misonidazole has been researched along with lomustine in 47 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 42 (89.36) | 18.7374 |
1990's | 5 (10.64) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Levin, VA | 1 |
Curry, B; Feldstein, M; Fulton, DS; Hanson, J; Huyser-Wierenga, D; Johnson, ES; Mielke, B; Scott-Brown, I; Urtasun, RC | 1 |
Siemann, DW; Sutherland, RM | 1 |
Wallen, CA; Wheeler, KT; Wong, KH | 2 |
Siemann, DW | 6 |
Ganz, JC; Hagen, S; Hatlevoll, R; Kristiansen, K; Lindegaard, KF; Mella, O; Nesbakken, R; Ringkjöb, R; Rosengren, B; Torvik, A | 1 |
Fulton, DS; McKinnon, S; Tanasichuk, H; Urtasun, RC | 1 |
Allalunis-Turner, MJ; Siemann, DW | 1 |
Gipp, JJ; Mulcahy, RT; Tanner, MA | 1 |
Anagnost, J; Bennett, JM; Boros, L; Mulcahy, RT; Siemann, DW; Sutherland, RM | 1 |
Cheeseman, KH; Lee, FY; Workman, P | 1 |
Chaplin, DJ; Durand, RE | 1 |
Hark, RR; Kende, AS; Mulcahy, RT; Wustrow, DJ | 1 |
Mulcahy, RT | 4 |
Workman, P | 1 |
Alliet, KL; Siemann, DW | 1 |
Alliet, K; Maddison, K; Siemann, DW; Wolf, K | 1 |
Mulcahy, RT; Siemann, DW | 2 |
Lee, FY; Walton, MI; Workman, P | 1 |
Hill, SA; Siemann, DW | 3 |
Hill, SA; Keng, PC; Maddison, K; Siemann, DW; Wolf, K | 1 |
Lee, FY; Workman, P | 4 |
Allen, J; Edwards, MS; Levin, VA; Ortega, J; Vestnys, P; Wara, WM | 1 |
Kehrberg, G; Moldenhauer, H; Rose, H; Saul, G; Wolf, G | 1 |
Adams, GE | 1 |
Hill, SA; Keng, PC; Siemann, DW | 1 |
Bauer, KD; Hill, SA; Keng, PC; Siemann, DW | 1 |
Siemann, DW; Wallen, CA; Wheeler, KT; Wolf, KL | 1 |
Morrissey, S; Siemann, DW; Wolf, K | 1 |
Twentyman, PR; Workman, P | 1 |
Twentyman, P; Workman, P | 1 |
Brown, JM; Hazlehurst, JL; Hirst, DG | 1 |
3 review(s) available for misonidazole and lomustine
Article | Year |
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[Intensification of cytostatic action by radiosensitizers--a review of the present status of chemosensitization].
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Chlorambucil; Cisplatin; Cricetinae; Cyclophosphamide; Doxorubicin; Etanidazole; Lomustine; Melphalan; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Modification of chemotherapy by nitroimidazoles.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; DNA Repair; Drug Synergism; Glutathione; Lomustine; Melphalan; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Time Factors | 1984 |
Potentiation of chemotherapy by hypoxic cell radiation sensitizers--a review.
Topics: Anaerobiosis; Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Drug Synergism; Lomustine; Mice; Misonidazole; Neoplasms, Experimental; Radiation-Sensitizing Agents | 1982 |
2 trial(s) available for misonidazole and lomustine
Article | Year |
---|---|
Increasing radiation dose intensity using hyperfractionation in patients with malignant glioma. Final report of a prospective phase I-II dose response study.
