mitomycin has been researched along with melphalan in 70 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 21 (30.00) | 18.7374 |
1990's | 22 (31.43) | 18.2507 |
2000's | 14 (20.00) | 29.6817 |
2010's | 12 (17.14) | 24.3611 |
2020's | 1 (1.43) | 2.80 |
Authors | Studies |
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Hansch, C; Khwaja, TA; Selassie, CD | 1 |
Barrows, LR; Ireland, CM; Kokoshka, JM | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Benfenati, E; Raska, I; Toropov, AA; Toropova, AP | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Averette, HE; Donato, D; Nguyen, HN; Penalver, M; Perras, J; Sevin, BU | 1 |
Cold, S; Pfeiffer, P; Rose, C | 1 |
D'Alessandro, N; Gebbia, N; Gebbia, V; Palmeri, S; Rausa, L; Russo, A | 1 |
Bernard, GS; Hobbs, ML; Mellard, DN; Meyn, RE; Murray, D; vanAnkeren, SC | 1 |
Gebhart, E; Herrera, LA; Ostrosky-Wegman, P; Tittelbach, H | 1 |
Fujimaru, J; Ogura, M; Takeda, Y; Tomiyoshi, Y; Wada, Y; Yoshida, S | 1 |
Basu, A; Lazo, JS | 1 |
Caldecott, K; Jeggo, P | 1 |
Ishige, H; Iwasawa, H; Sekiya, S; Takamizawa, H; Tanaka, N; Tokita, H | 1 |
Ezaki, T; Fujioka, T; Miyagi, N; Nakatani, K; Sakamoto, K; Shiratori, T; Sugisaki, T; Watanabe, A | 1 |
Aigner, KR; Link, KH; Müller, H; Voigt, H; Walther, H | 1 |
Portnoĭ, AS | 1 |
Imai, S; Kan, N; Nio, Y; Ohgaki, K; Tobe, T; Tsuchitani, T | 1 |
Erlichman, C; Vidgen, D; Wu, A | 1 |
Hickson, ID; Robson, CN | 1 |
Kimura, Y; Takeda, Y; Wada, Y; Yoshida, S | 1 |
Rubin, JS; Whitmore, GF | 1 |
Dozi-Vassiliades, J; Mourelatos, D | 1 |
Alberts, DS; Mason, N; Salmon, SE; Young, L | 1 |
Ben-Efraim, S; Bocian, RC; Dray, S; Mokyr, MB | 2 |
Hashimura, T; Hikasa, Y; Honda, K; Kern, DH; Mizuno, Y; Niwa, O; Satomura, K; Sugahara, T; Tanigawa, N; Yoshida, O | 1 |
Coombes, RC; Ford, HT; Gazet, JC; Perez, DJ; Powles, TJ | 1 |
Cook, RL; Houghton, JA; Houghton, PJ; Lutz, PJ | 1 |
Alaoui-Jamali, M; Aubin, R; Batist, G; Bramson, J; Christodoulopoulos, G; McQuillan, A; Panasci, LC | 1 |
Gorelik, L; Mokyr, MB; Prokhorova, A | 1 |
Folman, RS | 1 |
Hortobagyi, GN | 1 |
Powles, TJ; Smith, IE | 1 |
Abu-Abid, S; Chaitchik, S; Chen, Z; Gutman, M; Inbar, M; Klausner, JM; Lev, D; Oron, D; Sorkine, P | 1 |
Hanada, R; Hongo, T; Horikoshi, Y; Sakurai, M; Yajima, S | 1 |
Hisai, H; Ikeda, S; Katahira, T; Kondo, H; Saito, T; Takahashi, Y; Takayama, T | 1 |
Ben-Ari, GY | 1 |
Marinelli, A; Vahrmeijer, AL; van de Velde, CJ | 1 |
de Boeck, G; de Bruijn, EA; Eggermont, AM; ten Hagen, TL; van der Sijp, JR; van Ijken, MG | 1 |
Aalders, M; Beijnen, JH; Essers, M; Kuin, A; Lamfers, M; Smets, LA; van Zuidam, DJ | 1 |
Aquilina, G; Bignami, M; Colussi, C; Crescenzi, M; Fiumicino, S; Leonetti, C; Martinelli, S | 1 |
Danenberg, PV; Kornmann, M; Leder, GH; Link, KH; Pillasch, J | 1 |
