misonidazole has been researched along with tirapazamine in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.53) | 18.7374 |
| 1990's | 15 (78.95) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stratford, IJ | 1 |
| Chaplin, DJ | 1 |
| Durand, RE; Olive, PL | 1 |
| Adams, GE; Bremner, JC; Cole, S; Edwards, HS; Stratford, IJ | 1 |
| Hall, EJ; He, ZY; Hei, TK; Piao, CQ | 1 |
| Bridges, JM; Lappin, TR; MacManus, MP; McAleer, JJ; McKeown, SR | 1 |
| Adams, GE; Bowler, J; Bremner, JC; Stratford, IJ | 1 |
| Adams, GE; Godden, J; Keohane, A; Stratford, IJ | 1 |
| Kennedy, KA | 1 |
| Baker, MA; Brown, JM; Hirst, VK; Zeman, EM | 1 |
| Olive, PL | 1 |
| Koch, CJ | 1 |
| Stratford, IJ; Workman, P | 1 |
| Giuliano, J; Lee, DJ; Moini, M; Westra, WH | 1 |
| Chinje, EC; Harris, AL; Patterson, AV; Saunders, MP; Strafford, IJ; Talbot, DC | 1 |
| Melo, T; Misra, V; Rauth, AM | 1 |
| Fuchs, T; Gates, KS; Greenberg, MM; Hwang, JT | 1 |
| D'Costa, I; Fisher, R; Hart, R; Hicks, R; Hughes, P; Peters, L; Rischin, D; Sexton, M; von Roemeling, R | 1 |
| Binns, D; Corry, J; Fisher, R; Hicks, RJ; Peters, LJ; Porceddu, S; Rischin, D | 1 |
4 review(s) available for misonidazole and tirapazamine
| Article | Year |
|---|---|
Bioreductive drugs in cancer therapy.
Topics: Animals; Antineoplastic Agents; Antioxidants; Cell Hypoxia; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Prodrugs; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 1992 |
Hypoxic cells as specific drug targets for chemotherapy.
Topics: Animals; Antineoplastic Agents; DNA Damage; DNA Repair; Humans; Misonidazole; Mitomycin; Mitomycins; Oxygen; Tirapazamine; Triazines | 1987 |
The experimental development of bioreductive drugs and their role in cancer therapy.
Topics: Animals; Antineoplastic Agents; Aziridines; Combined Modality Therapy; DNA Damage; Humans; Indolequinones; Indoles; Misonidazole; Neoplasms; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 1993 |
Hypoxic sensitizer and cytotoxin for head and neck cancer.
Topics: Animals; Antineoplastic Agents; Carcinoma; Cell Hypoxia; Clinical Trials as Topic; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Etanidazole; Head and Neck Neoplasms; Humans; Hyperbaric Oxygenation; Mice; Microelectrodes; Misonidazole; Oxygen Consumption; Radiation Tolerance; Radiation-Sensitizing Agents; Survival Rate; Tirapazamine; Treatment Outcome; Triazines | 1996 |
2 trial(s) available for misonidazole and tirapazamine
| Article | Year |
|---|---|
Phase I trial of concurrent tirapazamine, cisplatin, and radiotherapy in patients with advanced head and neck cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cell Hypoxia; Cisplatin; Combined Modality Therapy; Dose Fractionation, Radiation; Drug Administration Schedule; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans; Middle Aged; Misonidazole; Radiation-Sensitizing Agents; Radiopharmaceuticals; Survival Analysis; Tirapazamine; Tomography, Emission-Computed; Triazines | 2001 |
Prognostic significance of [18F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: a substudy of Trans-Tasman Radiation Oncolog
Topics: Cell Hypoxia; Combined Modality Therapy; Female; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans; Male; Middle Aged; Misonidazole; Positron-Emission Tomography; Prognosis; Tirapazamine; Treatment Failure; Triazines | 2006 |
13 other study(ies) available for misonidazole and tirapazamine
| Article | Year |
|---|---|
Bioreductive therapy.