Topics: Adolescent; Adult; Age Factors; Aged; Astrocytoma; Brain; Brain Neoplasms; Cobalt Radioisotopes; Combined Modality Therapy; Cranial Irradiation; Dose-Response Relationship, Radiation; Female; Glioblastoma; Humans; Lomustine; Male; Middle Aged; Misonidazole; Multivariate Analysis; Necrosis; Proportional Hazards Models; Radiation Injuries; Radioisotope Teletherapy; Radiotherapy Dosage; Severity of Illness Index; Skin Diseases; Survival Analysis; Survival Rate; Treatment Outcome | 1992 |
Combined modality treatment of operated astrocytomas grade 3 and 4. A prospective and randomized study of misonidazole and radiotherapy with two different radiation schedules and subsequent CCNU chemotherapy. Stage II of a prospective multicenter trial of
Topics: Actuarial Analysis; Adult; Aged; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Female; Glioblastoma; Humans; Lomustine; Male; Middle Aged; Misonidazole; Nitroimidazoles; Radiotherapy Dosage; Random Allocation; Scandinavian and Nordic Countries; Telencephalon | 1985 |
42 other study(ies) available for misonidazole and lomustine
Article | Year |
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Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability.
Topics: Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Male; Models, Biological; Molecular Weight; Rats; Rats, Inbred F344; Solubility; Structure-Activity Relationship | 1980 |
Potentiation of alkylating chemotherapy by dual function nitrofurans in multi-cell spheroids and solid tumors.
Topics: Animals; Antineoplastic Agents; Aziridines; Bone Marrow; Carcinoma; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Lomustine; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Misonidazole; Nitrofurans; Radiation-Sensitizing Agents; Sarcoma, Experimental; Stem Cells; Tumor Cells, Cultured | 1992 |
2-Nitroimidazole potentiation of nitrosourea induced cytotoxicity in subcutaneous implants of rat 9L brain tumor cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Cell Line; Cell Survival; Drug Synergism; Etanidazole; Lomustine; Male; Misonidazole; Nitroimidazoles; Rats; Rats, Inbred F344; Streptozocin; Tumor Stem Cell Assay | 1991 |
Chemosensitization of the nitrosoureas by 2-nitroimidazoles in the subcutaneous 9L tumor model: pharmacokinetic and structure-activity considerations.
Topics: Animals; Carmustine; Drug Synergism; Etanidazole; Lomustine; Male; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Nitrosourea Compounds; Rats; Rats, Inbred F344; Structure-Activity Relationship | 1990 |
Enhancement of chemotherapy and nitroimidazole-induced chemopotentiation by the vasoactive agent hydralazine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Hypoxia; Cyclophosphamide; Drug Synergism; Female; Hydralazine; Lomustine; Melphalan; Mice; Mice, Inbred C3H; Misonidazole; Sarcoma, Experimental; Stem Cells | 1990 |
The chemosensitizing and cytotoxic effects of RSU 1164 and RSU 1165 in a murine tumor model.
Topics: Animals; Antineoplastic Agents; Cell Survival; Drug Synergism; Lomustine; Mice; Misonidazole; Oxygen; Radiation-Sensitizing Agents; Sarcoma, Experimental; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1989 |
Misonidazole and CCNU chemotherapy for recurrent primary brain tumor.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bone Marrow Diseases; Brain Neoplasms; Glioblastoma; Glioma; Humans; Lomustine; Middle Aged; Misonidazole; Neoplasm Recurrence, Local | 1987 |
Potentiation of combination chemotherapy by nitroheterocyclics.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Drug Synergism; Female; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1988 |
Enhancement of misonidazole chemopotentiation by mild hyperthermia (41 degrees C) in vitro and selective enhancement in vivo.
Topics: Aerobiosis; Animals; Cell Line; Combined Modality Therapy; Drug Synergism; Female; Hot Temperature; Hyperthermia, Induced; Lomustine; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Oxygen; Sarcoma, Experimental | 1987 |
Evaluation of CCNU and misonidazole in the treatment of advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Evaluation; Female; Humans; Lomustine; Male; Middle Aged; Misonidazole; Rectal Neoplasms | 1987 |
Misonidazole and benznidazole inhibit hydroxylation of CCNU by mouse liver microsomal cytochrome P-450 in vitro.
