Page last updated: 2024-09-03

mk 0663 and leflunomide

mk 0663 has been researched along with leflunomide in 2 studies

Compound Research Comparison

Studies (mk 0663)	Trials (mk 0663)	Recent Studies (post-2010) (mk 0663)	Studies (leflunomide)	Trials (leflunomide)	Recent Studies (post-2010) (leflunomide)
549	173	265	1,725	173	659

Protein Interaction Comparison

Protein	Taxonomy	leflunomide (IC50)
Dihydroorotate dehydrogenase (quinone), mitochondrial	Mus musculus (house mouse)	0.03
Cytochrome P450 1A2	Homo sapiens (human)	0.5
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	4.63
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	4.63
Sodium-dependent dopamine transporter	Homo sapiens (human)	2.884
Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens (human)	5.4
Dihydroorotate dehydrogenase (quinone), mitochondrial	Rattus norvegicus (Norway rat)	0.009

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Berens, N; Bröcker, EB; Seitz, CS; Trautmann, A	1

Reviews

1 review(s) available for mk 0663 and leflunomide

Article	Year
Leg ulceration in rheumatoid arthritis--an underreported multicausal complication with considerable morbidity: analysis of thirty-six patients and review of the literature. Dermatology (Basel, Switzerland), 2010, Volume: 220, Issue:3 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Arthritis, Rheumatoid; Etoricoxib; Female; Gram-Positive Bacterial Infections; Humans; Isoxazoles; Leflunomide; Leg; Leg Ulcer; Male; Methotrexate; Middle Aged; Prednisolone; Pseudomonas aeruginosa; Pseudomonas Infections; Pyridines; Retrospective Studies; Risk Factors; Sulfones	2010

Article

Year

Leg ulceration in rheumatoid arthritis--an underreported multicausal complication with considerable morbidity: analysis of thirty-six patients and review of the literature.

Dermatology (Basel, Switzerland), 2010, Volume: 220, Issue:3

Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Arthritis, Rheumatoid; Etoricoxib; Female; Gram-Positive Bacterial Infections; Humans; Isoxazoles; Leflunomide; Leg; Leg Ulcer; Male; Methotrexate; Middle Aged; Prednisolone; Pseudomonas aeruginosa; Pseudomonas Infections; Pyridines; Retrospective Studies; Risk Factors; Sulfones

2010

Other Studies

1 other study(ies) available for mk 0663 and leflunomide

Article	Year
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013

Article

Year

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013