Page last updated: 2024-08-22

misonidazole and melphalan

misonidazole has been researched along with melphalan in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	39 (95.12)	18.7374
1990's	2 (4.88)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
DeGraff, WG; Friedman, N; Mitchell, JB; Russo, A	1
Siemann, DW	2
Hickson, ID; Robson, CN; Stephens, M; Stratford, IJ	1
Berger, NA; Creger, RJ; Lazarus, HM; Spitzer, TR	1
Brown, JM; Horsman, MR; Wood, PJ	1
Artim, RA; Carlson, RW; Coleman, CN; Gribble, M; Halsey, J; Kohler, M; Lawrence, HJ; Sampson, WI; Sikic, BI; Wong, P	1
Roizin-Towle, L	1
Adams, GE; Godden, J; Howells, N; Nolan, J; Stratford, IJ; Timpson, N	1
Denekamp, J; Murray, JC; Randhawa, V	1
Noker, PE; Simpson-Herren, L; Wagoner, SD	1
Hall, EJ; Pirro, JP; Roizin-Towle, L	1
Denekamp, J; Randhawa, VS; Stewart, FA; Stratford, MR	1
Hall, EJ; Roizin-Towle, LA	1
Hall, EJ; Miller, RC; Osmak, R; Zimmerman, M	1
Coombs, A; Hanson, J; Moore, JL	1
Brown, JM	1
Kehrberg, G; Moldenhauer, H; Rose, H; Saul, G; Wolf, G	1
Hinchliffe, M; McNally, NJ	1
McNally, NJ	1
Brown, JM; Evans, JW; Horsman, MR	1
Clarke, C; Dawson, KB; Sheldon, PW; Simmons, DJ; Simpson, W	1
Biaglow, JE; Costello, T; Hall, EJ; Roizin-Towle, L; Varnes, ME	1
Brown, JM; Hsu, B; Sawyer, JM; Taylor, YC	1
Adams, GE; Ahmed, I; Sheldon, PW; Stratford, IJ	1
Maddison, K; Siemann, DW; Wolf, K	1
Hinchliffe, M; McNally, NJ; Stratford, MR	1
Meyn, RE; Murray, D	1
Jinks, S; Millar, BC	1
Brown, JM; Evans, JW; Taylor, YC	1
Twentyman, PR; Workman, P	1
de Ronde, J; Hinchliffe, M; McNally, NJ	1
Carter, SK; Coleman, CN; Friedman, MK; Gribble, M; Halsey, J; Hirst, VK; Ignoffo, R; Jacobs, C; Leibel, S; Phillips, TL	1
Adams, GE	1
Twentyman, P; Workman, P	1
Clutterbuck, RD; McElwain, TJ; Millar, JL	1
Brown, JM; Hirst, DG	1
Adams, GE; Smith, E; Stratford, IJ	1
Adams, GE; Horsman, MR; Kandaiya, S; Rajaratnam, S; Smith, E; Stratford, IJ; Williamson, C	1
De Ronde, J; Martin, WM; McNally, NJ	1
Catane, R; Clement, JJ; Gorman, MS; Johnson, RK; Wodinsky, I	1

Reviews

3 review(s) available for misonidazole and melphalan

Article	Year
[Intensification of cytostatic action by radiosensitizers--a review of the present status of chemosensitization]. Radiobiologia, radiotherapia, 1984, Volume: 25, Issue:2 Topics: Alkylating Agents; Animals; Antineoplastic Agents; Chlorambucil; Cisplatin; Cricetinae; Cyclophosphamide; Doxorubicin; Etanidazole; Lomustine; Melphalan; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents	1984
Modification of chemotherapy by nitroimidazoles. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Animals; Antineoplastic Agents; Cyclophosphamide; DNA Repair; Drug Synergism; Glutathione; Lomustine; Melphalan; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Time Factors	1984
Hypoxia-mediated drugs for radiation and chemotherapy. Cancer, 1981, Aug-01, Volume: 48, Issue:3 Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Electrons; Humans; Melphalan; Mice; Misonidazole; Neoplasms; Oxygen; Radiation-Sensitizing Agents; Radiotherapy Dosage; Structure-Activity Relationship; Technology, Pharmaceutical	1981

