mkc 231 has been researched along with choline in 7 studies
*Choline: A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. [MeSH]
*Choline: A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. [MeSH]
| Studies (mkc 231) | Trials (mkc 231) | Recent Studies (post-2010) (mkc 231) | Studies (choline) | Trials (choline) | Recent Studies (post-2010) (choline) |
|---|---|---|---|---|---|
| 11 | 0 | 3 | 19,628 | 608 | 4,345 |
| Protein | Taxonomy | mkc 231 (IC50) | choline (IC50) |
|---|---|---|---|
| Sodium- and chloride-dependent creatine transporter 1 | Rattus norvegicus (Norway rat) | 1.6 | |
| High affinity choline transporter 1 | Mus musculus (house mouse) | 1.6 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abe, E; Itoh, T; Masuda, Y; Murai, S; Odashima, J; Saito, H | 1 |
| Bessho, T; Chaki, H; Egawa, M; Ohshima, C; Saito, K; Tabata, R; Takashina, K; Tobe, A; Yamabe, H | 1 |
| Akaike, A; Kaneko, S; Maeda, T; Tamura, Y | 1 |
| Hotta, N; Iguchi, A; Miura, H; Surina-Baumgartner, DM; Tamagawa, T; Tamaya, N; Ueda, M; Uemura, K; Yoshioka, S | 1 |
| Bessho, T; Eguchi, J; Mori, R; Saito, K; Takashina, K | 1 |
| Bessho, T; Eguchi, J; Komatsu, T; Saito, K; Takashina, K | 1 |
| Bessho, T; Eguchi, J; Kawai, K; Mori, R; Saito, K; Takashina, K | 1 |
7 other study(ies) available for mkc 231 and choline
| Article | Year |
|---|---|
MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice.
Topics: Acetylcholine; Acetylcholinesterase; Amnesia; Animals; Aziridines; Choline; Choline Deficiency; Data Interpretation, Statistical; Habituation, Psychophysiologic; Hippocampus; Indoles; Injections, Intraventricular; Male; Maze Learning; Memory; Memory Disorders; Mice; Mice, Inbred Strains; Pyridines; Quinolines; Synaptic Transmission; Tacrine | 1994 |
Effect of the novel high affinity choline uptake enhancer 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b] quinolin-4-yl)acetoamide on deficits of water maze learning in rats.
Topics: Acetylcholinesterase; Animals; Aziridines; Body Temperature; Choline; Hippocampus; In Vitro Techniques; Male; Maze Learning; Neuromuscular Blocking Agents; Nootropic Agents; Quinolines; Rats; Rats, Wistar; Receptors, Muscarinic; Salivation; Tacrine; Tremor | 1996 |
Protective effect of MKC-231, a novel high affinity choline uptake enhancer, on glutamate cytotoxicity in cultured cortical neurons.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Choline; Glutamic Acid; Neurons; Nootropic Agents; Quinolines; Rats | 1998 |
Central nervous system-mediated hyperglycemic effects of NIK-247, a cholinesterase inhibitor, and MKC-231, a choline uptake enhancer, in rats.
Topics: Aminoquinolines; Animals; Blood Glucose; Central Nervous System; Choline; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Neostigmine; Nootropic Agents; Quinolines; Rats; Rats, Wistar; Sodium Chloride | 1999 |
MKC-231, a choline uptake enhancer: (2) Effect on synthesis and release of acetylcholine in AF64A-treated rats.
Topics: Acetylcholine; Analysis of Variance; Animals; Aziridines; Choline; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; In Vitro Techniques; Male; Microdialysis; Neuromuscular Blocking Agents; Potassium; Quinolines; Rats; Rats, Wistar; Synaptosomes; Tacrine; Tritium | 2008 |
MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats.
Topics: Animals; Aziridines; Behavior, Animal; Brain; Carbon Isotopes; Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Hippocampus; Learning Disabilities; Male; Maze Learning; Quinolines; Rats; Rats, Wistar; Synaptosomes; Time Factors | 2008 |
MKC-231, a choline uptake enhancer: (3) Mode of action of MKC-231 in the enhancement of high-affinity choline uptake.
Topics: Animals; Aziridines; Cell Membrane; Chlorocebus aethiops; Choline; COS Cells; Drug Interactions; Hemicholinium 3; Hippocampus; Male; Membrane Transport Proteins; Neurotransmitter Uptake Inhibitors; Protein Binding; Quinolines; Radioligand Assay; Rats; Rats, Wistar; Synaptosomes; Transfection; Tritium | 2008 |