mirtazapine and clozapine

mirtazapine has been researched along with clozapine in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's17 (54.84)29.6817
2010's9 (29.03)24.3611
2020's5 (16.13)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Alonso, JM; Andrés, JI; Cid, JM; Díaz, A; Fernández, J; Gil, P; Iturrino, L; Megens, A; Sipido, VK; Trabanco, AA1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Lombardo, F; Obach, RS; Waters, NJ1
Ahman, M; Holmén, AG; Wan, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC1
Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Canale, A; Crucitti, D; D'Arrigo, C; Malara, G; Muscatello, MR; Spina, E; Torre, DL; Zoccali, R1
Cedro, C; Di Rosa, AE; La Torre, D; Meduri, M; Muscatello, MR; Neri, P; Spina, E; Zoccali, R1
Heiser, P; Krieg, JC; Singh, S; Vedder, H1
Appel, H; Fiedler, U; Jockers-Scherübl, MC; Klein, JP; Quante, A1
Bajbouj, M; Danker-Hopfe, H; Gallinat, J; Hellen, F; Lang, UE; Lisanby, SH; Neu, P; Vesper, J1
Biondi, M; Delle Chiaie, R; Fiorentini, S; Salviati, M1
Chaput, C; Mannoury La Cour, C; Millan, MJ; Touzard, M1
Lin, D; Lin, GY; Pan, XJ; Wang, XB; Wang, XQ; Wu, JZ; Xiang, Z1
Deckert, J; Hommers, LG; Menke, A; Samanski, L; Scherf-Clavel, M; Unterecker, S1
Aghazarian, V; Arlotto, E; Bambina, E; Guise-Honore, S; Laguin, S; Lo Presti, C1
Breivik, H; Frost, J; Løkken, TN; Slørdal, L1
Frankle, WG; Lequesne, E; Rohs, A; Zhang, E1
Cai, Z; Chen, J; Fang, T; Li, Q; Lin, C; Song, X; Tian, H; Yang, L; Zhang, Q; Zhou, C; Zhuo, C1
Grover, S; Sahoo, S; Sarkar, S1
Carvalho, AF; Chen, MH; Chu, CS; Correll, CU; Hsu, CW; Il Shin, J; Liang, CS; Stubbs, B; Thompson, T; Tseng, PT; Tu, YK; Yang, FC; Yang, SN; Yeh, TC; Yu, CL1

Reviews

3 review(s) available for mirtazapine and clozapine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Augmentation strategies for clozapine resistance: a systematic review and meta-analysis.
    Acta neuropsychiatrica, 2023, Volume: 35, Issue:2

    Topics: Antipsychotic Agents; Clozapine; Humans; Mirtazapine; Risperidone; Schizophrenia

2023
Pharmacological and nonpharmacological augmentation treatments for clozapine-resistant schizophrenia: A systematic review and network meta-analysis with normalized entropy assessment.
    Asian journal of psychiatry, 2023, Volume: 79

    Topics: Antipsychotic Agents; Clozapine; Entropy; Humans; Memantine; Mirtazapine; Network Meta-Analysis; Schizophrenia

2023

Trials

3 trial(s) available for mirtazapine and clozapine

ArticleYear
The effect of mirtazapine augmentation of clozapine in the treatment of negative symptoms of schizophrenia: a double-blind, placebo-controlled study.
    International clinical psychopharmacology, 2004, Volume: 19, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adult; Antipsychotic Agents; Clozapine; Double-Blind Method; Drug Synergism; Female; Humans; Male; Mianserin; Middle Aged; Mirtazapine; Psychiatric Status Rating Scales; Receptors, Serotonin, 5-HT2; Receptors, Serotonin, 5-HT3; Schizophrenia; Serotonin Antagonists; Time Factors; Treatment Outcome

2004
Motor cortex excitability after vagus nerve stimulation in major depression.
    Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:2

    Topics: Adult; Benzodiazepines; Citalopram; Clomipramine; Clozapine; Depressive Disorder; Doxepin; Drug Therapy, Combination; Electric Stimulation; Female; Humans; Lamotrigine; Lithium Carbonate; Male; Mianserin; Middle Aged; Mirtazapine; Morpholines; Motor Cortex; Neural Conduction; Neural Inhibition; Olanzapine; Paroxetine; Psychiatric Status Rating Scales; Reboxetine; Tranylcypromine; Triazines; Vagus Nerve; Valproic Acid

2007
Add-on mirtazapine enhances effects on cognition in schizophrenic patients under stabilized treatment with clozapine.
    Experimental and clinical psychopharmacology, 2007, Volume: 15, Issue:6

    Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Antipsychotic Agents; Brief Psychiatric Rating Scale; Chronic Disease; Clozapine; Cognition; Cognition Disorders; Diagnostic and Statistical Manual of Mental Disorders; Drug Synergism; Female; Humans; Male; Mianserin; Mirtazapine; Schizophrenia; Time Factors