Bluestone, JA; Donepudi, M; Mokyr, MB; Sojka, DK | 1 |
Ben-Ari, G; Koller, M; Papa, M; Sareli, M; Scott, D; Zippel, D | 1 |
Eggermont, AM; Erdmann, W; Hofland, J; Tenbrinck, R; van Eijck, CH; van IJken, MG | 1 |
Amicucci, G; Deraco, M; Di Filippo, F; Fiorentini, G; Guadagni, S; Miotto, D; Patuzzo, R; Pilati, PL; Rossi, CR; Santinami, M; Valenti, M | 1 |
BERGSAGEL, DE | 1 |
SAMPEY, JR | 1 |
KNOCK, FE | 1 |
HANDLER, AH; SARRIS, TG; WILLS, C | 1 |
GARATTINI, S; PALMA, V; REYERS-DEGLIINNOCENTI, I | 1 |
Asada, Y; Fujisawa, K; Iida, Y; Kasahara, Y; Mitsui, T; Miura, S; Munemoto, Y; Ohata, K; Saito, H | 1 |
Cejka, P; Jiricny, J; Papouli, E | 1 |
de Bruijn, EA; Eggermont, AM; Guetens, G; Jeekel, J; ten Hagen, TL; van Eijck, CH; van Etten, B; van IJken, MG | 1 |
de Boeck, G; de Bruijn, EA; Eggermont, AM; ten Hagen, TL; van Eijck, CH; van IJken, MG | 1 |
de Bruijn, EA; Eggermont, AM; Guetens, G; Ten Hagen, TL; van Etten, B; van Ijken, MG; Wiggers, T | 1 |
Brody, JR; Cunningham, SC; DeMarzo, AM; Dezentje, DA; Gallmeier, E; Hruban, RH; Isacoff, WH; Kern, SE; Offerhaus, GJ; Swartz, MJ; van der Heijden, MS | 1 |
Arakawa, H; Araki, K; Bishop, DK; Buerstedde, JM; Fukushima, T; Hashimoto, N; Hirano, S; Hochegger, H; Ishiai, M; Kawamoto, T; Kikuchi, K; Nojima, K; Ohzeki, M; Orelli, BJ; Saberi, A; Sonoda, E; Takahashi, JA; Takata, M; Takeda, S; Yamamoto, K; Yamazoe, M; Yoshimura, M | 1 |
Glimelius, B; Graf, W; Grundmark, B; Larsson, R; Mahteme, H; Nygren, P; Påhlman, L; Tholander, B; von Heideman, A | 1 |
Desai, AP; Khan, MA; Lanitis, S; Rosin, RD | 1 |
Gushchin, V; Jimenez, WA; Macdonald, R; Nieroda, C; Sardi, A; Sittig, M | 1 |
Chou, WC; Kakadiya, R; Kuo, CY; Lee, TC; Su, TL; Wang, HC; Wong, TS; Wu, CC | 1 |
Alevizos, L; Daskalou, T; Eleftheriadis, S; Iatrou, C; Korakianitis, O; Mavroudis, C; Stamou, K; Tentes, AA; Vogiatzaki, T | 1 |
Alexandrov, VA; Belyaev, AM; Belyaeva, OA; Bespalov, VG; Kireeva, GS; Kopteva, OS; Krasilnikova, LA; Maidin, MA; Semenov, AL; Stukov, AN; Vasilieva, IN; Vyshinskaya, EA | 1 |
Belmont-Díaz, JA; Cruz-Muñiz, MY; Franco-Cendejas, R; García-Contreras, R; Hernández-Durán, M; Licona-Limón, P; López-Jacome, LE; Martinéz-Vázquez, M; Ramos-Balderas, JL; Wood, TK | 1 |
Barakova, NV; Bespalov, VG; Maidin, MA; Semenov, AL; Stukov, AN; Vasil'eva, IN; Vyshinskaya, EA | 1 |
Bogner, S; Peis, MW; Reinboldt, MP; Schuler, M; Tewes, M; Theysohn, JM; Welt, A | 1 |
Gushchin, V; King, MC; Nieroda, C; Sardi, A; Sipok, A; Sittig, M | 1 |
Baron, E; Gushchin, V; King, MC; Lopez-Ramirez, F; Nieroda, C; Nikiforchin, A; Sardi, A | 1 |
9 review(s) available for mitomycin and melphalan
Article | Year |
---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Cytotoxic treatment of metastatic breast cancer. Which drugs and drug combinations to use?
