mk-0524 has been researched along with sphingosine-1-phosphate* in 1 studies
1 review(s) available for mk-0524 and sphingosine-1-phosphate
Article | Year |
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HDL quality or cholesterol cargo: what really matters--spotlight on sphingosine-1-phosphate-rich HDL.
The absolute level of HDL cholesterol (HDL-C) may not be the only criterion contributing to their antiatherothrombotic effects. This review focuses on evidence in support of the concept that HDL-bound sphingosine-1-phosphate (S1P) plays a role in different HDL atheroprotective properties and may represent a potential target for therapeutic interventions.. Recent large randomized clinical trials testing the hypothesis of raising HDL-C with niacin and dalcetrapib in statin-treated patients failed to improve cardiovascular outcomes. Emerging evidence suggests that many of the cardioprotective functions of HDL, such as vasodilation, angiogenesis and endothelial barrier function, protection against ischemia/reperfusion injury, and inhibition of atherosclerosis, may be attributable to its S1P cargo. HDL-associated S1P may represent a future therapeutic target.. HDL functionality is affected by its composition and there is evidence to suggest S1P plays a role in some of HDL's functions and atheroprotective properties. Topics: Animals; Atherosclerosis; Cardiotonic Agents; Cholesterol, HDL; Coronary Artery Disease; Drug Therapy, Combination; Humans; Indoles; Lysophospholipids; Niacin; Randomized Controlled Trials as Topic; Sphingosine; Treatment Outcome | 2013 |