Topics: Animals; Cytochrome P-450 Enzyme System; Hydroxylation; In Vitro Techniques; Kinetics; Lomustine; Male; Mice; Mice, Inbred C3H; Microsomes, Liver; Misonidazole; Nitroimidazoles; Structure-Activity Relationship | 1987 |
Chemosensitization by misonidazole in CCNU-treated spheroids and tumours.
Topics: Animals; Cell Line; Cell Separation; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Humans; Lomustine; Misonidazole; Sarcoma, Experimental | 1987 |
Enhancement of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) toxicity by acetohydroxamic acid analogues of 3-nitropyrazole in vitro.
Topics: Cell Survival; Drug Synergism; Hydroxamic Acids; Lomustine; Misonidazole; Pyrazoles; Structure-Activity Relationship; Tumor Cells, Cultured | 1987 |
Misonidazole-induced chemopotentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea toxicity in O6-methylguanine-DNA methyltransferase proficient (Mer+) and deficient (Mer-) cell lines.
Topics: Animals; Cell Line; Cell Survival; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; HeLa Cells; Humans; Lomustine; Methyltransferases; Mice; Misonidazole; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase | 1986 |
Chemosensitization of lomustine by misonidazole, benznidazole, and RSU 1069.
Topics: Animals; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1986 |
Combinations of CCNU, MISO, and fractionated radiotherapy.
Topics: Animals; Combined Modality Therapy; Lomustine; Mice; Misonidazole; Radiation-Sensitizing Agents; Radiotherapy Dosage; Sarcoma, Experimental | 1986 |
Cross-link formation and chemopotentiation of EMT-6/Ro cells exposed to MISO after CCNU treatment in vitro.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Drug Synergism; In Vitro Techniques; Lomustine; Misonidazole; Neoplasms, Experimental | 1986 |
Enhancement of the antitumor efficacy of lomustine by the radiosensitizer RSU 1069.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Female; Lethal Dose 50; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Radiation-Protective Agents; Sarcoma | 1985 |
Sensitization of cancer chemotherapeutic agents by nitroheterocyclics.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cell Survival; Drug Synergism; Heterocyclic Compounds; Hydroxamic Acids; Hypoxia; Lomustine; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
Benznidazole: nitroreduction and inhibition of cytochrome P-450 in chemosensitization of tumour response to cytotoxic drugs.
Topics: Animals; Cell Survival; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Synergism; Kinetics; Lomustine; Mice; Microsomes, Liver; Misonidazole; Nitroimidazoles; Oxidation-Reduction | 1986 |
Increased therapeutic benefit through the addition of misonidazole to a nitrosourea-radiation combination.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Combined Modality Therapy; Dose-Response Relationship, Radiation; Female; Lomustine; Mice; Misonidazole; Neoplasms, Experimental; Skin | 1986 |
In vivo interaction between radiation and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the absence or presence of misonidazole in mice.
Topics: Animals; Combined Modality Therapy; Female; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Tumor Stem Cell Assay | 1985 |
Misonidazole protects mouse tumour and normal tissues from the toxicity of oral CCNU.
Topics: Administration, Oral; Animals; Drug Interactions; Fibrosarcoma; Injections, Intraperitoneal; Lethal Dose 50; Lomustine; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles | 1985 |
Chemopotentiation of CCNU metabolites by misonidazole.
Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Lomustine; Misonidazole; Nitroimidazoles | 1985 |
5-Fluorouracil and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) followed by hydroxyurea, misonidazole, and irradiation for brain stem gliomas: a pilot study of the Brain Tumor Research Center and the Childrens Cancer Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Brain Stem; Child; Child, Preschool; Cobalt Radioisotopes; Combined Modality Therapy; Dose-Response Relationship, Radiation; Female; Fluorouracil; Glioblastoma; Glioma; Humans; Hydroxyurea; Lomustine; Male; Misonidazole; Prognosis; Radioisotope Teletherapy | 1984 |
Radiosensitizers: a conference preview.
