mitomycin has been researched along with vitamin k semiquinone radical in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 11 (68.75) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Akman, SA; Forrest, GL; Hipsher, C; Johnson, R; Pan, SS | 1 |
| Ishidate, M; Sawada, M; Sofuni, T | 1 |
| Ghersi-Egea, JF; Livertoux, MH; Minn, A; Perrin, R; Siest, G | 1 |
| Smith, PJ; Walton, MI; Workman, P | 1 |
| Chang, JY; Cheng, AL; Chi, KH; Ngo, EO; Nutter, LM; Sun, TP; Wang, CC | 1 |
| Keyes, SR; Rockwell, S; Sartorelli, AC | 1 |
| De Leeuw, SJ; Joenje, H; Keizer, HG; Pinedo, HM; Van Rijn, J | 1 |
| Napetschnig, S; Sies, H | 1 |
| Lee, JH; Naito, M; Nakajima, M; Tsuruo, T | 1 |
| Akman, S; Doroshow, J; Forrest, GL; Gonzalez, B; Kaplan, WD; Rivera, H | 1 |
| Ahn, C; Akman, SA; Doroshow, JH; Leong, LA; Margolin, KA; Morgan, RJ; Raschko, JW; Somlo, G | 1 |
| Ahn, C; Akman, S; Chow, W; Coluzzi, P; Leong, L; Margolin, K; Morgan, RJ; Raschko, J; Shibata, S; Tetef, M | 1 |
| Ahn, C; Akman, S; Chow, W; Doroshow, JH; Leong, L; Margolin, K; Morgan, RJ; Raschko, J; Somlo, G; Tetef, M | 1 |
| Beall, HD; Bolton, EM; Gustafson, DL; Ross, D; Waldren, CA | 1 |
| Jaiswal, AK; Joseph, P | 1 |
| Iyanagi, T; Kimura, S; Matsuda, H | 1 |
3 trial(s) available for mitomycin and vitamin k semiquinone radical
| Article | Year |
|---|---|
Phase I study of mitomycin C and menadione in advanced solid tumors.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Erythrocytes; Female; Glucosephosphate Dehydrogenase; Glutathione; Hemolysis; Humans; Infusions, Intravenous; Male; Middle Aged; Mitomycin; Neoplasms; Vitamin K | 1995 |
Mitomycin C and menadione for the treatment of advanced gastrointestinal cancers: a phase II trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Mitomycin; Vitamin K | 1995 |
Mitomycin C and menadione for the treatment of lung cancer: a phase II trial.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Drug Interactions; Drugs, Investigational; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Mitomycin; Vitamin K | 1995 |
13 other study(ies) available for mitomycin and vitamin k semiquinone radical
| Article | Year |
|---|---|
The role of NAD(P)H:quinone oxidoreductase in mitomycin C- and porfiromycin-resistant HCT 116 human colon-cancer cells.
Topics: 2,6-Dichloroindophenol; Carbon Radioisotopes; Cell Extracts; Cell Size; Cell Survival; Colonic Neoplasms; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Intracellular Fluid; Microsomes; Mitomycin; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Porfiromycin; RNA, Messenger; Tissue Distribution; Transcription, Genetic; Tumor Cells, Cultured; Vitamin K | 1992 |
Isolation of a menadione-resistant subclone from Chinese hamster lung (CHL) cells in culture.
Topics: Animals; Cell Survival; Cells, Cultured; Chromosome Aberrations; Chromosome Banding; Cricetinae; Cricetulus; Doxorubicin; Ethylnitrosourea; Karyotyping; Lung; Methylnitronitrosoguanidine; Mitomycin; Mitomycins; Mutagenesis; NADPH-Ferrihemoprotein Reductase; Naphthoquinones; Superoxides; Vitamin K | 1991 |
Enzyme mediated superoxide radical formation initiated by exogenous molecules in rat brain preparations.
Topics: Animals; Brain Chemistry; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Flunitrazepam; Free Radicals; In Vitro Techniques; Male; Mitomycin; Mitomycins; NAD; NADP; Paraquat; Rats; Rats, Inbred Strains; Subcellular Fractions; Superoxides; Vitamin K; Xenobiotics | 1991 |
The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9.
