Page last updated: 2024-08-16

mitomycin and bmy 25067

mitomycin has been researched along with bmy 25067 in 21 studies

Research

Studies (21)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (9.52)	18.7374
1990's	18 (85.71)	18.2507
2000's	1 (4.76)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Singh, SV; Xu, BH	1
Erlichman, C	1
Doyle, TW; Vyas, DM	1
Covey, JM; Dusre, L; Eliot, HM; Rajagopalan, S; Sinha, BK	1
Bradner, WT; Florczyk, AP; Rose, WC; Schurig, JE	1
Politi, PM; Rajagopalan, S; Sinha, BK	1
Schurig, JE; Stringfellow, DA	1
Kelley, M; Kemple, B; Rockwell, S	1
Emerson, EO; Gupta, V; Jani, JP; Singh, SV; Xu, BH; Zaren, HA	1
Gupta, V; Singh, SV; Xu, BH	1
Khan, S; O'Brien, PJ; Silva, JM	1
Kelley, M; Rockwell, S	1
Benson, PJ; Gupta, V; Hu, X; Pinto, T; Singh, S; Xia, H; Zaren, HA	1
Au, JL; Yen, WC	1
Bloom, SE; Muscarella, DE	1
Bleicher, RJ; Gupta, V; Hu, X; Singh, SV; Srivastava, SK; Xia, H; Zaren, HA	1
Ganesan, TS; Green, JA; Harris, AL; LaCreta, FP; Macaulay, VM; McKinley, L; O'Byrne, KJ; Philip, PA; Talbot, DC; Winograd, B	1
Blaxall, JR; Hamilton, JW; Ihnat, MA; La Ronde, N; Lariviere, JP; Pierre, KM; Turpie, BW; Warren, AJ	1
Kohn, H; Wang, S	1
de Boer-Dennert, M; Planting, AS; Schellens, JH; Stoter, G; van der Burg, ME; Verweij, J; Winograd, B	1
Celli, CM; Jaiswal, AK; Knox, R; Tran, N	1

Reviews

2 review(s) available for mitomycin and bmy 25067

Article	Year
Novel chemotherapeutic agents in clinical development. Current opinion in oncology, 1991, Volume: 3, Issue:6 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Camptothecin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Humans; Mitomycin; Mitomycins; Paclitaxel; Pyrazoles; Quinazolines; Thiophenes; Topotecan	1991
Second generation analogs of etoposide and mitomycin C. Cancer treatment reviews, 1990, Volume: 17, Issue:2-3 Topics: Animals; Antineoplastic Agents; Dogs; Drug Screening Assays, Antitumor; Etoposide; Humans; Mice; Mitomycin; Mitomycins; Organophosphorus Compounds	1990

Trials

2 trial(s) available for mitomycin and bmy 25067

Article	Year
Phase I study of the mitomycin C analogue BMS-181174. British journal of cancer, 1998, Volume: 77, Issue:11 Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Female; Heart; Humans; Kidney; Lung; Male; Middle Aged; Mitomycin; Mitomycins; Neoplasms; Thrombophlebitis	1998
Phase I and pharmacologic study of BMS-181174 given as a 6 h infusion every 4 weeks to patients with advanced solid tumors. Anti-cancer drugs, 1999, Volume: 10, Issue:9 Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Area Under Curve; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hematologic Diseases; Humans; Infusions, Intravenous; Male; Middle Aged; Mitomycin; Mitomycins; Neoplasm Staging; Neoplasms; Vascular Diseases	1999

Article

Year

Phase I study of the mitomycin C analogue BMS-181174.

British journal of cancer, 1998, Volume: 77, Issue:11

Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Female; Heart; Humans; Kidney; Lung; Male; Middle Aged; Mitomycin; Mitomycins; Neoplasms; Thrombophlebitis

1998

Phase I and pharmacologic study of BMS-181174 given as a 6 h infusion every 4 weeks to patients with advanced solid tumors.

