Page last updated: 2024-09-03

mk 0663 and indomethacin

mk 0663 has been researched along with indomethacin in 24 studies

Compound Research Comparison

Studies
(mk 0663)
Trials
(mk 0663)
Recent Studies (post-2010)
(mk 0663)
Studies
(indomethacin)
Trials
(indomethacin)
Recent Studies (post-2010) (indomethacin)
54917326529,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomymk 0663 (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.17)18.2507
2000's12 (50.00)29.6817
2010's10 (41.67)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Brideau, C; Chan, CC; Charleson, S; Deschênes, D; Dubé, D; Ethier, D; Fortin, R; Friesen, RW; Gauthier, JY; Girard, Y; Gordon, R; Greig, GM; Riendeau, D; Savoie, C; Visco, D; Wang, Z; Wong, E; Xu, LJ; Young, RN1
Byun, Y; Choi, JK; Choi, YH; Chung, S; Jeong, YS; Kim, JK; Kim, JY; Koh, HJ; Lee, KW; Lim, KM; Moh, JH; Noh, MS; Oh, YI; Park, YH; Shin, SS1
Lombardo, F; Obach, RS; Waters, NJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Boice, JA; Daikh, DI; Malmstrom, K; Molina, J; Mukhopadhyay, S; Ng, J; Schumacher, HR; Tate, GA1
Boulet, J; Gottshall, S; Harrison, J; Mark, L; Pearson, M; Walker, K; Whiteside, GT1
Antigua, J; Burton, R; Chen, E; Geba, GP; Londoño, J; Lund, M; Najarian, DK; Navarra, S; Ozturk, ZE; Petruschke, RA; Pryhuber, KG; Rubin, BR1
Azoubel, MC; Bezerra, D; Brito, GA; Menezes, AM; Oriá, RB; Ribeiro, RA1
Navarra, S; Rubin, BR; Smugar, SS; Tershakovec, AM; Yu, Q1
Almeida, PR; Baltazar, F; Brito, GA; Ferreira, FV; Macedo, FY; Ribeiro, RA; Schmitt, FC; Távora, F1
Murphy, E; O'Connor, MB; Phelan, MJ; Regan, MJ1
Bressan, E; Tonussi, CR1
Norquist, JM; Schlesinger, N; Watson, DJ1
Anauate, MC; de Mello, SB; Torres, LM1
Sanyal, SN; Setia, S; Vaish, V1
Sanyal, SN; Setia, S2
Bao, CD; Chen, SL; Dai, Q; Gu, JR; Han, XH; Li, T; Li, XF; Li, ZG; Sun, LY; Wu, DH; Yang, NP; Zhang, MJ; Zhang, X1
Liu, P; Ma, JL; Wang, J; Zhang, S; Zhang, W; Zhang, Y1
Guan, M; Liu, S; Xu, L; Xue, Y1
Arfè, A; Castellsague, J; Garbe, E; Herings, R; Kollhorst, B; Lucchi, S; Masclee, GMC; Perez-Gutthann, S; Romio, S; Schade, R; Schink, T; Schuemie, MJ; Scotti, L; Straatman, H; Sturkenboom, MCJM; Valkhoff, VE; Varas-Lorenzo, C; Villa, M1
Bahra, A; Farag, M1

Reviews

1 review(s) available for mk 0663 and indomethacin

ArticleYear
Efficacy and safety of etoricoxib compared with NSAIDs in acute gout: a systematic review and a meta-analysis.
    Clinical rheumatology, 2016, Volume: 35, Issue:1

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Diclofenac; Etoricoxib; Gout; Humans; Indomethacin; Pain Measurement; Pyridines; Randomized Controlled Trials as Topic; Sulfones; Treatment Outcome

2016

Trials

6 trial(s) available for mk 0663 and indomethacin

ArticleYear
Randomised double blind trial of etoricoxib and indometacin in treatment of acute gouty arthritis.
    BMJ (Clinical research ed.), 2002, Jun-22, Volume: 324, Issue:7352

