mitomycin has been researched along with diepoxybutane in 41 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 8 (19.51) | 18.7374 |
1990's | 10 (24.39) | 18.2507 |
2000's | 16 (39.02) | 29.6817 |
2010's | 7 (17.07) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Buchwald, M; Gavish, H; Shannon, WR; Strathdee, CA | 1 |
Bernstein, R; Rosendorff, J | 1 |
Hoy, CA; Mooney, CL; Salazar, EP; Thompson, LH | 1 |
Cohen, MM; Fruchtman, CE; Martin, AO; Simpson, SJ | 1 |
Cervenka, J; Hirsch, BA | 1 |
de Koning, H; Eriksson, AW; Joenje, H; Kwee, ML; Poll, EH; van de Kamp, JJ | 1 |
Duckworth-Rysiecki, G; Hultén, M; Mann, J; Taylor, AM | 1 |
Buchwald, M; Ishida, R | 1 |
Cohen, MM; Honig, GR; Martin, AO; Maurer, HS; Nicklas, JW; Simpson, SJ | 1 |
Friedl, R; Hentze, S; Hoehn, H; Schindler, D; Schroeder-Kurth, T; Seyschab, H; Sun, Y | 1 |
Arwert, F; Neuteboom, I; Overkamp, WJ; Rooimans, MA; Telleman, P; Zdzienicka, MZ | 1 |
Millard, JT; White, MM | 1 |
Grompe, M; Jakobs, PM; Joenje, H; Moses, RE; Olson, S; Reifsteck, C; Sahaayaruban, P; Saito, H | 1 |
Fiddler-Odell, E; Grompe, M; Jakobs, PM; Moses, RE; Olson, S; Reifsteck, C | 1 |
Hirsch-Kauffmann, M; Meisslitzer, C; Ruppitsch, W; Schweiger, M | 1 |
Buchwald, M; Care, M; Carreau, M; Tomkins, DJ | 1 |
Cho, D; Cho, SH; Hong, WP; Hwang, TJ; Kim, CJ; Kook, H; Park, JY; Ryang, DW; Yoon, WS | 1 |
Eastmond, DA; Murg, MN; Schuler, M | 1 |
De Biase, A; Deeva, IB; Iaccarino, M; Korkina, LG; Oral, R; Pagano, G; Warnau, M | 1 |
Pagano, G | 2 |
Barale, R; Bosco, E; Frenzilli, G | 1 |
Dokal, I | 1 |
Burke, LW; Grant, SG; Latimer, JJ; Thull, D; Wenger, SL | 1 |
Korkina, LG; Pagano, G | 1 |
Bruun, D; Cox, B; D'Andrea, AD; Grompe, M; Hejna, J; Lucas, L; Moses, R; Olson, S; Reifsteck, C; Taniguchi, T; Thayer, M; Timmers, C | 1 |
Havenga, C; Jansen, S; Joubert, G; Pearson, T; Stones, DK | 1 |
Bryant, PE; D'Andrea, AD; Johnson, MA; Jones, NJ; May, S; Meyn, RE; Stuckert, AP; Trueman, KL; Wilson, JB | 1 |
De Biase, A; Degan, P; Iaccarino, M; Pagano, G; Warnau, M | 1 |
Badell, I; Callén, E; Creus, A; Frias, S; Marcos, R; Molina, B; Olivé, T; Ortega, JJ; Ramírez, MJ; Surrallés, J | 1 |
D'Andrea, AD; Haining, N; Montes de Oca, R; Moreau, LA; Nathan, DG; Shimamura, A; Svenson, JL | 1 |
Antonio Casado, J; Badell, I; Bueren, JA; Callén, E; Cantalejo, A; Castella, M; Cela, E; Cervera, J; Dasí, A; Estella, J; Ferro, T; Hanenberg, H; Jacome, A; José Ortega, J; Kalb, R; Lobitz, S; Madero, L; Molinés, A; Muñoz, A; Neveling, K; Olivé, T; Río, P; Rodriguez-Villa, A; Sánchez-Calero, J; Schindler, D; Segovia, JC; Sevilla, J; Surrallés, J; Tapia, M | 1 |
Al-Haggar, M; Al-Morsy, Z; Chalaby, N; Mesbah, A; Ragab, A; Yahia, S | 1 |
Auerbach, AD | 1 |
Ghosh, K; Korgaonkar, S; Vundinti, BR | 1 |