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Cyclophosphamide; Dactinomycin; Doxorubicin; Epirubicin; Etoposide; Female; Fluorouracil; Humans; Melphalan; Methotrexate; Mitomycin; Mitoxantrone; Neoplasm Metastasis; Vincristine | 1992 |
Metallothionein expression and transient resistance to electrophilic antineoplastic drugs.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Cisplatin; Cricetinae; Doxorubicin; Drug Resistance; Humans; Melphalan; Metallothionein; Mitomycin; Prednimustine | 1991 |
[Chemotherapy of prostatic cancer].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Dacarbazine; Diethylstilbestrol; Doxorubicin; Estramustine; Fluorouracil; Humans; Hydroxyurea; Male; Melphalan; Methotrexate; Mitomycin; Mitomycins; Prednisolone; Procarbazine; Prostatic Neoplasms; Streptozocin; Vincristine | 1985 |
Experience with mitomycin in the treatment of non-small cell lung cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Humans; Lung Neoplasms; Melphalan; Methotrexate; Mitomycin; Mitomycins; Progesterone; Vinblastine | 1993 |
Mitomycin: its evolving role in the treatment of breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Melphalan; Methotrexate; Mitomycin; Mitomycins | 1993 |
Phase I/II studies of isolated hepatic perfusion with mitomycin C or melphalan in patients with colorectal cancer hepatic metastases.
Topics: Animals; Antineoplastic Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Colorectal Neoplasms; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Melphalan; Mitomycin; Perfusion; Rats | 1998 |
NEW AND OLD DRUGS IN THE MANAGEMENT OF HODGKIN'S DISEASE.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anti-Bacterial Agents; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; Dexamethasone; Folic Acid Antagonists; Hodgkin Disease; Humans; Isoniazid; Mannomustine; Melphalan; Methotrexate; Mitomycin; Mitomycins; Nitrogen Mustard Compounds; Phenylbutazone; Prednisolone; Prednisone; Thiotepa | 1964 |
NEWER ANTICANCER AGENTS.
Topics: Alkylating Agents; Antineoplastic Agents; Arsenicals; Cyclophosphamide; Dactinomycin; Fluorouracil; Humans; Mechlorethamine; Melphalan; Methotrexate; Mitomycin; Mitomycins; Neoplasms; Pharmacology; Steroids; Triethylenemelamine; Vinblastine; Vincristine | 1964 |
7 trial(s) available for mitomycin and melphalan
Article | Year |
---|---|
Mitomycin: its evolving role in the treatment of breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Melphalan; Methotrexate; Mitomycin; Mitomycins | 1993 |
MMM (mitomycin/mitoxantrone/methotrexate): an effective new regimen in the treatment of metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Cyclophosphamide; Dactinomycin; Female; Fluorouracil; Humans; Melphalan; Menopause; Methotrexate; Middle Aged; Mitomycin; Neoplasm Metastasis; Neoplasm Staging; Vincristine | 1993 |
Regional perfusion with hemofiltration (chemofiltration) for the treatment of patients with regionally advanced cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Renal Cell; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Digestive System Neoplasms; Female; Fluorouracil; Genital Neoplasms, Female; Hemofiltration; Humans; Kidney Neoplasms; Male; Melanoma; Melphalan; Middle Aged; Mitomycin; Prognosis; Survival Rate | 1996 |
Cardiovascular effects of simultaneous occlusion of the inferior vena cava and aorta in patients treated with hypoxic abdominal perfusion for chemotherapy.
Topics: Aged; Antihypertensive Agents; Antineoplastic Combined Chemotherapy Protocols; Aorta, Thoracic; Chemotherapy, Cancer, Regional Perfusion; Constriction; Female; Hemodynamics; Humans; Hypertension; Male; Melphalan; Middle Aged; Mitomycin; Monitoring, Physiologic; Nitroprusside; Pancreatic Neoplasms; Vena Cava, Inferior | 2002 |
Hypoxic pelvic and limb perfusion with melphalan and mitomycin C for recurrent limb melanoma: a pilot study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Disease Progression; Extremities; Female; Humans; Hypoxia; Male; Maximum Tolerated Dose; Melanoma; Melphalan; Middle Aged; Mitomycin; Neoplasm Recurrence, Local; Pilot Projects; Skin Neoplasms; Survival Rate; Time Factors | 2003 |
Balloon catheter hypoxic abdominal perfusion with Mitomycin C and Melphalan for locally advanced pancreatic cancer: a phase I-II trial.
Topics: Aged; Antineoplastic Agents; Balloon Occlusion; Chemotherapy, Cancer, Regional Perfusion; Female; Humans; Hypoxia; Infusions, Intra-Arterial; Male; Melphalan; Middle Aged; Mitomycin; Pain; Pain Measurement; Pancreatic Neoplasms; Remission Induction; Treatment Outcome | 2004 |
Balloon catheter hypoxic pelvic perfusion with mitomycin C and melphalan for locally advanced tumours in the pelvic region: a phase I-II trial.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Catheterization; Chemotherapy, Cancer, Regional Perfusion; Feasibility Studies; Female; Humans; Magnetic Resonance Imaging; Male; Melphalan; Middle Aged; Mitomycin; Neoadjuvant Therapy; Neoplasm Staging; Pain Measurement; Pelvic Neoplasms; Radiotherapy Dosage; Remission Induction; Survival Rate; Tomography, X-Ray Computed | 2005 |
55 other study(ies) available for mitomycin and melphalan
Article | Year |
---|---|
Structure-activity relationships of antineoplastic agents in multidrug resistance.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
Cell-based screen for identification of inhibitors of tubulin polymerization.