Anti-cancer drugs, 1999, Volume: 10, Issue:9

Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Area Under Curve; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hematologic Diseases; Humans; Infusions, Intravenous; Male; Middle Aged; Mitomycin; Mitomycins; Neoplasm Staging; Neoplasms; Vascular Diseases

1999

Other Studies

17 other study(ies) available for mitomycin and bmy 25067

Article	Year
Effect of buthionine sulfoximine and ethacrynic acid on cytotoxic activity of mitomycin C analogues BMY 25282 and BMY 25067. Cancer research, 1992, Dec-01, Volume: 52, Issue:23 Topics: Animals; Buthionine Sulfoximine; DNA, Neoplasm; Drug Resistance; Drug Screening Assays, Antitumor; Ethacrynic Acid; Glutathione Transferase; Leukemia P388; Methionine Sulfoximine; Mitomycin; Mitomycins; Tumor Stem Cell Assay	1992
DNA interstrand cross-link and free radical formation in a human multidrug-resistant cell line from mitomycin C and its analogues. Cancer research, 1990, Feb-01, Volume: 50, Issue:3 Topics: Alkylating Agents; Cross-Linking Reagents; Dose-Response Relationship, Drug; Drug Resistance; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; In Vitro Techniques; Mitomycin; Mitomycins; Structure-Activity Relationship; Tumor Cells, Cultured	1990
Antitumor activity and toxicity in animals of N-7[2-(4-nitrophenyldithio) ethyl] mitomycin C (BMY-25067). Investigational new drugs, 1990, Volume: 8 Suppl 1 Topics: Animals; Antineoplastic Agents; Female; Injections, Intraperitoneal; Injections, Intravenous; Leukemia L1210; Leukemia P388; Male; Mice; Mice, Inbred BALB C; Mitomycin; Mitomycins	1990
Free-radical formation by mitomycin C and its novel analogs in cardiac microsomes and the perfused rat heart. Biochimica et biophysica acta, 1989, Sep-15, Volume: 992, Issue:3 Topics: Animals; Catalase; Electron Spin Resonance Spectroscopy; Free Radicals; Heart; Heart Rate; Hydroxides; Hydroxyl Radical; In Vitro Techniques; Kinetics; Male; Microsomes; Mitomycin; Mitomycins; Myocardium; Perfusion; Rats; Rats, Inbred Strains; Superoxides	1989
The search for more active and less toxic mitomycin and etoposide analogs. Cancer treatment reviews, 1987, Volume: 14, Issue:3-4 Topics: Animals; Antineoplastic Agents; Etoposide; Mice; Mitomycin; Mitomycins	1987
Cytotoxicity of BMS-181174. Effects of hypoxia, dicoumarol, and repair deficits. Biochemical pharmacology, 1995, Oct-12, Volume: 50, Issue:8 Topics: Animals; Antineoplastic Agents, Alkylating; Cell Hypoxia; Cell Line; Cell Survival; Cricetinae; Dicumarol; DNA Damage; Dose-Response Relationship, Drug; Mice; Mitomycin; Mitomycins; Tumor Cells, Cultured	1995
Characterization of a human bladder cancer cell line selected for resistance to BMY 25067, a novel analogue of mitomycin C. Cancer letters, 1995, Aug-16, Volume: 95, Issue:1-2 Topics: Antineoplastic Agents; Cell Cycle; Drug Resistance; Glutathione; Glutathione Transferase; Humans; In Vitro Techniques; Mitomycin; Mitomycins; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Tumor Cells, Cultured; Urinary Bladder Neoplasms	1995
Mechanism of differential sensitivity of human bladder cancer cells to mitomycin C and its analogue. British journal of cancer, 1994, Volume: 69, Issue:2 Topics: DNA, Neoplasm; Drug Resistance; Humans; Lipid Peroxidation; Mitomycin; Mitomycins; Tumor Cells, Cultured; Tumor Stem Cell Assay; Urinary Bladder Neoplasms	1994
Contrasting molecular cytotoxic mechanisms of mitomycin C and its two analogs, BMY 25282 and BMY 25067, in isolated rat hepatocytes. Biochemical pharmacology, 1993, Jun-09, Volume: 45, Issue:11 Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Dithiothreitol; Glutathione; Liver; Male; Mitomycin; Mitomycins; Oxidation-Reduction; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Substrate Cycling; Trypan Blue	1993
