Page last updated: 2024-09-03

mk 0663 and dinoprostone

mk 0663 has been researched along with dinoprostone in 17 studies

Compound Research Comparison

Studies
(mk 0663)
Trials
(mk 0663)
Recent Studies (post-2010)
(mk 0663)
Studies
(dinoprostone)
Trials
(dinoprostone)
Recent Studies (post-2010) (dinoprostone)
54917326529,1051,3466,357

Protein Interaction Comparison

ProteinTaxonomymk 0663 (IC50)dinoprostone (IC50)
Prostaglandin E2 receptor EP1 subtypeHomo sapiens (human)0.0155
Prostaglandin E2 receptor EP4 subtypeHomo sapiens (human)0.0031
Prostaglandin E2 receptor EP4 subtypeRattus norvegicus (Norway rat)0.0021
Prostaglandin E2 receptor EP3 subtypeHomo sapiens (human)0.002
Prostaglandin E2 receptor EP2 subtypeHomo sapiens (human)0.0087
Prostacyclin receptorHomo sapiens (human)0.26
Prostaglandin E2 receptor EP2 subtypeRattus norvegicus (Norway rat)0.0052

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (41.18)29.6817
2010's6 (35.29)24.3611
2020's4 (23.53)2.80

Authors

AuthorsStudies
Agrawal, N; Dallob, A; De Schepper, P; DeTora, L; Gertz, B; Gottesdiener, K; Greenberg, H; Hawkey, CJ; Wagner, J; Waldman, S; Wight, N; Wong, P1
Bretschneider, E; Censarek, P; Fischer, JW; Meyer-Kirchrath, J; Pape, R; Rabausch, K; Sarbia, M; Schrör, K; Weber, AA1
Geisslinger, G; Manderscheid, C; Niederberger, E1
Abdalla, GK; Castro, EC; Faria, GE; Michelin, MA; Reis, MA; Silva, KT1
Cavanaugh, PF; Chappell, DL; Dallob, AL; Flynn, ME; Hilliard, DA; Larson, PJ; Laterza, OF; Miller, J; Royalty, J; Schwartz, JI; Snyder, KM; Wagner, JA1
Azoubel, E; Azoubel, MC; Bittencourt, S; Brito, GA; Cangussú, V; Cunha, FQ; Ribeiro, RA; Sarmento, VA1
Sharma, P; Suresh, S1
Anauate, MC; de Mello, SB; Torres, LM1
Calvello, R; Carbone, ML; Cianciulli, A; Malerba, P; Panaro, MA; Perrone, MG; Scilimati, A; Vitale, P1
Antoniazzi, MM; Barbaro, KC; Faquim-Mauro, EL; Jared, SG; Kimura, LF; Pereira, NA; Prezotto-Neto, JP; Santoro, ML; Távora, BC; Teixeira, CF1
Ghosh, T; Sil, S1
Li, Z; Wang, D; Wang, S; Yang, Q; Yang, Y1
Fu, WZ; He, JW; Hu, YQ; Li, SS; Liu, YJ; Zhang, ZL1
Agnes, JP; Báfica, A; Bishop, AJR; Bruxel, MA; Casagrande, T; Cassali, GD; das Neves, RN; Delgobo, M; Falchetti, M; Garcia, APV; Gelain, DP; Gonçalves, RM; Mendes, DAGB; Moreira, JCF; Rafacho, A; Somensi, N; Vieira, TC; Zanotto-Filho, A1
Kleszcz, R; Krajka-Kuźniak, V; Kruhlenia, N; Majchrzak-Celińska, A; Misiorek, JO; Przybyl, L; Rolle, K1
Abo-Youssef, A; Ahmed, O; Ali, G; Hersi, F; Mohamed, W; Omar, H1
Gorbach, T; Koiro, O; Kudina, O; Shtrygol, S; Tovchiga, O; Yudkevich, T1

Trials

4 trial(s) available for mk 0663 and dinoprostone

ArticleYear
Characterization of etoricoxib, a novel, selective COX-2 inhibitor.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:6

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Cyclooxygenase 2; Dinoprostone; Double-Blind Method; Drug Tolerance; Etoricoxib; Female; Gastric Mucosa; Humans; Isoenzymes; Lipopolysaccharides; Male; Membrane Proteins; Middle Aged; Naproxen; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Pyridines; Sulfones

