Page last updated: 2024-08-16

mitomycin and porfiromycin

mitomycin has been researched along with porfiromycin in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (36.84)	18.7374
1990's	21 (55.26)	18.2507
2000's	3 (7.89)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bradner, WT; Cheng, L; Iyengar, BS; Lin, HJ; Remers, WA	1
Arai, H; Ashizawa, T; Gomi, K; Kasai, M; Kono, M; Saito, H	1
Hirayama, N; Yoda, N	1
Dembitsky, VM; Ismail, FM; Levitsky, DO	1
Akman, SA; Forrest, GL; Hipsher, C; Johnson, R; Pan, SS	1
Adams, GE; Carmichael, J; Houlbrook, S; Robertson, N; Stratford, IJ	1
Durand, RE; Olive, PL	1
Hughes, CS; Irvin, CG; Rockwell, S	1
Marshall, RS; Paterson, MC; Rauth, AM	2
Gustafson, DL; Pritsos, CA	1
Braunschweiger, PG; Furmanski, P; Johnson, CS; Jones, SA	1
Herman, TS; Holden, SA; Teicher, BA	1
Nambara, T; Ohkubo, T	1
Sartorelli, AC	1
Keyes, SR; Rockwell, S; Sartorelli, AC	2
Callery, PS; Musser, SM; Pan, SS	1
Keyes, SR; Pritsos, CA; Sartorelli, AC	1
Fracasso, PM; Sartorelli, AC	1
Iyengar, BS; Remers, WA	1
Fracasso, PM; Heimbrook, DC; Keyes, SR; Rockwell, S; Sartorelli, AC; Sligar, SG	1
Belcourt, MF; Hodnick, WF; Keyes, SR; Pritsos, CA; Rockwell, S; Sartorelli, AC	1
Caron, RM; Hamilton, JW	1
Arai, H; Beall, H; Gibson, NW; Kasai, M; Ross, D; Siegel, D	1
Kuehl, BL; Marshall, RS; Rauth, AM	1
Pan, SS; Yu, F	1
Belcourt, MF; Hodnick, WF; Rockwell, S; Sartorelli, AC	1
Kelley, M; Rockwell, S	1
Fischer, D; Fischer, JJ; Haffty, BG; Papac, R; Rockwell, S; Ross, D; Sartorelli, AC; Sasaki, CT; Son, YH; Wilson, LD	1
Hughes, CS; Rockwell, S	1
Belcourt, MF; Hodnick, WF; Johnson, DA; Penketh, PG; Rockwell, S; Sartorelli, AC; Sherman, DH	1
DUVALL, LR	1
IYER, VN; SZYBALSKI, W	1
WHITE, HL; WHITE, JR	1
BOSTWICK, L; EVANS, JS; MENGEL, GD	1
Eisbruch, A; Normolle, DP	1
Cho, EI; Fischer, DB; Fischer, JJ; Haffty, BG; Papac, RJ; Rockwell, S; Ross, DA; Sartorelli, AC; Sasaki, CT; Son, YH; Wilson, LD	1

Reviews

2 review(s) available for mitomycin and porfiromycin

Article	Year
Aziridine alkaloids as potential therapeutic agents. European journal of medicinal chemistry, 2009, Volume: 44, Issue:9 Topics: Alkaloids; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Aziridines; Humans	2009
Cellular approaches to bioreductive drug mechanisms. Cancer metastasis reviews, 1993, Volume: 12, Issue:2 Topics: Animals; Antineoplastic Agents; CHO Cells; Cricetinae; Humans; Mitomycin; Neoplasms; Oxidation-Reduction; Oxygen; Porfiromycin	1993

