mitiglinide has been researched along with glyburide in 17 studies
| Studies (mitiglinide) | Trials (mitiglinide) | Recent Studies (post-2010) (mitiglinide) | Studies (glyburide) | Trials (glyburide) | Recent Studies (post-2010) (glyburide) |
|---|---|---|---|---|---|
| 120 | 30 | 50 | 6,554 | 620 | 1,344 |
| Protein | Taxonomy | mitiglinide (IC50) | glyburide (IC50) |
|---|---|---|---|
| ATP-binding cassette sub-family C member 9 | Homo sapiens (human) | 0.22 | |
| Bile salt export pump | Rattus norvegicus (Norway rat) | 5.7 | |
| Bile salt export pump | Homo sapiens (human) | 5.5333 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 1.602 | |
| ATP-binding cassette sub-family C member 8 | Homo sapiens (human) | 0.0043 | |
| ATP-sensitive inward rectifier potassium channel 11 | Homo sapiens (human) | 0.1121 | |
| NACHT, LRR and PYD domains-containing protein 3 | Mus musculus (house mouse) | 10 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 1.8 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Kojima, I; Miyazaki, J; Mogami, H; Nobusawa, R; Ohnota, H; Satou, F; Shibata, H | 1 |
| Inoue, S; Kobayashi, M; Koizumi, T; Ohnota, H; Sato, F; Tsutsumi, N | 1 |
| Brasseur, R; Lins, L; Malaisse, WJ | 1 |
| Cai, Z; Lansdell, KA; Sheppard, DN | 1 |
| Dard-Brunelle, B; Malaisse, WJ | 1 |
| Gonoi, T; Ichikawa, K; Kusama, H; Seino, S; Shibasaki, T; Sunaga, Y; Yano, H | 1 |
| Ichikawa, K; Kojima, M; Kusama, H; Maruyama, K; Murakami, M; Tsuji, A; Yamato, T | 1 |
| Ichikawa, K; Kojima, M; Kusama, H; Ojima, K; Tsuji, A; Yamato, T | 1 |
| Ambrosi, F; Boemi, M; Carle, F; Filipponi, P; Gregorio, F | 1 |
| Kobayashi, K; Kobayashi, M; Kojima, M; Maruyama, I; Maruyama, K; Ojima, K; Shibata, N; Tomiyama, Y; Yamazaki, Y | 1 |
| Aoyagi, I; Fujimori, Y; Fuujimori, Y; Itoh, Y; Kojima, M; Kojima, S; Kusama, H; Mori, Y; Ojima, K; Shibata, N; Tajima, N; Yamazaki, Y | 1 |
| Kikuta, T; Nagamatsu, S; Nakamichi, Y; Nishiwaki, C; Ohara-Imaizumi, M | 1 |
| Abdelmoneim, AS; Brocks, DR; Hasenbank, SE; Light, PE; Seubert, JM; Simpson, SH | 1 |
| Fatehi, M; Lang, VY; Light, PE | 1 |
| Arimitsu, K; Fujimoto, H; Inagaki, N; Kimura, H; Matsuda, H; Mukai, E; Nakamura, H; Ogawa, Y; Ono, M; Saji, H; Takagi, M; Toyoda, K | 1 |
| Akahane, K; Inoue, T; Kiguchi, S; Kobayashi, M; Ojima, K; Takeda, H; Tatemichi, S; Yokoyama, A | 1 |
1 review(s) available for mitiglinide and glyburide
| Article | Year |
|---|---|
Variations in tissue selectivity amongst insulin secretagogues: a systematic review.
Topics: Animals; ATP-Binding Cassette Transporters; Carbamates; Cardiovascular Diseases; Cricetinae; Cyclohexanes; Diabetes Mellitus, Type 2; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Ischemic Preconditioning, Myocardial; Isoindoles; Mice; Muscle, Smooth, Vascular; Myocytes, Cardiac; Nateglinide; Phenylalanine; Piperidines; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Risk Factors; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide | 2012 |
16 other study(ies) available for mitiglinide and glyburide
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Inhibition of ATP-sensitive K+ channel by a non-sulfonylurea compound KAD-1229 in a pancreatic beta-cell line, MIN 6 cell.
Topics: Action Potentials; Adenosine Triphosphate; Binding, Competitive; Calcium; Cell Membrane; Cobalt; Dose-Response Relationship, Drug; Drug Synergism; Fura-2; Glucose; Glyburide; Humans; Hypoglycemic Agents; Indoles; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Isoindoles; Membrane Potentials; Nifedipine; Pancreatic Neoplasms; Patch-Clamp Techniques; Potassium Channel Blockers; Tumor Cells, Cultured | 1994 |
Novel rapid- and short-acting hypoglycemic agent, a calcium(2s)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) that acts on the sulfonylurea receptor: comparison of effects between KAD-1229 and gliclazide.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Biological Transport; Cells, Cultured; Dogs; Gliclazide; Glyburide; Hypoglycemic Agents; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Isoindoles; Male; Mice; Mice, Inbred ICR; Microsomes; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rubidium; Sulfonylurea Receptors | 1994 |
Conformational analysis of non-sulfonylurea hypoglycemic agents of the meglitinide family.
