Compounds > mk 0663
Page last updated: 2024-09-03

mk 0663 and tacrolimus

mk 0663 has been researched along with tacrolimus in 3 studies

Compound Research Comparison

Studies
(mk 0663)		Trials
(mk 0663)		Recent Studies (post-2010)
(mk 0663)		Studies
(tacrolimus)		Trials
(tacrolimus)		Recent Studies (post-2010) (tacrolimus)
54917326517,7572,3196,661

Protein Interaction Comparison

ProteinTaxonomymk 0663 (IC50)tacrolimus (IC50)
Bile salt export pumpHomo sapiens (human)7.18
Cytochrome P450 3A4Homo sapiens (human)0.58
Cytochrome P450 3A5Homo sapiens (human)0.385
Serine/threonine-protein kinase mTORHomo sapiens (human)0.0021
Peptidyl-prolyl cis-trans isomerase FKBP1AHomo sapiens (human)0.2547
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformHomo sapiens (human)0.0148
Splicing factor 3B subunit 3Homo sapiens (human)0.0123
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)3.3
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)3.7

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Burke, PA; Cai, M; Davide, JP; Mao, X; Ng, B; Sachs, AB; Sepp-Lorenzino, L; Tao, W1

Other Studies

3 other study(ies) available for mk 0663 and tacrolimus

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Mechanistically probing lipid-siRNA nanoparticle-associated toxicities identifies Jak inhibitors effective in mitigating multifaceted toxic responses.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2011, Volume: 19, Issue:3

    Topics: Animals; Cytokines; Dexamethasone; Enzyme Inhibitors; Etoricoxib; Female; Gene Knockout Techniques; I-kappa B Kinase; Interferon-gamma; Interleukin-6; Janus Kinases; Lipids; Mice; Mice, Inbred C57BL; Mice, Knockout; Nanoparticles; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor, Type II; RNA, Small Interfering; Sulfones; Tacrolimus; TOR Serine-Threonine Kinases

2011