Topics: Animals; Brain Neoplasms; Bucladesine; Cell Differentiation; Drug Screening Assays, Antitumor; Formazans; Glioma; Rats; Tubulin; Tumor Cells, Cultured | 1996 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations.
Topics: Antineoplastic Agents; Models, Chemical; Octanols; Quantitative Structure-Activity Relationship; Water | 2010 |
The use of ATP bioluminescence assays in selecting a drug screen panel for chemosensitivity testing of uterine cancer cell lines.
Topics: Adenocarcinoma; Adenosine Triphosphate; Alkaloids; Antineoplastic Agents; Cisplatin; Cyclophosphamide; Drug Screening Assays, Antitumor; Endometrial Neoplasms; Female; Humans; Intercalating Agents; Kinetics; Luminescent Measurements; Melphalan; Mitomycin; Tumor Cells, Cultured; Uterine Neoplasms | 1992 |
Combination chemotherapy with mitomycin C, vindesine and melphalan for refractory metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Melphalan; Middle Aged; Mitomycin; Mitomycins; Neoplasm Metastasis; Palliative Care; Vindesine | 1991 |
Isolation and characterization of nitrogen mustard-sensitive mutants of Chinese hamster ovary cells.
Topics: Aminacrine; Animals; Cells, Cultured; Cisplatin; Cricetinae; Cross Reactions; DNA; Dose-Response Relationship, Drug; Female; Gamma Rays; In Vitro Techniques; Mechlorethamine; Melphalan; Mitomycin; Mitomycins; Mutagens; Mutation; Nitrogen Mustard Compounds | 1991 |
Changes in the proliferation of human lymphocytes induced by several cytostatics and revealed by the premature chromosome condensation technique.
Topics: Cell Cycle; Cell Fusion; Cell Line; Cells, Cultured; Chromosomes; Cisplatin; Cyclophosphamide; Humans; Lymphocyte Activation; Lymphocytes; Melphalan; Mitomycin; Mitomycins; Phytohemagglutinins | 1991 |
[Sensitivity test of anti-tumor agents. 2. Application of MTT assay].
Topics: Antineoplastic Agents; Cisplatin; Doxorubicin; Drug Screening Assays, Antitumor; Melphalan; Mitomycin; Mitomycins; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1991 |
Cross-sensitivity of gamma-ray-sensitive hamster mutants to cross-linking agents.
Topics: Animals; Camptothecin; Cell Line; Cell Survival; CHO Cells; Cisplatin; Cricetinae; Cricetulus; Cross-Linking Reagents; DNA Damage; Female; Guinea Pigs; Mechlorethamine; Melphalan; Mitomycin; Mutation; Radiation Tolerance; Ultraviolet Rays | 1991 |
[A new in vitro chemosensitivity test. Individualized chemotherapy against ovarian cancer and its clinical effect].
Topics: Adult; Aged; Antineoplastic Agents; Bleomycin; Child; Cisplatin; Colony-Forming Units Assay; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Fluorouracil; Humans; Melphalan; Methotrexate; Middle Aged; Mitomycin; Mitomycins; Nimustine; Nitrosourea Compounds; Ovarian Neoplasms; Tumor Stem Cell Assay | 1985 |
[A study of the antineoplastic activity of K18].
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line; Drug Combinations; Drug Synergism; Fluorouracil; gamma-Globulins; Humans; Immunotoxins; Melphalan; Mice; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantation; Stomach Neoplasms; Tissue Distribution | 1986 |
[Systemically administered regional tumor therapy. Regional hemi-body chemotherapy of metastatic malignant melanoma--an experimental therapy concept].
Topics: Adult; Antineoplastic Agents; Catheters, Indwelling; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Dose-Response Relationship, Drug; Extremities; Female; Heart-Lung Machine; Hemofiltration; Humans; Infusions, Intra-Arterial; Male; Melanoma; Melphalan; Mitomycin; Mitomycins; Neoplasm Metastasis; Pilot Projects; Skin Neoplasms | 1989 |
[A new anti-cancer agent K-18 (conjugate of human IgG and melphalan). (II). Its inhibitory effects on in vitro DNA synthesis of human tumor cells].
Topics: Antineoplastic Agents; Cells, Cultured; DNA, Neoplasm; Doxorubicin; Humans; Immunoglobulin G; Melphalan; Mitomycin; Mitomycins; Neoplasms | 1986 |
Antineoplastic drug cytotoxicity in a human bladder cancer cell line: implications for intravesical chemotherapy.
