mitobronitol has been researched along with gamma-cyclodextrin* in 1 studies
1 other study(ies) available for mitobronitol and gamma-cyclodextrin
Article | Year |
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Charge-transfer chromatographic study of the complex formation of some anticancer drugs with gamma-cyclodextrin.
The interaction between 23 anticancer drugs and gamma-cyclodextrin (gamma-CD) was studied by reversed-phase charge-transfer thin-layer chromatography and the relative strength of interaction was calculated. gamma-CD formed inclusion complexes with 14 compounds, the complex always being more or less hydrophobic than the uncomplexed drug. The inclusion-forming capacity of a drug differed considerably depending on its chemical structure. The linear correlation between the hydrophobicity and the specific hydrophobic surface area of anticancer drugs indicated that they can be considered a homologous series of compounds, although their chemical structures are highly different. Topics: Antineoplastic Agents; Carboplatin; Chromatography; Cyclodextrins; gamma-Cyclodextrins; Mesylates; Mitobronitol; Structure-Activity Relationship | 1995 |