ml 1035 has been researched along with metoclopramide in 10 studies
| Studies (ml 1035) | Trials (ml 1035) | Recent Studies (post-2010) (ml 1035) | Studies (metoclopramide) | Trials (metoclopramide) | Recent Studies (post-2010) (metoclopramide) |
|---|---|---|---|---|---|
| 10 | 0 | 0 | 5,044 | 1,216 | 623 |
| Protein | Taxonomy | ml 1035 (IC50) | metoclopramide (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 2.383 | |
| Myeloperoxidase | Homo sapiens (human) | 0.35 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 2.721 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.8 | |
| D(2) dopamine receptor | Homo sapiens (human) | 0.127 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 7.8 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 7.8 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 7.7 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 7.7 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 7.7 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 7.8 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 3.675 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 2.383 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 7.8 | |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | 7.8 | |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | 7.8 | |
| D(3) dopamine receptor | Homo sapiens (human) | 0.2 | |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | 0.88 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.63 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 7.8 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 0.6237 | |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | 0.88 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hwang, KK; Otis, KW; Rao, N | 1 |
| Borcherding, DR; Butler, BT; Houston, DM; McPhail, AT; Radzik, DM; Silvey, G; ten Hoeve, W; van Echten, E; Vaughn, VL; Wynberg, H | 1 |
| Hwang, KK; Kuo, BS; Poole, JC | 1 |
| Battor, JL; Chang, J; Geary, JI; Hwang, KK; Kuo, BS; Mandagere, AK; Osborne, DR; Thompson, TN; Vaughn, V | 1 |
| Hwang, KK; Kuo, BS; Mandagere, A; Poole, JC | 1 |
| Ahmed, NK; Butler, BT; Gaddis, RR; Linnik, MD | 1 |
| Ahmed, NK; Butler, BT; Elsea, SH; Linnik, MD | 1 |
| Cheng, H; Hwang, KK; Kuo, BS; Poole, JC | 2 |
| Hwang, KK; Kuo, BS; Mandagere, AK; Poole, JC | 1 |
10 other study(ies) available for ml 1035 and metoclopramide
| Article | Year |
|---|---|
Sex-differences in the disposition of substituted benzamides: pharmacokinetics of a gastroprokinetic agent (4-amino-5-chloro-2-[2- (methylsulfinyl) ethoxy]-N-[2-(diethylamino)ethyl] benzamide hydrochloride) (ML-1035) in male and female New Zealand white r
Topics: Administration, Oral; Animals; Biological Availability; Chromatography, High Pressure Liquid; Female; Injections, Intravenous; Male; Metabolic Clearance Rate; Metoclopramide; Rabbits; Sex Factors; Structure-Activity Relationship | 1992 |
The resolution, isolation, and pharmacological characterization of the enantiomers of a benzamide containing a chiral sulfoxide.
Topics: Animals; Benzamides; Guinea Pigs; Ileum; In Vitro Techniques; Male; Metoclopramide; Muscle Contraction; Rats; Receptors, Serotonin; Stereoisomerism; X-Ray Diffraction | 1992 |
Validation of a column-switching high-performance liquid chromatographic (HPLC) method for determination of ML-1035 and its five metabolites in plasma.
Topics: Automation; Benzamides; Calibration; Chromatography, High Pressure Liquid; Metoclopramide; Reproducibility of Results; Sensitivity and Specificity | 1992 |
Determination of ML-1035 enantiomers in plasma by chiral high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Metoclopramide; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 1991 |
Column-switching liquid chromatographic determination of ML-1035 sulphoxide and its sulphone and sulphide metabolites in rat urine.
Topics: Animals; Chromatography, Liquid; Drug Stability; Metoclopramide; Molecular Structure; Rats; Reproducibility of Results; Sensitivity and Specificity | 1991 |
Analysis of serotonergic mechanisms underlying benzamide-induced gastroprokinesis.
Topics: Animals; Benzamides; Cisapride; Electric Stimulation; Female; Gastric Emptying; Gastrointestinal Transit; Guinea Pigs; Ileum; In Vitro Techniques; Male; Metoclopramide; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Serotonin Antagonists | 1991 |
Analysis of neurogenic contractions induced by ML-1035 and other benzamides in the guinea-pig non-stimulated isolated ileum.
Topics: Acetylcholine; Animals; Benzamides; Dose-Response Relationship, Drug; Drug Interactions; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Metoclopramide; Muscle Contraction; Muscle, Smooth; Neurons; Tetrodotoxin | 1994 |
Determination of bioavailability and systemically available fractions of drugs undergoing reversible metabolism: application to 4-amino-5-chloro-2-[2-(methylsulfinyl)ethoxy]-N-[2- (diethylamino)ethyl]benzamide and its sulfide and sulfone metabolites in ra
Topics: Animals; Biological Availability; Biotransformation; Half-Life; Male; Metoclopramide; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Sulfides; Sulfones | 1994 |
Pharmacokinetics and metabolic interconversion of intravenous 4-amino-5-chloro-2-[(methylsulfinyl)ethoxy]-N-[2-(diethylamino)ethyl] benzamide and its sulfide and sulfone metabolites in rats.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Injections, Intravenous; Male; Metoclopramide; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Sulfides; Sulfones | 1993 |
Disposition kinetics of ML-1035 sulfoxide enantiomers and the prochiral sulfide in rats.
Topics: Administration, Oral; Animals; Antiemetics; Chromatography, High Pressure Liquid; Injections, Intravenous; Male; Metoclopramide; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1993 |