Trials

1 trial(s) available for misonidazole and melphalan

Article	Year
Enhancement of the clinical activity of melphalan by the hypoxic cell sensitizer misonidazole. Cancer research, 1988, Jun-15, Volume: 48, Issue:12 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Melphalan; Middle Aged; Misonidazole	1988

Other Studies

37 other study(ies) available for misonidazole and melphalan

Article	Year
Misonidazole hypoxic cytotoxicity and chemosensitization in two cell lines with different intracellular glutathione levels. European journal of cancer (Oxford, England : 1990), 1990, Volume: 26, Issue:1 Topics: Animals; Cell Line; Cricetinae; Cricetulus; Drug Screening Assays, Antitumor; Glutathione; Humans; Melphalan; Misonidazole; Oxygen; Tumor Cells, Cultured	1990
Enhancement of chemotherapy and nitroimidazole-induced chemopotentiation by the vasoactive agent hydralazine. British journal of cancer, 1990, Volume: 62, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Hypoxia; Cyclophosphamide; Drug Synergism; Female; Hydralazine; Lomustine; Melphalan; Mice; Mice, Inbred C3H; Misonidazole; Sarcoma, Experimental; Stem Cells	1990
Radiosensitizing and cytotoxic effects of nitroimidazoles in CHO cells expressing elevated levels of glutathione-S-transferase. International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:5 Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Etanidazole; Glutathione Transferase; Melphalan; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents	1989
High-dose melphalan, misonidazole, and autologous bone marrow transplantation for the treatment of metastatic colorectal carcinoma. A phase I study. American journal of clinical oncology, 1989, Volume: 12, Issue:2 Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Humans; Male; Melphalan; Middle Aged; Misonidazole; Neoplasm Metastasis; Rectal Neoplasms; Remission Induction	1989
Misonidazole chemosensitization of EMT6 spheroids to melphalan. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1989, Volume: 15, Issue:1 Topics: Animals; Cell Line; Cell Survival; Drug Synergism; In Vitro Techniques; Melphalan; Mice; Misonidazole; Oxygen; Tumor Cells, Cultured	1989
Selective enhancement of hypoxic cell killing by melphalan via thiol depletion: in vitro studies with hypoxic cell sensitizers and buthionine sulfoximine. Journal of the National Cancer Institute, 1985, Volume: 74, Issue:1 Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Cricetinae; Cricetulus; Drug Synergism; Etanidazole; Melphalan; Methionine Sulfoximine; Misonidazole; Nitroimidazoles; Oxygen; Sulfhydryl Compounds	1985
Potentiation of the anti-tumour effect of melphalan by the vasoactive agent, hydralazine. British journal of cancer, 1988, Volume: 58, Issue:2 Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Hydralazine; Male; Melphalan; Mice; Mice, Inbred C3H; Misonidazole; Oxygen Consumption; Sarcoma, Experimental; Time Factors	1988
The effects of melphalan and misonidazole on the vasculature of a murine sarcoma. British journal of cancer, 1987, Volume: 55, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Basement Membrane; Benzimidazoles; Blood Vessels; Fluorescent Antibody Technique; Fluorescent Dyes; Melphalan; Mice; Mice, Inbred Strains; Misonidazole; Sarcoma, Experimental	1987
Distribution of nitroimidazoles and L-phenylalanine mustard in mammary adenocarcinoma 16/C tumors. Cancer chemotherapy and pharmacology, 1987, Volume: 20, Issue:3 Topics: Adenocarcinoma; Animals; Female; Lissamine Green Dyes; Mammary Neoplasms, Experimental; Melphalan; Metronidazole; Mice; Misonidazole; Nitroimidazoles; Time Factors	1987
Oxygen dependence for chemosensitization by misonidazole. British journal of cancer, 1986, Volume: 54, Issue:6 Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Drug Synergism; Melphalan; Misonidazole; Oxygen	1986
Factors influencing the chemosensitization of melphalan by misonidazole. British journal of cancer, 1985, Volume: 51, Issue:2 Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fibrosarcoma; Kinetics; Melphalan; Mice; Mice, Inbred Strains; Misonidazole; Nitroimidazoles; Temperature	1985
Enhanced cytotoxicity of antineoplastic agents following prolonged exposure to misonidazole. British journal of cancer, 1981, Volume: 44, Issue:2 Topics: Animals; Antineoplastic Agents; Bleomycin; Cell Line; Cell Survival; Cisplatin; Cricetinae; Cricetulus; Drug Synergism; Melphalan; Misonidazole; Nitroimidazoles; Oxygen	1981
