mitomycin has been researched along with kt 6149 in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.11) | 18.7374 |
| 1990's | 23 (85.19) | 18.2507 |
| 2000's | 1 (3.70) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ishikawa, A; Ishioka, C; Kanamaru, R; Konishi, Y; Shibata, H; Wakui, A | 1 |
| Asami, N; Inaba, M; Morimoto, M; Sudo, Y; Tsuruo, T | 1 |
| Hattori, T; Jinushi, K; Kim, R; Kirihara, Y; Niimoto, M; Nishiyama, M; Nosoh, Y; Saeki, K; Saeki, T; Takagami, S | 1 |
| Abe, O; Arisawa, Y; Inada, T; Inoue, S; Ishibiki, K; Kodaira, S; Kubota, T; Kuzuoka, M; Suto, A | 1 |
| Hattori, T; Jinushi, K; Kim, R; Kirihara, Y; Niimoto, M; Nishiyama, M; Saeki, T; Takagami, S; Toge, T | 1 |
| Bultinck, J; De Bruijn, EA; Denis, L; Kockx, M; Sorber, M; Van Oosterom, AT | 1 |
| Kasai, M; Kono, M; Saitoh, Y; Shirahata, K | 1 |
| Ardiet, C; Catimel, G; De Bruijn, E; Dirix, L; Dumortier, A; Evene, E; Joossens, E; Koier, I; Provè, A; Schrijvers, D | 1 |
| De Bruijn, EA; Dirix, LY; Gheuens, EE; van der Heyden, S; van Oosterom, AT | 1 |
| Arai, H; Gomi, K; Inaba, M; Kasai, M; Kobayashi, E; Kono, M; Lee, JH; Okabe, M; Tsuruo, T | 1 |
| Lee, JH; Naito, M; Tsuruo, T | 1 |
| Arai, H; Fujii, N; Kasai, M; Nakano, H; Saito, H | 1 |
| Gomi, K; Hirata, T; Kasai, M; Kobayashi, S; Kono, M; Morimoto, M; Okumura, S; Takai, K; Ueno, H; Ushiki, J | 1 |
| Ashizawa, T; Gomi, K; Hirata, T; Okabe, M | 1 |
| Bando, T; Fujimura, M; Heki, U; Iwasa, K; Kasahara, K; Matsuda, T; Numata, Y; Shibata, K; Shirasaki, H | 1 |
| Ardiet, C; Catimel, G; De Bruijn, E; Dirix, L; Tranchand, B; Van Oosterom, A; Verdonk, R | 1 |
| Arai, H; Ashizawa, T; Gomi, K; Kasai, M; Kobayashi, S; Okabe, M; Okamoto, A; Saito, H | 1 |
| De Bruijn, EA; Dirix, LY; Egelmeers, A; Lyczek, J; Scalliet, P; Van Oosterom, AT | 1 |
| Fukuoka, K; Ishida, T; Kurokawa, H; Nishio, K; Saijo, N | 1 |
| Connors, T; Hartley, JA; Hendriks, HR; Kelland, LR; Know, RJ; Masters, JR | 1 |
| Mikami, K; Shirakusa, T; Tsuruo, T | 1 |
| Arioka, H; Fukumoto, H; Fukuoka, K; Hasegawa, S; Ishida, T; Kurokawa, H; Nishio, K; Nomoto, T; Saijo, N; Yokote, H | 1 |
| Saijo, N | 1 |
| Hartley, JA; Knox, RJ; Masters, JR; McAdam, SR | 1 |
| Jakse, G; Kaviani, S; Raffenberg, G; Rohde, D; Wolff, J | 1 |
| Kohn, H; Wang, S | 1 |
| Hara, T; Harada, T; Ishii, A; Saijo, N; Takaba, K; Tamura, T; Yamamoto, N | 1 |
3 review(s) available for mitomycin and kt 6149
| Article | Year |
|---|---|
[gamma-Glutamylcysteine synthetase and chemosensitivity].
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Carcinoma, Small Cell; Cisplatin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Glutamate-Cysteine Ligase; Humans; Lung Neoplasms; Mice; Mitomycin; Mitomycins; RNA, Messenger | 1997 |
[DT-diaphorase].
Topics: Antibiotics, Antineoplastic; Aziridines; Colonic Neoplasms; Cytochrome Reductases; Cytochrome-B(5) Reductase; Drug Screening Assays, Antitumor; Humans; Indolequinones; Indoles; Mitomycin; Mitomycins; NAD(P)H Dehydrogenase (Quinone); NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Stomach Neoplasms; Tumor Cells, Cultured; Xanthine Dehydrogenase; Xanthine Oxidase | 1997 |
New chemotherapeutic agents for the treatment of non-small cell lung cancer: the Japanese experience.
Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carbazoles; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Docetaxel; Glucosides; Humans; Irinotecan; Japan; Lung Neoplasms; Mitomycin; Mitomycins; Neoplasms, Experimental; Paclitaxel; Purine Nucleosides; Staurosporine; Taxoids; Treatment Outcome; Vinblastine; Vinorelbine | 1998 |
2 trial(s) available for mitomycin and kt 6149
| Article | Year |
|---|---|
Phase I and pharmacokinetic study of a novel mitomycin C analog KW-2149.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Biotransformation; Bone Marrow Diseases; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gastrointestinal Diseases; Half-Life; Humans; Liver Neoplasms; Lung Diseases; Lung Neoplasms; Male; Middle Aged; Mitomycin; Mitomycins; Neoplasms; Neoplasms, Unknown Primary; Salvage Therapy | 1995 |
Phase I and pharmacokinetic study of KW-2149 given by 24 hours continuous infusion.
Topics: Antineoplastic Agents; Carcinoma; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drugs, Investigational; Female; Humans; Infusions, Intravenous; Lung; Male; Middle Aged; Mitomycin; Mitomycins; Ovarian Neoplasms | 1995 |
22 other study(ies) available for mitomycin and kt 6149
| Article | Year |
|---|---|
Comparative studies on the action of 7-N-[2-[[2-(gamma-L-glutamylamino)ethyl]dithio]ethyl]mitomycin C and of mitomycin C on cultured HL-60 cells and isolated phage and plasmid DNA.
Topics: Antineoplastic Agents; Cell Division; Dithiothreitol; DNA; DNA Damage; DNA, Viral; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Ferrous Compounds; Humans; Hydrogen-Ion Concentration; Leucine; Leukemia, Promyelocytic, Acute; Mitomycin; Mitomycins; Plasmids; Thymidine; Tritium; Tumor Cells, Cultured; Uridine | 1990 |
Antitumor activity of a derivative of mitomycin, 7-N-[2-[[2-(gamma-L-glutamylamino)ethyl]dithio]ethyl]mitomycin C (KW-2149), against murine and human tumors and a mitomycin C-resistant tumor in vitro and in vivo.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Weight; Colonic Neoplasms; Drug Screening Assays, Antitumor; Female; Humans; Leukemia P388; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantation | 1990 |
[Comparative study on the anticancer activities of KW2149 and mitomycin C against human tumor xenografts using subrenal capsule assay].
Topics: Animals; Antibiotics, Antineoplastic; Colonic Neoplasms; Humans; Mice; Mice, Inbred Strains; Mitomycin; Mitomycins; Neoplasm Transplantation; Remission Induction; Stomach Neoplasms; Subrenal Capsule Assay; Weight Loss | 1989 |
Antitumor activity of 7-N-(2-((2-(gamma-L-glutamylamino) ethyl) dithio) ethyl) mitomycin C (KW2149) against human tumor xenografts serially transplanted into nude mice.
Topics: Adenocarcinoma; Adenocarcinoma, Papillary; Animals; Antineoplastic Agents; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; Dose-Response Relationship, Drug; Humans; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantation; Random Allocation; Transplantation, Heterologous | 1989 |
[Anticancer activities of a new mitomycin derivative KW 2149, against human tumors xenografted into nude mice].
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Infusions, Parenteral; Lethal Dose 50; Mice; Mice, Inbred BALB C; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantation; Stomach Neoplasms | 1988 |
Effects and systemic uptake of the new mitomycin C analogue KW-2149 in beagle dogs after intravesical administration.
Topics: Administration, Intravesical; Animals; Antineoplastic Agents; Blood; Dogs; Female; Mitomycin; Mitomycins; Osmolar Concentration; Urinary Bladder; Urine | 1995 |
Isolation of albomitomycins from solutions of 7-amino substituted mitomycins; mitomycin C and KW-2149.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Mass Spectrometry; Mitomycin; Mitomycins; Solutions; Spectrophotometry, Ultraviolet | 1995 |
Cytotoxic activity of 7-N-(2-((2-(-gamma-L-glutamylamino)- ethyl)dithio)ethyl)-mitomycin C and metabolites in cell lines with different resistance patterns.
Topics: Animals; Colonic Neoplasms; Drug Resistance; Drug Screening Assays, Antitumor; Female; Humans; Kinetics; Mitomycin; Mitomycins; Ovarian Neoplasms; Rats; Tumor Cells, Cultured | 1994 |
Comparison of uptake of mitomycin C and KW-2149 by murine P388 leukemia cells sensitive or resistant to mitomycin C.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; DNA, Neoplasm; Drug Resistance; Leukemia P388; Membrane Glycoproteins; Mice; Mitomycin; Mitomycins; Tumor Cells, Cultured | 1993 |
Nonenzymatic reductive activation of 7-N-((2-([2-(gamma-L-glutamylamino)ethyl]dithio)ethyl))mitomycin C by thiol molecules: a novel mitomycin C derivative effective on mitomycin C-resistant tumor cells.
