mitomycin has been researched along with dicumarol in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (26.67) | 18.7374 |
| 1990's | 15 (50.00) | 18.2507 |
| 2000's | 5 (16.67) | 29.6817 |
| 2010's | 2 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Gustafson, DL; Pritsos, CA | 1 |
| Begleiter, A; Leith, MK; Robotham, E | 1 |
| Gibson, NW; Preusch, PC; Ross, D; Siegel, D | 1 |
| Smith, PJ; Walton, MI; Workman, P | 1 |
| Kennedy, KA; Mimnaugh, EG; Sinha, BK; Trush, MA | 1 |
| Sartorelli, AC | 1 |
| Keyes, SR; Rockwell, S; Sartorelli, AC | 4 |
| Marshall, RS; Paterson, MC; Rauth, AM | 1 |
| Begleiter, A; Lacey, G; Leith, MK; Robotham, E | 1 |
| Kelley, M; Kemple, B; Rockwell, S | 1 |
| Lee, JH; Naito, M; Nakajima, M; Tsuruo, T | 1 |
| de Mol, NJ; Groot, SE; Janssen, LH; Maliepaard, M; Wolfs, A | 1 |
| Budihna, M; Furlan, L; Lesnicar, H; Rudolf, Z; Smid, L; Soba, E; Zakotnik, B; Zargi, M | 1 |
| Aogi, K; Hirabayashi, N; Nishiyama, M; Saeki, S; Toge, T | 1 |
| Fischer, D; Fischer, JJ; Haffty, BG; Papac, R; Rockwell, S; Sartorelli, A; Sasaki, CT; Son, YH | 1 |
| Vokes, EE; Weichselbaum, RR | 1 |
| Arai, H; Bizanek, R; Chowdary, D; Hughes, CS; Kasai, M; Rockwell, S; Sartorelli, AC; Tomasz, M | 1 |
| Belej, T; Halinska, A; O'Brien, PJ | 1 |
| Beall, HD; Bolton, EM; Gustafson, DL; Ross, D; Waldren, CA | 1 |
| Nishiyama, M; Sakamoto, N; Toge, T | 1 |
| Migliore, L; Nesti, C; Scarpato, R; Trippi, F; Turchi, G | 1 |
| Belcourt, MF; Mehta, SS; Palom, Y; Pritsos, CA; Pritsos, KL; Rockwell, S; Sartorelli, AC; Tang, LQ; Tomasz, M | 1 |
| Begleiter, A; Digby, T; Leith, MK; Thliveris, JA | 1 |
| DeAngelis, LM; Gu, B | 1 |
| Hao, FR; Hu, ZH; Jin, YZ; Yan, MF | 1 |
2 trial(s) available for mitomycin and dicumarol
| Article | Year |
|---|---|
Radiotherapy, combined with simultaneous chemotherapy with mitomycin C and bleomycin for inoperable head and neck cancer--preliminary report.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Chlorpromazine; Combined Modality Therapy; Dicumarol; Female; Follow-Up Studies; Head and Neck Neoplasms; Humans; Male; Middle Aged; Mitomycin; Niacinamide; Prospective Studies; Radiotherapy Dosage | 1995 |
Mitomycin C as an adjunct to postoperative radiation therapy in squamous cell carcinoma of the head and neck: results from two randomized clinical trials.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Dicumarol; Female; Follow-Up Studies; Head and Neck Neoplasms; Humans; Male; Middle Aged; Mitomycin; Postoperative Period | 1993 |
28 other study(ies) available for mitomycin and dicumarol
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Enhancement of xanthine dehydrogenase mediated mitomycin C metabolism by dicumarol.
Topics: Animals; Biotransformation; Dicumarol; Mice; Mitomycin; Oxidation-Reduction; Xanthine Dehydrogenase; Xanthine Oxidase | 1992 |
Role of NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under hypoxia.
Topics: Animals; Biotransformation; Cell Hypoxia; Cell Survival; Cross-Linking Reagents; Dicumarol; DNA; DNA Damage; Mice; Mitomycin; NAD(P)H Dehydrogenase (Quinone); Tumor Cells, Cultured | 1992 |
Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.
Topics: Antineoplastic Agents; Cell Line; Chromatography, High Pressure Liquid; Colonic Neoplasms; Colony-Forming Units Assay; Dicumarol; DNA Damage; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Mitomycin; Mitomycins; NAD; NAD(P)H Dehydrogenase (Quinone); Quinone Reductases | 1990 |
The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9.