Topics: Administration, Intravesical; Antineoplastic Agents; Cell Survival; Cisplatin; Doxorubicin; Fluorouracil; Humans; In Vitro Techniques; Melphalan; Mitomycin; Mitomycins; Tumor Stem Cell Assay; Urinary Bladder Neoplasms; Vincristine | 1987 |
Isolation of alkylating agent-sensitive Chinese hamster ovary cell lines.
Topics: Alkylating Agents; Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA Damage; DNA Repair; Ethyl Methanesulfonate; Ethylnitrosourea; Melphalan; Methylnitrosourea; Mitomycin; Mitomycins; Mutation | 1987 |
[Application of cytopathology in a sensitivity test for anti-tumor agents. I. An experimental study].
Topics: Animals; Antineoplastic Agents; Cisplatin; Colonic Neoplasms; Colony-Forming Units Assay; Cytological Techniques; Doxorubicin; Drug Evaluation, Preclinical; Female; Humans; Melphalan; Mice; Mitomycin; Mitomycins; Ovarian Neoplasms; Tumor Stem Cell Assay | 1987 |
Complementation of DNA-repair deficiencies in Chinese hamster ovary cells.
Topics: Aerobiosis; Anaerobiosis; Animals; Cell Line; Cell Survival; Cricetinae; DNA Repair; Gamma Rays; Genes; Genetic Complementation Test; Melphalan; Mitomycin; Mitomycins; Mutation; Ultraviolet Rays | 1987 |
Prostaglandins act synergistically with antitumour agents on induction of sister chromatid exchanges in human lymphocytes.
Topics: Alprostadil; Antineoplastic Agents; Cells, Cultured; Dinoprost; Dinoprostone; Drug Synergism; Humans; Lymphocytes; Melphalan; Mitomycin; Mitomycins; Prostaglandins; Prostaglandins E; Prostaglandins F; Sister Chromatid Exchange | 1985 |
In vitro evaluation of anticancer drugs against ovarian cancer at concentrations achievable by intraperitoneal administration.
Topics: Anthraquinones; Antineoplastic Agents; Cisplatin; Colony-Forming Units Assay; Cytarabine; Doxorubicin; Female; Fluorouracil; Humans; Infusions, Parenteral; Melphalan; Mitomycin; Mitomycins; Mitoxantrone; Ovarian Neoplasms; Peritoneal Cavity; Tumor Stem Cell Assay | 1985 |
Melphalan-induced enhancement of tumor cell immunostimulatory capacity as a mechanism for the appearance of potent antitumor immunity in the spleen of mice bearing a large metastatic MOPC-315 tumor.
Topics: Animals; Cell Division; Cytotoxicity, Immunologic; Immunity, Cellular; Melphalan; Mice; Mitomycin; Mitomycins; Neoplasm Metastasis; Neoplasms, Experimental; Spleen | 1985 |
Comparison of drug sensitivity among tumor cells within a tumor, between primary tumor and metastases, and between different metastases in the human tumor colony-forming assay.
Topics: Antineoplastic Agents; Bleomycin; Cell Division; Cell Survival; Cells, Cultured; Cisplatin; Doxorubicin; Fluorouracil; Humans; Kinetics; Male; Melphalan; Mitomycin; Mitomycins; Neoplasm Metastasis; Neoplasms | 1984 |
Mitomycin C, melphalan and methotrexate combination chemotherapy for palliation of disseminated breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Evaluation; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Melphalan; Methotrexate; Middle Aged; Mitomycin; Mitomycins; Neoplasm Metastasis; Palliative Care | 1984 |
Childhood rhabdomyosarcoma xenografts: responses to DNA-interacting agents and agents used in current clinical therapy.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Line; Child; Cisplatin; Cyclophosphamide; Dacarbazine; Dactinomycin; Doxorubicin; Female; Humans; Melphalan; Mice; Mice, Inbred CBA; Mitomycin; Mitomycins; Neoplasm Transplantation; Rhabdomyosarcoma; Transplantation, Heterologous; Vincristine | 1984 |
Melphalan-mediated potentiation of antitumor immune responsiveness of immunosuppressed spleen cells from mice bearing a large MOPC-315 tumor.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line; Cytotoxicity, Immunologic; Female; Immunosuppression Therapy; Immunotherapy; Lymphocytes; Melphalan; Mice; Mice, Inbred BALB C; Mitomycin; Mitomycins; Plasmacytoma; Spleen | 1984 |
Nitrogen mustard drug resistant B-cell chronic lymphocytic leukemia as an in vivo model for crosslinking agent resistance.