Trials

2 trial(s) available for mitomycin and porfiromycin

Article	Year
Bioreductive alkylating agent porfiromycin in combination with radiation therapy for the management of squamous cell carcinoma of the head and neck. Radiation oncology investigations, 1997, Volume: 5, Issue:5 Topics: Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Therapy; Dose Fractionation, Radiation; Follow-Up Studies; Head and Neck Neoplasms; Humans; Mitomycin; Porfiromycin; Survival Rate; Time Factors	1997
Concurrent chemo-radiotherapy with mitomycin C compared with porfiromycin in squamous cell cancer of the head and neck: final results of a randomized clinical trial. International journal of radiation oncology, biology, physics, 2005, Jan-01, Volume: 61, Issue:1 Topics: Analysis of Variance; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Therapy; Disease-Free Survival; Female; Head and Neck Neoplasms; Humans; Leukopenia; Male; Middle Aged; Mitomycin; Porfiromycin; Prospective Studies; Radiotherapy Dosage; Statistics, Nonparametric; Thrombocytopenia	2005

Article

Year

Bioreductive alkylating agent porfiromycin in combination with radiation therapy for the management of squamous cell carcinoma of the head and neck.

Radiation oncology investigations, 1997, Volume: 5, Issue:5

Topics: Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Therapy; Dose Fractionation, Radiation; Follow-Up Studies; Head and Neck Neoplasms; Humans; Mitomycin; Porfiromycin; Survival Rate; Time Factors

1997

Concurrent chemo-radiotherapy with mitomycin C compared with porfiromycin in squamous cell cancer of the head and neck: final results of a randomized clinical trial.

International journal of radiation oncology, biology, physics, 2005, Jan-01, Volume: 61, Issue:1

Topics: Analysis of Variance; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Therapy; Disease-Free Survival; Female; Head and Neck Neoplasms; Humans; Leukopenia; Male; Middle Aged; Mitomycin; Porfiromycin; Prospective Studies; Radiotherapy Dosage; Statistics, Nonparametric; Thrombocytopenia