Topics: Animals; Antineoplastic Agents; Aziridines; Biotransformation; Carcinoma 256, Walker; Colonic Neoplasms; Dicumarol; DNA Damage; DNA, Bacterial; Humans; Indolequinones; Indoles; Kinetics; Mitomycin; Mitomycins; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Quinone Reductases; Quinones; Rats; Superoxide Dismutase; Tumor Cells, Cultured; Vitamin K | 1991 |
Menadione-induced DNA damage in a human tumor cell line.
Topics: Breast Neoplasms; DNA Damage; DNA Repair; Humans; Mitomycin; Tumor Cells, Cultured; Vitamin K | 1991 |
Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells.
Topics: Aerobiosis; Alkylating Agents; Anaerobiosis; Animals; Biological Transport; Cell Line; Cell Survival; Dicumarol; Doxorubicin; Kinetics; Mammary Neoplasms, Experimental; Methylcholanthrene; Mice; Mitomycin; Mitomycins; Oxidation-Reduction; Porfiromycin; Vitamin K | 1989 |
Effect of artificial electron acceptors on the cytotoxicity of mitomycin C and doxorubicin in human lung tumor cells.
Topics: Carcinoma, Squamous Cell; Doxorubicin; Drug Interactions; Ellipticines; Humans; Lung Neoplasms; Methylene Blue; Methylphenazonium Methosulfate; Mitomycin; Mitomycins; Oxygen Consumption; Peroxides; Phenazines; tert-Butylhydroperoxide; Tumor Cells, Cultured; Vitamin K | 1989 |
Generation of photoemissive species by mitomycin C redox cycling in rat liver microsomes.
Topics: Animals; Glutathione; Luminescent Measurements; Male; Microsomes, Liver; Mitomycin; Mitomycins; Oxidation-Reduction; Oxygen; Oxygen Consumption; Rats; Rats, Inbred Strains; Vitamin K | 1987 |
Isolation and characterization of a mitomycin C-resistant variant of human colon carcinoma HT-29 cells.
Topics: Aerobiosis; Alkylation; Biotransformation; Cell Survival; Colonic Neoplasms; Dicumarol; DNA, Neoplasm; Drug Resistance; Glutathione Transferase; Humans; Mitomycin; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Tumor Cells, Cultured; Vitamin K | 1993 |
Protection against daunorubicin cytotoxicity by expression of a cloned human carbonyl reductase cDNA in K562 leukemia cells.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Antibiotics, Antineoplastic; Base Sequence; Cells, Cultured; Cloning, Molecular; Daunorubicin; DNA Primers; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression; Humans; In Vitro Techniques; Leukemia, Erythroblastic, Acute; Mitomycin; Molecular Sequence Data; Oxidation-Reduction; Phenanthrenes; Recombinant Proteins; RNA, Messenger; RNA, Neoplasm; Vitamin K | 1995 |
Expression of human NAD(P)H: quinone oxidoreductase (DT-diaphorase) in Chinese hamster ovary cells: effect on the toxicity of antitumor quinones.
Topics: Animals; Antibiotics, Antineoplastic; Biotransformation; Cell Survival; CHO Cells; Cricetinae; Cytochrome Reductases; Cytochrome-B(5) Reductase; Dicumarol; DNA, Complementary; Enzyme Inhibitors; Humans; Mitomycin; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Quinones; Transfection; Vitamin K; Xanthine Dehydrogenase | 1996 |
A unique cytosolic activity related but distinct from NQO1 catalyses metabolic activation of mitomycin C.
Topics: Animals; Antibiotics, Antineoplastic; CHO Cells; Colon; Cricetinae; Cross-Linking Reagents; Cytosol; DNA Adducts; Humans; Liver; Mice; Mitomycin; Quinone Reductases; Vitamin K | 2000 |
One-electron reduction of quinones by the neuronal nitric-oxide synthase reductase domain.
Topics: Cytochrome P-450 Enzyme System; Doxorubicin; Electrons; Ferricyanides; Flavins; Kinetics; Mitomycin; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Oxidoreductases; Quinones; Recombinant Proteins; Spectrophotometry, Ultraviolet; Vitamin K | 2000 |