Topics: Benzamides; Carbamates; Cyclohexanes; Drug Design; Glyburide; Hypoglycemic Agents; Indoles; Isoindoles; Molecular Conformation; Nateglinide; Phenylalanine; Piperidines; Stereoisomerism; Structure-Activity Relationship; Sulfonylurea Compounds | 1995 |
Inhibition of heterologously expressed cystic fibrosis transmembrane conductance regulator Cl- channels by non-sulphonylurea hypoglycaemic agents.
Topics: Adenosine Triphosphate; Animals; Benzamides; Carbamates; Cell Line; Chloride Channels; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Electric Conductivity; Epithelial Cells; Glyburide; Humans; Hypoglycemic Agents; Indoles; Ion Channel Gating; Isoindoles; Kinetics; Mice; Patch-Clamp Techniques; Piperidines; Sulfonylurea Compounds; Transfection | 1999 |
Binding of tritiated S21403 to an artificial phospholipid bilayer.
Topics: Binding, Competitive; Glyburide; Hypoglycemic Agents; Indoles; Isoindoles; Lipid Bilayers; Liposomes; Phosphatidylcholines; Temperature; Time Factors; Tritium | 1999 |
The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide.
Topics: Animals; ATP-Binding Cassette Transporters; Cell Line; COS Cells; Cyclohexanes; Glyburide; Hypoglycemic Agents; Indoles; Insulin; Isoindoles; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide; Transfection | 2001 |
Absence of exacerbation of myocardial stunning in anesthetized dogs treated with KAD-1229, a novel hypoglycemic agent.
Topics: Animals; ATP-Binding Cassette Transporters; Binding, Competitive; Coronary Circulation; Dogs; Electrocardiography; Glyburide; Heart; Hemodynamics; Hypoglycemic Agents; Indoles; Isoindoles; Myocardial Reperfusion; Myocardial Stunning; Myocardium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors | 2001 |
Study of the insulinotropic effect of the novel antihyperglycemic agent KAD-1229 using HIT T15 cells, a hamster's insulinoma cell line.
Topics: Animals; Calcium Channel Blockers; Cell Line; Cell Membrane; Cricetinae; Glucose; Glyburide; Hypoglycemic Agents; Indoles; Insulin; Insulinoma; Islets of Langerhans; Isoindoles; Pancreatic Neoplasms; Potassium Channels; Rubidium Radioisotopes | 2002 |
Effects of S 21403 on hormone secretion from isolated rat pancreas at different glucose concentrations.
Topics: Animals; Carbamates; Dose-Response Relationship, Drug; Glucose; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Indoles; Insulin; Insulin Secretion; Isoindoles; Male; Pancreas; Piperidines; Rats; Rats, Sprague-Dawley; Time Factors | 2002 |
Effects of mitiglinide and sulfonylureas in isolated canine coronary arteries and perfused rat hearts.
Topics: Animals; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Glyburide; Heart; Hypoglycemic Agents; In Vitro Techniques; Indoles; Isoindoles; Male; Myocardial Reperfusion Injury; Perfusion; Rats; Rats, Wistar; Sulfonylurea Compounds; Time Factors; Vasodilation; Vasodilator Agents | 2006 |
Effects of mitiglinide on glucose-induced insulin release into the portal vein and fat-induced triglyceride elevation in prediabetic and diabetic OLETF rats.
Topics: Adipose Tissue; Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Glyburide; Indoles; Insulin; Insulin Secretion; Isoindoles; Lipoprotein Lipase; Male; Nateglinide; Phenylalanine; Portal Vein; Postprandial Period; Prediabetic State; Rats; Rats, Inbred OLETF; RNA, Messenger; Sulfonylurea Compounds; Triglycerides | 2006 |
Imaging docking and fusion of insulin granules induced by antidiabetes agents: sulfonylurea and glinide drugs preferentially mediate the fusion of newcomer, but not previously docked, insulin granules.
Topics: Animals; ATP-Binding Cassette Transporters; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Image Processing, Computer-Assisted; Indoles; Insulin; Insulin-Secreting Cells; Isoindoles; Male; Membrane Fusion; Mice; Mice, Knockout; Microscopy, Fluorescence; Multidrug Resistance-Associated Proteins; Potassium Channels, Inwardly Rectifying; Rats; Rats, Mutant Strains; Rats, Wistar; Receptors, Drug; Sulfonylurea Receptors | 2006 |
Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A.
Topics: ATP-Binding Cassette Transporters; Chlorpropamide; Cyclohexanes; Diabetes Mellitus, Type 2; Gene Expression Regulation; Gliclazide; Glyburide; Haplotypes; Homozygote; Humans; Isoindoles; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Polymorphism, Single Nucleotide; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Structure-Activity Relationship; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide | 2012 |
Synthesis and evaluation of 18F-labeled mitiglinide derivatives as positron emission tomography tracers for β-cell imaging.
Topics: Animals; Dose-Response Relationship, Drug; Fluorine Radioisotopes; Glyburide; Insulin-Secreting Cells; Isoindoles; Mice; Mice, Inbred Strains; Molecular Structure; Positron-Emission Tomography; Structure-Activity Relationship; Tissue Distribution | 2014 |
Comparison of the Effects of Mitiglinide and Glibenclamide Administered in Combination with the Dipeptidyl Peptidase-IV Inhibitor Sitagliptin in Rats with Streptozotocin-Nicotinamide-Induced Type 2 Diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Synergism; Glucose Tolerance Test; Glyburide; Isoindoles; Male; Rats; Sitagliptin Phosphate | 2017 |