Topics: B-Lymphocytes; Chlorambucil; Cisplatin; Cross-Linking Reagents; DNA Adducts; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Resistance; Humans; Inactivation, Metabolic; Leukemia, Lymphocytic, Chronic, B-Cell; Melphalan; Methyl Methanesulfonate; Mitomycin; Nitrogen Mustard Compounds; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1995 |
Low-dose melphalan-induced shift in the production of a Th2-type cytokine to a Th1-type cytokine in mice bearing a large MOPC-315 tumor.
Topics: Animals; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Female; Immunocompromised Host; Interferon-gamma; Interleukin-10; Lymphocytes, Tumor-Infiltrating; Melphalan; Mice; Mice, Inbred BALB C; Mitomycin; Neoplasm Transplantation; Plasmacytoma; Spleen; Stimulation, Chemical; T-Lymphocytes; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured | 1994 |
In vitro drug sensitivity testing can predict induction failure and early relapse of childhood acute lymphoblastic leukemia.
Topics: Aclarubicin; Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bleomycin; Bone Marrow; Cell Survival; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Etoposide; Follow-Up Studies; Humans; Infant; Infant, Newborn; Life Tables; Melphalan; Methotrexate; Mitomycin; Mitoxantrone; Neoplastic Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Recurrence; Remission Induction; Tumor Cells, Cultured; Vincristine | 1997 |
[Glutathione levels in human colon cancer cell line M7609 following culture in a low sulfur amino acid medium and its sensitivity to various anticancer drugs].
Topics: Amino Acids, Sulfur; Antineoplastic Agents; Cisplatin; Colonic Neoplasms; Culture Media; Doxorubicin; Glutathione; Humans; Melphalan; Mitomycin; Tumor Cells, Cultured | 1997 |
Treatment of abdominal malignancies using total abdominal stop-flow infusion and hypoxic perfusion.
Topics: Abdominal Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Doxorubicin; Female; Fluorouracil; Humans; Hypoxia; Melphalan; Mitomycin | 1997 |
Isolated hypoxic hepatic perfusion with tumor necrosis factor-alpha, melphalan, and mitomycin C using balloon catheter techniques: a pharmacokinetic study in pigs.
Topics: Animals; Catheterization; Cell Hypoxia; Chemotherapy, Cancer, Regional Perfusion; Feasibility Studies; Liver; Melphalan; Mitomycin; Swine; Tissue Distribution; Tumor Necrosis Factor-alpha | 1998 |
Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG).
Topics: 3-Iodobenzylguanidine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Antineoplastic Agents; Cell Division; Cell Survival; Chlorambucil; Chromium Radioisotopes; Doxorubicin; Drug Synergism; Edetic Acid; Glucose; Guanidines; Hydrogen-Ion Concentration; Kidney; Leukemia L1210; Melphalan; Mice; Mitomycin; Tumor Cells, Cultured | 1999 |
Sensitivity to DNA cross-linking chemotherapeutic agents in mismatch repair-defective cells in vitro and in xenografts.
Topics: Adenosine Triphosphatases; Animals; Base Pair Mismatch; Burkitt Lymphoma; Cell Division; Cross-Linking Reagents; DNA Repair Enzymes; DNA-Binding Proteins; HeLa Cells; Humans; Lomustine; Melphalan; Mice; Mice, Knockout; Mice, Nude; Micronucleus Tests; Mismatch Repair Endonuclease PMS2; Mitomycin; MutS Homolog 2 Protein; Proteins; Proto-Oncogene Proteins; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Theoretical considerations and in vitro concentration response studies with two human colorectal carcinoma cell lines. The rational experimental base for clinical studies in regional chemotherapy.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carcinoma; Cisplatin; Colorectal Neoplasms; Doxorubicin; Epirubicin; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Melphalan; Mitomycin; Mitoxantrone; Tumor Cells, Cultured | 2000 |
Melphalan and other anticancer modalities up-regulate B7-1 gene expression in tumor cells.
Topics: Animals; Antibiotics, Antineoplastic; Antigens, CD; Antineoplastic Agents, Alkylating; B7-1 Antigen; B7-2 Antigen; Cell Membrane; Drug Administration Schedule; Gamma Rays; Gene Expression Regulation, Neoplastic; Injections, Intraperitoneal; Mast-Cell Sarcoma; Melphalan; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mitomycin; Neoplasm Transplantation; Plasmacytoma; Protein Biosynthesis; Proteins; RNA; Tumor Cells, Cultured; Up-Regulation | 2000 |
Continuous hyperthermic peritoneal perfusion (CHPP) for malignant ascites and irresectable intra-abdominal cancer.