    Topics: Acute Disease; Adult; Aged; Arthritis, Gouty; Cyclooxygenase Inhibitors; Double-Blind Method; Etoricoxib; Female; Gout Suppressants; Humans; Indomethacin; Male; Middle Aged; Pain; Pain Measurement; Pyridines; Sulfones; Treatment Outcome

2002
Efficacy and safety profile of treatment with etoricoxib 120 mg once daily compared with indomethacin 50 mg three times daily in acute gout: a randomized controlled trial.
    Arthritis and rheumatism, 2004, Volume: 50, Issue:2

    Topics: Administration, Oral; Double-Blind Method; Drug Administration Schedule; Etoricoxib; Female; Gout; Gout Suppressants; Humans; Indomethacin; Male; Middle Aged; Pain; Pain Measurement; Pyridines; Sulfones; Treatment Outcome

2004
Association of baseline disease and patient characteristics with response to etoricoxib and indomethacin for acute gout.
    Current medical research and opinion, 2007, Volume: 23, Issue:7

    Topics: Acute Disease; Adult; Arthralgia; Arthritis; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Resistance; Etoricoxib; Female; Gout; Gout Suppressants; Humans; Indomethacin; Male; Middle Aged; Pyridines; Sulfones

2007
Serum urate during acute gout.
    The Journal of rheumatology, 2009, Volume: 36, Issue:6

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Cyclooxygenase Inhibitors; Etoricoxib; Female; Gout; Gout Suppressants; Humans; Indomethacin; Male; Middle Aged; Pyridines; Sulfones; Treatment Outcome; Uric Acid; Young Adult

2009
Etoricoxib versus indometacin in the treatment of Chinese patients with acute gouty arthritis: a randomized double-blind trial.
    Chinese medical journal, 2013, Volume: 126, Issue:10

    Topics: Adult; Aged; Arthritis, Gouty; Cyclooxygenase Inhibitors; Double-Blind Method; Etoricoxib; Female; Humans; Indomethacin; Male; Middle Aged; Pyridines; Sulfones

2013
Comparison of Prednisolone, Etoricoxib, and Indomethacin in Treatment of Acute Gouty Arthritis: An Open-Label, Randomized, Controlled Trial.
    Medical science monitor : international medical journal of experimental and clinical research, 2016, Mar-11, Volume: 22

    Topics: Adult; Arthritis, Gouty; Etoricoxib; Female; Humans; Indomethacin; Male; Pain Measurement; Prednisolone; Pyridines; Recurrence; Sulfones; Treatment Outcome

2016

Other Studies

17 other study(ies) available for mk 0663 and indomethacin

ArticleYear
2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: selective and orally active cyclooxygenase-2 inhibitors.
    Bioorganic & medicinal chemistry letters, 1998, Oct-06, Volume: 8, Issue:19

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; CHO Cells; Cricetinae; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Humans; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Structure-Activity Relationship

1998
In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives.
    Journal of medicinal chemistry, 2004, Feb-12, Volume: 47, Issue:4

    Topics: Adult; Animals; Arthritis, Experimental; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Furans; Humans; In Vitro Techniques; Isoenzymes; Macrophages, Peritoneal; Male; Membrane Proteins; Mice; Models, Molecular; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Pharmacological characterisation of a rat model of incisional pain.
    British journal of pharmacology, 2004, Volume: 141, Issue:1

    Topics: Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Evaluation, Preclinical; Etoricoxib; Foot; Gabapentin; gamma-Aminobutyric Acid; Hindlimb; Hyperalgesia; Indomethacin; Male; Morphine; Muscle, Skeletal; Naproxen; Nociceptors; Pain Threshold; Pain, Postoperative; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sulfonamides; Sulfones; Time Factors; Weight-Bearing

2004
[Rapidly acting and powerful antirheumatic drug now also approved in Germany. Arcoxia (etoricoxib, MSD)]].
    Krankenpflege Journal, 2004, Volume: 42, Issue:7-10