Comparison of the incidence of oncogenic transformation produced by X rays, misonidazole, and chemotherapy agents. Radiology, 1982, Volume: 145, Issue:2 Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Cisplatin; Doxorubicin; Fibroblasts; In Vitro Techniques; Melphalan; Mice; Misonidazole; Nitroimidazoles; Radiation, Ionizing; Vincristine; X-Rays	1982
Drug testing using a soft agar stem cell assay on patient and xenograft tumor material. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Animals; Antineoplastic Agents; Bleomycin; Cisplatin; Colony-Forming Units Assay; Drug Synergism; Etoposide; Female; Granulosa Cell Tumor; Humans; Melphalan; Methotrexate; Mice; Misonidazole; Neoplasm Transplantation; Neoplasms; Ovarian Neoplasms; Transplantation, Heterologous; Tumor Stem Cell Assay; Vinblastine	1984
Clinical perspectives for the use of new hypoxic cell sensitizers. International journal of radiation oncology, biology, physics, 1982, Volume: 8, Issue:9 Topics: Animals; Cyclophosphamide; Dogs; Drug Therapy, Combination; Etanidazole; Humans; Melphalan; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Solubility	1982
A comparison of the ability of some radiosensitizers undergoing clinical trials to act as chemosensitizers. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Etanidazole; Fibrosarcoma; Melphalan; Mice; Mice, Inbred CBA; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents	1984
The effect of misonidazole combined with WR2721 on tumour response and leucopenia due to cyclophosphamide or melphalan. British journal of cancer, 1982, Volume: 46, Issue:4 Topics: Amifostine; Animals; Cell Survival; Cyclophosphamide; Drug Therapy, Combination; Leukopenia; Melphalan; Mice; Mice, Inbred Strains; Misonidazole; Nitroimidazoles; Organothiophosphorus Compounds; Sarcoma, Experimental	1982
Enhancement of melphalan-induced tumour cell killing by misonidazole: an interaction of competing mechanisms. British journal of cancer, 1984, Volume: 50, Issue:3 Topics: Animals; Body Temperature; Cell Survival; Drug Synergism; Female; Kinetics; Melphalan; Metabolic Clearance Rate; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Sarcoma, Experimental; Time Factors	1984
Intestinal microflora as potential modifiers of sensitizer activity in vivo. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:8 Topics: Animals; Bacteria; Body Temperature; Combined Modality Therapy; Drug Synergism; Female; Intestines; Lung Neoplasms; Melphalan; Mice; Misonidazole; Nitroimidazoles; Penicillins; Radiation-Sensitizing Agents	1984
Chemosensitization: do thiols matter? International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Synergism; Melphalan; Methionine Sulfoximine; Misonidazole; Oxygen; Radiation-Sensitizing Agents; Sulfhydryl Compounds	1984
Mechanism of melphalan crosslink enhancement by misonidazole pretreatment. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA; Dose-Response Relationship, Drug; Drug Synergism; Melphalan; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents	1984
Radiation sensitization and chemopotentiation: RSU 1069, a compound more efficient than misonidazole in vitro and in vivo. British journal of cancer, 1984, Volume: 49, Issue:5 Topics: Animals; Aziridines; Azirines; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Drug Synergism; Female; Melphalan; Mice; Mice, Inbred Strains; Misonidazole; Neoplasms, Experimental; Oxygen; Radiation-Sensitizing Agents	1984
Potentiation of melphalan activity in the KHT sarcoma by the radiosensitizer RSU 1069. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Animals; Aziridines; Azirines; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Melphalan; Mice; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Time Factors	1984
The effect of radiosensitizers on the pharmacokinetics of melphalan and cyclophosphamide in the mouse. British journal of cancer, 1983, Volume: 48, Issue:3 Topics: Animals; Body Temperature; Cell Survival; Cyclophosphamide; Drug Synergism; Female; Half-Life; Kinetics; Male; Melphalan; Mice; Misonidazole; Nitroimidazoles; Time Factors	1983
Enhancement of the DNA cross-linking activity of melphalan by misonidazole in vivo. British journal of cancer, 1983, Volume: 47, Issue:2 Topics: Animals; Cross-Linking Reagents; DNA; DNA Repair; DNA, Neoplasm; Fibrosarcoma; Glutathione; Jejunum; Maleates; Melphalan; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Spleen	1983