Badell, I; Beléndez, C; Bueren, JA; Callén, E; Casado, JA; Castella, M; Cela, E; Dasí, Á; de Heredia, CD; de Toledo, JS; Estella, J; Ferro, T; Figuera, Á; Gómez, P; Madero, L; Molinés, A; Muñoz, A; Olivé, T; Pujol, R; Ramírez, MJ; Rodríguez-Villa, A; Sevilla, J; Surrallés, J; Talavera, M; Tapia, M | 1 |
Jones, NJ; Wu, JH | 1 |
Alter, BP; Fargo, JH; Giri, N; Olson, SB; Rochowski, A; Savage, SA | 1 |
Abraham, SK; Hintzsche, H; Khandelwal, N; Stopper, H | 1 |
Copeland, NA; Cunningham, R; Jones, NJ; Marriott, AS; McLennan, AG; Wilkinson, MC | 1 |
Barajas Torres, RL; Borjas Gutiérrez, C; Domínguez Cruz, MD; González García, JR; Magaña Torres, MT; Ramírez Dueñas, Mde L | 1 |
3 review(s) available for mitomycin and diepoxybutane
Article | Year |
---|---|
The genetics of Fanconi's anaemia.
Topics: Cells, Cultured; Chromosome Breakage; DNA Damage; Epoxy Compounds; Fanconi Anemia; Genetic Testing; Genetic Therapy; Humans; Mitomycin; Phenotype | 2000 |
Prospects for nutritional interventions in the clinical management of Fanconi anemia.
Topics: Anemia, Aplastic; Antibiotics, Antineoplastic; Cell Transformation, Neoplastic; Disease Progression; Epoxy Compounds; Fanconi Anemia; Humans; Mitomycin; Nutritional Status; Oxidative Stress; Phenotype | 2000 |
Fanconi anemia and its diagnosis.
Topics: Congenital Abnormalities; DNA Damage; Endocrine System Diseases; Epoxy Compounds; Fanconi Anemia; Genetic Predisposition to Disease; Growth Disorders; Humans; Mitomycin; Mosaicism; Neoplasms; Phenotype | 2009 |
2 trial(s) available for mitomycin and diepoxybutane
Article | Year |
---|---|
Fanconi anemia screening by diepoxybutane and mitomicin C tests in Korean children with bone marrow failure syndromes.
Topics: Adolescent; Bone Marrow Diseases; Child; Child, Preschool; Epoxy Compounds; Fanconi Anemia; Female; Humans; Infant; Infant, Newborn; Korea; Male; Mitomycin; Mutagens | 1998 |
Correlation of thyroid and growth hormones to chromosomal instability in Egyptian Fanconi anemia patients.
Topics: Adolescent; Cells, Cultured; Child; Child, Preschool; Chromosomal Instability; Chromosome Breakage; Dose-Response Relationship, Radiation; Egypt; Epoxy Compounds; Fanconi Anemia; Female; Growth Hormone; Humans; Insulin-Like Growth Factor I; Lymphocytes; Male; Mitomycin; Mutagens; Nucleic Acid Synthesis Inhibitors; Thyroid Hormones; Thyrotropin | 2008 |
36 other study(ies) available for mitomycin and diepoxybutane
Article | Year |
---|---|
Cloning of cDNAs for Fanconi's anaemia by functional complementation.
Topics: Amino Acid Sequence; Base Sequence; Blotting, Northern; Cell Line; Cell Survival; Cloning, Molecular; Dose-Response Relationship, Drug; Drug Resistance; Epoxy Compounds; Fanconi Anemia; Gene Library; Genetic Complementation Test; Humans; Mitomycin; Molecular Sequence Data; Mutagens; Mutation; Polymerase Chain Reaction; Restriction Mapping; Transfection | 1992 |
Fanconi's anemia--chromosome breakage studies in homozygotes and heterozygotes.
