mitomycin has been researched along with porfiromycin in 38 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 14 (36.84) | 18.7374 |
1990's | 21 (55.26) | 18.2507 |
2000's | 3 (7.89) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Bradner, WT; Cheng, L; Iyengar, BS; Lin, HJ; Remers, WA | 1 |
Arai, H; Ashizawa, T; Gomi, K; Kasai, M; Kono, M; Saito, H | 1 |
Hirayama, N; Yoda, N | 1 |
Dembitsky, VM; Ismail, FM; Levitsky, DO | 1 |
Akman, SA; Forrest, GL; Hipsher, C; Johnson, R; Pan, SS | 1 |
Adams, GE; Carmichael, J; Houlbrook, S; Robertson, N; Stratford, IJ | 1 |
Durand, RE; Olive, PL | 1 |
Hughes, CS; Irvin, CG; Rockwell, S | 1 |
Marshall, RS; Paterson, MC; Rauth, AM | 2 |
Gustafson, DL; Pritsos, CA | 1 |
Braunschweiger, PG; Furmanski, P; Johnson, CS; Jones, SA | 1 |
Herman, TS; Holden, SA; Teicher, BA | 1 |
Nambara, T; Ohkubo, T | 1 |
Sartorelli, AC | 1 |
Keyes, SR; Rockwell, S; Sartorelli, AC | 2 |
Callery, PS; Musser, SM; Pan, SS | 1 |
Keyes, SR; Pritsos, CA; Sartorelli, AC | 1 |
Fracasso, PM; Sartorelli, AC | 1 |
Iyengar, BS; Remers, WA | 1 |
Fracasso, PM; Heimbrook, DC; Keyes, SR; Rockwell, S; Sartorelli, AC; Sligar, SG | 1 |
Belcourt, MF; Hodnick, WF; Keyes, SR; Pritsos, CA; Rockwell, S; Sartorelli, AC | 1 |
Caron, RM; Hamilton, JW | 1 |
Arai, H; Beall, H; Gibson, NW; Kasai, M; Ross, D; Siegel, D | 1 |
Kuehl, BL; Marshall, RS; Rauth, AM | 1 |
Pan, SS; Yu, F | 1 |
Belcourt, MF; Hodnick, WF; Rockwell, S; Sartorelli, AC | 1 |
Kelley, M; Rockwell, S | 1 |
Fischer, D; Fischer, JJ; Haffty, BG; Papac, R; Rockwell, S; Ross, D; Sartorelli, AC; Sasaki, CT; Son, YH; Wilson, LD | 1 |
Hughes, CS; Rockwell, S | 1 |
Belcourt, MF; Hodnick, WF; Johnson, DA; Penketh, PG; Rockwell, S; Sartorelli, AC; Sherman, DH | 1 |
DUVALL, LR | 1 |
IYER, VN; SZYBALSKI, W | 1 |
WHITE, HL; WHITE, JR | 1 |
BOSTWICK, L; EVANS, JS; MENGEL, GD | 1 |
Eisbruch, A; Normolle, DP | 1 |
Cho, EI; Fischer, DB; Fischer, JJ; Haffty, BG; Papac, RJ; Rockwell, S; Ross, DA; Sartorelli, AC; Sasaki, CT; Son, YH; Wilson, LD | 1 |
2 review(s) available for mitomycin and porfiromycin
Article | Year |
---|---|
Aziridine alkaloids as potential therapeutic agents.
Topics: Alkaloids; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Aziridines; Humans | 2009 |
Cellular approaches to bioreductive drug mechanisms.
Topics: Animals; Antineoplastic Agents; CHO Cells; Cricetinae; Humans; Mitomycin; Neoplasms; Oxidation-Reduction; Oxygen; Porfiromycin | 1993 |
2 trial(s) available for mitomycin and porfiromycin
Article | Year |
---|---|
Bioreductive alkylating agent porfiromycin in combination with radiation therapy for the management of squamous cell carcinoma of the head and neck.
