mitoquinone has been researched along with ruboxistaurin* in 1 studies
1 other study(ies) available for mitoquinone and ruboxistaurin
| Article | Year |
|---|---|
PKCβ and reactive oxygen species mediate enhanced pulmonary vasoconstrictor reactivity following chronic hypoxia in neonatal rats.
Reactive oxygen species (ROS), mitochondrial dysfunction, and excessive vasoconstriction are important contributors to chronic hypoxia (CH)-induced neonatal pulmonary hypertension. On the basis of evidence that PKCβ and mitochondrial oxidative stress are involved in several cardiovascular and metabolic disorders, we hypothesized that PKCβ and mitochondrial ROS (mitoROS) signaling contribute to enhanced pulmonary vasoconstriction in neonatal rats exposed to CH. To test this hypothesis, we examined effects of the PKCβ inhibitor LY-333,531, the ROS scavenger 1-oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine (TEMPOL), and the mitochondrial antioxidants mitoquinone mesylate (MitoQ) and (2-(2,2,6,6-tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride (MitoTEMPO) on vasoconstrictor responses in saline Topics: Animals; Animals, Newborn; Chronic Disease; Cyclic N-Oxides; Enzyme Inhibitors; Female; Free Radical Scavengers; Hypoxia; Indoles; Maleimides; Organophosphorus Compounds; Oxidative Stress; Pregnancy; Protein Kinase C beta; Pulmonary Artery; Pulmonary Circulation; Rats; Reactive Oxygen Species; Spin Labels; Ubiquinone; Vasoconstriction; Vasoconstrictor Agents | 2020 |