Topics: Abdominal Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Ascites; Cell Division; Cisplatin; Combined Modality Therapy; Female; Fluorouracil; Humans; Hyperthermia, Induced; Infusions, Parenteral; Male; Melphalan; Middle Aged; Mitomycin; Perfusion; Survival Rate | 2000 |
Phase II trials of mitomycin C, AB-100, NSC-1026, L-sarcolysin, and meta-sarcolysin, in the treatment of multiple myeloma.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Cell- and Tissue-Based Therapy; Cycloleucine; Cycloparaffins; Melphalan; Mitomycin; Multiple Myeloma; Plasma; Plasma Cells | 1962 |
CHEMOTHERAPY STUDIES ON PRIMARY TUMOR GRAFTS AND METASTASES IN HAMSTERS AND MICE.
Topics: Antineoplastic Agents; Cricetinae; Cyclophosphamide; Dactinomycin; Melphalan; Mice; Mitomycin; Mitomycins; Neoplasm Metastasis; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Sarcoma; Sarcoma, Experimental; Thiotepa | 1964 |
INTERACTION BETWEEN 5-HYDROXYTRYPTAMINE AND ANTITUMOURAL DRUGS.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cyclophosphamide; Fluorouracil; Melphalan; Mice; Mitomycin; Mitomycins; Nitrogen Mustard Compounds; Pharmacology; Research; Sarcoma 180; Serotonin; Toxicology; Triethylenemelamine | 1964 |
Significance of postoperative adjuvant immunochemotherapy after curative resection of colorectal cancers: identification of responders incorporating the age factor.
Topics: Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; CA-19-9 Antigen; Carcinoembryonic Antigen; Chemotherapy, Adjuvant; Colonic Neoplasms; Complement C3; Complement C4; Female; Fluorouracil; Humans; Immunotherapy; Lymphocyte Activation; Male; Medroxyprogesterone Acetate; Melphalan; Middle Aged; Mitomycin; Multivariate Analysis; Neoplasm Proteins; Phytohemagglutinins; Prognosis; Proportional Hazards Models; Proteoglycans; Pyrimidines; Time Factors; Treatment Outcome | 2004 |
Dependence of the cytotoxicity of DNA-damaging agents on the mismatch repair status of human cells.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Base Pair Mismatch; Camptothecin; Carrier Proteins; Cell Line; Cisplatin; DNA Repair; Drug Screening Assays, Antitumor; Etoposide; Furocoumarins; Humans; Inhibitory Concentration 50; Melphalan; Mitomycin; MutL Protein Homolog 1; Neoplasm Proteins; Nitrosourea Compounds; Nuclear Proteins | 2004 |
Balloon catheter hypoxic abdominal and pelvic perfusion with tumour necrosis factor-alpha, Melphalan and Mitomycin C: a pharmacokinetic study in pigs.
Topics: Abdominal Neoplasms; Animals; Antineoplastic Agents; Balloon Occlusion; Chemotherapy, Cancer, Regional Perfusion; Hypoxia; Melphalan; Mitomycin; Models, Animal; Pelvic Neoplasms; Swine; Tumor Necrosis Factor-alpha | 2004 |
In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor.
Topics: Animals; Antineoplastic Agents; Apoptosis; BRCA2 Protein; Caspases; Cell Cycle; Cell Line, Tumor; Cell Survival; Chlorambucil; Cisplatin; Cross-Linking Reagents; Deoxycytidine; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Fanconi Anemia Complementation Group C Protein; Fanconi Anemia Complementation Group G Protein; Fanconi Anemia Complementation Group Proteins; Female; Fluorouracil; Gemcitabine; Humans; Inhibitory Concentration 50; Melphalan; Mice; Mice, Nude; Mitomycin; Mutation; Paclitaxel; Pancreatic Neoplasms; Time Factors; Vinblastine; Xenograft Model Antitumor Assays | 2005 |
Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.
Topics: Animals; Antigens, Nuclear; Antineoplastic Agents, Alkylating; Chickens; Cisplatin; Cross-Linking Reagents; DNA; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins; DNA-Directed DNA Polymerase; Epistasis, Genetic; Fanconi Anemia Complementation Group C Protein; Genes, rev; Ku Autoantigen; Melphalan; Mitomycin; Nucleic Acid Synthesis Inhibitors; Recombination, Genetic; Signal Transduction | 2005 |
Heterogeneous activity of cytotoxic drugs in patient samples of peritoneal carcinomatosis.