2007

Other Studies

25 other study(ies) available for mirtazapine and clozapine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.
    Journal of medicinal chemistry, 2005, Mar-24, Volume: 48, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; In Vitro Techniques; Mice; Psychotropic Drugs; Radioligand Assay; Rats; Stereoisomerism; Structure-Activity Relationship

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
    Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24

    Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility

2010
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3

    Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Lack of a pharmacokinetic interaction between mirtazapine and the newer antipsychotics clozapine, risperidone and olanzapine in patients with chronic schizophrenia.
    Pharmacological research, 2003, Volume: 48, Issue:4

    Topics: Administration, Oral; Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Clinical Trials as Topic; Clozapine; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Italy; Male; Mianserin; Middle Aged; Mirtazapine; Olanzapine; Psychiatric Status Rating Scales; Risperidone; Schizophrenia; Time Factors

2003
Effects of different antipsychotics and the antidepressant mirtazapine on glucose transporter mRNA levels in human blood cells.
    Journal of psychiatric research, 2006, Volume: 40, Issue:4

    Topics: Actins; Analysis of Variance; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Blood Cells; Clozapine; Glucose Transporter Type 3; Glucose Transporter Type 4; Glucose Transporter Type 5; Haloperidol; Humans; Mianserin; Mirtazapine; Olanzapine; RNA, Messenger; U937 Cells

2006
Massive creatine kinase elevations with quetiapine: report of two cases.
    Pharmacopsychiatry, 2006, Volume: 39, Issue:1

    Topics: Adult; Aged; Antipsychotic Agents; Benzodiazepines; Clozapine; Creatine Kinase; Depressive Disorder, Major; Dibenzothiazepines; Humans; Male; Mianserin; Mirtazapine; Olanzapine; Pain; Psychotic Disorders; Quetiapine Fumarate

2006
An immunocapture/scintillation proximity analysis of G alpha q/11 activation by native serotonin (5-HT)2A receptors in rat cortex: blockade by clozapine and mirtazapine.
    Synapse (New York, N.Y.), 2009, Volume: 63, Issue:2

    Topics: Adrenergic alpha-Antagonists; Amphetamines; Animals; Cerebral Cortex; Clozapine; GTP-Binding Protein alpha Subunits, Gq-G11; Male; Mianserin; Mirtazapine; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Scintillation Counting; Serotonin Antagonists; Serotonin Receptor Agonists

2009
[Simultaneous determination of clozapine, olanzapine and mirtazapine in human plasma by LC-MS/MS].
    Fa yi xue za zhi, 2009, Volume: 25, Issue:2

    Topics: Benzodiazepines; Chromatography, Liquid; Clozapine; Forensic Toxicology; Humans; Mianserin; Mirtazapine; Olanzapine; Tandem Mass Spectrometry

2009
Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2.
    International clinical psychopharmacology, 2019, Volume: 34, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Clozapine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Desvenlafaxine Succinate; Doxepin; Drug Monitoring; Female; Glucuronosyltransferase; Humans; Male; Middle Aged; Mirtazapine; Nortriptyline; Paliperidone Palmitate; Quetiapine Fumarate; Retrospective Studies; Risperidone; Smoking; Venlafaxine Hydrochloride

2019
Case report: Pharmacokinetic interaction between clozapine and mirtazapine.
    L'Encephale, 2019, Volume: 45, Issue:4

    Topics: Antidepressive Agents; Antipsychotic Agents; Clozapine; Drug Interactions; Drug Therapy, Combination; Humans; Male; Middle Aged; Mirtazapine; Schizophrenia

2019
A Validated Method for the Simultaneous Determination of Quetiapine, Clozapine and Mirtazapine in Postmortem Blood and Tissue Samples.
    Journal of analytical toxicology, 2020, Apr-02, Volume: 44, Issue:5

    Topics: Antipsychotic Agents; Autopsy; Clozapine; Forensic Toxicology; Humans; Mirtazapine; Psychotropic Drugs; Quetiapine Fumarate

2020
Suspected Recurrence of Symptomatic COVID-19: Management During Inpatient Psychiatric Treatment.
    Journal of psychiatric practice, 2021, Mar-05, Volume: 27, Issue:2

    Topics: Adult; Alcoholism; Antidepressive Agents; Antipsychotic Agents; Clozapine; COVID-19; COVID-19 Nucleic Acid Testing; Depressive Disorder, Major; Hospitals, Psychiatric; Humans; Inpatients; Male; Mirtazapine; Psychotic Disorders; Recurrence; SARS-CoV-2; Sertraline; Suicide, Attempted

2021
Electrical stimulus combined with venlafaxine and mirtazapine improves brain Ca
    Journal of affective disorders, 2022, 12-15, Volume: 319

    Topics: Animals; Clozapine; Depressive Disorder, Major; Humans; Mice; Mirtazapine; Prefrontal Cortex; Schizophrenia; Venlafaxine Hydrochloride

2022