2005

Other Studies

34 other study(ies) available for mitomycin and porfiromycin

Article	Year
Development of new mitomycin C and porfiromycin analogues. Journal of medicinal chemistry, 1981, Volume: 24, Issue:8 Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Leukemia, Experimental; Melanoma; Mice; Mitomycins; Neoplasms, Experimental; Porfiromycin; Structure-Activity Relationship	1981
Synthesis and antitumor activity of various 6-demethylmitomycins and 6-demethyl-6-halomitomycins. Journal of medicinal chemistry, 1995, Aug-04, Volume: 38, Issue:16 Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Mice; Mitomycins; Sarcoma 180; Structure-Activity Relationship	1995
Structure-activity relationships for mitomycins. Application of the distance and charge analysis method. Journal of medicinal chemistry, 1993, May-14, Volume: 36, Issue:10 Topics: Mitomycins; Models, Molecular; Molecular Structure; Structure-Activity Relationship	1993
The role of NAD(P)H:quinone oxidoreductase in mitomycin C- and porfiromycin-resistant HCT 116 human colon-cancer cells. Cancer chemotherapy and pharmacology, 1992, Volume: 31, Issue:1 Topics: 2,6-Dichloroindophenol; Carbon Radioisotopes; Cell Extracts; Cell Size; Cell Survival; Colonic Neoplasms; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Intracellular Fluid; Microsomes; Mitomycin; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Porfiromycin; RNA, Messenger; Tissue Distribution; Transcription, Genetic; Tumor Cells, Cultured; Vitamin K	1992
The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase? Biochemical pharmacology, 1992, Aug-04, Volume: 44, Issue:3 Topics: Antineoplastic Agents; Aziridines; Dihydrolipoamide Dehydrogenase; Humans; Indolequinones; Indoles; Mitomycin; Oxidation-Reduction; Porfiromycin; Quinones; Tumor Cells, Cultured	1992
Evaluation of bioreductive drugs in multicell spheroids. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:4 Topics: Animals; Antineoplastic Agents; Cell Aggregation; Cell Hypoxia; Cell Survival; Cricetinae; Evaluation Studies as Topic; In Vitro Techniques; Misonidazole; Mitomycin; Models, Biological; Nitrofurans; Porfiromycin; Prodrugs; Tirapazamine; Triazines	1992
Effect of deficiencies in DNA repair on the toxicity of mitomycin C and porfiromycin to CHO cells under aerobic and hypoxic conditions. Cancer communications, 1991, Volume: 3, Issue:2 Topics: Aerobiosis; Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line; Cell Survival; Cricetinae; DNA Repair; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Mitomycin; Mitomycins; Porfiromycin; Time Factors	1991
Studies on the mechanism of resistance to mitomycin C and porfiromycin in a human cell strain derived from a cancer-prone individual. Biochemical pharmacology, 1991, May-01, Volume: 41, Issue:9 Topics: Cell Line; Cell Survival; Child; Drug Resistance; Female; Glutathione; Humans; Kinetics; Mitomycin; Mitomycins; NAD(P)H Dehydrogenase (Quinone); Neoplasms; Oxygen; Porfiromycin; Precipitin Tests; Quinone Reductases; Tumor Cells, Cultured	1991
Inhibition of mitomycin C's aerobic toxicity by the seleno-organic antioxidant PZ-51. Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:3 Topics: Acetylcysteine; Aerobiosis; Animals; Antineoplastic Agents; Antioxidants; Azoles; Cell Hypoxia; Cell Line; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Isoindoles; Mice; Mitomycin; Mitomycins; Organoselenium Compounds; Porfiromycin; Selenium; Tumor Cells, Cultured	1991
Potentiation of mitomycin C and porfiromycin antitumor activity in solid tumor models by recombinant human interleukin 1 alpha. Cancer research, 1991, Oct-15, Volume: 51, Issue:20 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dexamethasone; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Interleukin-1; Ketoconazole; Mice; Mice, Inbred C57BL; Mitomycin; Neoplasms; Porfiromycin; Recombinant Proteins; Tumor Cells, Cultured	1991
Addition of a hypoxic cell selective cytotoxic agent (mitomycin C or porfiromycin) to Fluosol-DA/carbogen/radiation. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1990, Volume: 18, Issue:1 Topics: Animals; Carbon Dioxide; Cell Hypoxia; Dose-Response Relationship, Radiation; Drug Combinations; Fluorocarbons; Hydroxyethyl Starch Derivatives; Male; Mice; Mitomycin; Mitomycins; Neoplasms, Experimental; Oxygen; Porfiromycin; Radiation-Sensitizing Agents; Tumor Cells, Cultured	1990
