Page last updated: 2024-09-04

ml 1035 and metoclopramide

ml 1035 has been researched along with metoclopramide in 10 studies

Compound Research Comparison

Studies
(ml 1035)
Trials
(ml 1035)
Recent Studies (post-2010)
(ml 1035)
Studies
(metoclopramide)
Trials
(metoclopramide)
Recent Studies (post-2010) (metoclopramide)
10005,0441,216623

Protein Interaction Comparison

ProteinTaxonomyml 1035 (IC50)metoclopramide (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)2.383
MyeloperoxidaseHomo sapiens (human)0.35
Alpha-2A adrenergic receptorHomo sapiens (human)2.721
Cytochrome P450 2D6Homo sapiens (human)0.8
D(2) dopamine receptorHomo sapiens (human)0.127
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)7.8
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)7.8
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)7.7
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)7.7
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)7.7
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)7.8
5-hydroxytryptamine receptor 2AHomo sapiens (human)3.675
5-hydroxytryptamine receptor 2CHomo sapiens (human)2.383
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)7.8
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)7.8
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)7.8
D(3) dopamine receptorHomo sapiens (human)0.2
5-hydroxytryptamine receptor 3ARattus norvegicus (Norway rat)0.88
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.63
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)7.8
D(2) dopamine receptorRattus norvegicus (Norway rat)0.6237
5-hydroxytryptamine receptor 3BRattus norvegicus (Norway rat)0.88

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hwang, KK; Otis, KW; Rao, N1
Borcherding, DR; Butler, BT; Houston, DM; McPhail, AT; Radzik, DM; Silvey, G; ten Hoeve, W; van Echten, E; Vaughn, VL; Wynberg, H1
Hwang, KK; Kuo, BS; Poole, JC1
Battor, JL; Chang, J; Geary, JI; Hwang, KK; Kuo, BS; Mandagere, AK; Osborne, DR; Thompson, TN; Vaughn, V1
Hwang, KK; Kuo, BS; Mandagere, A; Poole, JC1
Ahmed, NK; Butler, BT; Gaddis, RR; Linnik, MD1
Ahmed, NK; Butler, BT; Elsea, SH; Linnik, MD1
Cheng, H; Hwang, KK; Kuo, BS; Poole, JC2
Hwang, KK; Kuo, BS; Mandagere, AK; Poole, JC1

Other Studies

10 other study(ies) available for ml 1035 and metoclopramide

ArticleYear
Sex-differences in the disposition of substituted benzamides: pharmacokinetics of a gastroprokinetic agent (4-amino-5-chloro-2-[2- (methylsulfinyl) ethoxy]-N-[2-(diethylamino)ethyl] benzamide hydrochloride) (ML-1035) in male and female New Zealand white r
    Biopharmaceutics & drug disposition, 1992, Volume: 13, Issue:9

    Topics: Administration, Oral; Animals; Biological Availability; Chromatography, High Pressure Liquid; Female; Injections, Intravenous; Male; Metabolic Clearance Rate; Metoclopramide; Rabbits; Sex Factors; Structure-Activity Relationship

1992
The resolution, isolation, and pharmacological characterization of the enantiomers of a benzamide containing a chiral sulfoxide.
    Chirality, 1992, Volume: 4, Issue:3

    Topics: Animals; Benzamides; Guinea Pigs; Ileum; In Vitro Techniques; Male; Metoclopramide; Muscle Contraction; Rats; Receptors, Serotonin; Stereoisomerism; X-Ray Diffraction

1992
Validation of a column-switching high-performance liquid chromatographic (HPLC) method for determination of ML-1035 and its five metabolites in plasma.
    Pharmaceutical research, 1992, Volume: 9, Issue:1

    Topics: Automation; Benzamides; Calibration; Chromatography, High Pressure Liquid; Metoclopramide; Reproducibility of Results; Sensitivity and Specificity

1992
Determination of ML-1035 enantiomers in plasma by chiral high-performance liquid chromatography.
    Journal of pharmaceutical and biomedical analysis, 1991, Volume: 9, Issue:10-12

    Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Metoclopramide; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism

1991
Column-switching liquid chromatographic determination of ML-1035 sulphoxide and its sulphone and sulphide metabolites in rat urine.
    Journal of pharmaceutical and biomedical analysis, 1991, Volume: 9, Issue:10-12

    Topics: Animals; Chromatography, Liquid; Drug Stability; Metoclopramide; Molecular Structure; Rats; Reproducibility of Results; Sensitivity and Specificity

1991
Analysis of serotonergic mechanisms underlying benzamide-induced gastroprokinesis.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:2

    Topics: Animals; Benzamides; Cisapride; Electric Stimulation; Female; Gastric Emptying; Gastrointestinal Transit; Guinea Pigs; Ileum; In Vitro Techniques; Male; Metoclopramide; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Serotonin Antagonists

1991
Analysis of neurogenic contractions induced by ML-1035 and other benzamides in the guinea-pig non-stimulated isolated ileum.
    The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:6

    Topics: Acetylcholine; Animals; Benzamides; Dose-Response Relationship, Drug; Drug Interactions; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Metoclopramide; Muscle Contraction; Muscle, Smooth; Neurons; Tetrodotoxin

1994
Determination of bioavailability and systemically available fractions of drugs undergoing reversible metabolism: application to 4-amino-5-chloro-2-[2-(methylsulfinyl)ethoxy]-N-[2- (diethylamino)ethyl]benzamide and its sulfide and sulfone metabolites in ra
    Journal of pharmaceutical sciences, 1994, Volume: 83, Issue:3

    Topics: Animals; Biological Availability; Biotransformation; Half-Life; Male; Metoclopramide; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Sulfides; Sulfones

1994
Pharmacokinetics and metabolic interconversion of intravenous 4-amino-5-chloro-2-[(methylsulfinyl)ethoxy]-N-[2-(diethylamino)ethyl] benzamide and its sulfide and sulfone metabolites in rats.
    Journal of pharmaceutical sciences, 1993, Volume: 82, Issue:7

    Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Injections, Intravenous; Male; Metoclopramide; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Sulfides; Sulfones

1993
Disposition kinetics of ML-1035 sulfoxide enantiomers and the prochiral sulfide in rats.
    Chirality, 1993, Volume: 5, Issue:6

    Topics: Administration, Oral; Animals; Antiemetics; Chromatography, High Pressure Liquid; Injections, Intravenous; Male; Metoclopramide; Rats; Rats, Sprague-Dawley; Stereoisomerism

1993