mitomycin has been researched along with apaziquone in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (75.00) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Adams, GE; Butler, S; Everett, SA; Jaffar, M; Naylor, MA; Nolan, J; Patel, KB; Stephens, MA; Stratford, IJ | 1 |
| Adams, GE; Carmichael, J; Houlbrook, S; Robertson, N; Stratford, IJ | 1 |
| Sugget, N; Walton, MI; Workman, P | 1 |
| Bibby, MC; Double, JA; Hulbert, PB; Phillips, RM; Sleigh, NR | 1 |
| Riley, RJ; Workman, P | 1 |
| Smith, PJ; Walton, MI; Workman, P | 1 |
| de Mol, NJ; Groot, SE; Janssen, LH; Maliepaard, M; Wolfs, A | 1 |
| Baas, P; Michielsen, C; Oppelaar, H; Stewart, FA; van Zandwijk, N | 1 |
| Plumb, JA; Workman, P | 1 |
| Camalier, R; Fitzsimmons, SA; Grever, M; Lewis, AD; Paull, K; Workman, P | 1 |
| Pritsos, C | 1 |
| Beall, HD; Gustafson, DL; Ross, D; Siegel, D; Traver, RD | 1 |
| Begleiter, A; Curphey, TJ; Leith, MK | 1 |
| Hall, EJ; Hei, TK; Liu, SX | 1 |
| Mikami, K; Shirakusa, T; Tsuruo, T | 1 |
| Boyer, MJ | 1 |
| Begleiter, A; Curphey, TJ; Doherty, GP; Leith, MK; Wang, X | 1 |
| Melo, T; Misra, V; Rauth, AM | 1 |
| Begleiter, A | 1 |
| Butler, J; Hargreaves, RH; Hartley, JA | 1 |
| Jansen, CF; Schalken, JA; van der Heijden, AG; Verhaegh, G; Witjes, JA | 1 |
| Celli, CM; Jaiswal, AK; Knox, R; Tran, N | 1 |
| Batista da Costa, J; Black, PC; Mannas, M; Nykopp, TK | 1 |
| Alsyouf, M; Groegler, J; Hu, B; Pierorazio, P | 1 |
8 review(s) available for mitomycin and apaziquone
| Article | Year |
|---|---|
DT-diaphorase and cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Aziridines; Benzoquinones; Dihydrolipoamide Dehydrogenase; Drug Design; Enzyme Induction; Gene Expression Regulation, Enzymologic; Humans; Indolequinones; Indoles; Mitomycin; Neoplasms; Precancerous Conditions; Tirapazamine; Triazines | 1992 |
Enzymology of bioreductive drug activation.
Topics: Animals; Antineoplastic Agents; Aziridines; Biotransformation; Indolequinones; Indoles; Mitomycin; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction | 1996 |
[DT-diaphorase].
Topics: Antibiotics, Antineoplastic; Aziridines; Colonic Neoplasms; Cytochrome Reductases; Cytochrome-B(5) Reductase; Drug Screening Assays, Antitumor; Humans; Indolequinones; Indoles; Mitomycin; Mitomycins; NAD(P)H Dehydrogenase (Quinone); NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Stomach Neoplasms; Tumor Cells, Cultured; Xanthine Dehydrogenase; Xanthine Oxidase | 1997 |
Bioreductive agents: a clinical update.
Topics: Antineoplastic Agents; Aziridines; Biotransformation; Clinical Trials as Topic; Humans; Indolequinones; Indoles; Mitomycin; Oxidation-Reduction; Tirapazamine; Triazines | 1997 |
Clinical applications of quinone-containing alkylating agents.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Aziridines; Benzoquinones; Clinical Trials as Topic; Drug Evaluation, Preclinical; History, 20th Century; Humans; Indolequinones; Indoles; Mitomycin; Neoplasms; Quinones; Structure-Activity Relationship | 2000 |
Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones.
Topics: Alkylation; Antineoplastic Agents, Alkylating; Aziridines; Benzimidazoles; Benzoquinones; Carbazilquinone; DNA; Doxorubicin; Humans; Indolequinones; Indoles; Mitomycin; Molecular Structure; Oxidation-Reduction; Quinones; Structure-Activity Relationship | 2000 |
Current Clinical Trials in Non-muscle Invasive Bladder Cancer.
Topics: Adjuvants, Immunologic; Administration, Intravesical; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Immunological; Aziridines; BCG Vaccine; Carcinoma, Transitional Cell; Chemotherapy, Adjuvant; Clinical Trials as Topic; Combined Modality Therapy; Humans; Indolequinones; Injections, Intradermal; Mitomycin; Muscle, Smooth; Neoplasm Invasiveness; Polysaccharides, Bacterial; Proteins; Recombinant Fusion Proteins; Tamoxifen; Typhoid-Paratyphoid Vaccines; Urinary Bladder Neoplasms; Urologic Surgical Procedures | 2018 |
Chemoablation in Urothelial Carcinoma: A Systematic Review and Future Perspectives.
Topics: Administration, Intravesical; Antineoplastic Agents; Aziridines; BCG Vaccine; Carcinoma, Transitional Cell; Clinical Trials as Topic; Cystoscopy; Deoxycytidine; Epirubicin; Ethanol; Forecasting; Gemcitabine; Humans; Indolequinones; Injections, Intralesional; Interferon-alpha; Interleukin-2; Mitomycin; Urinary Bladder Neoplasms; Urothelium | 2020 |
16 other study(ies) available for mitomycin and apaziquone
| Article | Year |
|---|---|
2-Cyclopropylindoloquinones and their analogues as bioreductively activated antitumor agents: structure-activity in vitro and efficacy in vivo.