2003
Comparative inhibitory activity of etoricoxib, celecoxib, and diclofenac on COX-2 versus COX-1 in healthy subjects.
    Journal of clinical pharmacology, 2008, Volume: 48, Issue:6

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Double-Blind Method; Etoricoxib; Female; Humans; Male; Middle Aged; Pyrazoles; Pyridines; Sulfonamides; Sulfones; Thromboxane B2

2008
Adjunctive benefits of systemic etoricoxib in non-surgical treatment of aggressive periodontitis: short-term evaluation.
    Journal of periodontology, 2008, Volume: 79, Issue:9

    Topics: Adolescent; Adult; Alveolar Bone Loss; Combined Modality Therapy; Cyclooxygenase Inhibitors; Dental Scaling; Dinoprostone; Double-Blind Method; Etoricoxib; Female; Follow-Up Studies; Gingival Crevicular Fluid; Gingival Hemorrhage; Humans; Male; Periodontal Attachment Loss; Periodontal Pocket; Periodontitis; Pilot Projects; Placebos; Pyridines; Root Planing; Sulfones; Tooth Cervix

2008
Clinical, Biochemical, and Genetic Features of 41 Han Chinese Families With Primary Hypertrophic Osteoarthropathy, and Their Therapeutic Response to Etoricoxib: Results From a Six-Month Prospective Clinical Intervention.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017, Volume: 32, Issue:8

    Topics: Adult; Asian People; China; Dinoprostone; Etoricoxib; Family; Female; Humans; Male; Middle Aged; Organic Anion Transporters; Osteoarthropathy, Primary Hypertrophic; Prospective Studies; Pyridines; Sulfones

2017

Other Studies

13 other study(ies) available for mk 0663 and dinoprostone

ArticleYear
Regulation of thrombomodulin expression in human vascular smooth muscle cells by COX-2-derived prostaglandins.
    Circulation research, 2005, Jan-07, Volume: 96, Issue:1

    Topics: Alprostadil; Blood Coagulation; Bucladesine; Carotid Artery Diseases; Carotid Artery, Internal; Cells, Cultured; Colforsin; Coronary Vessels; Culture Media, Serum-Free; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Epoprostenol; Etoricoxib; Gene Expression Profiling; Gene Expression Regulation; Humans; Iloprost; Isoquinolines; Mammary Arteries; Membrane Proteins; Models, Biological; Myocytes, Smooth Muscle; Oligonucleotide Array Sequence Analysis; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyridines; Receptors, Prostaglandin; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; RNA, Messenger; Saphenous Vein; Second Messenger Systems; Sulfonamides; Sulfones; Tetradecanoylphorbol Acetate; Thrombomodulin; Thrombophilia; Vasodilator Agents

2005
Different COX-independent effects of the COX-2 inhibitors etoricoxib and lumiracoxib.
    Biochemical and biophysical research communications, 2006, Apr-14, Volume: 342, Issue:3

    Topics: Animals; Cell Nucleus; Cell Proliferation; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Etoricoxib; Gene Expression Regulation; Macrophages; Mice; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Organic Chemicals; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyridines; Sulfones; Transcription Factor AP-1

2006
Trypanosoma cruzi: the role of PGE2 in immune response during the acute phase of experimental infection.
    Experimental parasitology, 2008, Volume: 118, Issue:4

    Topics: Acute Disease; Animals; Cells, Cultured; Chagas Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Etoricoxib; Fibrosis; Male; Meloxicam; Mice; Mice, Inbred BALB C; Myocardium; Parasitemia; Prostaglandins; Pyridines; Spleen; Sulfones; Thiazines; Thiazoles; Trypanosoma cruzi

2008
Influence of COX-2-induced PGE2 on the initiation and progression of tail regeneration in Northern House Gecko, Hemidactylus flaviviridis.
    Folia biologica, 2008, Volume: 54, Issue:6

    Topics: Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Etoricoxib; Female; Lizards; Male; Pyrazoles; Pyridines; Regeneration; Sulfonamides; Sulfones; Tail

2008
Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX-1, COX-2 activity and nitric oxide production on whole-blood assay.
    Phytotherapy research : PTR, 2010, Volume: 24, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Chemical Analysis; Blood Coagulation; Blood Platelets; Cinnamates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Etoricoxib; Female; Glycosides; Harpagophytum; Humans; Indomethacin; Inflammation Mediators; Iridoids; Lipopolysaccharides; Nitric Oxide; Plant Extracts; Pyrans; Pyridines; Sulfones; Thromboxane B2