Determination of mitomycin C in serum by high-performance liquid chromatography with dual-electrode coulometric detection. Journal of chromatography, 1990, May-18, Volume: 527, Issue:2 Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Humans; Mitomycin; Mitomycins; Molecular Structure; Porfiromycin	1990
The role of mitomycin antibiotics in the chemotherapy of solid tumors. Biochemical pharmacology, 1986, Jan-01, Volume: 35, Issue:1 Topics: Anaerobiosis; Animals; Biotransformation; Cytochromes; Dicumarol; Drug Synergism; Female; Mammary Neoplasms, Experimental; Mitomycin; Mitomycins; NAD(P)H Dehydrogenase (Quinone); Neoplasms, Experimental; Porfiromycin; Quinone Reductases; Rats; Sarcoma, Experimental	1986
Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions. British journal of cancer, 1989, Volume: 59, Issue:3 Topics: Biotransformation; Cell Survival; Cells, Cultured; Dicumarol; Drug Resistance; Fibroblasts; Humans; Mitomycin; Mitomycins; Oxygen; Porfiromycin; Skin	1989
Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells. Cancer research, 1989, Jun-15, Volume: 49, Issue:12 Topics: Aerobiosis; Alkylating Agents; Anaerobiosis; Animals; Biological Transport; Cell Line; Cell Survival; Dicumarol; Doxorubicin; Kinetics; Mammary Neoplasms, Experimental; Methylcholanthrene; Mice; Mitomycin; Mitomycins; Oxidation-Reduction; Porfiromycin; Vitamin K	1989
Liquid chromatography-thermospray mass spectrometry of DNA adducts formed with mitomycin C, porfiromycin and thiotepa. Journal of chromatography, 1989, Jul-14, Volume: 474, Issue:1 Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; DNA; Hydrolysis; Mass Spectrometry; Mitomycin; Mitomycins; Porfiromycin; Spectrophotometry, Ultraviolet; Thiotepa; Thymus Gland	1989
Effect of the superoxide dismutase inhibitor, diethyldithiocarbamate, on the cytotoxicity of mitomycin antibiotics. Cancer biochemistry biophysics, 1989, Volume: 10, Issue:4 Topics: Aerobiosis; Animals; Cell Hypoxia; Cell Survival; Ditiocarb; DNA Damage; Free Radicals; Mammary Neoplasms, Experimental; Mice; Mitomycin; Mitomycins; Oxidation-Reduction; Oxygen; Porfiromycin; Superoxide Dismutase; Tumor Cells, Cultured	1989
Cytotoxicity and DNA lesions produced by mitomycin C and porfiromycin in hypoxic and aerobic EMT6 and Chinese hamster ovary cells. Cancer research, 1986, Volume: 46, Issue:8 Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; DNA; DNA, Single-Stranded; Female; Mice; Mitomycin; Mitomycins; Ovary; Oxygen; Porfiromycin	1986
A comparison of mechanisms proposed for the conversion of mitomycins into mitosenes. Journal of medicinal chemistry, 1985, Volume: 28, Issue:7 Topics: Acetates; Acetic Acid; Chemical Phenomena; Chemistry; Deuterium; Mitomycin; Mitomycins; Molecular Conformation; Porfiromycin; Stereoisomerism	1985
Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro. Cancer research, 1985, Volume: 45, Issue:8 Topics: Alkylating Agents; Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mitomycin; Mitomycins; Oxygen; Porfiromycin	1985
Chemotherapeutic attack of hypoxic tumor cells by the bioreductive alkylating agent mitomycin C. Advances in enzyme regulation, 1985, Volume: 23 Topics: Animals; Antibiotics, Antineoplastic; Cell Line; Cell Survival; Cricetinae; Female; Mammary Neoplasms, Experimental; Mesocricetus; Mice; Mice, Inbred BALB C; Mitomycin; Mitomycins; Oxygen; Porfiromycin	1985
Preferential kill of hypoxic EMT6 mammary tumor cells by the bioreductive alkylating agent porfiromycin. Advances in enzyme regulation, 1995, Volume: 35 Topics: Animals; Antibiotics, Antineoplastic; Cell Hypoxia; Cell Survival; Free Radicals; Hydroxyl Radical; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mitomycin; Molecular Structure; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Oxygen Consumption; Porfiromycin	1995
Preferential effects of the chemotherapeutic DNA crosslinking agent mitomycin C on inducible gene expression in vivo. Environmental and molecular mutagenesis, 1995, Volume: 25, Issue:1 Topics: 5-Aminolevulinate Synthetase; Animals; Chick Embryo; Cross-Linking Reagents; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation, Enzymologic; Liver; Mitomycin; Porfiromycin; RNA, Messenger	1995
