Page last updated: 2024-09-04

mk 996 and losartan

mk 996 has been researched along with losartan in 6 studies

Compound Research Comparison

Studies
(mk 996)
Trials
(mk 996)
Recent Studies (post-2010)
(mk 996)
Studies
(losartan)
Trials
(losartan)
Recent Studies (post-2010) (losartan)
8017,2311,2452,118

Protein Interaction Comparison

ProteinTaxonomymk 996 (IC50)losartan (IC50)
Bile salt export pumpHomo sapiens (human)9.01
Cytochrome P450 2C9 Homo sapiens (human)2.882
Angiotensin-converting enzyme Homo sapiens (human)0.019
Atrial natriuretic peptide receptor 3Homo sapiens (human)0.0018
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.019
Type-1A angiotensin II receptor Rattus norvegicus (Norway rat)0.0247
Type-1B angiotensin II receptorRattus norvegicus (Norway rat)0.0234
Adenosine receptor A2aRattus norvegicus (Norway rat)0.0032
Type-1 angiotensin II receptorHomo sapiens (human)0.047
Type-1 angiotensin II receptorOryctolagus cuniculus (rabbit)0.025
Type-2 angiotensin II receptorRattus norvegicus (Norway rat)0.0118
Type-2 angiotensin II receptorHomo sapiens (human)0.019
Platelet glycoprotein VIHomo sapiens (human)4
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)1.1481
Type-1 angiotensin II receptorCavia porcellus (domestic guinea pig)0.018
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)0.2884

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (66.67)18.2507
2000's0 (0.00)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chakravarty, PK; Chang, RS; Chen, A; Chen, TB; Faust, KA; Gable, RA; Kivlighn, SD; Lotti, VJ; Naylor, EM; Zingaro, GJ1
Goldberg, MR; Greenlee, WJ; Irvin, JD; Prendergast, K; Smith, RD; Timmermans, PB; Wexler, RR1
Giridhar, R; Murumkar, P; Naik, P; Yadav, MR1
Meanwell, NA1
Broten, TP; Chakravarty, PK; Gabel, RA; Greenlee, WJ; Kivlighn, SD; Naylor, EM; Patchett, AA; Schaffer, LW; Schorn, TW; Zingaro, GJ1
Barbera, FA; Bernard, R; Bozarth, TA; Gibson, RE; Herblin, WF; Watson, CA; Wong, PC1

Reviews

2 review(s) available for mk 996 and losartan

ArticleYear
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
    Journal of medicinal chemistry, 1996, Feb-02, Volume: 39, Issue:3

    Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Humans; Receptors, Angiotensin; Structure-Activity Relationship

1996
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
    Bioorganic & medicinal chemistry, 2010, Dec-15, Volume: 18, Issue:24

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Losartan

2010

Other Studies

4 other study(ies) available for mk 996 and losartan

ArticleYear
A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist.
    Journal of medicinal chemistry, 1994, Nov-25, Volume: 37, Issue:24

    Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Dogs; Imidazoles; Macaca mulatta; Pyridines; Rats

1994
Synopsis of some recent tactical application of bioisosteres in drug design.
    Journal of medicinal chemistry, 2011, Apr-28, Volume: 54, Issue:8

    Topics: Cytochrome P-450 Enzyme System; Drug Design

2011
In vivo pharmacology of a novel AT1 selective angiotensin II receptor antagonist, MK-996.
    American journal of hypertension, 1995, Volume: 8, Issue:1

    Topics: Administration, Oral; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Bradykinin; Dogs; Enalapril; Female; Imidazoles; Injections, Intravenous; Losartan; Macaca mulatta; Male; Nitroglycerin; Pan troglodytes; Pyridines; Rats; Rats, Sprague-Dawley; Tetrazoles

1995
Nonpeptide angiotensin II receptor antagonists: in vivo inhibition of [125I-Sar1,Ile8]angiotensin II binding by losartan, EXP597 and L-159,282 in rats.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 1996, Volume: 18, Issue:2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetrazoles

1996