mk 0663 has been researched along with colchicine in 6 studies
| Studies (mk 0663) | Trials (mk 0663) | Recent Studies (post-2010) (mk 0663) | Studies (colchicine) | Trials (colchicine) | Recent Studies (post-2010) (colchicine) |
|---|---|---|---|---|---|
| 549 | 173 | 265 | 15,472 | 404 | 2,974 |
| Protein | Taxonomy | mk 0663 (IC50) | colchicine (IC50) |
|---|---|---|---|
| Tubulin alpha-1A chain | Sus scrofa (pig) | 3.7639 | |
| Tubulin beta chain | Sus scrofa (pig) | 3.8663 | |
| Tubulin beta-4A chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta chain | Homo sapiens (human) | 2.7244 | |
| Tubulin alpha-3C chain | Homo sapiens (human) | 2.4334 | |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | 4.3 | |
| Tubulin alpha-1B chain | Homo sapiens (human) | 2.4334 | |
| Tubulin alpha-4A chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-4B chain | Homo sapiens (human) | 2.4334 | |
| Vesicular acetylcholine transporter | Tetronarce californica (Pacific electric ray) | 2.62 | |
| Tubulin beta-3 chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-2A chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-8 chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-2B chain | Bos taurus (cattle) | 2.8255 | |
| Tubulin alpha-3E chain | Homo sapiens (human) | 2.4334 | |
| Tubulin alpha-1A chain | Homo sapiens (human) | 2.4334 | |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | 3.0611 | |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | 3.1553 | |
| Tubulin alpha-1C chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-6 chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-2B chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-1 chain | Homo sapiens (human) | 2.4334 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Ghosh, T; Sil, S | 3 |
6 other study(ies) available for mk 0663 and colchicine
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Role of cox-2 mediated neuroinflammation on the neurodegeneration and cognitive impairments in colchicine induced rat model of Alzheimer's Disease.
Topics: Alzheimer Disease; Analysis of Variance; Animals; Cognition Disorders; Colchicine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytokines; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Etoricoxib; Injections, Intraventricular; Male; Maze Learning; Neurodegenerative Diseases; Plaque, Amyloid; Pyridines; Rats; Sulfones; Time Factors | 2016 |
Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease.
Topics: Alzheimer Disease; Animals; Anxiety; Behavior, Animal; Colchicine; Corticosterone; Cyclooxygenase 2; Disease Models, Animal; Etoricoxib; Male; Memory; Pyridines; Rats; Sulfones | 2016 |
Etoricoxib inhibits peripheral inflammation and alters immune responses in intracerebroventricular colchicine injected rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Cyclooxygenase 2; Etoricoxib; Inflammation; Injections, Intraventricular; Male; Rats; Tubulin Modulators | 2018 |