Topics: Anemia, Aplastic; Cells, Cultured; Chromosome Aberrations; Epoxy Compounds; Fanconi Anemia; Heterozygote; Homozygote; Humans; Lymphocytes; Mitomycin; Mitomycins | 1988 |
Defective DNA cross-link removal in Chinese hamster cell mutants hypersensitive to bifunctional alkylating agents.
Topics: Alkylating Agents; Animals; Cells, Cultured; Cricetinae; Cricetulus; Cross-Linking Reagents; DNA Repair; Epoxy Compounds; Kinetics; Mitomycin; Mitomycins; Mutation; Phenotype; Quinacrine Mustard | 1985 |
The cytogenetic response of Fanconi's anemia lymphoblastoid cell lines to various clastogens.
Topics: Adult; Anemia, Aplastic; Ataxia Telangiectasia; Bleomycin; Cell Line; Child; Child, Preschool; Epoxy Compounds; Fanconi Anemia; Female; Humans; Karyotyping; Lymphocytes; Male; Mechlorethamine; Middle Aged; Mitomycin; Mitomycins; Mutagens; Xeroderma Pigmentosum | 1982 |
Cytogenetic differentiation of Fanconi anemia, "idiopathic" aplastic anemia, and Fanconi anemia heterozygotes.
Topics: Adolescent; Adult; Anemia, Aplastic; Blood Preservation; Child; Child, Preschool; Chromosome Aberrations; Chromosomes, Human; Diagnosis, Differential; Epoxy Compounds; Fanconi Anemia; Female; Genetic Carrier Screening; Humans; Lymphocytes; Male; Mitomycin; Mitomycins; Mutagens; Sister Chromatid Exchange | 1983 |
Unusual response to bifunctional alkylating agents in a case of Fanconi anaemia.
Topics: Adolescent; Alkylating Agents; Anemia, Aplastic; Cells, Cultured; Child; Child, Preschool; Chromosomes, Human; Cisplatin; Epoxy Compounds; Fanconi Anemia; Female; Humans; In Vitro Techniques; Lymphocytes; Male; Mitomycin; Mitomycins; Pedigree | 1983 |
Clinical and cytogenetic diversity in Fanconi's anaemia.
Topics: Adolescent; Adult; Anemia, Aplastic; Child; Chromosome Aberrations; Chromosomes, Human; Diagnosis, Differential; Epoxy Compounds; Ethers, Cyclic; Fanconi Anemia; Female; Genetic Carrier Screening; Humans; Male; Mitomycin; Mitomycins | 1984 |
Susceptibility of Fanconi's anemia lymphoblasts to DNA-cross-linking and alkylating agents.
Topics: 4-Nitroquinoline-1-oxide; Alkylating Agents; Anemia, Aplastic; Antibiotics, Antineoplastic; Carcinogens; Cell Line; Cell Survival; Cross-Linking Reagents; DNA; Epoxy Compounds; Fanconi Anemia; Humans; Lymphocytes; Mitomycin; Mitomycins; Nitrosourea Compounds; Xeroderma Pigmentosum | 1982 |
The identification of fanconi anemia genotypes by clastogenic stress.
Topics: Adolescent; Anemia, Aplastic; Child; Child, Preschool; Chromosomes, Human; Epoxy Compounds; Fanconi Anemia; Female; Genetic Carrier Screening; Genotype; Humans; Infant; Lymphocytes; Male; Mitomycin; Mitomycins; Mutagens | 1982 |
Comparative evaluation of diepoxybutane sensitivity and cell cycle blockage in the diagnosis of Fanconi anemia.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosomes; Cross-Linking Reagents; Drug Resistance; Epoxy Compounds; Fanconi Anemia; Flow Cytometry; G2 Phase; Hematologic Diseases; Humans; Lymphocyte Activation; Lymphocytes; Mitomycin; Mutagens; Single-Blind Method | 1995 |
Genetic diversity of mitomycin C-hypersensitive Chinese hamster cell mutants: a new complementation group with chromosomal instability.