Topics: Antineoplastic Agents; Cell Hypoxia; Humans; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Prodrugs; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 1992 |
Evaluation of bioreductive drugs in multicell spheroids.
Topics: Animals; Antineoplastic Agents; Cell Aggregation; Cell Hypoxia; Cell Survival; Cricetinae; Evaluation Studies as Topic; In Vitro Techniques; Misonidazole; Mitomycin; Models, Biological; Nitrofurans; Porfiromycin; Prodrugs; Tirapazamine; Triazines | 1992 |
Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9.
Topics: Animals; Antineoplastic Agents; Aziridines; Cell Hypoxia; Cell Survival; Combined Modality Therapy; Dose-Response Relationship, Drug; Indolequinones; Indoles; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Prodrugs; Tirapazamine; Triazines | 1992 |
Mechanism of oncogenicity for bioreductive drugs.
Topics: Animals; Antineoplastic Agents; Aziridines; Cell Hypoxia; Cell Line; Cell Transformation, Neoplastic; Mice; Misonidazole; Neoplasms, Second Primary; Nitrofurans; Prodrugs; Radiation-Sensitizing Agents; Risk; Tirapazamine; Triazines | 1992 |
Hypobaric hypoxia: a method for testing bioreductive drugs in vivo.
Topics: Animals; Biotransformation; Cell Hypoxia; Dose-Response Relationship, Drug; Mammary Neoplasms, Experimental; Mechlorethamine; Mice; Mice, Inbred Strains; Misonidazole; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 1992 |
Bioreductive drugs and the selective induction of tumour hypoxia.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Constriction; Hydralazine; Mice; Mice, Inbred C3H; Misonidazole; Mitomycin; Mitomycins; Radiation-Sensitizing Agents; Sarcoma, Experimental; Tirapazamine; Triazines | 1990 |
The effects of three bioreductive drugs (mitomycin C, RSU-1069 and SR4233) on cell lines selected for their sensitivity to mitomycin C or ionising radiation.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line; Cell Survival; Misonidazole; Mitomycin; Mitomycins; Radiation Tolerance; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 1990 |
Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Cricetinae; Female; Free Radicals; Glutathione; Misonidazole; Ovary; Oxygen; Oxygen Consumption; Thiobarbiturates; Tirapazamine; Triazines | 1988 |
Use of the comet assay to detect hypoxic cells in murine tumours and normal tissues exposed to bioreductive drugs.
Topics: Aerobiosis; Animals; Antineoplastic Agents; Bone Marrow; Carcinoma, Squamous Cell; Cell Hypoxia; DNA Damage; DNA, Single-Stranded; Dose-Response Relationship, Radiation; Electrophoresis, Agar Gel; Hydrogen-Ion Concentration; Male; Mice; Mice, Inbred C3H; Misonidazole; Organ Specificity; Oxidation-Reduction; Radiation-Sensitizing Agents; Spleen; Tirapazamine; Triazines | 1995 |
Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin.
Topics: Animals; Cell Hypoxia; Cell Line; Cricetinae; Cricetulus; Fibroblasts; Misonidazole; Oxygen; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 1993 |
Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069.
Topics: Antineoplastic Agents; Breast Neoplasms; Female; Humans; Misonidazole; NADPH-Ferrihemoprotein Reductase; Radiation-Sensitizing Agents; Tirapazamine; Transfection; Triazines; Tumor Cells, Cultured | 1997 |
Bioreductive therapies: an overview of drugs and their mechanisms of action.
Topics: Animals; Antineoplastic Agents; Aziridines; Cell Hypoxia; DNA, Neoplasm; Forecasting; Humans; Indolequinones; Indoles; Misonidazole; Mitomycin; Nitrofurans; Nitroimidazoles; Oxidation-Reduction; Prodrugs; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 1998 |
Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1'-radical in single-stranded and double-stranded DNA: the drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions.
Topics: Antineoplastic Agents; Antioxidants; Cell Hypoxia; Cyclic N-Oxides; DNA; DNA Damage; DNA, Single-Stranded; Free Radicals; Misonidazole; Reactive Oxygen Species; Sugar Acids; Tirapazamine; Triazines | 1999 |