mitomycin has been researched along with nadp in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (17.65) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Ghersi-Egea, JF; Livertoux, MH; Minn, A; Perrin, R; Siest, G | 1 |
| Hayazaki, T; Hirai, Y; Okuda, J | 1 |
| Davies, KJ; Doroshow, JH | 1 |
| Lipman, R; Tomasz, M | 1 |
| Weiner, LM | 1 |
| Hodnick, WF; Sartorelli, AC | 1 |
| Barber, CV; Fantel, AG | 1 |
| Eickelmann, P; Schulz, WA; Sies, H | 1 |
| Cummings, J; Lipman, R; Suresh Kumar, G; Tomasz, M | 1 |
| Caldwell, GW; Lang, W; Masucci, JA | 1 |
| Adikesavan, AK; Jaiswal, AK | 1 |
| Clynes, M; Martinez, VG; O'Connor, R; Stratford, IJ; Williams, KJ | 1 |
| Arinç, E; Celik, H | 2 |
| Gray, JP; Heck, DE; Laskin, DL; Laskin, JD; Mishin, V; Wang, Y | 1 |
| Holmgren, A; Lu, J; Paz, MM; Zhang, X | 1 |
| Baird, L; Yamamoto, M | 1 |
17 other study(ies) available for mitomycin and nadp
| Article | Year |
|---|---|
Enzyme mediated superoxide radical formation initiated by exogenous molecules in rat brain preparations.
Topics: Animals; Brain Chemistry; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Flunitrazepam; Free Radicals; In Vitro Techniques; Male; Mitomycin; Mitomycins; NAD; NADP; Paraquat; Rats; Rats, Inbred Strains; Subcellular Fractions; Superoxides; Vitamin K; Xenobiotics | 1991 |
Mechanism of inhibition of erythrocyte glutathione reductase by mitomycin-C.
Topics: Erythrocytes; Glutathione Reductase; Humans; In Vitro Techniques; Kinetics; Mitomycin; Mitomycins; NADP; Oxidation-Reduction | 1989 |
Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical.
Topics: Animals; Anthraquinones; Antibiotics, Antineoplastic; Cattle; Chemical Phenomena; Chemistry; Daunorubicin; Doxorubicin; Electron Spin Resonance Spectroscopy; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Methane; Mitochondria, Heart; Mitomycin; Mitomycins; Mitoxantrone; NAD; NADP; Naphthacenes; Oxidation-Reduction; Oxygen Consumption; Rotenone; Superoxides | 1986 |
Reductive metabolism and alkylating activity of mitomycin C induced by rat liver microsomes.
Topics: Alkylation; Animals; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; Mitomycin; Mitomycins; NADP; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1981 |
Oxygen radicals generation and DNA scission by anticancer and synthetic quinones.
Topics: Antineoplastic Agents; Cyclic N-Oxides; Daunorubicin; DNA Damage; Doxorubicin; Electron Spin Resonance Spectroscopy; Hydroxyl Radical; Kinetics; Mitomycin; Molecular Structure; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Quinones; Spectrophotometry, Ultraviolet; Spin Labels; Superoxides | 1994 |
Reductive activation of mitomycin C by NADH:cytochrome b5 reductase.
Topics: Aerobiosis; Alkylation; Animals; Biotransformation; Cell Hypoxia; Cell Line; Cytochrome Reductases; Cytochrome-B(5) Reductase; Erythrocytes; Kinetics; Mammary Neoplasms, Experimental; Mice; Mitomycin; NAD; NADP; Oxidation-Reduction; Rabbits; Tumor Cells, Cultured | 1993 |
The role of oxygenation in embryotoxic mechanisms of three bioreducible agents.
Topics: Animals; DNA Damage; Doxorubicin; Embryo, Mammalian; Gestational Age; Mitomycin; NAD; NADP; Niridazole; Organ Culture Techniques; Oxidation-Reduction; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Teratogens | 1993 |
Free radicals in toxicology: redox cycling and NAD(P)H:quinone oxidoreductase.