Topics: Animals; Cell Survival; CHO Cells; Chromosome Aberrations; Cisplatin; Cricetinae; DNA Damage; Dose-Response Relationship, Drug; Doxorubicin; Epoxy Compounds; Genetic Complementation Test; Genetic Variation; Mitomycin; Mutation | 1993 |
Diepoxybutane cross-links DNA at 5'-GNC sequences.
Topics: Base Sequence; Binding Sites; Cross-Linking Reagents; DNA; Epoxy Compounds; Mitomycin; Molecular Sequence Data; Nucleic Acid Denaturation; Oligodeoxyribonucleotides; Structure-Activity Relationship | 1993 |
Immortalization of four new Fanconi anemia fibroblast cell lines by an improved procedure.
Topics: Cell Culture Techniques; Cell Fusion; Cell Line, Transformed; Cell Survival; Chromosome Aberrations; Epoxy Compounds; Ethyl Methanesulfonate; Fanconi Anemia; Fibroblasts; Genetic Complementation Test; Humans; Karyotyping; Mitomycin; Mutagens; Phenotype; Skin | 1996 |
Complementation group assignments in Fanconi anemia fibroblast cell lines from North America.
Topics: Cell Cycle Proteins; Cell Fusion; Cell Survival; DNA Mutational Analysis; DNA-Binding Proteins; Epoxy Compounds; Fanconi Anemia; Fanconi Anemia Complementation Group C Protein; Fanconi Anemia Complementation Group Proteins; Genes; Genetic Complementation Test; Genetic Linkage; Humans; Mitomycin; North America; Nuclear Proteins; Proteins; Transfection | 1997 |
Overexpression of thioredoxin in Fanconi anemia fibroblasts prevents the cytotoxic and DNA damaging effect of mitomycin C and diepoxybutane.
Topics: Antioxidants; Cell Line; Cell Survival; Chromosome Breakage; Cytokines; DNA Damage; Epoxy Compounds; Fanconi Anemia; Gene Expression Regulation; Humans; Male; Micronucleus Tests; Mitomycin; Neoplasm Proteins; NF-kappa B; Oxidative Stress; Thioredoxins; Transfection; Transformation, Genetic | 1998 |
Development and characterization of immortalized fibroblastoid cell lines from an FA(C) mouse model.
Topics: Animals; Cell Cycle Proteins; Cell Line, Transformed; Cell Transformation, Viral; Chromosome Aberrations; Cross-Linking Reagents; Disease Models, Animal; DNA-Binding Proteins; Dose-Response Relationship, Drug; Epoxy Compounds; Fanconi Anemia; Fanconi Anemia Complementation Group Proteins; Fibroblasts; Mice; Mice, Knockout; Mitomycin; Mutagenicity Tests; Nuclear Proteins; Phenotype; Proteins; Toxicity Tests | 1998 |
Persistence of chromosomal alterations affecting the 1cen-q12 region in a human lymphoblastoid cell line exposed to diepoxybutane and mitomycin C.
Topics: Bromodeoxyuridine; Cell Cycle; Cell Line; Cell Survival; Chromosome Aberrations; Chromosomes, Human, Pair 1; Environmental Monitoring; Epoxy Compounds; Fluorescent Antibody Technique; Humans; In Situ Hybridization, Fluorescence; Lymphocyte Activation; Lymphocytes; Micronucleus Tests; Mitomycin; Mutagens; Staining and Labeling; Time Factors | 1999 |
Redox-dependent toxicity of diepoxybutane and mitomycin C in sea urchin embryogenesis.
Topics: Animals; Catalase; Embryo, Nonmammalian; Epoxy Compounds; Glutathione; Larva; Luminescent Measurements; Mitomycin; Oxidation-Reduction; Oxidative Stress; Oxygen; Reactive Oxygen Species; Sea Urchins; Superoxide Dismutase | 2000 |
Mitomycin C and diepoxybutane action mechanisms and FANCC protein functions: further insights into the role for oxidative stress in Fanconi's anaemia phenotype.