Topics: Animals; Antineoplastic Agents; Aziridines; Biotransformation; Carcinoma 256, Walker; Colonic Neoplasms; Dicumarol; DNA Damage; DNA, Bacterial; Humans; Indolequinones; Indoles; Kinetics; Mitomycin; Mitomycins; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Quinone Reductases; Quinones; Rats; Superoxide Dismutase; Tumor Cells, Cultured; Vitamin K | 1991 |
Effects of glutathione and ethylxanthate on mitomycin C activation by isolated rat hepatic or EMT6 mouse mammary tumor nuclei.
Topics: Animals; Biotransformation; Cell Nucleus; Dicumarol; Edetic Acid; Glutathione; Hot Temperature; In Vitro Techniques; Liver; Male; Mammary Neoplasms, Experimental; Mice; Mitomycin; Mitomycins; NAD; Oxygen; Pentetic Acid; Rats; Rats, Inbred Strains; Thiones | 1985 |
The role of mitomycin antibiotics in the chemotherapy of solid tumors.
Topics: Anaerobiosis; Animals; Biotransformation; Cytochromes; Dicumarol; Drug Synergism; Female; Mammary Neoplasms, Experimental; Mitomycin; Mitomycins; NAD(P)H Dehydrogenase (Quinone); Neoplasms, Experimental; Porfiromycin; Quinone Reductases; Rats; Sarcoma, Experimental | 1986 |
Modulation of the cytotoxicity of mitomycin C to EMT6 mouse mammary tumor cells by dicoumarol in vitro.
Topics: Animals; Cell Line; Cell Survival; Dicumarol; Drug Synergism; Hypoxia; Mammary Neoplasms, Experimental; Mice; Mitomycin; Mitomycins; Tumor Cells, Cultured | 1988 |
Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions.
Topics: Biotransformation; Cell Survival; Cells, Cultured; Dicumarol; Drug Resistance; Fibroblasts; Humans; Mitomycin; Mitomycins; Oxygen; Porfiromycin; Skin | 1989 |
Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells.
Topics: Aerobiosis; Alkylating Agents; Anaerobiosis; Animals; Biological Transport; Cell Line; Cell Survival; Dicumarol; Doxorubicin; Kinetics; Mammary Neoplasms, Experimental; Methylcholanthrene; Mice; Mitomycin; Mitomycins; Oxidation-Reduction; Porfiromycin; Vitamin K | 1989 |
Increased sensitivity of quinone resistant cells to mitomycin C.
Topics: Animals; Antineoplastic Agents; Benzoquinones; Cell Line; Cell Survival; Dicumarol; DNA Damage; Drug Resistance; Leukemia L5178; Leukemia, Experimental; Mice; Mitomycin; Mitomycins; NAD(P)H Dehydrogenase (Quinone); Quinone Reductases; Quinones; Tumor Cells, Cultured | 1989 |
Modulation of the antineoplastic efficacy of mitomycin C by dicoumarol in vivo.
Topics: Animals; Cell Survival; Dicumarol; Drug Interactions; Hematopoietic Stem Cells; Mice; Mice, Inbred BALB C; Mitomycin; Mitomycins; NAD(P)H Dehydrogenase (Quinone); Neoplasms, Experimental; Quinone Reductases; Skin; Whole-Body Irradiation | 1989 |
Enhancement of mitomycin C cytotoxicity to hypoxic tumor cells by dicoumarol in vivo and in vitro.
Topics: Anaerobiosis; Animals; Antibiotics, Antineoplastic; Cell Line; Cell Survival; Combined Modality Therapy; Dicumarol; Drug Evaluation, Preclinical; Drug Synergism; Fibrosarcoma; Kinetics; Leukopenia; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mitomycin; Mitomycins | 1985 |
Cytotoxicity of BMS-181174. Effects of hypoxia, dicoumarol, and repair deficits.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Hypoxia; Cell Line; Cell Survival; Cricetinae; Dicumarol; DNA Damage; Dose-Response Relationship, Drug; Mice; Mitomycin; Mitomycins; Tumor Cells, Cultured | 1995 |
Isolation and characterization of a mitomycin C-resistant variant of human colon carcinoma HT-29 cells.
Topics: Aerobiosis; Alkylation; Biotransformation; Cell Survival; Colonic Neoplasms; Dicumarol; DNA, Neoplasm; Drug Resistance; Glutathione Transferase; Humans; Mitomycin; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Tumor Cells, Cultured; Vitamin K | 1993 |
Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase.
