Compounds > mk 0663
Page last updated: 2024-09-03

mk 0663 and cinnarizine

mk 0663 has been researched along with cinnarizine in 2 studies

Compound Research Comparison

Studies
(mk 0663)		Trials
(mk 0663)		Recent Studies (post-2010)
(mk 0663)		Studies
(cinnarizine)		Trials
(cinnarizine)		Recent Studies (post-2010) (cinnarizine)
549173265855148190

Protein Interaction Comparison

ProteinTaxonomymk 0663 (IC50)cinnarizine (IC50)
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)2.832
Muscarinic acetylcholine receptor M4Homo sapiens (human)3.66
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.759
Alpha-2A adrenergic receptorHomo sapiens (human)0.444
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.513
D(2) dopamine receptorHomo sapiens (human)0.776
Alpha-2B adrenergic receptorHomo sapiens (human)2.242
Alpha-2C adrenergic receptorHomo sapiens (human)0.652
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)1.083
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.762
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.832
Alpha-1D adrenergic receptorHomo sapiens (human)1.167
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.36
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)1.083
Sodium-dependent serotonin transporterHomo sapiens (human)1.09
Histamine H1 receptorHomo sapiens (human)0.074
Mu-type opioid receptorHomo sapiens (human)2.272
D(3) dopamine receptorHomo sapiens (human)0.252
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.731
Sodium-dependent dopamine transporter Homo sapiens (human)1.641
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.04

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1

Other Studies

2 other study(ies) available for mk 0663 and cinnarizine

ArticleYear
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013