Topics: Cell Cycle Proteins; DNA-Binding Proteins; Epoxy Compounds; Fanconi Anemia; Fanconi Anemia Complementation Group C Protein; Fanconi Anemia Complementation Group Proteins; Humans; Mitomycin; Nuclear Proteins; Oxidative Stress; Phenotype; Proteins | 2000 |
Validation of single cell gel assay in human leukocytes with 18 reference compounds.
Topics: 4-Nitroquinoline-1-oxide; Adult; Animals; Ascorbic Acid; Benzaldehydes; Benzo(a)pyrene; Biotransformation; Bleomycin; Chlorophyllides; Cyclophosphamide; DNA Damage; Epoxy Compounds; Female; Formaldehyde; Glucose; Glutaral; Griseofulvin; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Leukocytes; Mannitol; Methylmercury Compounds; Microsomes, Liver; Mitomycin; Mutagenicity Tests; Pyrenes; Rats; Reproducibility of Results; Sodium Azide | 2000 |
Analysis of genomic instability using multiple assays in a patient with Rothmund-Thomson syndrome.
Topics: Adult; Blood Group Antigens; Child; Child, Preschool; Chromosome Fragility; DNA Damage; DNA Repair; Epoxy Compounds; Erythrocytes; Female; Flow Cytometry; Glycophorins; Humans; Infant; Infant, Newborn; Karyotyping; Loss of Heterozygosity; Lymphocytes; Male; Mitomycin; Mutation; Rothmund-Thomson Syndrome | 2000 |
Positional cloning of a novel Fanconi anemia gene, FANCD2.
Topics: Alleles; Amino Acid Sequence; Base Sequence; Blotting, Western; Cell Line; Chromosome Breakage; Cloning, Molecular; DNA Mutational Analysis; Drosophila Proteins; Epoxy Compounds; Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Female; Gene Expression Profiling; Genetic Complementation Test; Humans; Male; Mitomycin; Molecular Sequence Data; Mutation; Nuclear Proteins; Pedigree; Phenotype; Protein Isoforms; RNA, Messenger; Sequence Alignment; Transduction, Genetic | 2001 |
Fanconi anemia. a statistical evaluation of cytogenetic results obtained from South African families.
Topics: Case-Control Studies; Cells, Cultured; Epoxy Compounds; Evaluation Studies as Topic; Fanconi Anemia; Genetic Carrier Screening; Homozygote; Humans; Lymphocytes; Mitomycin; South Africa | 2001 |
The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquitinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchange.
Topics: Animals; Bleomycin; Cell Line; CHO Cells; Cricetinae; DNA Damage; DNA-Binding Proteins; Epoxy Compounds; Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Fanconi Anemia Complementation Group G Protein; Gamma Rays; Genetic Complementation Test; Humans; Hybrid Cells; Mechlorethamine; Mitomycin; Mutagens; Mutation; Nuclear Proteins; Sister Chromatid Exchange; Ubiquitin; Ultraviolet Rays | 2001 |
Diepoxybutane and mitomycin C toxicity is associated with the induction of oxidative DNA damage in sea urchin embryos.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Abnormalities, Drug-Induced; Animals; Deoxyguanosine; DNA Damage; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Epoxy Compounds; Mitomycin; Mutagens; Organ Culture Techniques; Oxidation-Reduction; Oxidative Stress; Sea Urchins | 2001 |
Redox-modulated xenobiotic action and ROS formation: a mirror or a window?
Topics: Cell Differentiation; Cell Division; Chromosome Aberrations; DNA Damage; Epoxy Compounds; Fanconi Anemia; Humans; Mitomycin; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Xenobiotics | 2002 |
The clastogenic response of the 1q12 heterochromatic region to DNA cross-linking agents is independent of the Fanconi anaemia pathway.
Topics: Case-Control Studies; Chromosomes, Human, Pair 1; Cross-Linking Reagents; Epoxy Compounds; Fanconi Anemia; Genetic Carrier Screening; Humans; In Situ Hybridization, Fluorescence; Mitomycin; Mutagens | 2002 |
A novel diagnostic screen for defects in the Fanconi anemia pathway.
