases; Leukotriene B4; Lipoxygenase Inhibitors; Microsomes; Molecular Dynamics Simulation; Prostaglandin-E Synthases; Protein Binding; Protein Conformation; Pyrroles; Recombinant Proteins; Structure-Activity Relationship | 2012 |
Licofelone modulates neuroinflammation and attenuates mechanical hypersensitivity in the chronic phase of spinal cord injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Female; Gas Chromatography-Mass Spectrometry; Hindlimb; Hot Temperature; Hyperalgesia; Inflammation; Leukotriene B4; Locomotion; Metabolomics; Oxidative Stress; Physical Stimulation; Pyrroles; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 2013 |