Topics: Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Therapy; Dose Fractionation, Radiation; Follow-Up Studies; Head and Neck Neoplasms; Humans; Mitomycin; Porfiromycin; Survival Rate; Time Factors | 1997 |
Concurrent chemo-radiotherapy with mitomycin C compared with porfiromycin in squamous cell cancer of the head and neck: final results of a randomized clinical trial.
Topics: Analysis of Variance; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Therapy; Disease-Free Survival; Female; Head and Neck Neoplasms; Humans; Leukopenia; Male; Middle Aged; Mitomycin; Porfiromycin; Prospective Studies; Radiotherapy Dosage; Statistics, Nonparametric; Thrombocytopenia | 2005 |
34 other study(ies) available for mitomycin and porfiromycin
Article | Year |
---|---|
Development of new mitomycin C and porfiromycin analogues.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Leukemia, Experimental; Melanoma; Mice; Mitomycins; Neoplasms, Experimental; Porfiromycin; Structure-Activity Relationship | 1981 |
Synthesis and antitumor activity of various 6-demethylmitomycins and 6-demethyl-6-halomitomycins.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Mice; Mitomycins; Sarcoma 180; Structure-Activity Relationship | 1995 |
Structure-activity relationships for mitomycins. Application of the distance and charge analysis method.
Topics: Mitomycins; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 1993 |
The role of NAD(P)H:quinone oxidoreductase in mitomycin C- and porfiromycin-resistant HCT 116 human colon-cancer cells.
Topics: 2,6-Dichloroindophenol; Carbon Radioisotopes; Cell Extracts; Cell Size; Cell Survival; Colonic Neoplasms; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Intracellular Fluid; Microsomes; Mitomycin; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Porfiromycin; RNA, Messenger; Tissue Distribution; Transcription, Genetic; Tumor Cells, Cultured; Vitamin K | 1992 |
The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase?
Topics: Antineoplastic Agents; Aziridines; Dihydrolipoamide Dehydrogenase; Humans; Indolequinones; Indoles; Mitomycin; Oxidation-Reduction; Porfiromycin; Quinones; Tumor Cells, Cultured | 1992 |
Evaluation of bioreductive drugs in multicell spheroids.
Topics: Animals; Antineoplastic Agents; Cell Aggregation; Cell Hypoxia; Cell Survival; Cricetinae; Evaluation Studies as Topic; In Vitro Techniques; Misonidazole; Mitomycin; Models, Biological; Nitrofurans; Porfiromycin; Prodrugs; Tirapazamine; Triazines | 1992 |
Effect of deficiencies in DNA repair on the toxicity of mitomycin C and porfiromycin to CHO cells under aerobic and hypoxic conditions.
Topics: Aerobiosis; Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line; Cell Survival; Cricetinae; DNA Repair; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Mitomycin; Mitomycins; Porfiromycin; Time Factors | 1991 |
Studies on the mechanism of resistance to mitomycin C and porfiromycin in a human cell strain derived from a cancer-prone individual.
Topics: Cell Line; Cell Survival; Child; Drug Resistance; Female; Glutathione; Humans; Kinetics; Mitomycin; Mitomycins; NAD(P)H Dehydrogenase (Quinone); Neoplasms; Oxygen; Porfiromycin; Precipitin Tests; Quinone Reductases; Tumor Cells, Cultured | 1991 |
Inhibition of mitomycin C's aerobic toxicity by the seleno-organic antioxidant PZ-51.
Topics: Acetylcysteine; Aerobiosis; Animals; Antineoplastic Agents; Antioxidants; Azoles; Cell Hypoxia; Cell Line; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Isoindoles; Mice; Mitomycin; Mitomycins; Organoselenium Compounds; Porfiromycin; Selenium; Tumor Cells, Cultured | 1991 |
Potentiation of mitomycin C and porfiromycin antitumor activity in solid tumor models by recombinant human interleukin 1 alpha.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dexamethasone; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Interleukin-1; Ketoconazole; Mice; Mice, Inbred C57BL; Mitomycin; Neoplasms; Porfiromycin; Recombinant Proteins; Tumor Cells, Cultured | 1991 |
Addition of a hypoxic cell selective cytotoxic agent (mitomycin C or porfiromycin) to Fluosol-DA/carbogen/radiation.