Topics: Buthionine Sulfoximine; Colonic Neoplasms; Cysteine; Cytochrome P-450 Enzyme System; DNA, Neoplasm; Drug Interactions; Drug Resistance; Glutathione; Humans; Methionine Sulfoximine; Mitomycin; Mitomycins; Oxidation-Reduction; Sulfhydryl Compounds; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1994 |
Induction of protein-DNA complexes in HeLa S3 cells by KW-2149, a new derivative of mitomycin C.
Topics: Antineoplastic Agents; Camptothecin; DNA, Neoplasm; Dose-Response Relationship, Drug; HeLa Cells; Humans; Kinetics; Mercaptoethanol; Mitomycin; Mitomycins; Molecular Structure; Neoplasm Proteins; Protein Binding; Structure-Activity Relationship; Thymidine | 1993 |
Disposition and metabolism of KW-2149, a novel anticancer agent.
Topics: Animals; Antineoplastic Agents; Female; Half-Life; HeLa Cells; Humans; Leukemia P388; Male; Mice; Mitomycin; Mitomycins; Spectrometry, Mass, Fast Atom Bombardment; Tissue Distribution | 1993 |
Reduced bone marrow toxicity of KW-2149, a mitomycin C derivative, in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Blood Cell Count; Bone Marrow Diseases; Colony-Forming Units Assay; Female; Hematopoietic Stem Cells; Lung Diseases; Male; Megakaryocytes; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mitomycin; Mitomycins; Organ Size; Spleen; Tumor Cells, Cultured | 1993 |
Modulation of sensitivity to mitomycin C and a dithiol analogue by tempol in non-small-cell lung cancer cell lines under hypoxia.
Topics: Antineoplastic Agents; Antioxidants; Biotransformation; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Hypoxia; Cyclic N-Oxides; Cytochrome Reductases; Cytochrome-B(5) Reductase; Drug Combinations; Drug Resistance, Neoplasm; Humans; Lung Neoplasms; Mitomycin; Mitomycins; NAD(P)H Dehydrogenase (Quinone); Spin Labels; Tumor Cells, Cultured | 1996 |
Characteristics of the antitumor activity of M-16 and M-18, major metabolites of a new mitomycin C derivative KW-2149, in mice.
Topics: Animals; Antineoplastic Agents; Biotransformation; Breast Neoplasms; Cell Survival; HeLa Cells; Humans; Lethal Dose 50; Leukemia P388; Male; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Mitomycin; Mitomycins; Rats; Sarcoma 180; Tumor Cells, Cultured | 1995 |
The influence of hypoxia on the cytotoxicity of concomitant KW-2149 and ionizing irradiation in Chinese hamster fibroblasts.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Hypoxia; Cell Line; Cricetinae; Mitomycin; Mitomycins | 1996 |
KW-2149 (7-N-[2-[gamma-L-glutamylamino]ethyldithioethyl]mitomycin C). A new mitomycin C analogue activated by serum.
Topics: Animals; Antineoplastic Agents; Biotransformation; Blood; DNA Adducts; Humans; Mice; Mitomycin; Mitomycins; Tumor Cells, Cultured | 1997 |
Circumvention of glutathione-mediated mitomycin C resistance by a novel mitomycin C analogue, KW-2149.
Topics: 3T3 Cells; Animals; Antibiotics, Antineoplastic; Cell Division; Cross-Linking Reagents; DNA; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Glutamate-Cysteine Ligase; Glutathione; Humans; Mice; Mitomycin; Mitomycins; Transfection; Tumor Cells, Cultured | 1997 |
KW-2149 (7-N-[2-[gamma-L-glutamylamino]ethyldithioethyl] mitomycin C): DNA interactions and drug uptake following serum activation.
Topics: Antibiotics, Antineoplastic; Biological Factors; Cross-Linking Reagents; DNA, Neoplasm; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Glutathione; Humans; Mitomycin; Mitomycins; Sequence Analysis, DNA; Taq Polymerase; Tumor Cells, Cultured | 1998 |
7-N-(2-([2-(gamma-L-glutamylamino)-ethyl]-dithio)-ethyl)-mitomycin C (KW-2149) is more active than mitomycin C on chemonaive and drug-resistant urothelial carcinoma cells.
Topics: Anti-Bacterial Agents; Antibiotics, Antineoplastic; Carcinoma, Transitional Cell; Drug Interactions; Drug Resistance, Neoplasm; Humans; Hydrogen-Ion Concentration; Mitomycin; Mitomycins; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1998 |
Studies on the mode of action of mitomycin C(7) aminoethylene disulfides (BMS-181174 and KW-2149): reactivity of 7-N-(mercaptoethyl)mitomycin C.
Topics: Antineoplastic Agents, Alkylating; Chromatography, High Pressure Liquid; Mitomycin; Mitomycins; Sulfhydryl Compounds | 1999 |
Inhibitory effects of repeated intravenous injections of dexamethasone on pulmonary toxicity of a new mitomycin C analogue, KW-2149, in a novel rat model.
Topics: Animals; Antibiotics, Antineoplastic; Dexamethasone; Lung; Male; Mitomycin; Mitomycins; Rats; Rats, Sprague-Dawley | 2000 |