Topics: Blotting, Western; Bone Marrow Diseases; Cell Line, Transformed; Chromosome Breakage; Chromosomes, Human; DNA, Complementary; Epoxy Compounds; Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Genetic Heterogeneity; Genetic Testing; Genetic Vectors; Humans; Lymphocytes; Microscopy, Fluorescence; Mitomycin; Nuclear Proteins; Protein Processing, Post-Translational; Retroviridae; Transfection; Ubiquitin | 2002 |
A comprehensive strategy for the subtyping of patients with Fanconi anaemia: conclusions from the Spanish Fanconi Anemia Research Network.
Topics: Algorithms; Cells, Cultured; Consanguinity; Drug Resistance; Epoxy Compounds; Fanconi Anemia; Fanconi Anemia Complementation Group A Protein; Fanconi Anemia Complementation Group Proteins; Fibroblasts; Genetic Complementation Test; Genetic Heterogeneity; Genotype; Humans; Incidence; Mitomycin; Mosaicism; Registries; Retroviridae; Roma; Spain; T-Lymphocytes; Transduction, Genetic | 2007 |
Clinical, genetic and cytogenetic study of Fanconi anemia in an Indian population.
Topics: Adolescent; Carcinoma, Squamous Cell; Cells, Cultured; Child; Child, Preschool; Chromosome Breakage; Chromosome Fragility; Chromosomes, Human; Consanguinity; Epoxy Compounds; Fanconi Anemia; Female; Humans; India; Infant; Leukemia, Myeloid; Male; Mitomycin; Myelodysplastic Syndromes; Young Adult | 2010 |
Chromosome fragility in patients with Fanconi anaemia: diagnostic implications and clinical impact.
Topics: Chromosome Fragility; Cross-Linking Reagents; Epoxy Compounds; Fanconi Anemia; Humans; Mitomycin; Mosaicism; Phenotype | 2011 |
Assessment of DNA interstrand crosslinks using the modified alkaline comet assay.
Topics: Animals; Cell Line; Comet Assay; Cross-Linking Reagents; DNA; DNA Damage; Epoxy Compounds; Ficusin; Gamma Rays; Humans; Mitomycin; Mutagens; Ultraviolet Rays | 2012 |
Comparison of chromosome breakage in non-mosaic and mosaic patients with Fanconi anemia, relatives, and patients with other inherited bone marrow failure syndromes.
Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Bone Marrow Diseases; Bone Marrow Failure Disorders; Child; Child, Preschool; Chromosome Breakage; Cohort Studies; Epoxy Compounds; Fanconi Anemia; Female; Genetic Carrier Screening; Genotype; Hemoglobinuria, Paroxysmal; Humans; Infant; Lymphocytes; Male; Middle Aged; Mitomycin; Mosaicism; Mutagens; Young Adult | 2014 |
Antigenotoxic effects of resveratrol: assessment of in vitro and in vivo response.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antimutagenic Agents; Bone Marrow Cells; Chromosome Aberrations; Chromosomes; DNA Damage; Epoxy Compounds; HL-60 Cells; Humans; Male; Methyl Methanesulfonate; Mice; Micronucleus Tests; Mitomycin; Procarbazine; Quinolones; Resveratrol; Stilbenes | 2016 |
Diadenosine 5', 5'''-P(1),P(4)-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication.
Topics: 3T3 Cells; Adenosine Diphosphate Ribose; Animals; Cell Proliferation; CHO Cells; Chromatography, Ion Exchange; Cricetinae; Cricetulus; Dinucleoside Phosphates; DNA Damage; DNA Replication; Epoxy Compounds; Gene Knockdown Techniques; HeLa Cells; Humans; Intracellular Space; Mice; Mitomycin; Phosphoric Monoester Hydrolases; Poly(ADP-ribose) Polymerases; RNA, Small Interfering | 2015 |
1,2:3,4-Diepoxybutane Induces Multipolar Mitosis in Cultured Human Lymphocytes.
Topics: Aneuploidy; Butadienes; Cells, Cultured; Epoxy Compounds; Healthy Volunteers; Humans; Lymphocytes; Mitomycin; Mitosis; Mutagens; Toxicity Tests | 2016 |