Topics: Camptothecin; Cisplatin; Cytotoxins; Doxorubicin; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Irinotecan; Male; Melphalan; Mitomycin; Organoplatinum Compounds; Oxaliplatin; Perioperative Care; Peritoneal Neoplasms; Tumor Cells, Cultured | 2008 |
Therapeutic isolated limb perfusion (ILP) in the management of patients with advanced or recurrent limb melanoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Humans; Lower Extremity; Melanoma; Melphalan; Mitomycin; Neoplasm Recurrence, Local; Skin Neoplasms; Upper Extremity | 2012 |
Repeated cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis from appendiceal cancer: analysis of survival outcomes.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Appendiceal Neoplasms; Carboplatin; Carcinoma; Chemotherapy, Adjuvant; Databases, Factual; Digestive System Surgical Procedures; Female; Humans; Hyperthermia, Induced; Infusions, Parenteral; Kaplan-Meier Estimate; Length of Stay; Male; Melphalan; Middle Aged; Mitomycin; Peritoneal Neoplasms; Reoperation; Retrospective Studies; Treatment Outcome | 2013 |
Repairing of N-mustard derivative BO-1055 induced DNA damage requires NER, HR, and MGMT-dependent DNA repair mechanisms.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Ataxia Telangiectasia Mutated Proteins; Cell Death; CHO Cells; Cricetulus; DNA Damage; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Dose-Response Relationship, Drug; Drug Synergism; HEK293 Cells; Humans; MCF-7 Cells; Melphalan; Mitomycin; Nitrogen Mustard Compounds; Phenylurea Compounds; Protein Kinase Inhibitors; Recombinational DNA Repair; RNA Interference; S Phase Cell Cycle Checkpoints; Signal Transduction; Time Factors; Transfection; Tumor Suppressor Proteins | 2015 |
Lack of significant intraoperative coagulopathy in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) indicates that epidural anaesthesia is a safe option.
Topics: Adult; Aged; Analgesia, Epidural; Antineoplastic Agents; Blood Coagulation; Cisplatin; Combined Modality Therapy; Cytoreduction Surgical Procedures; Deoxycytidine; Doxorubicin; Female; Fibrinogen; Gemcitabine; Humans; Hyperthermia, Induced; Integrin beta3; Male; Melphalan; Middle Aged; Mitomycin; Peritoneal Neoplasms; Platelet Count; Platelet Glycoprotein GPIb-IX Complex; Young Adult | 2015 |
[Intraperitoneal chemotherapy--a method of improving treatment effectiveness in ovarian cancer].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Deoxycytidine; Female; Gemcitabine; Infusions, Intravenous; Infusions, Parenteral; Maximum Tolerated Dose; Melphalan; Mitomycin; Ovarian Neoplasms; Paclitaxel; Peritoneal Neoplasms; Rats; Rats, Wistar; Triazines | 2015 |
Repurposing the anticancer drug mitomycin C for the treatment of persistent Acinetobacter baumannii infections.
Topics: Acinetobacter baumannii; Acinetobacter Infections; Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Cisplatin; Disease Models, Animal; Drug Repositioning; Fluorouracil; Larva; Lepidoptera; Melphalan; Microbial Sensitivity Tests; Microbial Viability; Mitomycin; Survival Analysis; Treatment Outcome | 2017 |
Comparative Study of Antitumor Efficiency of Intraperitoneal and Intravenous Cytostatics in Experimental Rats with Disseminated Ovarian Cancer.
Topics: Adenocarcinoma, Papillary; Animals; Antineoplastic Agents; Ascites; Cisplatin; Female; Injections, Intraperitoneal; Injections, Intravenous; Melphalan; Mitomycin; Neoplasm Transplantation; Ovarian Neoplasms; Paclitaxel; Rats; Survival Analysis; Treatment Outcome; Triazines | 2017 |
Hepatic arterial infusion chemotherapy for extensive liver metastases of breast cancer: efficacy, safety and prognostic parameters.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Melphalan; Middle Aged; Mitomycin; Retrospective Studies; Salvage Therapy | 2017 |
Comparison of Survival in Patients with Isolated Peritoneal Carcinomatosis from Colorectal Cancer Treated with Cytoreduction and Melphalan or Mitomycin-C as Hyperthermic Intraperitoneal Chemotherapy Agent.
Topics: Antineoplastic Agents, Alkylating; Colorectal Neoplasms; Combined Modality Therapy; Cytoreduction Surgical Procedures; Female; Humans; Hyperthermia, Induced; Male; Melphalan; Middle Aged; Mitomycin; Peritoneal Neoplasms; Retrospective Studies; Survival Rate; United States | 2018 |
Safety of Nephrectomy Performed During CRS/HIPEC: A Propensity Score-Matched Study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cytoreduction Surgical Procedures; Humans; Hyperthermia, Induced; Hyperthermic Intraperitoneal Chemotherapy; Melphalan; Mitomycin; Nephrectomy; Peritoneal Neoplasms; Propensity Score; Retrospective Studies; Survival Rate | 2023 |