Page last updated: 2024-09-05

mkc 231 and choline

mkc 231 has been researched along with choline in 7 studies

*Choline: A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. [MeSH]

*Choline: A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. [MeSH]

Compound Research Comparison

Studies
(mkc 231)
Trials
(mkc 231)
Recent Studies (post-2010)
(mkc 231)
Studies
(choline)
Trials
(choline)
Recent Studies (post-2010) (choline)
110319,6286084,345

Protein Interaction Comparison

ProteinTaxonomymkc 231 (IC50)choline (IC50)
Sodium- and chloride-dependent creatine transporter 1Rattus norvegicus (Norway rat)1.6
High affinity choline transporter 1Mus musculus (house mouse)1.6

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (57.14)18.2507
2000's3 (42.86)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Abe, E; Itoh, T; Masuda, Y; Murai, S; Odashima, J; Saito, H1
Bessho, T; Chaki, H; Egawa, M; Ohshima, C; Saito, K; Tabata, R; Takashina, K; Tobe, A; Yamabe, H1
Akaike, A; Kaneko, S; Maeda, T; Tamura, Y1
Hotta, N; Iguchi, A; Miura, H; Surina-Baumgartner, DM; Tamagawa, T; Tamaya, N; Ueda, M; Uemura, K; Yoshioka, S1
Bessho, T; Eguchi, J; Mori, R; Saito, K; Takashina, K1
Bessho, T; Eguchi, J; Komatsu, T; Saito, K; Takashina, K1
Bessho, T; Eguchi, J; Kawai, K; Mori, R; Saito, K; Takashina, K1

Other Studies

7 other study(ies) available for mkc 231 and choline

ArticleYear
MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice.
    Journal of neural transmission. General section, 1994, Volume: 98, Issue:1

    Topics: Acetylcholine; Acetylcholinesterase; Amnesia; Animals; Aziridines; Choline; Choline Deficiency; Data Interpretation, Statistical; Habituation, Psychophysiologic; Hippocampus; Indoles; Injections, Intraventricular; Male; Maze Learning; Memory; Memory Disorders; Mice; Mice, Inbred Strains; Pyridines; Quinolines; Synaptic Transmission; Tacrine

1994
Effect of the novel high affinity choline uptake enhancer 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b] quinolin-4-yl)acetoamide on deficits of water maze learning in rats.
    Arzneimittel-Forschung, 1996, Volume: 46, Issue:4

    Topics: Acetylcholinesterase; Animals; Aziridines; Body Temperature; Choline; Hippocampus; In Vitro Techniques; Male; Maze Learning; Neuromuscular Blocking Agents; Nootropic Agents; Quinolines; Rats; Rats, Wistar; Receptors, Muscarinic; Salivation; Tacrine; Tremor

1996
Protective effect of MKC-231, a novel high affinity choline uptake enhancer, on glutamate cytotoxicity in cultured cortical neurons.
    Japanese journal of pharmacology, 1998, Volume: 76, Issue:2

    Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Choline; Glutamic Acid; Neurons; Nootropic Agents; Quinolines; Rats

1998
Central nervous system-mediated hyperglycemic effects of NIK-247, a cholinesterase inhibitor, and MKC-231, a choline uptake enhancer, in rats.
    Japanese journal of pharmacology, 1999, Volume: 79, Issue:1

    Topics: Aminoquinolines; Animals; Blood Glucose; Central Nervous System; Choline; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Neostigmine; Nootropic Agents; Quinolines; Rats; Rats, Wistar; Sodium Chloride

1999
MKC-231, a choline uptake enhancer: (2) Effect on synthesis and release of acetylcholine in AF64A-treated rats.
    Journal of neural transmission (Vienna, Austria : 1996), 2008, Volume: 115, Issue:7

    Topics: Acetylcholine; Analysis of Variance; Animals; Aziridines; Choline; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; In Vitro Techniques; Male; Microdialysis; Neuromuscular Blocking Agents; Potassium; Quinolines; Rats; Rats, Wistar; Synaptosomes; Tacrine; Tritium

2008
MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats.
    Journal of neural transmission (Vienna, Austria : 1996), 2008, Volume: 115, Issue:7

    Topics: Animals; Aziridines; Behavior, Animal; Brain; Carbon Isotopes; Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Hippocampus; Learning Disabilities; Male; Maze Learning; Quinolines; Rats; Rats, Wistar; Synaptosomes; Time Factors

2008
MKC-231, a choline uptake enhancer: (3) Mode of action of MKC-231 in the enhancement of high-affinity choline uptake.
    Journal of neural transmission (Vienna, Austria : 1996), 2008, Volume: 115, Issue:7

    Topics: Animals; Aziridines; Cell Membrane; Chlorocebus aethiops; Choline; COS Cells; Drug Interactions; Hemicholinium 3; Hippocampus; Male; Membrane Transport Proteins; Neurotransmitter Uptake Inhibitors; Protein Binding; Quinolines; Radioligand Assay; Rats; Rats, Wistar; Synaptosomes; Transfection; Tritium

2008