In vitro inhibition of misonidazole toxicity and melphalan chemopotentiation by metyrapone. The British journal of radiology, 1983, Volume: 56, Issue:663 Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Dexamethasone; Dose-Response Relationship, Drug; Drug Synergism; Glutathione; Melphalan; Metyrapone; Misonidazole; Nitroimidazoles; Oxygen	1983
Mechanism of sensitization of Chinese hamster ovary cells to melphalan by hypoxic treatment with misonidazole. Cancer research, 1983, Volume: 43, Issue:7 Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA; DNA Repair; Dose-Response Relationship, Drug; Drug Synergism; Female; Glutathione; Maleates; Melphalan; Misonidazole; Nitroimidazoles; Ovary; Oxygen	1983
Chemosensitization by lipophilic nitroimidazoles. British journal of cancer, 1983, Volume: 48, Issue:1 Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Leukocyte Count; Lomustine; Male; Melphalan; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Time Factors	1983
Enhancement of the action of alkylating agents by single high, or chronic low doses of misonidazole. British journal of cancer, 1983, Volume: 48, Issue:2 Topics: Animals; Cell Survival; Cyclophosphamide; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Leukopenia; Melphalan; Mice; Mice, Inbred Strains; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Time Factors	1983
Phase I trial of intravenous L-phenylalanine mustard plus the sensitizer misonidazole. Cancer research, 1983, Volume: 43, Issue:10 Topics: Adult; Aged; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Melphalan; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles	1983
Effect of misonidazole or metronidazole pretreatment on the response of the RIF-1 mouse sarcoma to melphalan, cyclophosphamide, chlorambucil and CCNU. British journal of cancer, 1982, Volume: 45, Issue:3 Topics: Animals; Antineoplastic Agents; Cell Survival; Chlorambucil; Cyclophosphamide; Drug Synergism; Drug Therapy, Combination; Female; Lethal Dose 50; Leukocyte Count; Lomustine; Male; Melphalan; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental	1982
Misonidazole enhancement of the action of BCNU and melphalan against human melanoma xenografts. American journal of clinical oncology, 1982, Volume: 5, Issue:1 Topics: Animals; Antineoplastic Agents; Bone Marrow; Carmustine; Cell Line; Drug Synergism; Drug Therapy, Combination; Female; Humans; Male; Melanoma; Melphalan; Mice; Mice, Inbred CBA; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Transplantation, Heterologous	1982
Effect of clinical levels of misonidazole on the response of tumour and normal tissues in the mouse to alkylating agents. British journal of cancer, 1982, Volume: 45, Issue:5 Topics: Animals; Bone Marrow; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Female; Lethal Dose 50; Leukocyte Count; Melphalan; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental	1982
Enhancing effect of pre-treatment of cells with misonidazole in hypoxia on their response to melphalan in air. British journal of cancer, 1982, Volume: 46, Issue:1 Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Dithiothreitol; Dose-Response Relationship, Drug; Drug Synergism; Melphalan; Misonidazole; Nitroimidazoles; Oxygen; Time Factors	1982
The interaction of misonidazole with radiation, chemotherapeutic agents, or heat: a preliminary report. Cancer clinical trials, 1980,Fall, Volume: 3, Issue:3 Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Cisplatin; Cricetinae; Hot Temperature; Hypoxia; Mechlorethamine; Melphalan; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents	1980
Enhancement of the effect of cytotoxic drugs by radiosensitizers. British journal of cancer, 1981, Volume: 43, Issue:6 Topics: Animals; Cell Survival; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Fibrosarcoma; In Vitro Techniques; Melphalan; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Urination	1981
Enhancement of antitumor activity of alkylating agents by the radiation sensitizer misonidazole. Cancer research, 1980, Volume: 40, Issue:11 Topics: Alkylating Agents; Animals; Aziridines; Benzoquinones; Cyclohexenes; Cyclophosphamide; Drug Therapy, Combination; Female; Melphalan; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Quinones; Semustine	1980