Topics: Animals; Carbon Dioxide; Cell Hypoxia; Dose-Response Relationship, Radiation; Drug Combinations; Fluorocarbons; Hydroxyethyl Starch Derivatives; Male; Mice; Mitomycin; Mitomycins; Neoplasms, Experimental; Oxygen; Porfiromycin; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1990 |
Determination of mitomycin C in serum by high-performance liquid chromatography with dual-electrode coulometric detection.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Humans; Mitomycin; Mitomycins; Molecular Structure; Porfiromycin | 1990 |
The role of mitomycin antibiotics in the chemotherapy of solid tumors.
Topics: Anaerobiosis; Animals; Biotransformation; Cytochromes; Dicumarol; Drug Synergism; Female; Mammary Neoplasms, Experimental; Mitomycin; Mitomycins; NAD(P)H Dehydrogenase (Quinone); Neoplasms, Experimental; Porfiromycin; Quinone Reductases; Rats; Sarcoma, Experimental | 1986 |
Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions.
Topics: Biotransformation; Cell Survival; Cells, Cultured; Dicumarol; Drug Resistance; Fibroblasts; Humans; Mitomycin; Mitomycins; Oxygen; Porfiromycin; Skin | 1989 |
Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells.
Topics: Aerobiosis; Alkylating Agents; Anaerobiosis; Animals; Biological Transport; Cell Line; Cell Survival; Dicumarol; Doxorubicin; Kinetics; Mammary Neoplasms, Experimental; Methylcholanthrene; Mice; Mitomycin; Mitomycins; Oxidation-Reduction; Porfiromycin; Vitamin K | 1989 |
Liquid chromatography-thermospray mass spectrometry of DNA adducts formed with mitomycin C, porfiromycin and thiotepa.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; DNA; Hydrolysis; Mass Spectrometry; Mitomycin; Mitomycins; Porfiromycin; Spectrophotometry, Ultraviolet; Thiotepa; Thymus Gland | 1989 |
Effect of the superoxide dismutase inhibitor, diethyldithiocarbamate, on the cytotoxicity of mitomycin antibiotics.
Topics: Aerobiosis; Animals; Cell Hypoxia; Cell Survival; Ditiocarb; DNA Damage; Free Radicals; Mammary Neoplasms, Experimental; Mice; Mitomycin; Mitomycins; Oxidation-Reduction; Oxygen; Porfiromycin; Superoxide Dismutase; Tumor Cells, Cultured | 1989 |
Cytotoxicity and DNA lesions produced by mitomycin C and porfiromycin in hypoxic and aerobic EMT6 and Chinese hamster ovary cells.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; DNA; DNA, Single-Stranded; Female; Mice; Mitomycin; Mitomycins; Ovary; Oxygen; Porfiromycin | 1986 |
A comparison of mechanisms proposed for the conversion of mitomycins into mitosenes.
Topics: Acetates; Acetic Acid; Chemical Phenomena; Chemistry; Deuterium; Mitomycin; Mitomycins; Molecular Conformation; Porfiromycin; Stereoisomerism | 1985 |
Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro.
Topics: Alkylating Agents; Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mitomycin; Mitomycins; Oxygen; Porfiromycin | 1985 |
Chemotherapeutic attack of hypoxic tumor cells by the bioreductive alkylating agent mitomycin C.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line; Cell Survival; Cricetinae; Female; Mammary Neoplasms, Experimental; Mesocricetus; Mice; Mice, Inbred BALB C; Mitomycin; Mitomycins; Oxygen; Porfiromycin | 1985 |
Preferential kill of hypoxic EMT6 mammary tumor cells by the bioreductive alkylating agent porfiromycin.
Topics: Animals; Antibiotics, Antineoplastic; Cell Hypoxia; Cell Survival; Free Radicals; Hydroxyl Radical; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mitomycin; Molecular Structure; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Oxygen Consumption; Porfiromycin | 1995 |
Preferential effects of the chemotherapeutic DNA crosslinking agent mitomycin C on inducible gene expression in vivo.