Topics: Animals; Antineoplastic Agents; Aziridines; Biotransformation; Cross-Linking Reagents; Dicumarol; DNA; Indolequinones; Indoles; Liver; Male; Mitomycin; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Rats; Rats, Wistar; Xanthine Oxidase | 1995 |
[Mitomycin C and its bioreduction: relevance of NAD(P)H: quinone oxidoreductase activity to mitomycin C-induced DNA damage and cytotoxicity].
Topics: Carcinoma, Squamous Cell; Cell Division; Dicumarol; DNA Damage; Humans; Leukemia, Myeloid; Mitomycin; Mouth Neoplasms; NAD(P)H Dehydrogenase (Quinone); Pancreatic Neoplasms; Stomach Neoplasms; Tumor Cells, Cultured | 1993 |
Measurable impact: multimodality therapy of head and neck cancer.
Topics: Combined Modality Therapy; Dicumarol; Head and Neck Neoplasms; Humans; Mitomycin | 1993 |
Adducts of mitomycin C and DNA in EMT6 mouse mammary tumor cells: effects of hypoxia and dicumarol on adduct patterns.
Topics: Aerobiosis; Animals; Cell Hypoxia; Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Dicumarol; DNA; DNA Adducts; DNA, Neoplasm; Mammary Neoplasms, Experimental; Mice; Mitomycin; Thiosulfates; Tritium; Tumor Cells, Cultured | 1993 |
Cytotoxic mechanisms of anti-tumour quinones in parental and resistant lymphoblasts.
Topics: Animals; Antineoplastic Agents; Catalase; Dicumarol; DNA Damage; Drug Resistance; Mice; Mitomycin; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Oxygen Consumption; Quinones; Tumor Cells, Cultured | 1996 |
Expression of human NAD(P)H: quinone oxidoreductase (DT-diaphorase) in Chinese hamster ovary cells: effect on the toxicity of antitumor quinones.
Topics: Animals; Antibiotics, Antineoplastic; Biotransformation; Cell Survival; CHO Cells; Cricetinae; Cytochrome Reductases; Cytochrome-B(5) Reductase; Dicumarol; DNA, Complementary; Enzyme Inhibitors; Humans; Mitomycin; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Quinones; Transfection; Vitamin K; Xanthine Dehydrogenase | 1996 |
Tumor-specific synergistic therapy of mitomycin C: modulation of bioreductive activation.
Topics: 3-Iodobenzylguanidine; Animals; Antibiotics, Antineoplastic; Biotransformation; Cell Division; Dicumarol; DNA Damage; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Iodobenzenes; Mice; Mice, Nude; Mitomycin; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Neoplasms, Experimental; Rats; Tumor Cells, Cultured | 1997 |
Cytokinesis-block micronucleus assay in primary human liver fibroblasts exposed to griseofulvin and mitomycin C.
Topics: Antifungal Agents; Cells, Cultured; Chromosomes; Dicumarol; DNA Damage; Enzyme Inhibitors; Fibroblasts; Griseofulvin; Humans; In Situ Hybridization; In Situ Hybridization, Fluorescence; Liver; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mitomycin; Nucleic Acid Synthesis Inhibitors | 2000 |
Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol.
Topics: Animals; Biological Transport; Cell Division; Cell-Free System; Dicumarol; DNA Adducts; Drug Interactions; Enzyme Inhibitors; Mammary Neoplasms, Animal; Mice; Mitomycin; Mitomycins; NADH Dehydrogenase; Radiopharmaceuticals; Tritium; Tumor Cells, Cultured; Xanthine Dehydrogenase | 2001 |
Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo.
Topics: Animals; Antibiotics, Antineoplastic; Bone Marrow; Colonic Neoplasms; Dicumarol; Diet Therapy; Dimethyl Fumarate; Drug Therapy, Combination; Enzyme Induction; Enzyme Inhibitors; Female; Fumarates; Humans; Mice; Mice, Nude; Mitomycin; NAD(P)H Dehydrogenase (Quinone); Tumor Cells, Cultured | 2004 |
Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells.
Topics: Antineoplastic Agents; Carmustine; Cell Death; Cell Line, Tumor; Cytochrome-B(5) Reductase; Dicumarol; Dimethyl Fumarate; Drug Synergism; Enzyme Induction; Fumarates; Glioblastoma; Glutathione Transferase; Humans; Mitomycin; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Streptonigrin | 2005 |
[Metabolism of mitomycin C by human liver microsomes in vitro].
Topics: Antibiotics, Antineoplastic; Chromatography, High Pressure Liquid; Dicumarol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Microsomes, Liver; Mitomycin | 2007 |