mirtazapine and 8-hydroxymirtazapine

mirtazapine has been researched along with 8-hydroxymirtazapine in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (58.33)29.6817
2010's5 (41.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Greenblatt, DJ; Störmer, E; von Moltke, LL1
Baumann, P; Cochard, N; Eap, CB; Jonzier-Perey, M; Paus, E1
Brockmöller, J; Kirchheiner, J; Meineke, I; Steinmetz, H1
Baumann, P; Jonzier-Perey, M; Nikisch, G; Paus, E1
Aturki, Z; D'Orazio, G; Fanali, S; Raggi, MA; Rocco, A; Scotti, V1
Bonato, PS; de Santana, FJ; Lanchote, VL1
Ahlner, J; Baumann, P; Bengtsson, F; Dahl, ML; Jonzier-Perey, M; Lind, AB; Powell Golay, K; Reis, M1
Bonato, PS; Cesarino, EJ; de Santana, FJ; Jabor, VA; Lanchote, VL1
Giorgi, M; Yun, H1
Cao, WQ; Fan, GR; Gao, FY; Li, J; Wen, J; Yang, N; Zhang, WT1
Aghamohammadhasani, M; Chamsaz, M; Ghorbani, M; Lahoori, NA; Rounaghi, GH; Seyedin, O1
Akiyama, K; Hayashi, Y; Inoue, Y; Kato, K; Komahashi-Sasaki, H; Ozeki, Y; Pierce, J; Sasaki, T; Shimoda, K; Shinozaki, M; Tsuchimine, S; Watanabe, T; Yasui-Furukori, N1

Trials

1 trial(s) available for mirtazapine and 8-hydroxymirtazapine

ArticleYear
Chirality in the new generation of antidepressants: stereoselective analysis of the enantiomers of mirtazapine, N-demethylmirtazapine, and 8-hydroxymirtazapine by LC-MS.
    Therapeutic drug monitoring, 2004, Volume: 26, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Chromatography, Liquid; Female; Humans; Male; Mass Spectrometry; Mianserin; Middle Aged; Mirtazapine; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism

2004

Other Studies

11 other study(ies) available for mirtazapine and 8-hydroxymirtazapine

ArticleYear
Scaling drug biotransformation data from cDNA-expressed cytochrome P-450 to human liver: a comparison of relative activity factors and human liver abundance in studies of mirtazapine metabolism.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:2

    Topics: Biotransformation; Cytochrome P-450 Enzyme System; Data Interpretation, Statistical; DNA, Complementary; Humans; Isoenzymes; Kinetics; Mianserin; Microsomes, Liver; Mirtazapine; Predictive Value of Tests; Recombinant Proteins

2000
Therapeutic drug monitoring of mirtazapine, desmethylmirtazapine, 8-hydroxymirtazapine, and mirtazapine-N-oxide by enantioselective HPLC with fluorescence detection.
    Therapeutic drug monitoring, 2006, Volume: 28, Issue:6

    Topics: Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Cyclic N-Oxides; Drug Monitoring; Fluorescence; Humans; Male; Mianserin; Mirtazapine; Quality Control; Stereoisomerism

2006
Mirtazapine enantiomers in blood and cerebrospinal fluid.
    Neuropsychobiology, 2006, Volume: 54, Issue:3

    Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Administration Schedule; Humans; Male; Mianserin; Mirtazapine; Severity of Illness Index; Stereoisomerism

2006
Enantioselective separation of the novel antidepressant mirtazapine and its main metabolites by CEC.
    Electrophoresis, 2007, Volume: 28, Issue:15

    Topics: Antidepressive Agents; Capillary Electrochromatography; Humans; Mianserin; Mirtazapine; Stereoisomerism; Vancomycin

2007
Capillary electrophoretic chiral determination of mirtazapine and its main metabolites in human urine after enzymatic hydrolysis.
    Electrophoresis, 2008, Volume: 29, Issue:18

    Topics: Electrophoresis, Capillary; Humans; Hydrolysis; Mianserin; Mirtazapine; Temperature

2008
Steady-state concentrations of mirtazapine, N-desmethylmirtazapine, 8-hydroxymirtazapine and their enantiomers in relation to cytochrome P450 2D6 genotype, age and smoking behaviour.
    Clinical pharmacokinetics, 2009, Volume: 48, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Female; Genotype; Humans; Male; Mianserin; Middle Aged; Mirtazapine; Prospective Studies; Smoking; Stereoisomerism

2009
Enantioselective analysis of mirtazapine, demethylmirtazapine and 8-hydroxy mirtazapine in human urine after solid-phase microextraction.
    Journal of separation science, 2010, Volume: 33, Issue:2

    Topics: Antidepressive Agents, Tricyclic; Buffers; Chromatography, Liquid; Humans; Hydrogen-Ion Concentration; Mianserin; Mirtazapine; Osmolar Concentration; Reproducibility of Results; Solid Phase Microextraction; Stereoisomerism; Tandem Mass Spectrometry

2010
Pharmacokinetics of mirtazapine and its main metabolites in Beagle dogs: a pilot study.
    Veterinary journal (London, England : 1997), 2012, Volume: 192, Issue:2

    Topics: Administration, Oral; Animals; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Dogs; Half-Life; Male; Metabolic Clearance Rate; Mianserin; Mirtazapine; Pilot Projects

2012
Enantioselective separation of mirtazapine and its metabolites by capillary electrophoresis with acetonitrile field-amplified sample stacking and its application.
    Molecules (Basel, Switzerland), 2014, Apr-17, Volume: 19, Issue:4

    Topics: Acetonitriles; Administration, Oral; Antidepressive Agents, Tricyclic; beta-Cyclodextrins; Biotransformation; Buffers; Chemical Fractionation; Cyclic N-Oxides; Electrophoresis, Capillary; Humans; Limit of Detection; Male; Mianserin; Mirtazapine; Reproducibility of Results; Stereoisomerism

2014
Development of a novel ultrasonic-assisted magnetic dispersive solid-phase microextraction method coupled with high performance liquid chromatography for determination of mirtazapine and its metabolites in human urine and water samples employing experimen
    Analytical and bioanalytical chemistry, 2016, Volume: 408, Issue:27

    Topics: Adsorption; Aniline Compounds; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Factor Analysis, Statistical; Fresh Water; Graphite; Healthy Volunteers; Humans; Magnets; Mianserin; Mirtazapine; Nanocomposites; Oxides; Solid Phase Microextraction; Sonication; Water Pollutants, Chemical

2016
8-Hydroxylation and Glucuronidation of Mirtazapine in Japanese Psychiatric Patients: Significance of the Glucuronidation Pathway of 8-Hydroxy-Mirtazapine.
    Pharmacopsychiatry, 2019, Volume: 52, Issue:5

    Topics: Age Factors; Alleles; Anti-Anxiety Agents; Asian People; Cytochrome P-450 CYP2D6; Genotype; Glucuronides; Humans; Hydroxylation; Japan; Mental Disorders; Mianserin; Mirtazapine; Smoking

2019