Topics: 5-Aminolevulinate Synthetase; Animals; Chick Embryo; Cross-Linking Reagents; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation, Enzymologic; Liver; Mitomycin; Porfiromycin; RNA, Messenger | 1995 |
pH-dependent inactivation of DT-diaphorase by mitomycin C and porfiromycin.
Topics: Animals; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Kinetics; Mitomycin; NAD; NAD(P)H Dehydrogenase (Quinone); Porfiromycin; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured | 1993 |
Effect of pH on DNA alkylation by enzyme-activated mitomycin C and porfiromycin.
Topics: Alkylation; Animals; Biotransformation; Cattle; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; DNA; DNA Adducts; Hydrogen-Ion Concentration; Liver; Mitomycin; NADPH-Ferrihemoprotein Reductase; Phosphodiesterase I; Phosphoric Diester Hydrolases; Porfiromycin; Rats; Xanthine Oxidase | 1993 |
Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase.
Topics: Aerobiosis; Animals; Biotransformation; CHO Cells; Cricetinae; Glutathione Transferase; Humans; Hypoxia; Mitomycin; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Porfiromycin; Recombinant Proteins | 1996 |
Interactions of BMS-181174 and radiation: studies with EMT6 cells in vitro and in solid tumors.
Topics: Aerobiosis; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Cell Hypoxia; Cell Survival; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Resistance, Neoplasm; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mitomycin; Mitomycins; Neoplasm Transplantation; Porfiromycin; Radiation-Sensitizing Agents; Radiotherapy Dosage; Skin Neoplasms; Specific Pathogen-Free Organisms; Tumor Cells, Cultured | 1996 |
Effects of mitomycin C and porfiromycin on exponentially growing and plateau phase cultures.
Topics: Aerobiosis; Anaerobiosis; Animals; Antibiotics, Antineoplastic; Cell Division; Female; Mammary Neoplasms, Experimental; Mice; Mitomycin; Porfiromycin; Tumor Cells, Cultured | 1994 |
Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA.
Topics: Aerobiosis; Animals; Bacterial Proteins; Biotransformation; Cell Hypoxia; Cell Survival; CHO Cells; Cloning, Molecular; Cricetinae; Drug Resistance; Mitomycin; Oxidoreductases; Porfiromycin; Prodrugs; Recombinant Proteins; Streptomyces; Transfection | 1999 |
PORFIROMYCIN.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antineoplastic Agents; Chemical Phenomena; Chemistry; Dermatologic Agents; Dogs; Haplorhini; Mice; Mitomycin; Mitomycins; Pharmacology; Porfiromycin; Rats; Research; Toxicology | 1963 |
MITOMYCINS AND PORFIROMYCIN: CHEMICAL MECHANISM OF ACTIVATION AND CROSS-LINKING OF DNA.
Topics: Anti-Bacterial Agents; Bacillus subtilis; Chemical Phenomena; Chemistry; Cytophaga; Cytosine; DNA; DNA, Bacterial; Guanine; Mitomycin; Mitomycins; Porfiromycin; Research; Sarcina; Ultraviolet Rays | 1964 |
PHENETHYL ALCOHOL SYNERGISM WITH MITOMYCIN C, PORFIROMYCIN, AND STREPTONIGRIN.
Topics: Alcohols; Anti-Bacterial Agents; Antineoplastic Agents; Cyanides; Escherichia coli; Mitomycin; Pharmacology; Phenols; Phenylethyl Alcohol; Porfiromycin; Research; Streptonigrin | 1964 |
SYNERGISM OF THE ANTINEOPLASTIC ACTIVITY OF CYTOSINE ARABINOSIDE BY PORFIROMYCIN.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Body Weight; Cytarabine; Cytosine; Leukemia; Leukemia L1210; Leukemia, Experimental; Mice; Mitomycin; Mitomycins; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Porfiromycin; Research; Survival | 1964 |
Testing new chemoradiation regimens for head-and-neck cancer.
Topics: Antibiotics, Antineoplastic; Combined Modality Therapy; Head and Neck Neoplasms; Humans; Mitomycin; Porfiromycin; Randomized Controlled Trials as Topic | 2005 |