Compounds > mitotane

mitotane and 2,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid

mitotane has been researched along with 2,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19901 (11.11)18.7374
1990's1 (11.11)18.2507
2000's1 (11.11)29.6817
2010's5 (55.56)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Inouye, M; Mio, T; Sumino, K1
Andersen, A; Kasperlik-Zaluska, AA; Warren, DJ1
Cichocki, A; Kasperlik-Zaluska, AA1
Allolio, B; Baudin, E; Berruti, A; Chadarevian, R; Daffara, F; den Hartigh, J; Fassnacht, M; Haak, HR; Hermsen, IG; Houterman, S; Leboulleux, S; Schlumberger, M; Terzolo, M1
Al Ghuzlan, A; Baudin, E; Brailly-Tabard, S; Hescot, S; Lombès, M; Paci, A; Seck, A; Slama, A; Trabado, S; Viengchareun, S; Young, J1
Fassnacht, M; Heinz, W; Kendl, S; Klinker, H; Kroiss, M; Lapa, C; Plonné, D; Ronchi, CL; Sbiera, S; Schirbel, A; Schirmer, D; Zink, M1
Haralampiev, I; Huster, D; Kroiss, M; Müller, P; Sbiera, S; Scheidt, HA; Schirbel, A; Theisgen, S1
Allegra, S; Berruti, A; Carrella, S; Cusato, J; D'Avolio, A; Daffara, FC; De Francia, S; De Martino, F; Di Carlo, F; Ferrero, A; Piccione, FM; Pirro, E; Tampellini, M; Terzolo, M1
Bach de Assis, C; Cavalcante de Figueiredo, B; Cruz Bonk, B; de Almeida Veiga, A; de Toledo Nogueira, B; Lada Degaut Pontes, F; Mera de Souza, L; Regina Rocha Martins, L; Rita Corso, C; Stadler, G1

Trials

1 trial(s) available for mitotane and 2,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid

ArticleYear
Determination of mitotane (o,p-DDD) and its metabolites o,p-DDA and o,p-DDE in plasma by high-performance liquid chromatography.
    Therapeutic drug monitoring, 1999, Volume: 21, Issue:3

    Topics: Adrenal Cortex Neoplasms; Adrenergic Agents; Adult; Aged; Antineoplastic Agents, Hormonal; Chromatography, High Pressure Liquid; Drug Stability; Female; Humans; Linear Models; Male; Middle Aged; Mitotane

1999

Other Studies

8 other study(ies) available for mitotane and 2,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid

ArticleYear
Use of GC/MS/SIM for rapid determination of plasma levels of o,p'-DDD, o,p'-DDE and o,p'-DDA.
    Clinica chimica acta; international journal of clinical chemistry, 1987, Volume: 170, Issue:2-3

    Topics: Circadian Rhythm; Gas Chromatography-Mass Spectrometry; Humans; Mitotane

1987
Clinical role of determination of plasma mitotane and its metabolites levels in patients with adrenal cancer: results of a long-term follow-up.
    Journal of experimental therapeutics & oncology, 2005, Volume: 5, Issue:2

    Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Antineoplastic Agents, Hormonal; Child; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mitotane

2005
Plasma concentrations of o,p'DDD, o,p'DDA, and o,p'DDE as predictors of tumor response to mitotane in adrenocortical carcinoma: results of a retrospective ENS@T multicenter study.
    The Journal of clinical endocrinology and metabolism, 2011, Volume: 96, Issue:6

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Female; Humans; Male; Middle Aged; Mitotane; Predictive Value of Tests; Retrospective Studies; Sensitivity and Specificity

2011
The lack of antitumor effects of o,p'DDA excludes its role as an active metabolite of mitotane for adrenocortical carcinoma treatment.
    Hormones & cancer, 2014, Volume: 5, Issue:5

    Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Apoptosis; Cell Line, Tumor; Cell Proliferation; Electron Transport Complex IV; Enzyme Activation; Humans; Mitochondrial Turnover; Mitotane; Oxidative Stress; Steroids

2014
Association of mitotane with chylomicrons and serum lipoproteins: practical implications for treatment of adrenocortical carcinoma.
    European journal of endocrinology, 2016, Volume: 174, Issue:3

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Antineoplastic Agents, Hormonal; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Chyle; Chylomicrons; Cohort Studies; Endoplasmic Reticulum Stress; Female; Gastrointestinal Absorption; Humans; Lipoproteins; Lipoproteins, HDL2; Lipoproteins, IDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Middle Aged; Mitotane

2016
The adrenal specific toxicant mitotane directly interacts with lipid membranes and alters membrane properties depending on lipid composition.
    Molecular and cellular endocrinology, 2016, 06-15, Volume: 428

    Topics: Adrenal Glands; Ascorbic Acid; Biological Assay; Electron Spin Resonance Spectroscopy; Fluorescence; Lipid Bilayers; Lipids; Mitotane; Organ Specificity; Phosphatidylcholines; Phosphatidylethanolamines; Proton Magnetic Resonance Spectroscopy; Unilamellar Liposomes

2016
Circannual variation of mitotane and its metabolites plasma levels in patients with adrenocortical carcinoma.
    The Journal of pharmacy and pharmacology, 2017, Volume: 69, Issue:11

    Topics: Adipose Tissue; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Antineoplastic Agents, Hormonal; Chemotherapy, Adjuvant; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Mitotane; Seasons; Sex Factors; Time Factors; Young Adult

2017
Two-dimensional chromatography for enantiomeric analysis of mitotane and its metabolite o,p'-DDA in patients with adrenocortical carcinoma indicates enantioselective metabolism.
    Bioorganic chemistry, 2023, Volume: 141

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Chromatography, High Pressure Liquid; Humans; Mitotane; Stereoisomerism

2023