mitomycin has been researched along with bmy 25067 in 21 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (9.52) | 18.7374 |
1990's | 18 (85.71) | 18.2507 |
2000's | 1 (4.76) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Singh, SV; Xu, BH | 1 |
Erlichman, C | 1 |
Doyle, TW; Vyas, DM | 1 |
Covey, JM; Dusre, L; Eliot, HM; Rajagopalan, S; Sinha, BK | 1 |
Bradner, WT; Florczyk, AP; Rose, WC; Schurig, JE | 1 |
Politi, PM; Rajagopalan, S; Sinha, BK | 1 |
Schurig, JE; Stringfellow, DA | 1 |
Kelley, M; Kemple, B; Rockwell, S | 1 |
Emerson, EO; Gupta, V; Jani, JP; Singh, SV; Xu, BH; Zaren, HA | 1 |
Gupta, V; Singh, SV; Xu, BH | 1 |
Khan, S; O'Brien, PJ; Silva, JM | 1 |
Kelley, M; Rockwell, S | 1 |
Benson, PJ; Gupta, V; Hu, X; Pinto, T; Singh, S; Xia, H; Zaren, HA | 1 |
Au, JL; Yen, WC | 1 |
Bloom, SE; Muscarella, DE | 1 |
Bleicher, RJ; Gupta, V; Hu, X; Singh, SV; Srivastava, SK; Xia, H; Zaren, HA | 1 |
Ganesan, TS; Green, JA; Harris, AL; LaCreta, FP; Macaulay, VM; McKinley, L; O'Byrne, KJ; Philip, PA; Talbot, DC; Winograd, B | 1 |
Blaxall, JR; Hamilton, JW; Ihnat, MA; La Ronde, N; Lariviere, JP; Pierre, KM; Turpie, BW; Warren, AJ | 1 |
Kohn, H; Wang, S | 1 |
de Boer-Dennert, M; Planting, AS; Schellens, JH; Stoter, G; van der Burg, ME; Verweij, J; Winograd, B | 1 |
Celli, CM; Jaiswal, AK; Knox, R; Tran, N | 1 |
2 review(s) available for mitomycin and bmy 25067
Article | Year |
---|---|
Novel chemotherapeutic agents in clinical development.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Camptothecin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Humans; Mitomycin; Mitomycins; Paclitaxel; Pyrazoles; Quinazolines; Thiophenes; Topotecan | 1991 |
Second generation analogs of etoposide and mitomycin C.
Topics: Animals; Antineoplastic Agents; Dogs; Drug Screening Assays, Antitumor; Etoposide; Humans; Mice; Mitomycin; Mitomycins; Organophosphorus Compounds | 1990 |
2 trial(s) available for mitomycin and bmy 25067
Article | Year |
---|---|
Phase I study of the mitomycin C analogue BMS-181174.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Female; Heart; Humans; Kidney; Lung; Male; Middle Aged; Mitomycin; Mitomycins; Neoplasms; Thrombophlebitis | 1998 |
Phase I and pharmacologic study of BMS-181174 given as a 6 h infusion every 4 weeks to patients with advanced solid tumors.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Area Under Curve; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hematologic Diseases; Humans; Infusions, Intravenous; Male; Middle Aged; Mitomycin; Mitomycins; Neoplasm Staging; Neoplasms; Vascular Diseases | 1999 |
17 other study(ies) available for mitomycin and bmy 25067
Article | Year |
---|---|
Effect of buthionine sulfoximine and ethacrynic acid on cytotoxic activity of mitomycin C analogues BMY 25282 and BMY 25067.
Topics: Animals; Buthionine Sulfoximine; DNA, Neoplasm; Drug Resistance; Drug Screening Assays, Antitumor; Ethacrynic Acid; Glutathione Transferase; Leukemia P388; Methionine Sulfoximine; Mitomycin; Mitomycins; Tumor Stem Cell Assay | 1992 |
DNA interstrand cross-link and free radical formation in a human multidrug-resistant cell line from mitomycin C and its analogues.
Topics: Alkylating Agents; Cross-Linking Reagents; Dose-Response Relationship, Drug; Drug Resistance; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; In Vitro Techniques; Mitomycin; Mitomycins; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
Antitumor activity and toxicity in animals of N-7[2-(4-nitrophenyldithio) ethyl] mitomycin C (BMY-25067).
Topics: Animals; Antineoplastic Agents; Female; Injections, Intraperitoneal; Injections, Intravenous; Leukemia L1210; Leukemia P388; Male; Mice; Mice, Inbred BALB C; Mitomycin; Mitomycins | 1990 |
Free-radical formation by mitomycin C and its novel analogs in cardiac microsomes and the perfused rat heart.