2010
Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells.
    Pharmacological research, 2012, Volume: 65, Issue:1

    Topics: Animals; Aspirin; Celecoxib; Cell Line; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Etoricoxib; I-kappa B Proteins; Inflammation Mediators; Intramolecular Oxidoreductases; Lipopolysaccharides; Membrane Proteins; Mice; Microglia; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type II; Phosphorylation; Prostaglandin-E Synthases; Pyrazoles; Pyridines; RNA, Messenger; Sulfonamides; Sulfones

2012
Mast cells and histamine play an important role in edema and leukocyte recruitment induced by Potamotrygon motoro stingray venom in mice.
    Toxicon : official journal of the International Society on Toxinology, 2015, Volume: 103

    Topics: Animals; Cell Line, Tumor; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Dinoprostone; Edema; Elasmobranchii; Etoricoxib; Fish Venoms; Histamine; Histamine H1 Antagonists; Leukocytes; Male; Mast Cells; Membrane Proteins; Mice; Promethazine; Prostaglandin D2; Pyridines; Rats; Sulfones

2015
Role of cox-2 mediated neuroinflammation on the neurodegeneration and cognitive impairments in colchicine induced rat model of Alzheimer's Disease.
    Journal of neuroimmunology, 2016, Feb-15, Volume: 291

    Topics: Alzheimer Disease; Analysis of Variance; Animals; Cognition Disorders; Colchicine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytokines; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Etoricoxib; Injections, Intraventricular; Male; Maze Learning; Neurodegenerative Diseases; Plaque, Amyloid; Pyridines; Rats; Sulfones; Time Factors

2016
Successful treatment of pachydermoperiostosis with etoricoxib in a patient with a homozygous splice-site mutation in the SLCO2A1 gene.
    The British journal of dermatology, 2019, Volume: 180, Issue:3

    Topics: Adult; Cyclooxygenase 2 Inhibitors; Dinoprostone; Etoricoxib; Homozygote; Humans; Male; Mutation; Organic Anion Transporters; Osteoarthropathy, Primary Hypertrophic; RNA Splice Sites; Treatment Outcome

2019
COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice.
    Cancer letters, 2021, 04-01, Volume: 502

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aromatase; Breast Neoplasms; Cell Line, Tumor; Chemokine CCL2; Cyclooxygenase 2; Diet, High-Fat; Dinoprostone; Disease Models, Animal; Etoricoxib; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-6; MCF-7 Cells; Medroxyprogesterone Acetate; Mice; Sugars; Up-Regulation

2021
COXIBs and 2,5-dimethylcelecoxib counteract the hyperactivated Wnt/β-catenin pathway and COX-2/PGE2/EP4 signaling in glioblastoma cells.
    BMC cancer, 2021, May-03, Volume: 21, Issue:1

    Topics: Aged; Antineoplastic Agents, Alkylating; Apoptosis; beta Catenin; Brain Neoplasms; Celecoxib; Cell Cycle; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Etoricoxib; Female; Glioblastoma; Humans; Isoxazoles; Lactones; Male; Methylation; Middle Aged; Neoplasm Proteins; Pyrazoles; Receptors, Prostaglandin E, EP4 Subtype; Sulfonamides; Sulfones; Temozolomide; Tumor Suppressor Proteins; Wnt Signaling Pathway

2021
The Protective Role of Etoricoxib Against Diethylnitrosamine/2-acetylaminofluorene- Induced Hepatocarcinogenesis in Wistar Rats: The Impact of NF-κB/COX-2/PGE2 Signaling.
    Current molecular pharmacology, 2022, Volume: 15, Issue:1

    Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cyclooxygenase 2; Diethylnitrosamine; Dinoprostone; Etoricoxib; Female; Humans; Liver Neoplasms; Male; NF-kappa B; Rats; Rats, Wistar

2022
The effect of non-steroidal anti-inflammatory drugs with different mechanisms of action on the body temperature and cyclooxygenase pathway of the arachidonic acid cascade on the model of acute general cooling (air hypothermia) in rats.
    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2022,Fall, Volume: 71, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Body Temperature; Cyclooxygenase 2; Diclofenac; Dinoprost; Dinoprostone; Etoricoxib; Hypothermia; Rats

2022