pH-dependent inactivation of DT-diaphorase by mitomycin C and porfiromycin. Molecular pharmacology, 1993, Volume: 44, Issue:6 Topics: Animals; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Kinetics; Mitomycin; NAD; NAD(P)H Dehydrogenase (Quinone); Porfiromycin; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured	1993
Effect of pH on DNA alkylation by enzyme-activated mitomycin C and porfiromycin. Molecular pharmacology, 1993, Volume: 43, Issue:6 Topics: Alkylation; Animals; Biotransformation; Cattle; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; DNA; DNA Adducts; Hydrogen-Ion Concentration; Liver; Mitomycin; NADPH-Ferrihemoprotein Reductase; Phosphodiesterase I; Phosphoric Diester Hydrolases; Porfiromycin; Rats; Xanthine Oxidase	1993
Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase. Proceedings of the National Academy of Sciences of the United States of America, 1996, Jan-09, Volume: 93, Issue:1 Topics: Aerobiosis; Animals; Biotransformation; CHO Cells; Cricetinae; Glutathione Transferase; Humans; Hypoxia; Mitomycin; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Porfiromycin; Recombinant Proteins	1996
Interactions of BMS-181174 and radiation: studies with EMT6 cells in vitro and in solid tumors. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1996, Volume: 39, Issue:1 Topics: Aerobiosis; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Cell Hypoxia; Cell Survival; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Resistance, Neoplasm; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mitomycin; Mitomycins; Neoplasm Transplantation; Porfiromycin; Radiation-Sensitizing Agents; Radiotherapy Dosage; Skin Neoplasms; Specific Pathogen-Free Organisms; Tumor Cells, Cultured	1996
Effects of mitomycin C and porfiromycin on exponentially growing and plateau phase cultures. Cell proliferation, 1994, Volume: 27, Issue:3 Topics: Aerobiosis; Anaerobiosis; Animals; Antibiotics, Antineoplastic; Cell Division; Female; Mammary Neoplasms, Experimental; Mice; Mitomycin; Porfiromycin; Tumor Cells, Cultured	1994
Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA. Proceedings of the National Academy of Sciences of the United States of America, 1999, Aug-31, Volume: 96, Issue:18 Topics: Aerobiosis; Animals; Bacterial Proteins; Biotransformation; Cell Hypoxia; Cell Survival; CHO Cells; Cloning, Molecular; Cricetinae; Drug Resistance; Mitomycin; Oxidoreductases; Porfiromycin; Prodrugs; Recombinant Proteins; Streptomyces; Transfection	1999
PORFIROMYCIN. Cancer chemotherapy reports, 1963, Volume: 30 Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antineoplastic Agents; Chemical Phenomena; Chemistry; Dermatologic Agents; Dogs; Haplorhini; Mice; Mitomycin; Mitomycins; Pharmacology; Porfiromycin; Rats; Research; Toxicology	1963
MITOMYCINS AND PORFIROMYCIN: CHEMICAL MECHANISM OF ACTIVATION AND CROSS-LINKING OF DNA. Science (New York, N.Y.), 1964, Jul-03, Volume: 145, Issue:3627 Topics: Anti-Bacterial Agents; Bacillus subtilis; Chemical Phenomena; Chemistry; Cytophaga; Cytosine; DNA; DNA, Bacterial; Guanine; Mitomycin; Mitomycins; Porfiromycin; Research; Sarcina; Ultraviolet Rays	1964
PHENETHYL ALCOHOL SYNERGISM WITH MITOMYCIN C, PORFIROMYCIN, AND STREPTONIGRIN. Science (New York, N.Y.), 1964, Sep-18, Volume: 145, Issue:3638 Topics: Alcohols; Anti-Bacterial Agents; Antineoplastic Agents; Cyanides; Escherichia coli; Mitomycin; Pharmacology; Phenols; Phenylethyl Alcohol; Porfiromycin; Research; Streptonigrin	1964
SYNERGISM OF THE ANTINEOPLASTIC ACTIVITY OF CYTOSINE ARABINOSIDE BY PORFIROMYCIN. Biochemical pharmacology, 1964, Volume: 13 Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Body Weight; Cytarabine; Cytosine; Leukemia; Leukemia L1210; Leukemia, Experimental; Mice; Mitomycin; Mitomycins; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Porfiromycin; Research; Survival	1964
Testing new chemoradiation regimens for head-and-neck cancer. International journal of radiation oncology, biology, physics, 2005, Jan-01, Volume: 61, Issue:1 Topics: Antibiotics, Antineoplastic; Combined Modality Therapy; Head and Neck Neoplasms; Humans; Mitomycin; Porfiromycin; Randomized Controlled Trials as Topic	2005