Topics: Animals; Catalase; Electron Spin Resonance Spectroscopy; Free Radicals; Heart; Heart Rate; Hydroxides; Hydroxyl Radical; In Vitro Techniques; Kinetics; Male; Microsomes; Mitomycin; Mitomycins; Myocardium; Perfusion; Rats; Rats, Inbred Strains; Superoxides | 1989 |
The search for more active and less toxic mitomycin and etoposide analogs.
Topics: Animals; Antineoplastic Agents; Etoposide; Mice; Mitomycin; Mitomycins | 1987 |
Cytotoxicity of BMS-181174. Effects of hypoxia, dicoumarol, and repair deficits.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Hypoxia; Cell Line; Cell Survival; Cricetinae; Dicumarol; DNA Damage; Dose-Response Relationship, Drug; Mice; Mitomycin; Mitomycins; Tumor Cells, Cultured | 1995 |
Characterization of a human bladder cancer cell line selected for resistance to BMY 25067, a novel analogue of mitomycin C.
Topics: Antineoplastic Agents; Cell Cycle; Drug Resistance; Glutathione; Glutathione Transferase; Humans; In Vitro Techniques; Mitomycin; Mitomycins; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1995 |
Mechanism of differential sensitivity of human bladder cancer cells to mitomycin C and its analogue.
Topics: DNA, Neoplasm; Drug Resistance; Humans; Lipid Peroxidation; Mitomycin; Mitomycins; Tumor Cells, Cultured; Tumor Stem Cell Assay; Urinary Bladder Neoplasms | 1994 |
Contrasting molecular cytotoxic mechanisms of mitomycin C and its two analogs, BMY 25282 and BMY 25067, in isolated rat hepatocytes.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Dithiothreitol; Glutathione; Liver; Male; Mitomycin; Mitomycins; Oxidation-Reduction; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Substrate Cycling; Trypan Blue | 1993 |
Interactions of BMS-181174 and radiation: studies with EMT6 cells in vitro and in solid tumors.
Topics: Aerobiosis; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Cell Hypoxia; Cell Survival; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Resistance, Neoplasm; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mitomycin; Mitomycins; Neoplasm Transplantation; Porfiromycin; Radiation-Sensitizing Agents; Radiotherapy Dosage; Skin Neoplasms; Specific Pathogen-Free Organisms; Tumor Cells, Cultured | 1996 |
Lack of a role of glutathione in cellular nonenzymatic activation of BMS-181174, a novel analogue of mitomycin C.
Topics: Antineoplastic Agents, Alkylating; Biotransformation; Buthionine Sulfoximine; Cysteine; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Glutathione; Humans; Methionine Sulfoximine; Mitomycin; Mitomycins; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1996 |
Pharmacodynamic evaluation of mitomycin C analog BMS-181174 for potential use in intravesical bladder cancer therapy.
Topics: Administration, Intravesical; Antineoplastic Agents, Alkylating; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Survival; Mitomycin; Mitomycins; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1997 |
Involvement of gene-specific DNA damage and apoptosis in the differential toxicity of mitomycin C analogs towards B-lineage versus T-lineage lymphoma cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cell Division; Chickens; DNA; DNA Damage; Lymphoma, B-Cell; Lymphoma, T-Cell; Mitomycin; Mitomycins; Tumor Cells, Cultured | 1997 |
Characterization of a BMS-181174-resistant human bladder cancer cell line.
Topics: Antineoplastic Agents, Alkylating; Cell Survival; Drug Resistance; Humans; Mitomycin; Mitomycins; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1997 |
Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Survival; Cisplatin; Colonic Neoplasms; Cross-Linking Reagents; DNA Damage; DNA, Neoplasm; Doxorubicin; Drug Resistance, Multiple; Female; Humans; K562 Cells; Liver Neoplasms; Mitomycin; Mitomycins; Neuroblastoma; Rats; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Verapamil | 1997 |
Studies on the mode of action of mitomycin C(7) aminoethylene disulfides (BMS-181174 and KW-2149): reactivity of 7-N-(mercaptoethyl)mitomycin C.
Topics: Antineoplastic Agents, Alkylating; Chromatography, High Pressure Liquid; Mitomycin; Mitomycins; Sulfhydryl Compounds | 1999 |
NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs.
Topics: Animals; Antineoplastic Agents; Aziridines; Benzopyrenes; Biotransformation; Cell Survival; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Cross-Linking Reagents; DNA, Complementary; Dose-Response Relationship, Drug; Hydroquinones; Indolequinones; Keratinocytes; Mice; Mice, Knockout; Mitomycin; Mitomycins; Quinone Reductases; Quinones; Transfection; Vitamin K 3 | 2006 |