mk 436 has been researched along with azomycin in 19 studies
| Studies (mk 436) | Trials (mk 436) | Recent Studies (post-2010) (mk 436) | Studies (azomycin) | Trials (azomycin) | Recent Studies (post-2010) (azomycin) |
|---|---|---|---|---|---|
| 20 | 0 | 0 | 4,790 | 418 | 1,580 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (57.89) | 18.7374 |
| 1990's | 8 (42.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jennings, FW | 3 |
| Cunha Neto, E; Rizzo, LV; Silva, R; Teixeira, AR | 1 |
| Cunha Neto, E; Rizzo, LV; Santana, JM; Silva, R; Teixeira, AR | 1 |
| Andrade, SG; Santiago, CM; Silva, RC | 1 |
| Andrade, SG; Freitas, LA; Santiago, CM; Silva, RC | 1 |
| Berglund, RM; Mrozik, H; Skeggs, HR; VandenHeuvel, WJ; Wislocki, PG; Wolf, FJ | 1 |
| Habbersett, MC; Meurer, RD; Murray, PK | 1 |
| Jennings, FW; Miller, BM; Murray, PK; Urquhart, GM | 3 |
| Arison, BH; Flynn, H; Gatto, GJ; Mertel, HE; VandenHeuvel, WJ; Wislocki, PG | 1 |
| Arison, BH; Skeggs, H; Vandenheuvel, WJ; Wislocki, PG | 1 |
| Gutteridge, WE; Hargadon, MR; Hudson, JE; Ross, J | 1 |
| Arison, BH; Kirkman-Bey, N; Onofrey, D; Pile, J; Vandenheuvel, WJ; Zweig, JS | 1 |
| Calixto, MA; Teixeira, AR; Teixeira, ML | 1 |
| Atouguia, JM; Jennings, FW; Murray, M | 1 |
| Moreno, SN; Yan, W | 1 |
1 review(s) available for mk 436 and azomycin
| Article | Year |
|---|---|
Combination chemotherapy of CNS trypanosomiasis.
Topics: Arsenicals; Central Nervous System Diseases; Drug Therapy, Combination; Humans; Melarsoprol; Nitroimidazoles; Trypanocidal Agents; Trypanosomiasis, African | 1993 |
18 other study(ies) available for mk 436 and azomycin
| Article | Year |
|---|---|
Chemotherapy of CNS-trypanosomiasis: combination chemotherapy with a 5-nitroimidazole (MK 436), an arsenical (Cymelarsan) and suramin.
Topics: Animals; Arsenicals; Brain Diseases; Disease Models, Animal; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1991 |
Chemotherapy of CNS-trypanosomiasis: the combined use of the arsenicals and nitro-compounds.
Topics: Animals; Antiprotozoal Agents; Arsenicals; Brain Diseases; Drug Synergism; Drug Therapy, Combination; Female; Ketoconazole; Metronidazole; Mice; Nifurtimox; Nitro Compounds; Nitroimidazoles; Oxidation-Reduction; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1991 |
Trypanocidal nitroarene treatment of experimental Trypanosoma cruzi infection does not prevent progression of chronic-phase heart lesions in rabbits.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Nifurtimox; Nitroimidazoles; Rabbits; Trypanocidal Agents | 1990 |
Malignant, non-Hodgkin's lymphomas in Trypanosoma cruzi-infected rabbits treated with nitroarenes.
Topics: Animals; Chagas Cardiomyopathy; Female; Injections, Intraperitoneal; Lymphoma, Non-Hodgkin; Male; Myocarditis; Myositis; Nifurtimox; Nitrofurans; Nitroimidazoles; Rabbits; Trypanosoma cruzi | 1990 |
Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Drug Evaluation, Preclinical; Mice; Nitroimidazoles | 1989 |
Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Female; Male; Mice; Myocardium; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1987 |
Effect of liver enzymes on the mutagenicity of nitroheterocyclic compounds: activation of 3a,4,5,6,7,7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)- 1,2-benzisoxazole and deactivation of nitrofurans and nitroimidazoles in the Ames test.