    Topics: Acute Disease; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Approval; Etoricoxib; Gout; Humans; Indomethacin; Osteoarthritis; Pain Measurement; Pyridines; Sulfones

2004
Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2007, Volume: 40, Issue:1

    Topics: Alveolar Bone Loss; Animals; Cyclooxygenase Inhibitors; Etoricoxib; Female; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Periodontitis; Pyridines; Rats; Rats, Wistar; Sulfones

2007
Cyclooxygenase-2 expression on ifosfamide-induced hemorrhagic cystitis in rats.
    Journal of cancer research and clinical oncology, 2008, Volume: 134, Issue:1

    Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cystitis; Drug Therapy, Combination; Etoricoxib; Hemorrhage; Ifosfamide; Immunoenzyme Techniques; Indomethacin; Male; Mesna; Pentoxifylline; Protective Agents; Pyridines; Rats; Rats, Wistar; Sulfones; Thalidomide

2008
Primary stabbing headache can be responsive to etoricoxib, a selective COX-2 inhibitor.
    European journal of neurology, 2008, Volume: 15, Issue:1

    Topics: Acute Disease; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Etoricoxib; Female; Headache Disorders, Primary; Humans; Indomethacin; Ophthalmic Nerve; Pain, Intractable; Pyridines; Sulfones; Treatment Outcome

2008
Antiinflammatory effects of etoricoxib alone and combined with NSAIDs in LPS-induced reactive arthritis.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2008, Volume: 57, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygenase Inhibitors; Etoricoxib; Gastric Mucosa; Indomethacin; Knee Joint; Leukocytes; Lipopolysaccharides; Male; Pain Measurement; Piroxicam; Pyridines; Rats; Rats, Wistar; Sulfones; Synovial Fluid

2008
Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX-1, COX-2 activity and nitric oxide production on whole-blood assay.
    Phytotherapy research : PTR, 2010, Volume: 24, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Chemical Analysis; Blood Coagulation; Blood Platelets; Cinnamates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Etoricoxib; Female; Glycosides; Harpagophytum; Humans; Indomethacin; Inflammation Mediators; Iridoids; Lipopolysaccharides; Nitric Oxide; Plant Extracts; Pyrans; Pyridines; Sulfones; Thromboxane B2

2010
Chemopreventive effects of NSAIDs as inhibitors of cyclooxygenase-2 and inducers of apoptosis in experimental lung carcinogenesis.
    Molecular and cellular biochemistry, 2012, Volume: 366, Issue:1-2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bronchoalveolar Lavage Fluid; Carcinoma, Non-Small-Cell Lung; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; DNA Fragmentation; Drug Screening Assays, Antitumor; Etoricoxib; Female; Indomethacin; Lung; Lung Neoplasms; Membrane Proteins; Neoplasms, Experimental; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfones; Tumor Burden

2012
Nuclear factor kappa B: a pro-inflammatory, transcription factor-mediated signalling pathway in lung carcinogenesis and its inhibition by nonsteroidal anti-inflammatory drugs.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2012, Volume: 31, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Proliferation; Chemoprevention; Disease Models, Animal; Etoricoxib; Indomethacin; Lung Neoplasms; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Pyridines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Sulfones; Transcription Factors

2012
Upregulation of intrinsic apoptotic pathway in NSAIDs mediated chemoprevention of experimental lung carcinogenesis.
    Pharmacological reports : PR, 2012, Volume: 64, Issue:3

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; DNA Fragmentation; Etoricoxib; Female; Indomethacin; Lung Neoplasms; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Sulfones; Up-Regulation

2012
Risk of acute myocardial infarction during use of individual NSAIDs: A nested case-control study from the SOS project.
    PloS one, 2018, Volume: 13, Issue:11

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Diclofenac; Etoricoxib; Female; Humans; Indomethacin; Ketorolac; Lactones; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Risk Factors; Sulfones

2018
Etoricoxib and celecoxib sensitive indomethacin-responsive headache disorders.
    Headache, 2022, Volume: 62, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Etoricoxib; Headache; Headache Disorders; Humans; Indomethacin

2022