Interactions of BMS-181174 and radiation: studies with EMT6 cells in vitro and in solid tumors. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1996, Volume: 39, Issue:1 Topics: Aerobiosis; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Cell Hypoxia; Cell Survival; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Resistance, Neoplasm; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mitomycin; Mitomycins; Neoplasm Transplantation; Porfiromycin; Radiation-Sensitizing Agents; Radiotherapy Dosage; Skin Neoplasms; Specific Pathogen-Free Organisms; Tumor Cells, Cultured	1996
Lack of a role of glutathione in cellular nonenzymatic activation of BMS-181174, a novel analogue of mitomycin C. Cancer research, 1996, Aug-01, Volume: 56, Issue:15 Topics: Antineoplastic Agents, Alkylating; Biotransformation; Buthionine Sulfoximine; Cysteine; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Glutathione; Humans; Methionine Sulfoximine; Mitomycin; Mitomycins; Tumor Cells, Cultured; Urinary Bladder Neoplasms	1996
Pharmacodynamic evaluation of mitomycin C analog BMS-181174 for potential use in intravesical bladder cancer therapy. Pharmaceutical research, 1997, Volume: 14, Issue:2 Topics: Administration, Intravesical; Antineoplastic Agents, Alkylating; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Survival; Mitomycin; Mitomycins; Tumor Cells, Cultured; Urinary Bladder Neoplasms	1997
Involvement of gene-specific DNA damage and apoptosis in the differential toxicity of mitomycin C analogs towards B-lineage versus T-lineage lymphoma cells. Biochemical pharmacology, 1997, Mar-21, Volume: 53, Issue:6 Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cell Division; Chickens; DNA; DNA Damage; Lymphoma, B-Cell; Lymphoma, T-Cell; Mitomycin; Mitomycins; Tumor Cells, Cultured	1997
Characterization of a BMS-181174-resistant human bladder cancer cell line. British journal of cancer, 1997, Volume: 76, Issue:4 Topics: Antineoplastic Agents, Alkylating; Cell Survival; Drug Resistance; Humans; Mitomycin; Mitomycins; Tumor Cells, Cultured; Urinary Bladder Neoplasms	1997
Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents. Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:8 Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Survival; Cisplatin; Colonic Neoplasms; Cross-Linking Reagents; DNA Damage; DNA, Neoplasm; Doxorubicin; Drug Resistance, Multiple; Female; Humans; K562 Cells; Liver Neoplasms; Mitomycin; Mitomycins; Neuroblastoma; Rats; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Verapamil	1997
Studies on the mode of action of mitomycin C(7) aminoethylene disulfides (BMS-181174 and KW-2149): reactivity of 7-N-(mercaptoethyl)mitomycin C. Journal of medicinal chemistry, 1999, Mar-11, Volume: 42, Issue:5 Topics: Antineoplastic Agents, Alkylating; Chromatography, High Pressure Liquid; Mitomycin; Mitomycins; Sulfhydryl Compounds	1999
NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs. Biochemical pharmacology, 2006, Jul-28, Volume: 72, Issue:3 Topics: Animals; Antineoplastic Agents; Aziridines; Benzopyrenes; Biotransformation; Cell Survival; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Cross-Linking Reagents; DNA, Complementary; Dose-Response Relationship, Drug; Hydroquinones; Indolequinones; Keratinocytes; Mice; Mice, Knockout; Mitomycin; Mitomycins; Quinone Reductases; Quinones; Transfection; Vitamin K 3	2006