Topics: Animals; Aroclors; Biotransformation; Enzyme Induction; Microsomes, Liver; Mutagenicity Tests; Nitrofurans; Nitroimidazoles; Rats; Salmonella typhimurium | 1984 |
Trypanosoma cruzi: efficacy of the 2-substituted, 5-nitroimidazoles, MK-436 and L634,549, in tissue culture and mice.
Topics: Animals; Antiprotozoal Agents; Benzimidazoles; Cell Line; Chagas Disease; Drug Evaluation, Preclinical; Female; Fibroblasts; Humans; Mice; Mice, Inbred BALB C; Muscles; Nifurtimox; Nitroimidazoles; Rats; Trypanosoma cruzi | 1983 |
The use of 2-substituted 5-nitroimidazoles in the treatment of chronic murine Trypanosoma brucei infections with central nervous system involvement.
Topics: Animals; Antiprotozoal Agents; Brain; Chronic Disease; Drug Therapy, Combination; Female; Mice; Mice, Inbred Strains; Nitroimidazoles; Rodent Diseases; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1984 |
Urinary metabolites of the antiprotozoal agent cis-3a,4,5,6,7,7a- hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,2-benzisoxazole in the rat.
Topics: Animals; Antiprotozoal Agents; Biotransformation; Hydrolysis; Mass Spectrometry; Nitroimidazoles; Rats; Rats, Inbred Strains | 1984 |
Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murine Trypanosoma brucei infections with central nervous system involvement.
Topics: Animals; Antiprotozoal Agents; Cattle; Central Nervous System Diseases; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African | 1983 |
Identification of in vitro (rat liver postmitochondrial S9 fraction) metabolites of the antiprotozoal agent 3a,4,5,6,7,7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,2-benzisoxazole .
Topics: Animals; Antiprotozoal Agents; Biotransformation; In Vitro Techniques; Liver; Magnetic Resonance Spectroscopy; Mass Spectrometry; Nitroimidazoles; Rats | 1983 |
Crithidia fasciculata: a catalase-containing trypanosomatid sensitive to nitroheterocyclic drugs.
Topics: Animals; Catalase; Crithidia; Nifurtimox; Nitroimidazoles | 1982 |
'Berenil' and nitroimidazole combinations in the treatment of Trypanosoma brucei infection with central nervous system involvement.
Topics: Amidines; Animals; Benzamidines; Central Nervous System Diseases; Diminazene; Ethidium; Female; Isoxazoles; Mice; Nitroimidazoles; Phenanthridines; Ronidazole; Time Factors; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1980 |
Identification of canine urinary metabolites of the antiprotozoal agent 3a,4,5,6,7,7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,2-benzisoxazole .
Topics: Animals; Antiprotozoal Agents; Chromatography, Gas; Chromatography, High Pressure Liquid; Dogs; Gas Chromatography-Mass Spectrometry; Isoxazoles; Magnetic Resonance Spectroscopy; Nitroimidazoles; Oxazoles | 1980 |
Chagas' disease: carcinogenic activity of the antitrypanosomal nitroarenes in mice.
Topics: Animals; Carcinogens; Cell Division; Chagas Disease; Female; Liver; Lymph Nodes; Lymphoma; Mice; Molecular Structure; Nifurtimox; Nitroimidazoles; Trypanocidal Agents | 1994 |
Topical chemotherapy for experimental murine African CNS-trypanosomiasis: the successful use of the arsenical, melarsoprol, combined with the 5-nitroimidazoles, fexinidazole or MK-436.
Topics: Administration, Topical; Animals; Antiprotozoal Agents; Dose-Response Relationship, Drug; Drug Combinations; Female; Gels; Melarsoprol; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosomiasis, African | 1996 |
A method to assess invasion and intracellular replication of Trypanosoma cruzi based on differential uracil incorporation.
Topics: Animals; Cells, Cultured; DNA Replication; DNA, Protozoan; Drug Evaluation, Preclinical; Drug Resistance; Gamma Rays; Muscle, Skeletal; Nifurtimox; Nitroimidazoles; Rats; Reproduction; Thiadiazoles; Trypanocidal Agents; Trypanosoma cruzi; Uracil | 1998 |