Topics: Animals; Aziridines; Buthionine Sulfoximine; Carmustine; Combined Modality Therapy; Drug Synergism; Etanidazole; Humans; Ketones; Lomustine; Maleates; Methionine Sulfoximine; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Nitroimidazoles as modifiers of nitrosourea pharmacokinetics.
Topics: Animals; Antineoplastic Agents; Carmustine; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Radiation-Sensitizing Agents; Semustine; Streptozocin; Time Factors | 1984 |
Response of murine tumours to combinations of CCNU with misonidazole and other radiation sensitizers.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Etanidazole; Female; Leukocyte Count; Lomustine; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1982 |
Effect of oxygen on misonidazole chemosensitization and cytotoxicity in vitro.
Topics: Aerobiosis; Animals; Cell Line; Cell Survival; Kinetics; Lomustine; Mammary Neoplasms, Experimental; Mice; Misonidazole; Nitroimidazoles; Oxygen | 1984 |
Survival in subpopulations of cells derived from solid KHT sarcomas by centrifugal elutriation following treatment with CCNU and MISO.
Topics: Animals; Cell Cycle; Cell Separation; Cell Survival; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1984 |
The effect in the KHT sarcoma of CCNU and MISO on cell cycle progression evaluated by flow-cytometry.
Topics: Animals; Cell Cycle; DNA, Neoplasm; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; RNA, Neoplasm; Sarcoma, Experimental | 1984 |
Enhanced tumor responses through therapies combining CCNU, MISO and radiation.
Topics: Animals; Combined Modality Therapy; Drug Synergism; Drug Therapy, Combination; Female; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Time Factors | 1984 |
Chemopotentiation in vivo: no loss of sensitization with fractionation.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Female; Leukocyte Count; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Sarcoma, Experimental | 1984 |
Misonidazole and CCNU: further evidence for a pharmacokinetic mechanism of chemosensitization and therapeutic gain.
Topics: Animals; Bone Marrow; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Intestine, Small; Kinetics; Lomustine; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1984 |
Hypoxic cells and in situ chemopotentiation of the nitrosoureas by misonidazole.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Lomustine; Misonidazole; Nitroimidazoles; Oxygen; Rats; Skin Neoplasms; Tumor Stem Cell Assay | 1984 |
In vivo potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by the radiation sensitizer benznidazole.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Radiation-Sensitizing Agents; Sarcoma, Experimental; Time Factors | 1983 |
Modification of CCNU pharmacokinetics by misonidazole--a major mechanism of chemosensitization in mice.
Topics: Animals; Blood Proteins; Cell Line; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Female; Half-Life; Kinetics; Lomustine; Male; Mice; Mice, Inbred Strains; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Nitrosourea Compounds | 1983 |
Chemosensitization by lipophilic nitroimidazoles.
Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Leukocyte Count; Lomustine; Male; Melphalan; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Time Factors | 1983 |
In vivo chemosensitization by misonidazole in sensitive and resistant tumor lines.
Topics: Animals; Carmustine; Cell Line; Drug Resistance; Drug Synergism; Humans; Leukemia L1210; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Sarcoma, Experimental | 1983 |
Effect of misonidazole or metronidazole pretreatment on the response of the RIF-1 mouse sarcoma to melphalan, cyclophosphamide, chlorambucil and CCNU.
Topics: Animals; Antineoplastic Agents; Cell Survival; Chlorambucil; Cyclophosphamide; Drug Synergism; Drug Therapy, Combination; Female; Lethal Dose 50; Leukocyte Count; Lomustine; Male; Melphalan; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1982 |
Enhancement of CCNU cytotoxicity by misonidazole: possible therapeutic gain.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Hematopoietic Stem Cells; Lomustine; Male; Mice; Mice, Inbred Strains; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Nitrosourea Compounds; Spermatogonia; Time Factors | 1982 |
In vivo combination of misonidazole and the chemotherapeutic agent CCNU.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Lomustine; Mice; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Sarcoma, Experimental; Time Factors | 1981 |