Topics: Antibiotics, Antineoplastic; Carcinoma, Renal Cell; Drug Resistance, Microbial; Free Radicals; Gene Expression Regulation, Enzymologic; Humans; Kidney Neoplasms; Mitomycin; NADP; Oxidation-Reduction; Polymorphism, Genetic; Quinone Reductases; Quinones; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1996 |
Mitomycin C-DNA adducts generated by DT-diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin C.
Topics: Alkylation; Animals; Antibiotics, Antineoplastic; Carcinoma; DNA Adducts; DNA, Bacterial; Hydrogen-Ion Concentration; Liver; Liver Neoplasms; Mitomycin; NAD; NAD(P)H Dehydrogenase (Quinone); NADP; Oxidation-Reduction; Prodrugs; Rats | 1997 |
Evaluation of the effect of oxygen exposure on human liver microsomal metabolism of mitomycin C in the presence of glutathione using liquid chromatography-quadrupole time of flight mass spectrometry.
Topics: Chromatography, Liquid; Glutathione; Humans; Mass Spectrometry; Microsomes, Liver; Mitomycin; NADP; Oxygen; Time Factors | 2005 |
Thioredoxin-like domains required for glucose regulatory protein 58 mediated reductive activation of mitomycin C leading to DNA cross-linking.
Topics: Animals; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Cross-Linking Reagents; DNA; DNA Damage; Humans; Insulin; Mitomycin; Molecular Chaperones; Mutagenesis, Site-Directed; Mutagens; NADP; Protein Disulfide-Isomerases; Protein Structure, Tertiary; RNA, Small Interfering; Thioredoxins | 2007 |
Overexpression of cytochrome P450 NADPH reductase sensitises MDA 231 breast carcinoma cells to 5-fluorouracil: possible mechanisms involved.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; Fluorouracil; Glutathione; Humans; Microsomes; Mitomycin; NADP; NADPH-Ferrihemoprotein Reductase; Reactive Oxygen Species; Transfection; Vincristine | 2008 |
Bioreduction of idarubicin and formation of ROS responsible for DNA cleavage by NADPH-cytochrome P450 reductase and its potential role in the antitumor effect.
Topics: Animals; Cytochrome P-450 Enzyme System; DNA; DNA Cleavage; Humans; Idarubicin; Lung; Microsomes; Mitomycin; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Reactive Oxygen Species; Sheep | 2008 |
Distinct roles of cytochrome P450 reductase in mitomycin C redox cycling and cytotoxicity.
Topics: Animals; Cell Death; Cell Extracts; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Intracellular Space; Kinetics; Mitomycin; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxygen Consumption; Reactive Oxygen Species; Recombinant Proteins | 2010 |
A new mechanism of action for the anticancer drug mitomycin C: mechanism-based inhibition of thioredoxin reductase.
Topics: Alkylating Agents; Alkylation; Animals; Catalytic Domain; Cell Line, Tumor; Circular Dichroism; Humans; Hydrogen-Ion Concentration; Kinetics; Mitomycin; NADP; Oxidation-Reduction; Rats; Recombinant Proteins; Spectrophotometry, Ultraviolet; Thioredoxin-Disulfide Reductase | 2012 |
Evaluation of bioreductive activation of anticancer drugs idarubicin and mitomycin C by NADH-cytochrome b5 reductase and cytochrome P450 2B4.
Topics: Animals; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Cattle; Cytochrome P450 Family 2; Cytochrome-B(5) Reductase; DNA Breaks; Idarubicin; Microsomes, Liver; Mitomycin; NAD; NADP; Oxidation-Reduction; Plasmids; Rabbits | 2013 |
NRF2-Dependent Bioactivation of Mitomycin C as a Novel Strategy To Target KEAP1-NRF2 Pathway Activation in Human Cancer.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Reporter; Green Fluorescent Proteins; Humans; Kelch-Like ECH-Associated Protein 1; Luminescent Proteins; Mitomycin; NAD(P)H Dehydrogenase (Quinone); NADP; NADPH-Ferrihemoprotein Reductase; NF-E2-Related Factor 2; Oxidative Stress; Paclitaxel; Pentose Phosphate Pathway; Red Fluorescent Protein; Signal Transduction | 2021 |