Compounds > mk 0663
Page last updated: 2024-09-03

mk 0663 and prochlorperazine

mk 0663 has been researched along with prochlorperazine in 3 studies

Compound Research Comparison

Studies
(mk 0663)		Trials
(mk 0663)		Recent Studies (post-2010)
(mk 0663)		Studies
(prochlorperazine)		Trials
(prochlorperazine)		Recent Studies (post-2010) (prochlorperazine)
5491732651,125206110

Protein Interaction Comparison

ProteinTaxonomymk 0663 (IC50)prochlorperazine (IC50)
Mcl-1Homo sapiens (human)3.7733
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.078
Bile salt export pumpHomo sapiens (human)10
Cytochrome P450 1A2Homo sapiens (human)2
Tyrosine-protein kinase FynHomo sapiens (human)5.684
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.4
Muscarinic acetylcholine receptor M2Homo sapiens (human)3.112
Muscarinic acetylcholine receptor M4Homo sapiens (human)1.363
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.22
Alpha-2A adrenergic receptorHomo sapiens (human)0.169
Cytochrome P450 2D6Homo sapiens (human)0.3
Muscarinic acetylcholine receptor M1Homo sapiens (human)1.013
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)1.8481
D(2) dopamine receptorHomo sapiens (human)0.011
Alpha-2B adrenergic receptorHomo sapiens (human)0.01
Alpha-2C adrenergic receptorHomo sapiens (human)0.082
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.95
Muscarinic acetylcholine receptor M3Homo sapiens (human)1.514
D(1A) dopamine receptorHomo sapiens (human)0.155
D(4) dopamine receptorHomo sapiens (human)2.311
Sodium-dependent noradrenaline transporter Homo sapiens (human)0.4
Alpha-1D adrenergic receptorHomo sapiens (human)0.034
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.0071
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.078
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.95
Sodium-dependent serotonin transporterHomo sapiens (human)1.169
Pleiotropic ABC efflux transporter of multiple drugsSaccharomyces cerevisiae S288C1.7
Histamine H1 receptorHomo sapiens (human)0.024
D(3) dopamine receptorHomo sapiens (human)0.013
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.102
5-hydroxytryptamine receptor 6Homo sapiens (human)0.267
Sodium-dependent dopamine transporter Homo sapiens (human)1.735
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.8481
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)1.8481
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.054

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1

Other Studies

3 other study(ies) available for mk 0663 and prochlorperazine

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013