Topics: Animals; Antineoplastic Agents; Biotransformation; Cell Hypoxia; Cell Line; Cricetinae; Magnetic Resonance Spectroscopy; Mice; Oxidation-Reduction; Quinones; Structure-Activity Relationship; Tumor Cells, Cultured | 1997 |
The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase?
Topics: Antineoplastic Agents; Aziridines; Dihydrolipoamide Dehydrogenase; Humans; Indolequinones; Indoles; Mitomycin; Oxidation-Reduction; Porfiromycin; Quinones; Tumor Cells, Cultured | 1992 |
The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.
Topics: Animals; Antineoplastic Agents; Aziridines; Carcinoma 256, Walker; Cell Hypoxia; Colonic Neoplasms; Humans; In Vitro Techniques; Indolequinones; Indoles; Mitomycin; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Prodrugs; Rats; Tirapazamine; Triazines | 1992 |
In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicity.
Topics: Animals; Antineoplastic Agents; Aziridines; Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; Indolequinones; Indoles; Mice; Mitomycin | 1992 |
The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9.
Topics: Animals; Antineoplastic Agents; Aziridines; Biotransformation; Carcinoma 256, Walker; Colonic Neoplasms; Dicumarol; DNA Damage; DNA, Bacterial; Humans; Indolequinones; Indoles; Kinetics; Mitomycin; Mitomycins; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Quinone Reductases; Quinones; Rats; Superoxide Dismutase; Tumor Cells, Cultured; Vitamin K | 1991 |
Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase.
Topics: Animals; Antineoplastic Agents; Aziridines; Biotransformation; Cross-Linking Reagents; Dicumarol; DNA; Indolequinones; Indoles; Liver; Male; Mitomycin; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Rats; Rats, Wistar; Xanthine Oxidase | 1995 |
Enhancement of interstitial photodynamic therapy by mitomycin C and EO9 in a mouse tumour model.
Topics: Animals; Antineoplastic Agents; Aziridines; Combined Modality Therapy; Drug Screening Assays, Antitumor; Female; Indolequinones; Indoles; Mice; Mice, Inbred C3H; Mitomycin; Neoplasms, Experimental; Photochemotherapy | 1994 |
Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.
Topics: Aerobiosis; Antineoplastic Agents; Aziridines; Cell Hypoxia; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Indolequinones; Indoles; Mitomycin; NAD(P)H Dehydrogenase (Quinone); Tumor Cells, Cultured | 1994 |
Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9.
Topics: Antineoplastic Agents; Aziridines; Cytochrome Reductases; Cytochrome-B(5) Reductase; Humans; Indolequinones; Indoles; Mitomycin; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Neoplasms; Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 1996 |
Re: Reductase enzyme expression across the National Cancer Institute tumor cell line panel: correlation with sensitivity to mitomycin C and E09.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Aziridines; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Indolequinones; Indoles; Mitomycin; National Institutes of Health (U.S.); Oxidoreductases; Tumor Cells, Cultured; United States | 1996 |
Induction of DT-diaphorase by 1,2-dithiole-3-thione and increase of antitumour activity of bioreductive agents.
Topics: Animals; Antineoplastic Agents; Aziridines; Biotransformation; Enzyme Induction; Indolequinones; Indoles; Lymphoma; Mice; Mice, Inbred DBA; Mitomycin; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Thiones; Thiophenes; Tumor Cells, Cultured | 1996 |
Oncogenic potential of bifunctional bioreductive drugs.
Topics: Animals; Antineoplastic Agents; Aziridines; Cell Survival; Cell Transformation, Neoplastic; Indolequinones; Indoles; Mice; Mice, Inbred C3H; Mitomycin; Oxidation-Reduction; Pyrazines; Structure-Activity Relationship | 1996 |
Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents.
Topics: Antineoplastic Agents; Aziridines; Bone Marrow; Cell Survival; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Induction; Humans; Indolequinones; Indoles; Kidney; Lung; Mitomycin; NAD(P)H Dehydrogenase (Quinone); Thiones; Thiophenes; Tumor Cells, Cultured | 1998 |
Bioreductive therapies: an overview of drugs and their mechanisms of action.
Topics: Animals; Antineoplastic Agents; Aziridines; Cell Hypoxia; DNA, Neoplasm; Forecasting; Humans; Indolequinones; Indoles; Misonidazole; Mitomycin; Nitrofurans; Nitroimidazoles; Oxidation-Reduction; Prodrugs; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 1998 |
Effect of hyperthermia on the cytotoxicity of 4 chemotherapeutic agents currently used for the treatment of transitional cell carcinoma of the bladder: an in vitro study.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aziridines; Carcinoma, Transitional Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coloring Agents; Combined Modality Therapy; Deoxycytidine; Epirubicin; Gemcitabine; Humans; Hyperthermia, Induced; Indolequinones; Mitomycin; Tetrazolium Salts; Thiazoles; Urinary Bladder Neoplasms | 2005 |
NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs.
Topics: Animals; Antineoplastic Agents; Aziridines; Benzopyrenes; Biotransformation; Cell Survival; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Cross-Linking Reagents; DNA, Complementary; Dose-Response Relationship, Drug; Hydroquinones; Indolequinones; Keratinocytes; Mice; Mice, Knockout; Mitomycin; Mitomycins; Quinone Reductases; Quinones; Transfection; Vitamin K 3 | 2006 |